6D65
Crystal structure of the human dual specificity phosphatase 1 catalytic domain (C258S) as a maltose binding protein fusion in complex with the designed AR protein off7
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0005515 | molecular_function | protein binding |
| A | 0006470 | biological_process | protein dephosphorylation |
| A | 0006974 | biological_process | DNA damage response |
| A | 0008643 | biological_process | carbohydrate transport |
| A | 0015144 | molecular_function | carbohydrate transmembrane transporter activity |
| A | 0015768 | biological_process | maltose transport |
| A | 0016020 | cellular_component | membrane |
| A | 0016311 | biological_process | dephosphorylation |
| A | 0030288 | cellular_component | outer membrane-bounded periplasmic space |
| A | 0034219 | biological_process | carbohydrate transmembrane transport |
| A | 0034289 | biological_process | detection of maltose stimulus |
| A | 0042597 | cellular_component | periplasmic space |
| A | 0042956 | biological_process | maltodextrin transmembrane transport |
| A | 0043190 | cellular_component | ATP-binding cassette (ABC) transporter complex |
| A | 0055052 | cellular_component | ATP-binding cassette (ABC) transporter complex, substrate-binding subunit-containing |
| A | 0055085 | biological_process | transmembrane transport |
| A | 0060326 | biological_process | cell chemotaxis |
| A | 1901982 | molecular_function | maltose binding |
| A | 1990060 | cellular_component | maltose transport complex |
| C | 0005515 | molecular_function | protein binding |
| C | 0006470 | biological_process | protein dephosphorylation |
| C | 0006974 | biological_process | DNA damage response |
| C | 0008643 | biological_process | carbohydrate transport |
| C | 0015144 | molecular_function | carbohydrate transmembrane transporter activity |
| C | 0015768 | biological_process | maltose transport |
| C | 0016020 | cellular_component | membrane |
| C | 0016311 | biological_process | dephosphorylation |
| C | 0030288 | cellular_component | outer membrane-bounded periplasmic space |
| C | 0034219 | biological_process | carbohydrate transmembrane transport |
| C | 0034289 | biological_process | detection of maltose stimulus |
| C | 0042597 | cellular_component | periplasmic space |
| C | 0042956 | biological_process | maltodextrin transmembrane transport |
| C | 0043190 | cellular_component | ATP-binding cassette (ABC) transporter complex |
| C | 0055052 | cellular_component | ATP-binding cassette (ABC) transporter complex, substrate-binding subunit-containing |
| C | 0055085 | biological_process | transmembrane transport |
| C | 0060326 | biological_process | cell chemotaxis |
| C | 1901982 | molecular_function | maltose binding |
| C | 1990060 | cellular_component | maltose transport complex |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 2 |
| Details | binding site for residue GOL A 1401 |
| Chain | Residue |
| A | ASN186 |
| A | ALA187 |
| site_id | AC2 |
| Number of Residues | 2 |
| Details | binding site for residue GOL A 1402 |
| Chain | Residue |
| A | PHE195 |
| A | ASP198 |
| site_id | AC3 |
| Number of Residues | 4 |
| Details | binding site for residue GOL A 1403 |
| Chain | Residue |
| A | ASN428 |
| A | HIS429 |
| A | LYS430 |
| C | LYS430 |
| site_id | AC4 |
| Number of Residues | 3 |
| Details | binding site for residue SO4 A 1404 |
| Chain | Residue |
| A | ASP42 |
| A | LYS47 |
| A | PRO41 |
| site_id | AC5 |
| Number of Residues | 4 |
| Details | binding site for residue SO4 A 1405 |
| Chain | Residue |
| A | ARG391 |
| A | ASP393 |
| A | MET394 |
| A | HOH1501 |
| site_id | AC6 |
| Number of Residues | 2 |
| Details | binding site for residue SO4 A 1406 |
| Chain | Residue |
| A | LYS421 |
| A | SER422 |
| site_id | AC7 |
| Number of Residues | 8 |
| Details | binding site for residue SO4 A 1407 |
| Chain | Residue |
| A | SER458 |
| A | GLN459 |
| A | ALA460 |
| A | GLY461 |
| A | ILE462 |
| A | SER463 |
| A | ARG464 |
| A | HOH1554 |
| site_id | AC8 |
| Number of Residues | 8 |
| Details | binding site for residue SO4 A 1408 |
| Chain | Residue |
| A | SER407 |
| A | ASN409 |
| A | CYS410 |
| A | GLU426 |
| A | GLN459 |
| A | ARG464 |
| A | HOH1517 |
| A | HOH1537 |
| site_id | AC9 |
| Number of Residues | 6 |
| Details | binding site for residue SO4 A 1409 |
| Chain | Residue |
| A | LYS392 |
| A | PHE414 |
| A | GLU415 |
| A | GLY416 |
| A | HIS417 |
| D | LYS17 |
| site_id | AD1 |
| Number of Residues | 3 |
| Details | binding site for residue EOH A 1410 |
| Chain | Residue |
| A | GLY14 |
| A | HIS40 |
| A | ASP42 |
| site_id | AD2 |
| Number of Residues | 4 |
| Details | binding site for residue EOH A 1411 |
| Chain | Residue |
| A | PRO272 |
| A | LYS274 |
| A | GLU275 |
| A | HOH1570 |
| site_id | AD3 |
| Number of Residues | 3 |
| Details | binding site for residue EOH A 1412 |
| Chain | Residue |
| A | THR287 |
| A | ASP288 |
| A | GLU289 |
| site_id | AD4 |
| Number of Residues | 3 |
| Details | binding site for residue EOH A 1413 |
| Chain | Residue |
| A | ALA78 |
| A | GLU79 |
| A | LYS314 |
| site_id | AD5 |
| Number of Residues | 3 |
| Details | binding site for residue SO4 A 1414 |
| Chain | Residue |
| A | HIS429 |
| A | ASN498 |
| A | PHE499 |
| site_id | AD6 |
| Number of Residues | 1 |
| Details | binding site for residue GOL A 1415 |
| Chain | Residue |
| A | SER493 |
| site_id | AD7 |
| Number of Residues | 1 |
| Details | binding site for residue EOH A 1417 |
| Chain | Residue |
| A | ARG391 |
| site_id | AD8 |
| Number of Residues | 3 |
| Details | binding site for residue EOH A 1418 |
| Chain | Residue |
| A | TYR18 |
| A | ASN19 |
| A | HOH1597 |
| site_id | AD9 |
| Number of Residues | 6 |
| Details | binding site for residue SO4 A 1419 |
| Chain | Residue |
| A | ASN151 |
| A | GLN153 |
| A | GLU154 |
| A | ASP210 |
| A | TYR211 |
| A | HOH1541 |
| site_id | AE1 |
| Number of Residues | 5 |
| Details | binding site for residue SO4 B 201 |
| Chain | Residue |
| B | GLY58 |
| B | HIS59 |
| B | LEU60 |
| B | GLU61 |
| B | HOH318 |
| site_id | AE2 |
| Number of Residues | 6 |
| Details | binding site for residue SO4 B 202 |
| Chain | Residue |
| B | GLY91 |
| B | HIS92 |
| B | LEU93 |
| B | GLU94 |
| B | HOH310 |
| B | HOH320 |
| site_id | AE3 |
| Number of Residues | 5 |
| Details | binding site for residue SO4 B 203 |
| Chain | Residue |
| B | GLY124 |
| B | TYR125 |
| B | LEU126 |
| B | GLU127 |
| B | HOH307 |
| site_id | AE4 |
| Number of Residues | 3 |
| Details | binding site for residue EOH B 204 |
| Chain | Residue |
| B | ARG23 |
| B | TYR56 |
| B | HOH336 |
| site_id | AE5 |
| Number of Residues | 2 |
| Details | binding site for residue EOH B 205 |
| Chain | Residue |
| B | ASP72 |
| B | HOH308 |
| site_id | AE6 |
| Number of Residues | 2 |
| Details | binding site for residue SO4 C 1401 |
| Chain | Residue |
| C | TYR91 |
| C | GLN326 |
| site_id | AE7 |
| Number of Residues | 3 |
| Details | binding site for residue SO4 C 1402 |
| Chain | Residue |
| C | PHE195 |
| C | ASP198 |
| C | HOH1616 |
| site_id | AE8 |
| Number of Residues | 2 |
| Details | binding site for residue SO4 C 1403 |
| Chain | Residue |
| C | ASN438 |
| C | HOH1577 |
| site_id | AE9 |
| Number of Residues | 5 |
| Details | binding site for residue SO4 C 1404 |
| Chain | Residue |
| B | LYS17 |
| C | PHE414 |
| C | GLU415 |
| C | GLY416 |
| C | HIS417 |
| site_id | AF1 |
| Number of Residues | 4 |
| Details | binding site for residue SO4 C 1405 |
| Chain | Residue |
| C | ARG391 |
| C | ASP393 |
| C | MET394 |
| C | HOH1502 |
| site_id | AF2 |
| Number of Residues | 7 |
| Details | binding site for residue SO4 C 1406 |
| Chain | Residue |
| C | ARG355 |
| C | ALA408 |
| C | ASN409 |
| C | GLN459 |
| C | ARG464 |
| C | HOH1612 |
| C | HOH1615 |
| site_id | AF3 |
| Number of Residues | 8 |
| Details | binding site for residue SO4 C 1407 |
| Chain | Residue |
| C | ASP427 |
| C | SER458 |
| C | GLN459 |
| C | ALA460 |
| C | GLY461 |
| C | ILE462 |
| C | SER463 |
| C | ARG464 |
| site_id | AF4 |
| Number of Residues | 2 |
| Details | binding site for residue SO4 C 1408 |
| Chain | Residue |
| C | LYS421 |
| C | SER422 |
| site_id | AF5 |
| Number of Residues | 2 |
| Details | binding site for residue SO4 C 1409 |
| Chain | Residue |
| C | ARG492 |
| C | SER493 |
| site_id | AF6 |
| Number of Residues | 1 |
| Details | binding site for residue EOH C 1410 |
| Chain | Residue |
| C | LYS143 |
| site_id | AF7 |
| Number of Residues | 4 |
| Details | binding site for residue EOH C 1411 |
| Chain | Residue |
| C | PRO272 |
| C | ASN273 |
| C | LYS274 |
| C | GLU275 |
| site_id | AF8 |
| Number of Residues | 5 |
| Details | binding site for residue EOH C 1412 |
| Chain | Residue |
| C | ASN151 |
| C | GLU154 |
| C | ASP210 |
| C | TYR211 |
| C | HOH1579 |
| site_id | AF9 |
| Number of Residues | 2 |
| Details | binding site for residue GOL C 1413 |
| Chain | Residue |
| C | ASN186 |
| C | ALA187 |
| site_id | AG1 |
| Number of Residues | 2 |
| Details | binding site for residue EOH C 1414 |
| Chain | Residue |
| C | THR357 |
| C | ASP359 |
| site_id | AG2 |
| Number of Residues | 1 |
| Details | binding site for residue EOH C 1415 |
| Chain | Residue |
| C | GLY373 |
| site_id | AG3 |
| Number of Residues | 1 |
| Details | binding site for residue EOH C 1416 |
| Chain | Residue |
| C | ARG391 |
| site_id | AG4 |
| Number of Residues | 1 |
| Details | binding site for residue EOH C 1417 |
| Chain | Residue |
| C | HIS429 |
| site_id | AG5 |
| Number of Residues | 3 |
| Details | binding site for residue EOH C 1418 |
| Chain | Residue |
| C | ARG478 |
| C | VAL512 |
| C | LEU513 |
| site_id | AG6 |
| Number of Residues | 4 |
| Details | binding site for residue EOH C 1419 |
| Chain | Residue |
| C | HIS429 |
| C | ASN498 |
| C | PHE499 |
| C | HOH1542 |
| site_id | AG7 |
| Number of Residues | 1 |
| Details | binding site for residue EOH C 1420 |
| Chain | Residue |
| C | HIS40 |
| site_id | AG8 |
| Number of Residues | 3 |
| Details | binding site for residue GOL C 1421 |
| Chain | Residue |
| C | PRO41 |
| C | ASP42 |
| C | LYS47 |
| site_id | AG9 |
| Number of Residues | 5 |
| Details | binding site for residue SO4 D 201 |
| Chain | Residue |
| D | GLY58 |
| D | HIS59 |
| D | LEU60 |
| D | GLU61 |
| D | HOH316 |
| site_id | AH1 |
| Number of Residues | 6 |
| Details | binding site for residue SO4 D 202 |
| Chain | Residue |
| D | GLY91 |
| D | HIS92 |
| D | LEU93 |
| D | GLU94 |
| D | HOH322 |
| D | HOH327 |
| site_id | AH2 |
| Number of Residues | 4 |
| Details | binding site for residue SO4 D 203 |
| Chain | Residue |
| D | GLY124 |
| D | TYR125 |
| D | LEU126 |
| D | GLU127 |
| site_id | AH3 |
| Number of Residues | 3 |
| Details | binding site for residue EOH D 204 |
| Chain | Residue |
| C | LYS141 |
| D | ARG23 |
| D | TYR56 |
| site_id | AH4 |
| Number of Residues | 4 |
| Details | binding site for residue EOH D 205 |
| Chain | Residue |
| D | GLY25 |
| D | ASP27 |
| D | ASP28 |
| D | HOH306 |
Functional Information from PROSITE/UniProt
| site_id | PS01037 |
| Number of Residues | 18 |
| Details | SBP_BACTERIAL_1 Bacterial extracellular solute-binding proteins, family 1 signature. PIAvEalSLIYNkdlLpN |
| Chain | Residue | Details |
| A | PRO108-ASN125 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 2 |
| Details | ACT_SITE: Phosphocysteine intermediate => ECO:0000255|PROSITE-ProRule:PRU00160 |
| Chain | Residue | Details |
| A | SER458 | |
| C | SER458 |
