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6D7M

Crystal structure of the W184R/W231R Importin alpha mutant

Functional Information from GO Data
ChainGOidnamespacecontents
B0005515molecular_functionprotein binding
B0005634cellular_componentnucleus
B0005654cellular_componentnucleoplasm
B0005737cellular_componentcytoplasm
B0005829cellular_componentcytosol
B0006606biological_processprotein import into nucleus
B0006607biological_processNLS-bearing protein import into nucleus
B0008139molecular_functionnuclear localization sequence binding
B0010494cellular_componentcytoplasmic stress granule
B0014069cellular_componentpostsynaptic density
B0015031biological_processprotein transport
B0042564cellular_componentNLS-dependent protein nuclear import complex
B0043657cellular_componenthost cell
B0061608molecular_functionnuclear import signal receptor activity
B0075506biological_processentry of viral genome into host nucleus through nuclear pore complex via importin
B0098978cellular_componentglutamatergic synapse
B0099527biological_processpostsynapse to nucleus signaling pathway
B0140297molecular_functionDNA-binding transcription factor binding
B1903902biological_processpositive regulation of viral life cycle
Functional Information from PDB Data
site_idAC1
Number of Residues2
Detailsbinding site for residue EDO B 601
ChainResidue
BLEU221
BALA222

site_idAC2
Number of Residues4
Detailsbinding site for residue EDO B 602
ChainResidue
BGLN371
BVAL374
BGLU411
BGLN412

site_idAC3
Number of Residues4
Detailsbinding site for residue EDO B 603
ChainResidue
BASN361
BVAL321
BGLY323
BTHR328

site_idAC4
Number of Residues1
Detailsbinding site for residue CL B 604
ChainResidue
BGLN297

site_idAC5
Number of Residues4
Detailsbinding site for residue SIN B 605
ChainResidue
BSER77
BVAL78
BARG106
BHOH734

Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues1
DetailsMOD_RES: Phosphoserine => ECO:0007744|PubMed:21183079
ChainResidueDetails
BMET64

220113

PDB entries from 2024-05-22

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