6D8A
RsAgo Ternary Complex with guide RNA and Target DNA Containing A-A Bulge Within the Seed Segment of the Target Strand
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0003676 | molecular_function | nucleic acid binding |
| A | 0003677 | molecular_function | DNA binding |
| A | 0003723 | molecular_function | RNA binding |
| A | 0004520 | molecular_function | DNA endonuclease activity |
| A | 0044355 | biological_process | clearance of foreign intracellular DNA |
| A | 0046872 | molecular_function | metal ion binding |
| F | 0003676 | molecular_function | nucleic acid binding |
| F | 0003677 | molecular_function | DNA binding |
| F | 0003723 | molecular_function | RNA binding |
| F | 0004520 | molecular_function | DNA endonuclease activity |
| F | 0044355 | biological_process | clearance of foreign intracellular DNA |
| F | 0046872 | molecular_function | metal ion binding |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 9 |
| Details | binding site for residue MPD A 801 |
| Chain | Residue |
| A | PRO607 |
| A | LEU608 |
| A | PHE634 |
| A | VAL635 |
| A | THR636 |
| A | SER705 |
| A | LEU706 |
| A | HIS707 |
| A | PRO708 |
| site_id | AC2 |
| Number of Residues | 6 |
| Details | binding site for residue MG C 101 |
| Chain | Residue |
| A | LEU777 |
| A | HOH915 |
| C | U1 |
| C | U2 |
| C | A3 |
| C | HOH206 |
| site_id | AC3 |
| Number of Residues | 4 |
| Details | binding site for residue MPD G 101 |
| Chain | Residue |
| C | A3 |
| G | DA0 |
| G | DG1 |
| G | DT4 |
| site_id | AC4 |
| Number of Residues | 2 |
| Details | binding site for residue MPD F 801 |
| Chain | Residue |
| F | LYS115 |
| H | G11 |
| site_id | AC5 |
| Number of Residues | 8 |
| Details | binding site for residue MPD F 802 |
| Chain | Residue |
| F | GLU28 |
| F | TYR159 |
| F | PRO161 |
| F | ARG167 |
| F | ARG309 |
| F | ILE310 |
| F | VAL311 |
| F | HOH918 |
| site_id | AC6 |
| Number of Residues | 4 |
| Details | binding site for residue ACT F 803 |
| Chain | Residue |
| F | MET528 |
| F | ARG606 |
| F | PRO607 |
| H | G14 |
| site_id | AC7 |
| Number of Residues | 6 |
| Details | binding site for residue MG H 101 |
| Chain | Residue |
| F | LEU777 |
| F | HOH950 |
| H | U1 |
| H | U2 |
| H | A3 |
| H | HOH207 |
| site_id | AC8 |
| Number of Residues | 1 |
| Details | binding site for residue MPD J 101 |
| Chain | Residue |
| J | DG-14 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 624 |
| Details | Domain: {"description":"Piwi","evidences":[{"source":"PROSITE-ProRule","id":"PRU00150","evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI2 |
| Number of Residues | 148 |
| Details | Region: {"description":"Linker L1","evidences":[{"source":"PubMed","id":"27325485","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI3 |
| Number of Residues | 120 |
| Details | Region: {"description":"PAZ domain","evidences":[{"source":"PubMed","id":"27325485","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI4 |
| Number of Residues | 194 |
| Details | Region: {"description":"Linker L2","evidences":[{"source":"PubMed","id":"27325485","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI5 |
| Number of Residues | 334 |
| Details | Region: {"description":"Mid domain","evidences":[{"source":"PubMed","id":"27325485","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI6 |
| Number of Residues | 534 |
| Details | Region: {"description":"PIWI domain","evidences":[{"source":"PubMed","id":"27325485","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI7 |
| Number of Residues | 2 |
| Details | Binding site: {"evidences":[{"source":"PubMed","id":"27325485","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"29996105","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"5AWH","evidenceCode":"ECO:0000312"},{"source":"PDB","id":"6D8P","evidenceCode":"ECO:0000312"}]} |
| Chain | Residue | Details |
