6E7I
Human ppGalNAcT2 I253A/L310A Mutant with EA2 and UDP
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 23 |
| Details | binding site for residue UDP A 601 |
| Chain | Residue |
| A | THR143 |
| A | HIS226 |
| A | VAL330 |
| A | TRP331 |
| A | HIS359 |
| A | ARG362 |
| A | HIS365 |
| A | TYR367 |
| A | MN602 |
| A | HOH705 |
| A | HOH746 |
| A | PHE144 |
| A | HOH803 |
| A | HOH855 |
| A | HOH889 |
| P | THR7 |
| A | HIS145 |
| A | ASP176 |
| A | ARG201 |
| A | GLY203 |
| A | LEU204 |
| A | ASP224 |
| A | SER225 |
| site_id | AC2 |
| Number of Residues | 5 |
| Details | binding site for residue MN A 602 |
| Chain | Residue |
| A | ASP224 |
| A | HIS226 |
| A | HIS359 |
| A | UDP601 |
| A | HOH855 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 7 |
| Details | BINDING: BINDING => ECO:0000269|PubMed:16434399, ECO:0000269|PubMed:24954443, ECO:0000269|PubMed:25939779, ECO:0007744|PDB:2FFU, ECO:0007744|PDB:2FFV, ECO:0007744|PDB:4D0T, ECO:0007744|PDB:4D11, ECO:0007744|PDB:5AJP, ECO:0007744|PDB:5FV9 |
| Chain | Residue | Details |
| A | THR143 | |
| A | ASP176 | |
| A | ARG201 | |
| A | SER225 | |
| A | TRP331 | |
| A | ARG362 | |
| A | HIS365 |
| site_id | SWS_FT_FI2 |
| Number of Residues | 3 |
| Details | BINDING: BINDING => ECO:0000269|PubMed:16434399, ECO:0000269|PubMed:24954443, ECO:0000269|PubMed:25939779, ECO:0007744|PDB:2FFU, ECO:0007744|PDB:2FFV, ECO:0007744|PDB:4D0T, ECO:0007744|PDB:4D0Z, ECO:0007744|PDB:4D11, ECO:0007744|PDB:5AJP, ECO:0007744|PDB:5FV9 |
| Chain | Residue | Details |
| A | ASP224 | |
| A | HIS226 | |
| A | HIS359 |
| site_id | SWS_FT_FI3 |
| Number of Residues | 1 |
| Details | BINDING: BINDING => ECO:0000269|PubMed:16434399, ECO:0000269|PubMed:24954443, ECO:0000269|PubMed:25939779, ECO:0007744|PDB:2FFU, ECO:0007744|PDB:2FFV, ECO:0007744|PDB:4D0T, ECO:0007744|PDB:4D0Z, ECO:0007744|PDB:4D11, ECO:0007744|PDB:5AJN, ECO:0007744|PDB:5AJO, ECO:0007744|PDB:5AJP, ECO:0007744|PDB:5FV9, ECO:0007744|PDB:5NDF, ECO:0007744|PDB:6EGS |
| Chain | Residue | Details |
| A | TYR367 |
| site_id | SWS_FT_FI4 |
| Number of Residues | 1 |
| Details | SITE: Not glycosylated |
| Chain | Residue | Details |
| A | ASN516 |
| site_id | SWS_FT_FI5 |
| Number of Residues | 1 |
| Details | MOD_RES: Phosphoserine => ECO:0007744|PubMed:23186163 |
| Chain | Residue | Details |
| A | SER536 |
