Summary Structural details Experimental details Functional details Sequence Neighbor History Downloads

6DFT

Trypanosoma brucei deoxyhypusine synthase

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0005515	molecular_function	protein binding
A	0005737	cellular_component	cytoplasm
A	0008216	biological_process	spermidine metabolic process
A	0008612	biological_process	peptidyl-lysine modification to peptidyl-hypusine
A	0016020	cellular_component	membrane
A	0016740	molecular_function	transferase activity
A	0034038	molecular_function	deoxyhypusine synthase activity
A	0042803	molecular_function	protein homodimerization activity
A	0051290	biological_process	protein heterotetramerization
A	1902494	cellular_component	catalytic complex
A	2000765	biological_process	regulation of cytoplasmic translation
B	0005737	cellular_component	cytoplasm
B	0008047	molecular_function	enzyme activator activity
B	0008216	biological_process	spermidine metabolic process
B	0008612	biological_process	peptidyl-lysine modification to peptidyl-hypusine
B	0019899	molecular_function	enzyme binding
B	0034038	molecular_function	deoxyhypusine synthase activity
B	0042803	molecular_function	protein homodimerization activity
B	0043085	biological_process	positive regulation of catalytic activity
B	0051290	biological_process	protein heterotetramerization
B	1902494	cellular_component	catalytic complex
B	2000765	biological_process	regulation of cytoplasmic translation
C	0005515	molecular_function	protein binding
C	0005737	cellular_component	cytoplasm
C	0008216	biological_process	spermidine metabolic process
C	0008612	biological_process	peptidyl-lysine modification to peptidyl-hypusine
C	0016020	cellular_component	membrane
C	0016740	molecular_function	transferase activity
C	0034038	molecular_function	deoxyhypusine synthase activity
C	0042803	molecular_function	protein homodimerization activity
C	0051290	biological_process	protein heterotetramerization
C	1902494	cellular_component	catalytic complex
C	2000765	biological_process	regulation of cytoplasmic translation
D	0005737	cellular_component	cytoplasm
D	0008047	molecular_function	enzyme activator activity
D	0008216	biological_process	spermidine metabolic process
D	0008612	biological_process	peptidyl-lysine modification to peptidyl-hypusine
D	0019899	molecular_function	enzyme binding
D	0034038	molecular_function	deoxyhypusine synthase activity
D	0042803	molecular_function	protein homodimerization activity
D	0043085	biological_process	positive regulation of catalytic activity
D	0051290	biological_process	protein heterotetramerization
D	1902494	cellular_component	catalytic complex
D	2000765	biological_process	regulation of cytoplasmic translation
E	0005515	molecular_function	protein binding
E	0005737	cellular_component	cytoplasm
E	0008216	biological_process	spermidine metabolic process
E	0008612	biological_process	peptidyl-lysine modification to peptidyl-hypusine
E	0016020	cellular_component	membrane
E	0016740	molecular_function	transferase activity
E	0034038	molecular_function	deoxyhypusine synthase activity
E	0042803	molecular_function	protein homodimerization activity
E	0051290	biological_process	protein heterotetramerization
E	1902494	cellular_component	catalytic complex
E	2000765	biological_process	regulation of cytoplasmic translation
F	0005737	cellular_component	cytoplasm
F	0008047	molecular_function	enzyme activator activity
F	0008216	biological_process	spermidine metabolic process
F	0008612	biological_process	peptidyl-lysine modification to peptidyl-hypusine
F	0019899	molecular_function	enzyme binding
F	0034038	molecular_function	deoxyhypusine synthase activity
F	0042803	molecular_function	protein homodimerization activity
F	0043085	biological_process	positive regulation of catalytic activity
F	0051290	biological_process	protein heterotetramerization
F	1902494	cellular_component	catalytic complex
F	2000765	biological_process	regulation of cytoplasmic translation
G	0005515	molecular_function	protein binding
G	0005737	cellular_component	cytoplasm
G	0008216	biological_process	spermidine metabolic process
G	0008612	biological_process	peptidyl-lysine modification to peptidyl-hypusine
G	0016020	cellular_component	membrane
G	0016740	molecular_function	transferase activity
G	0034038	molecular_function	deoxyhypusine synthase activity
G	0042803	molecular_function	protein homodimerization activity
G	0051290	biological_process	protein heterotetramerization
G	1902494	cellular_component	catalytic complex
G	2000765	biological_process	regulation of cytoplasmic translation
H	0005737	cellular_component	cytoplasm
H	0008047	molecular_function	enzyme activator activity
H	0008216	biological_process	spermidine metabolic process
H	0008612	biological_process	peptidyl-lysine modification to peptidyl-hypusine
H	0019899	molecular_function	enzyme binding
H	0034038	molecular_function	deoxyhypusine synthase activity
H	0042803	molecular_function	protein homodimerization activity
H	0043085	biological_process	positive regulation of catalytic activity
H	0051290	biological_process	protein heterotetramerization
H	1902494	cellular_component	catalytic complex
H	2000765	biological_process	regulation of cytoplasmic translation
I	0005515	molecular_function	protein binding
I	0005737	cellular_component	cytoplasm
I	0008216	biological_process	spermidine metabolic process
I	0008612	biological_process	peptidyl-lysine modification to peptidyl-hypusine
I	0016020	cellular_component	membrane
I	0016740	molecular_function	transferase activity
I	0034038	molecular_function	deoxyhypusine synthase activity
I	0042803	molecular_function	protein homodimerization activity
I	0051290	biological_process	protein heterotetramerization
I	1902494	cellular_component	catalytic complex
I	2000765	biological_process	regulation of cytoplasmic translation
J	0005737	cellular_component	cytoplasm
J	0008047	molecular_function	enzyme activator activity
J	0008216	biological_process	spermidine metabolic process
J	0008612	biological_process	peptidyl-lysine modification to peptidyl-hypusine
J	0019899	molecular_function	enzyme binding
J	0034038	molecular_function	deoxyhypusine synthase activity
J	0042803	molecular_function	protein homodimerization activity
J	0043085	biological_process	positive regulation of catalytic activity
J	0051290	biological_process	protein heterotetramerization
J	1902494	cellular_component	catalytic complex
J	2000765	biological_process	regulation of cytoplasmic translation
K	0005515	molecular_function	protein binding
K	0005737	cellular_component	cytoplasm
K	0008216	biological_process	spermidine metabolic process
K	0008612	biological_process	peptidyl-lysine modification to peptidyl-hypusine
K	0016020	cellular_component	membrane
K	0016740	molecular_function	transferase activity
K	0034038	molecular_function	deoxyhypusine synthase activity
K	0042803	molecular_function	protein homodimerization activity
K	0051290	biological_process	protein heterotetramerization
K	1902494	cellular_component	catalytic complex
K	2000765	biological_process	regulation of cytoplasmic translation
L	0005737	cellular_component	cytoplasm
L	0008047	molecular_function	enzyme activator activity
L	0008216	biological_process	spermidine metabolic process
L	0008612	biological_process	peptidyl-lysine modification to peptidyl-hypusine
L	0019899	molecular_function	enzyme binding
L	0034038	molecular_function	deoxyhypusine synthase activity
L	0042803	molecular_function	protein homodimerization activity
L	0043085	biological_process	positive regulation of catalytic activity
L	0051290	biological_process	protein heterotetramerization
L	1902494	cellular_component	catalytic complex
L	2000765	biological_process	regulation of cytoplasmic translation

Functional Information from PDB Data

site_id	AC1
Number of Residues	1
Details	binding site for residue NA A 501

Chain	Residue
A	ASN100

site_id	AC2
Number of Residues	24
Details	binding site for residue NAD A 502

Chain	Residue
A	ASP328
A	GLY371
A	GLY372
A	ASN396
A	ASN397
A	ALA398
A	GLU431
A	VAL432
B	GLY262
B	LEU263
A	THR98
B	HIS266
B	ASP287
B	CYS289
B	GLU290
B	SER291
B	NAD500
A	ASN100
A	LEU101
A	SER161
A	GLY162
A	GLY163
A	SER323
A	ASP326

site_id	AC3
Number of Residues	28
Details	binding site for residue NAD B 500

Chain	Residue
A	GLY373
A	VAL374
A	HIS377
A	ASP402
A	SER404
A	ASP405
A	ALA406
A	NAD502
B	THR71
B	SER72
B	ASN73
B	THR98
B	ALA99
B	GLY100
B	GLU103
B	GLU104
B	ASP213
B	GLY214
B	GLY260
B	ALA261
B	VAL280
B	THR281
B	THR282
B	GLY283
B	SER291
B	GLY315
B	ASP316
B	ALA317

site_id	AC4
Number of Residues	24
Details	binding site for residue NAD C 500

Chain	Residue
C	THR98
C	ALA99
C	ASN100
C	LEU101
C	SER161
C	GLY162
C	GLY163
C	SER323
C	ASP326
C	ASP328
C	GLY371
C	GLY372
C	ASN397
C	ALA398
C	GLU431
C	VAL432
D	GLY262
D	LEU263
D	HIS266
D	ASP287
D	CYS289
D	GLU290
D	SER291
D	NAD500

site_id	AC5
Number of Residues	24
Details	binding site for residue NAD D 500

Chain	Residue
D	ASP316
D	ALA317
C	GLY373
C	HIS377
C	ASP402
C	SER404
C	ASP405
C	ALA406
C	NAD500
D	THR71
D	SER72
D	ASN73
D	THR98
D	ALA99
D	GLY100
D	GLU104
D	ASP213
D	GLY260
D	ALA261
D	VAL280
D	THR281
D	THR282
D	GLY283
D	SER291

site_id	AC6
Number of Residues	21
Details	binding site for residue NAD E 500

Chain	Residue
E	THR98
E	ALA99
E	ASN100
E	LEU101
E	SER161
E	GLY162
E	SER323
E	ASP326
E	ASP328
E	GLY372
E	ASN397
E	ALA398
E	GLU431
E	VAL432
F	LEU263
F	HIS266
F	ASP287
F	CYS289
F	GLU290
F	SER291
F	NAD500

site_id	AC7
Number of Residues	24
Details	binding site for residue NAD F 500

Chain	Residue
E	GLY373
E	HIS377
E	ASP402
E	SER404
E	ASP405
E	ALA406
E	NAD500
F	THR71
F	SER72
F	ASN73
F	LEU74
F	THR98
F	ALA99
F	GLY100
F	ASP213
F	GLY260
F	ALA261
F	VAL280
F	THR281
F	THR282
F	GLY283
F	GLY315
F	ASP316
F	ALA317

site_id	AC8
Number of Residues	23
Details	binding site for residue NAD G 500

Chain	Residue
G	THR98
G	ALA99
G	ASN100
G	SER161
G	GLY162
G	GLY163
G	HIS167
G	TYR213
G	SER323
G	ASP326
G	ASP328
G	GLY372
G	ASN397
G	ALA398
G	GLU431
G	VAL432
H	LEU263
H	HIS266
H	ASP287
H	CYS289
H	GLU290
H	SER291
H	NAD500

site_id	AC9
Number of Residues	25
Details	binding site for residue NAD H 500

Chain	Residue
G	GLY373
G	VAL374
G	HIS377
G	ASP402
G	SER404
G	ASP405
G	ALA406
G	NAD500
H	THR71
H	SER72
H	ASN73
H	LEU74
H	THR98
H	GLY100
H	GLU104
H	ASP213
H	GLY260
H	ALA261
H	VAL280
H	THR281
H	THR282
H	GLY283
H	GLY315
H	ASP316
H	ALA317

site_id	AD1
Number of Residues	21
Details	binding site for residue NAD I 500

Chain	Residue
I	THR98
I	ASN100
I	LEU101
I	SER161
I	GLY162
I	SER323
I	ASP326
I	ASP328
I	GLY372
I	ASN397
I	ALA398
I	GLU431
I	VAL432
J	GLY262
J	LEU263
J	HIS266
J	ASP287
J	CYS289
J	GLU290
J	SER291
J	NAD500

site_id	AD2
Number of Residues	27
Details	binding site for residue NAD J 500

Chain	Residue
I	GLY373
I	HIS377
I	ASP402
I	SER404
I	ASP405
I	ALA406
I	NAD500
J	THR71
J	SER72
J	ASN73
J	LEU74
J	SER76
J	THR98
J	ALA99
J	GLY100
J	GLU104
J	VAL133
J	ASP213
J	GLY260
J	ALA261
J	VAL280
J	THR281
J	THR282
J	GLY283
J	GLY315
J	ASP316
J	ALA317

site_id	AD3
Number of Residues	21
Details	binding site for residue NAD K 500

Chain	Residue
K	THR98
K	ASN100
K	LEU101
K	SER161
K	GLY162
K	GLY163
K	HIS167
K	SER323
K	ASP326
K	ASP328
K	GLY372
K	ASN397
K	GLU431
K	VAL432
L	LEU263
L	HIS266
L	ASP287
L	CYS289
L	GLU290
L	SER291
L	NAD500

site_id	AD4
Number of Residues	23
Details	binding site for residue NAD L 500

Chain	Residue
K	GLY373
K	HIS377
K	ASP402
K	SER404
K	ALA406
K	NAD500
L	THR71
L	SER72
L	ASN73
L	LEU74
L	THR98
L	ALA99
L	GLY100
L	GLU103
L	ASP213
L	ALA261
L	VAL280
L	THR281
L	THR282
L	GLY283
L	GLY315
L	ASP316
L	ALA317

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	36
Details	BINDING: BINDING => ECO:0000250\|UniProtKB:P49366

Chain	Residue	Details
B	SER72
D	ASP213
D	THR282
D	ASP316
F	SER72
F	THR98
F	GLU104
F	ASP213
F	THR282
F	ASP316
H	SER72
B	THR98
H	THR98
H	GLU104
H	ASP213
H	THR282
H	ASP316
J	SER72
J	THR98
J	GLU104
J	ASP213
J	THR282
B	GLU104
J	ASP316
L	SER72
L	THR98
L	GLU104
L	ASP213
L	THR282
L	ASP316
B	ASP213
B	THR282
B	ASP316
D	SER72
D	THR98
D	GLU104

site_id	SWS_FT_FI2
Number of Residues	6
Details	ACT_SITE: Nucleophile => ECO:0000250\|UniProtKB:P49366

Chain	Residue	Details
A	LYS418
C	LYS418
E	LYS418
G	LYS418
I	LYS418
K	LYS418

site_id	SWS_FT_FI3
Number of Residues	30
Details	BINDING: BINDING => ECO:0000250\|UniProtKB:P49366

Chain	Residue	Details
A	GLU166
C	GLU412
E	GLU166
E	GLU331
E	HIS377
E	GLY403
E	GLU412
G	GLU166
G	GLU331
G	HIS377
G	GLY403
A	GLU331
G	GLU412
I	GLU166
I	GLU331
I	HIS377
I	GLY403
I	GLU412
K	GLU166
K	GLU331
K	HIS377
K	GLY403
A	HIS377
K	GLU412
A	GLY403
A	GLU412
C	GLU166
C	GLU331
C	HIS377
C	GLY403

		Sequence (fasta)
		PDBx/mmCIF
		PDBML format (no-atom)
		PDB format (full)
		Validation report (PDF)
		EDMap 2fo-fc (MTZ)