6E4Z

Anti-PCSK9 fab 6E2 bound to the modified N-terminal peptide from PCSK9

Functional Information from PDB Data

site_id	AC1
Number of Residues	4
Details	binding site for residue ZN H 301

Chain	Residue
H	ASP53
L	ASP60
L	HOH446
P	GLU48

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site_id	AC2
Number of Residues	4
Details	binding site for residue ZN L 301

Chain	Residue
H	HIS164
L	ASN137
L	ASN138
L	HOH414

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site_id	AC3
Number of Residues	3
Details	binding site for residue ZN L 302

Chain	Residue
L	HIS189
L	SO4305
L	ASP185

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site_id	AC4
Number of Residues	2
Details	binding site for residue ZN L 303

Chain	Residue
L	GLU81
L	HOH438

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site_id	AC5
Number of Residues	4
Details	binding site for residue ZN L 304

Chain	Residue
L	HIS27
L	HOH442
P	SEP47
P	GLU49

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site_id	AC6
Number of Residues	4
Details	binding site for residue SO4 L 305

Chain	Residue
L	GLN155
L	ASP185
L	HIS189
L	ZN302

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Functional Information from PROSITE/UniProt

site_id	PS00290
Number of Residues	7
Details	IG_MHC Immunoglobulins and major histocompatibility complex proteins signature. YACEVTH

Chain	Residue	Details
H	TYR194-HIS200
L	TYR192-HIS198

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Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	1
Details	MOD_RES: Sulfotyrosine => ECO:0000269|PubMed:16912035

Chain	Residue	Details
P	TYS38

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site_id	SWS_FT_FI2
Number of Residues	1
Details	MOD_RES: Phosphoserine; by FAM20C => ECO:0000269|PubMed:18498363, ECO:0000269|PubMed:26091039

Chain	Residue	Details
P	SEP47

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