6D7M
Crystal structure of the W184R/W231R Importin alpha mutant
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| B | 0005515 | molecular_function | protein binding |
| B | 0005634 | cellular_component | nucleus |
| B | 0005654 | cellular_component | nucleoplasm |
| B | 0005737 | cellular_component | cytoplasm |
| B | 0005829 | cellular_component | cytosol |
| B | 0006606 | biological_process | protein import into nucleus |
| B | 0006607 | biological_process | NLS-bearing protein import into nucleus |
| B | 0008139 | molecular_function | nuclear localization sequence binding |
| B | 0010494 | cellular_component | cytoplasmic stress granule |
| B | 0014069 | cellular_component | postsynaptic density |
| B | 0015031 | biological_process | protein transport |
| B | 0031965 | cellular_component | nuclear membrane |
| B | 0032481 | biological_process | positive regulation of type I interferon production |
| B | 0038061 | biological_process | non-canonical NF-kappaB signal transduction |
| B | 0042564 | cellular_component | NLS-dependent protein nuclear import complex |
| B | 0042826 | molecular_function | histone deacetylase binding |
| B | 0043657 | cellular_component | host cell |
| B | 0045893 | biological_process | positive regulation of DNA-templated transcription |
| B | 0046015 | biological_process | regulation of transcription by glucose |
| B | 0061608 | molecular_function | nuclear import signal receptor activity |
| B | 0075506 | biological_process | entry of viral genome into host nucleus through nuclear pore complex via importin |
| B | 0098978 | cellular_component | glutamatergic synapse |
| B | 0099527 | biological_process | postsynapse to nucleus signaling pathway |
| B | 0140297 | molecular_function | DNA-binding transcription factor binding |
| B | 1903902 | biological_process | positive regulation of viral life cycle |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 2 |
| Details | binding site for residue EDO B 601 |
| Chain | Residue |
| B | LEU221 |
| B | ALA222 |
| site_id | AC2 |
| Number of Residues | 4 |
| Details | binding site for residue EDO B 602 |
| Chain | Residue |
| B | GLN371 |
| B | VAL374 |
| B | GLU411 |
| B | GLN412 |
| site_id | AC3 |
| Number of Residues | 4 |
| Details | binding site for residue EDO B 603 |
| Chain | Residue |
| B | ASN361 |
| B | VAL321 |
| B | GLY323 |
| B | THR328 |
| site_id | AC4 |
| Number of Residues | 1 |
| Details | binding site for residue CL B 604 |
| Chain | Residue |
| B | GLN297 |
| site_id | AC5 |
| Number of Residues | 4 |
| Details | binding site for residue SIN B 605 |
| Chain | Residue |
| B | SER77 |
| B | VAL78 |
| B | ARG106 |
| B | HOH734 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 39 |
| Details | Repeat: {"description":"ARM 2"} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI2 |
| Number of Residues | 41 |
| Details | Repeat: {"description":"ARM 3"} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI3 |
| Number of Residues | 44 |
| Details | Repeat: {"description":"ARM 4"} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI4 |
| Number of Residues | 36 |
| Details | Repeat: {"description":"ARM 5"} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI5 |
| Number of Residues | 39 |
| Details | Repeat: {"description":"ARM 6"} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI6 |
| Number of Residues | 39 |
| Details | Repeat: {"description":"ARM 7"} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI7 |
| Number of Residues | 42 |
| Details | Repeat: {"description":"ARM 8"} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI8 |
| Number of Residues | 46 |
| Details | Repeat: {"description":"ARM 9"} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI9 |
| Number of Residues | 39 |
| Details | Repeat: {"description":"ARM 10; atypical"} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI10 |
| Number of Residues | 96 |
| Details | Region: {"description":"NLS binding site (major)","evidences":[{"source":"PubMed","id":"10764582","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI11 |
| Number of Residues | 88 |
| Details | Region: {"description":"NLS binding site (minor)","evidences":[{"source":"PubMed","id":"10764582","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
