6DC9
Fab/epitope complex of human chimeric monoclonal antibody h4E6 targeting a phosphorylated tau epitope.
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 2 |
| Details | binding site for residue GOL L 301 |
| Chain | Residue |
| L | THR18 |
| L | THR20 |
| site_id | AC2 |
| Number of Residues | 6 |
| Details | binding site for residue PO4 L 302 |
| Chain | Residue |
| L | TRP32 |
| L | TYR49 |
| L | GLU50 |
| P | PRO405 |
| P | ARG406 |
| P | HIS407 |
| site_id | AC3 |
| Number of Residues | 5 |
| Details | binding site for residue PO4 M 301 |
| Chain | Residue |
| M | GLU50 |
| Q | PRO405 |
| Q | ARG406 |
| Q | HIS407 |
| M | TRP32 |
Functional Information from PROSITE/UniProt
| site_id | PS00290 |
| Number of Residues | 7 |
| Details | IG_MHC Immunoglobulins and major histocompatibility complex proteins signature. YACEVTH |
| Chain | Residue | Details |
| L | TYR193-HIS199 | |
| H | TYR191-HIS197 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 6 |
| Details | SITE: Not glycated => ECO:0000269|PubMed:9326300 |
| Chain | Residue | Details |
| P | LYS383 | |
| P | LYS385 | |
| P | LYS395 | |
| Q | LYS383 | |
| Q | LYS385 | |
| Q | LYS395 |
| site_id | SWS_FT_FI2 |
| Number of Residues | 2 |
| Details | MOD_RES: N6-acetyllysine; alternate => ECO:0000250|UniProtKB:P10637 |
| Chain | Residue | Details |
| P | LYS385 | |
| Q | LYS385 |
| site_id | SWS_FT_FI3 |
| Number of Residues | 2 |
| Details | MOD_RES: Phosphotyrosine => ECO:0000250|UniProtKB:P10637 |
| Chain | Residue | Details |
| P | TYR394 | |
| Q | TYR394 |
| site_id | SWS_FT_FI4 |
| Number of Residues | 2 |
| Details | MOD_RES: Phosphoserine; by CK1 and PDPK1 => ECO:0000269|PubMed:14761950, ECO:0000269|PubMed:15546861, ECO:0000269|PubMed:16443603, ECO:0000269|PubMed:19451179, ECO:0000269|PubMed:21327254, ECO:0000269|PubMed:9614189, ECO:0007744|PubMed:19690332, ECO:0007744|PubMed:23186163 |
| Chain | Residue | Details |
| P | SEP396 | |
| Q | SEP396 |
| site_id | SWS_FT_FI5 |
| Number of Residues | 2 |
| Details | MOD_RES: Phosphoserine; alternate => ECO:0007744|PubMed:19690332 |
| Chain | Residue | Details |
| P | SER400 | |
| Q | SER400 |
| site_id | SWS_FT_FI6 |
| Number of Residues | 2 |
| Details | MOD_RES: Phosphothreonine => ECO:0000250|UniProtKB:P10637 |
| Chain | Residue | Details |
| P | THR403 | |
| Q | THR403 |
| site_id | SWS_FT_FI7 |
| Number of Residues | 2 |
| Details | MOD_RES: Phosphoserine; by CK1 and PDPK1 => ECO:0000269|PubMed:14761950, ECO:0000269|PubMed:15546861, ECO:0000269|PubMed:19451179, ECO:0000269|PubMed:21327254, ECO:0000269|PubMed:9614189, ECO:0007744|PubMed:19690332, ECO:0007744|PubMed:23186163 |
| Chain | Residue | Details |
| P | SEP404 | |
| Q | SEP404 |
| site_id | SWS_FT_FI8 |
| Number of Residues | 2 |
| Details | CARBOHYD: O-linked (GlcNAc) serine; alternate => ECO:0000269|PubMed:21327254 |
| Chain | Residue | Details |
| P | SER400 | |
| Q | SER400 |
| site_id | SWS_FT_FI9 |
| Number of Residues | 4 |
| Details | CROSSLNK: Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin); alternate => ECO:0000250|UniProtKB:P10637 |
| Chain | Residue | Details |
| P | LYS385 | |
| Q | LYS385 |
