Summary Structural details Experimental details Functional details Sequence Neighbor History Downloads

6D65

Crystal structure of the human dual specificity phosphatase 1 catalytic domain (C258S) as a maltose binding protein fusion in complex with the designed AR protein off7

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0005515	molecular_function	protein binding
A	0006470	biological_process	protein dephosphorylation
A	0006974	biological_process	DNA damage response
A	0008643	biological_process	carbohydrate transport
A	0015144	molecular_function	carbohydrate transmembrane transporter activity
A	0015768	biological_process	maltose transport
A	0016020	cellular_component	membrane
A	0016311	biological_process	dephosphorylation
A	0030288	cellular_component	outer membrane-bounded periplasmic space
A	0034219	biological_process	carbohydrate transmembrane transport
A	0034289	biological_process	detection of maltose stimulus
A	0042597	cellular_component	periplasmic space
A	0042956	biological_process	maltodextrin transmembrane transport
A	0043190	cellular_component	ATP-binding cassette (ABC) transporter complex
A	0055052	cellular_component	ATP-binding cassette (ABC) transporter complex, substrate-binding subunit-containing
A	0055085	biological_process	transmembrane transport
A	0060326	biological_process	cell chemotaxis
A	1901982	molecular_function	maltose binding
C	0005515	molecular_function	protein binding
C	0006470	biological_process	protein dephosphorylation
C	0006974	biological_process	DNA damage response
C	0008643	biological_process	carbohydrate transport
C	0015144	molecular_function	carbohydrate transmembrane transporter activity
C	0015768	biological_process	maltose transport
C	0016020	cellular_component	membrane
C	0016311	biological_process	dephosphorylation
C	0030288	cellular_component	outer membrane-bounded periplasmic space
C	0034219	biological_process	carbohydrate transmembrane transport
C	0034289	biological_process	detection of maltose stimulus
C	0042597	cellular_component	periplasmic space
C	0042956	biological_process	maltodextrin transmembrane transport
C	0043190	cellular_component	ATP-binding cassette (ABC) transporter complex
C	0055052	cellular_component	ATP-binding cassette (ABC) transporter complex, substrate-binding subunit-containing
C	0055085	biological_process	transmembrane transport
C	0060326	biological_process	cell chemotaxis
C	1901982	molecular_function	maltose binding

Functional Information from PDB Data

site_id	AC1
Number of Residues	2
Details	binding site for residue GOL A 1401

Chain	Residue
A	ASN186
A	ALA187

site_id	AC2
Number of Residues	2
Details	binding site for residue GOL A 1402

Chain	Residue
A	PHE195
A	ASP198

site_id	AC3
Number of Residues	4
Details	binding site for residue GOL A 1403

Chain	Residue
A	ASN428
A	HIS429
A	LYS430
C	LYS430

site_id	AC4
Number of Residues	3
Details	binding site for residue SO4 A 1404

Chain	Residue
A	ASP42
A	LYS47
A	PRO41

site_id	AC5
Number of Residues	4
Details	binding site for residue SO4 A 1405

Chain	Residue
A	ARG391
A	ASP393
A	MET394
A	HOH1501

site_id	AC6
Number of Residues	2
Details	binding site for residue SO4 A 1406

Chain	Residue
A	LYS421
A	SER422

site_id	AC7
Number of Residues	8
Details	binding site for residue SO4 A 1407

Chain	Residue
A	SER458
A	GLN459
A	ALA460
A	GLY461
A	ILE462
A	SER463
A	ARG464
A	HOH1554

site_id	AC8
Number of Residues	8
Details	binding site for residue SO4 A 1408

Chain	Residue
A	SER407
A	ASN409
A	CYS410
A	GLU426
A	GLN459
A	ARG464
A	HOH1517
A	HOH1537

site_id	AC9
Number of Residues	6
Details	binding site for residue SO4 A 1409

Chain	Residue
A	LYS392
A	PHE414
A	GLU415
A	GLY416
A	HIS417
D	LYS17

site_id	AD1
Number of Residues	3
Details	binding site for residue EOH A 1410

Chain	Residue
A	GLY14
A	HIS40
A	ASP42

site_id	AD2
Number of Residues	4
Details	binding site for residue EOH A 1411

Chain	Residue
A	PRO272
A	LYS274
A	GLU275
A	HOH1570

site_id	AD3
Number of Residues	3
Details	binding site for residue EOH A 1412

Chain	Residue
A	THR287
A	ASP288
A	GLU289

site_id	AD4
Number of Residues	3
Details	binding site for residue EOH A 1413

Chain	Residue
A	ALA78
A	GLU79
A	LYS314

site_id	AD5
Number of Residues	3
Details	binding site for residue SO4 A 1414

Chain	Residue
A	HIS429
A	ASN498
A	PHE499

site_id	AD6
Number of Residues	1
Details	binding site for residue GOL A 1415

Chain	Residue
A	SER493

site_id	AD7
Number of Residues	1
Details	binding site for residue EOH A 1417

Chain	Residue
A	ARG391

site_id	AD8
Number of Residues	3
Details	binding site for residue EOH A 1418

Chain	Residue
A	TYR18
A	ASN19
A	HOH1597

site_id	AD9
Number of Residues	6
Details	binding site for residue SO4 A 1419

Chain	Residue
A	ASN151
A	GLN153
A	GLU154
A	ASP210
A	TYR211
A	HOH1541

site_id	AE1
Number of Residues	5
Details	binding site for residue SO4 B 201

Chain	Residue
B	GLY58
B	HIS59
B	LEU60
B	GLU61
B	HOH318

site_id	AE2
Number of Residues	6
Details	binding site for residue SO4 B 202

Chain	Residue
B	GLY91
B	HIS92
B	LEU93
B	GLU94
B	HOH310
B	HOH320

site_id	AE3
Number of Residues	5
Details	binding site for residue SO4 B 203

Chain	Residue
B	GLY124
B	TYR125
B	LEU126
B	GLU127
B	HOH307

site_id	AE4
Number of Residues	3
Details	binding site for residue EOH B 204

Chain	Residue
B	ARG23
B	TYR56
B	HOH336

site_id	AE5
Number of Residues	2
Details	binding site for residue EOH B 205

Chain	Residue
B	ASP72
B	HOH308

site_id	AE6
Number of Residues	2
Details	binding site for residue SO4 C 1401

Chain	Residue
C	TYR91
C	GLN326

site_id	AE7
Number of Residues	3
Details	binding site for residue SO4 C 1402

Chain	Residue
C	PHE195
C	ASP198
C	HOH1616

site_id	AE8
Number of Residues	2
Details	binding site for residue SO4 C 1403

Chain	Residue
C	ASN438
C	HOH1577

site_id	AE9
Number of Residues	5
Details	binding site for residue SO4 C 1404

Chain	Residue
B	LYS17
C	PHE414
C	GLU415
C	GLY416
C	HIS417

site_id	AF1
Number of Residues	4
Details	binding site for residue SO4 C 1405

Chain	Residue
C	ARG391
C	ASP393
C	MET394
C	HOH1502

site_id	AF2
Number of Residues	7
Details	binding site for residue SO4 C 1406

Chain	Residue
C	ARG355
C	ALA408
C	ASN409
C	GLN459
C	ARG464
C	HOH1612
C	HOH1615

site_id	AF3
Number of Residues	8
Details	binding site for residue SO4 C 1407

Chain	Residue
C	ASP427
C	SER458
C	GLN459
C	ALA460
C	GLY461
C	ILE462
C	SER463
C	ARG464

site_id	AF4
Number of Residues	2
Details	binding site for residue SO4 C 1408

Chain	Residue
C	LYS421
C	SER422

site_id	AF5
Number of Residues	2
Details	binding site for residue SO4 C 1409

Chain	Residue
C	ARG492
C	SER493

site_id	AF6
Number of Residues	1
Details	binding site for residue EOH C 1410

Chain	Residue
C	LYS143

site_id	AF7
Number of Residues	4
Details	binding site for residue EOH C 1411

Chain	Residue
C	PRO272
C	ASN273
C	LYS274
C	GLU275

site_id	AF8
Number of Residues	5
Details	binding site for residue EOH C 1412

Chain	Residue
C	ASN151
C	GLU154
C	ASP210
C	TYR211
C	HOH1579

site_id	AF9
Number of Residues	2
Details	binding site for residue GOL C 1413

Chain	Residue
C	ASN186
C	ALA187

site_id	AG1
Number of Residues	2
Details	binding site for residue EOH C 1414

Chain	Residue
C	THR357
C	ASP359

site_id	AG2
Number of Residues	1
Details	binding site for residue EOH C 1415

Chain	Residue
C	GLY373

site_id	AG3
Number of Residues	1
Details	binding site for residue EOH C 1416

Chain	Residue
C	ARG391

site_id	AG4
Number of Residues	1
Details	binding site for residue EOH C 1417

Chain	Residue
C	HIS429

site_id	AG5
Number of Residues	3
Details	binding site for residue EOH C 1418

Chain	Residue
C	ARG478
C	VAL512
C	LEU513

site_id	AG6
Number of Residues	4
Details	binding site for residue EOH C 1419

Chain	Residue
C	HIS429
C	ASN498
C	PHE499
C	HOH1542

site_id	AG7
Number of Residues	1
Details	binding site for residue EOH C 1420

Chain	Residue
C	HIS40

site_id	AG8
Number of Residues	3
Details	binding site for residue GOL C 1421

Chain	Residue
C	PRO41
C	ASP42
C	LYS47

site_id	AG9
Number of Residues	5
Details	binding site for residue SO4 D 201

Chain	Residue
D	GLY58
D	HIS59
D	LEU60
D	GLU61
D	HOH316

site_id	AH1
Number of Residues	6
Details	binding site for residue SO4 D 202

Chain	Residue
D	GLY91
D	HIS92
D	LEU93
D	GLU94
D	HOH322
D	HOH327

site_id	AH2
Number of Residues	4
Details	binding site for residue SO4 D 203

Chain	Residue
D	GLY124
D	TYR125
D	LEU126
D	GLU127

site_id	AH3
Number of Residues	3
Details	binding site for residue EOH D 204

Chain	Residue
C	LYS141
D	ARG23
D	TYR56

site_id	AH4
Number of Residues	4
Details	binding site for residue EOH D 205

Chain	Residue
D	GLY25
D	ASP27
D	ASP28
D	HOH306

Functional Information from PROSITE/UniProt

site_id	PS01037
Number of Residues	18
Details	SBP_BACTERIAL_1 Bacterial extracellular solute-binding proteins, family 1 signature. PIAvEalSLIYNkdlLpN

Chain	Residue	Details
A	PRO108-ASN125

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	2
Details	Active site: {"description":"Phosphocysteine intermediate","evidences":[{"source":"PROSITE-ProRule","id":"PRU00160","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

		Sequence (fasta)
		PDBx/mmCIF
		PDBML format (no-atom)
		PDB format (full)
		Validation report (PDF)
		EDMap 2fo-fc (MTZ)