6DS6

Crystal structure of p300 ZZ domain in complex with histone H3 peptide

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0004402	molecular_function	histone acetyltransferase activity
A	0006355	biological_process	regulation of DNA-templated transcription
A	0008270	molecular_function	zinc ion binding

Functional Information from PDB Data

site_id	AC1
Number of Residues	4
Details	binding site for residue ZN A 5001

Chain	Residue
A	CYS14
A	CYS17
A	CYS36
A	CYS39

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site_id	AC2
Number of Residues	4
Details	binding site for residue ZN A 5002

Chain	Residue
A	CYS27
A	CYS30
A	HIS45
A	HIS47

---

site_id	AC3
Number of Residues	4
Details	binding site for residue CL A 5003

Chain	Residue
A	ILE37
A	LYS51
A	HOH5141
A	TRP25

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Functional Information from PROSITE/UniProt

site_id	PS01357
Number of Residues	26
Details	ZF_ZZ_1 Zinc finger ZZ-type signature. CneCkhhvet..RWhCtv...CeDYdLCitC

Chain	Residue	Details
A	CYS14-CYS39

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Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	48
Details	ZN_FING: ZZ-type => ECO:0000255|PROSITE-ProRule:PRU00228

Chain	Residue	Details
A	ARG9-ASP57

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site_id	SWS_FT_FI2
Number of Residues	8
Details	BINDING: BINDING => ECO:0000255|PROSITE-ProRule:PRU00228

Chain	Residue	Details
A	CYS14
A	CYS17
A	CYS27
A	CYS30
A	CYS36
A	CYS39
A	HIS45
A	HIS47

---

site_id	SWS_FT_FI3
Number of Residues	3
Details	MOD_RES: N6-acetyllysine => ECO:0000269|PubMed:18995842

Chain	Residue	Details
A	LYS43
A	LYS48
A	LYS51

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