6DC9

Fab/epitope complex of human chimeric monoclonal antibody h4E6 targeting a phosphorylated tau epitope.

Functional Information from PDB Data

site_id	AC1
Number of Residues	2
Details	binding site for residue GOL L 301

Chain	Residue
L	THR18
L	THR20

---

site_id	AC2
Number of Residues	6
Details	binding site for residue PO4 L 302

Chain	Residue
L	TRP32
L	TYR49
L	GLU50
P	PRO405
P	ARG406
P	HIS407

---

site_id	AC3
Number of Residues	5
Details	binding site for residue PO4 M 301

Chain	Residue
M	GLU50
Q	PRO405
Q	ARG406
Q	HIS407
M	TRP32

---

Functional Information from PROSITE/UniProt

site_id	PS00290
Number of Residues	7
Details	IG_MHC Immunoglobulins and major histocompatibility complex proteins signature. YICNVNH

Chain	Residue	Details
H	TYR191-HIS197
L	TYR193-HIS199

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	2
Details	Modified residue: {"description":"Phosphoserine; alternate","evidences":[{"source":"PubMed","id":"19690332","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI2
Number of Residues	2
Details	Modified residue: {"description":"Phosphothreonine","evidences":[{"source":"UniProtKB","id":"P10637","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI3
Number of Residues	2
Details	Modified residue: {"description":"Phosphoserine; by CK1 and PDPK1","evidences":[{"source":"PubMed","id":"14761950","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"15546861","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"19451179","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"21327254","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"9614189","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"19690332","evidenceCode":"ECO:0007744"},{"source":"PubMed","id":"23186163","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI4
Number of Residues	2
Details	Glycosylation: {"description":"O-linked (GlcNAc) serine; alternate","evidences":[{"source":"PubMed","id":"21327254","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---