6DJW
Crystal Structure of pParkin (REP and RING2 deleted)-pUb-UbcH7 complex
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0004842 | molecular_function | ubiquitin-protein transferase activity |
| A | 0005739 | cellular_component | mitochondrion |
| A | 0005829 | cellular_component | cytosol |
| A | 0008270 | molecular_function | zinc ion binding |
| C | 0000151 | cellular_component | ubiquitin ligase complex |
| C | 0000166 | molecular_function | nucleotide binding |
| C | 0000209 | biological_process | protein polyubiquitination |
| C | 0003713 | molecular_function | transcription coactivator activity |
| C | 0003723 | molecular_function | RNA binding |
| C | 0004842 | molecular_function | ubiquitin-protein transferase activity |
| C | 0005515 | molecular_function | protein binding |
| C | 0005524 | molecular_function | ATP binding |
| C | 0005634 | cellular_component | nucleus |
| C | 0005654 | cellular_component | nucleoplasm |
| C | 0005737 | cellular_component | cytoplasm |
| C | 0005829 | cellular_component | cytosol |
| C | 0006351 | biological_process | DNA-templated transcription |
| C | 0006355 | biological_process | regulation of DNA-templated transcription |
| C | 0006511 | biological_process | ubiquitin-dependent protein catabolic process |
| C | 0008283 | biological_process | cell population proliferation |
| C | 0016567 | biological_process | protein ubiquitination |
| C | 0016740 | molecular_function | transferase activity |
| C | 0019787 | molecular_function | ubiquitin-like protein transferase activity |
| C | 0019899 | molecular_function | enzyme binding |
| C | 0031398 | biological_process | positive regulation of protein ubiquitination |
| C | 0031625 | molecular_function | ubiquitin protein ligase binding |
| C | 0032446 | biological_process | protein modification by small protein conjugation |
| C | 0036211 | biological_process | protein modification process |
| C | 0044770 | biological_process | cell cycle phase transition |
| C | 0045893 | biological_process | positive regulation of DNA-templated transcription |
| C | 0061631 | molecular_function | ubiquitin conjugating enzyme activity |
| C | 0070979 | biological_process | protein K11-linked ubiquitination |
| C | 0071383 | biological_process | cellular response to steroid hormone stimulus |
| C | 0071385 | biological_process | cellular response to glucocorticoid stimulus |
| C | 0097027 | molecular_function | ubiquitin-protein transferase activator activity |
| C | 1903955 | biological_process | positive regulation of protein targeting to mitochondrion |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 4 |
| Details | binding site for residue ZN A 1001 |
| Chain | Residue |
| A | CYS192 |
| A | CYS195 |
| A | CYS222 |
| A | CYS229 |
| site_id | AC2 |
| Number of Residues | 4 |
| Details | binding site for residue ZN A 1002 |
| Chain | Residue |
| A | CYS177 |
| A | CYS180 |
| A | CYS246 |
| A | HIS249 |
| site_id | AC3 |
| Number of Residues | 4 |
| Details | binding site for residue ZN A 1003 |
| Chain | Residue |
| A | CYS276 |
| A | CYS295 |
| A | CYS298 |
| A | CYS273 |
| site_id | AC4 |
| Number of Residues | 4 |
| Details | binding site for residue ZN A 1004 |
| Chain | Residue |
| A | CYS288 |
| A | HIS292 |
| A | CYS324 |
| A | CYS328 |
| site_id | AC5 |
| Number of Residues | 4 |
| Details | binding site for residue ZN A 1005 |
| Chain | Residue |
| A | CYS396 |
| A | CYS399 |
| A | HIS404 |
| A | CYS408 |
| site_id | AC6 |
| Number of Residues | 4 |
| Details | binding site for residue ZN A 1006 |
| Chain | Residue |
| A | CYS367 |
| A | CYS372 |
| A | CYS387 |
| A | CYS391 |
Functional Information from PROSITE/UniProt
| site_id | PS00299 |
| Number of Residues | 26 |
| Details | UBIQUITIN_1 Ubiquitin domain signature. KakIqDkegIPpdqQrLIFaGkqleD |
| Chain | Residue | Details |
| B | LYS27-ASP52 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI3 |
| Number of Residues | 1 |
| Details | Site: {"description":"Interacts with activating enzyme"} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI4 |
| Number of Residues | 1 |
| Details | Site: {"description":"Essential for function"} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI5 |
| Number of Residues | 1 |
| Details | Modified residue: {"description":"Phosphoserine; by PINK1","evidences":[{"source":"UniProtKB","id":"P62979","evidenceCode":"ECO:0000250"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI6 |
| Number of Residues | 8 |
| Details | Cross-link: {"description":"Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin)","evidences":[{"source":"UniProtKB","id":"P62979","evidenceCode":"ECO:0000250"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI7 |
| Number of Residues | 147 |
| Details | Domain: {"description":"UBC core","evidences":[{"source":"PROSITE-ProRule","id":"PRU00388","evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI8 |
| Number of Residues | 1 |
| Details | Active site: {"description":"Glycyl thioester intermediate","evidences":[{"source":"PROSITE-ProRule","id":"PRU00388","evidenceCode":"ECO:0000255"},{"source":"PROSITE-ProRule","id":"PRU10133","evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI9 |
| Number of Residues | 1 |
| Details | Modified residue: {"description":"N6-acetyllysine","evidences":[{"source":"PubMed","id":"19608861","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
Catalytic Information from CSA
