6D5K

Structure of Human ATP:Cobalamin Adenosyltransferase bound to ATP, and Adenosylcobalamin

Functional Information from PDB Data

site_id	AC1
Number of Residues	9
Details	binding site for residue 5AD A 301

Chain	Residue
A	ARG190
A	GLU193
A	ARG194
A	B12302
C	SER68
C	SER69
C	LYS78
C	PHE83
C	EPE303

---

site_id	AC2
Number of Residues	18
Details	binding site for residue B12 A 302

Chain	Residue
A	THR168
A	ALA169
A	PHE170
A	ILE171
A	ARG186
A	ARG190
A	SER217
A	ASP218
A	PHE221
A	MET239
A	5AD301
C	PHE71
C	VAL86
C	ASP90
C	GLN122
C	SER126
C	ALA129
C	EPE303

---

site_id	AC3
Number of Residues	15
Details	binding site for residue B12 A 303

Chain	Residue
A	VAL86
A	ASP90
A	GLN122
A	SER126
A	HOH403
B	LYS57
B	LEU167
B	THR168
B	PHE170
B	ILE171
B	ARG186
B	ARG190
B	SER217
B	PHE221
B	5AD301

---

site_id	AC4
Number of Residues	4
Details	binding site for residue SO4 A 304

Chain	Residue
A	HIS108
A	THR109
A	PHE110
A	TYR226

---

site_id	AC5
Number of Residues	5
Details	binding site for residue 5AD B 301

Chain	Residue
A	PHE83
A	B12303
B	ARG190
B	GLU193
B	ARG194

---

site_id	AC6
Number of Residues	4
Details	binding site for residue SO4 B 302

Chain	Residue
B	HIS108
B	THR109
B	PHE110
B	TYR226

---

site_id	AC7
Number of Residues	3
Details	binding site for residue SO4 B 303

Chain	Residue
B	LYS211
C	LYS141
C	TYR142

---

site_id	AC8
Number of Residues	19
Details	binding site for residue ATP C 301

Chain	Residue
B	THR60
B	LYS61
B	THR62
B	GLY63
B	SER68
B	SER69
B	LYS78
B	PHE83
C	ARG190
C	GLU193
C	ARG194
C	ASN214
C	MG302
C	MG306
C	HOH401
C	HOH402
C	HOH404
C	HOH405
C	HOH407

---

site_id	AC9
Number of Residues	7
Details	binding site for residue MG C 302

Chain	Residue
B	ILE58
C	ASP218
C	ATP301
C	HOH401
C	HOH403
C	HOH404
C	HOH407

---

site_id	AD1
Number of Residues	7
Details	binding site for residue EPE C 303

Chain	Residue
A	ASN214
A	ASP218
A	5AD301
A	B12302
C	SER68
C	SER69
C	ARG75

---

site_id	AD2
Number of Residues	5
Details	binding site for residue SO4 C 304

Chain	Residue
C	HIS108
C	THR109
C	PHE110
C	TYR226
C	LYS230

---

site_id	AD3
Number of Residues	2
Details	binding site for residue SO4 C 305

Chain	Residue
C	ALA147
C	ASN208

---

site_id	AD4
Number of Residues	4
Details	binding site for residue MG C 306

Chain	Residue
C	ATP301
C	HOH402
C	HOH405
C	ASN214

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	22
Details	Binding site: {"evidences":[{"source":"PubMed","id":"17176040","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI2
Number of Residues	3
Details	Modified residue: {"description":"N6-succinyllysine","evidences":[{"source":"UniProtKB","id":"Q9D273","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI3
Number of Residues	3
Details	Modified residue: {"description":"N6-succinyllysine; alternate","evidences":[{"source":"UniProtKB","id":"Q9D273","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI4
Number of Residues	2
Details	Modified residue: {"description":"Phosphoserine","evidences":[{"source":"PubMed","id":"24275569","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---