6D8F

RsAgo Ternary Complex with Guide RNA and Target DNA Containing T-T Bulge Within the Seed Segment

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0003676	molecular_function	nucleic acid binding
A	0003677	molecular_function	DNA binding
A	0003723	molecular_function	RNA binding
A	0004520	molecular_function	DNA endonuclease activity
A	0044355	biological_process	clearance of foreign intracellular DNA
A	0046872	molecular_function	metal ion binding
F	0003676	molecular_function	nucleic acid binding
F	0003677	molecular_function	DNA binding
F	0003723	molecular_function	RNA binding
F	0004520	molecular_function	DNA endonuclease activity
F	0044355	biological_process	clearance of foreign intracellular DNA
F	0046872	molecular_function	metal ion binding

Functional Information from PDB Data

site_id	AC1
Number of Residues	3
Details	binding site for residue MPD A 801

Chain	Residue
A	TYR111
A	PHE152
A	ARG286

---

site_id	AC2
Number of Residues	4
Details	binding site for residue MPD A 802

Chain	Residue
A	LEU256
A	GLY257
A	HIS258
A	ASN259

---

site_id	AC3
Number of Residues	1
Details	binding site for residue ACT A 803

Chain	Residue
A	ARG384

---

site_id	AC4
Number of Residues	4
Details	binding site for residue MG C 101

Chain	Residue
A	HOH1022
C	U1
C	A3
A	LEU777

---

site_id	AC5
Number of Residues	4
Details	binding site for residue MPD F 801

Chain	Residue
F	LYS115
H	G11
J	DC-6
J	DC-7

---

site_id	AC6
Number of Residues	3
Details	binding site for residue MPD F 802

Chain	Residue
F	GLU377
F	SER381
F	ARG384

---

site_id	AC7
Number of Residues	6
Details	binding site for residue MG H 101

Chain	Residue
F	LEU777
F	HOH953
H	U1
H	U2
H	A3
H	HOH204

---

site_id	AC8
Number of Residues	4
Details	binding site for residue MG J 101

Chain	Residue
J	DG-4
J	HOH212
J	HOH219
J	HOH223

---

site_id	AC9
Number of Residues	4
Details	binding site for residue MPD J 102

Chain	Residue
F	TRP343
F	GLN497
J	DA6
J	DC7

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	624
Details	Domain: {"description":"Piwi","evidences":[{"source":"PROSITE-ProRule","id":"PRU00150","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI2
Number of Residues	148
Details	Region: {"description":"Linker L1","evidences":[{"source":"PubMed","id":"27325485","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI3
Number of Residues	120
Details	Region: {"description":"PAZ domain","evidences":[{"source":"PubMed","id":"27325485","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI4
Number of Residues	194
Details	Region: {"description":"Linker L2","evidences":[{"source":"PubMed","id":"27325485","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI5
Number of Residues	334
Details	Region: {"description":"Mid domain","evidences":[{"source":"PubMed","id":"27325485","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI6
Number of Residues	534
Details	Region: {"description":"PIWI domain","evidences":[{"source":"PubMed","id":"27325485","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI7
Number of Residues	2
Details	Binding site: {"evidences":[{"source":"PubMed","id":"27325485","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"29996105","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"5AWH","evidenceCode":"ECO:0000312"},{"source":"PDB","id":"6D8P","evidenceCode":"ECO:0000312"}]}

Chain

Residue

Details

---