6CYC

PDE2 in complex with compound 5

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0004114	molecular_function	3',5'-cyclic-nucleotide phosphodiesterase activity
A	0007165	biological_process	signal transduction
A	0008081	molecular_function	phosphoric diester hydrolase activity
B	0004114	molecular_function	3',5'-cyclic-nucleotide phosphodiesterase activity
B	0007165	biological_process	signal transduction
B	0008081	molecular_function	phosphoric diester hydrolase activity

Functional Information from PDB Data

site_id	AC1
Number of Residues	6
Details	binding site for residue ZN A 1001

Chain	Residue
A	HIS660
A	HIS696
A	ASP697
A	ASP808
A	HOH1101
A	HOH1192

---

site_id	AC2
Number of Residues	6
Details	binding site for residue MG A 1002

Chain	Residue
A	HOH1142
A	HOH1156
A	HOH1218
A	ASP697
A	HOH1101
A	HOH1104

---

site_id	AC3
Number of Residues	15
Details	binding site for residue FKJ A 1003

Chain	Residue
A	TYR655
A	HIS656
A	THR768
A	LEU770
A	THR805
A	ASP808
A	LEU809
A	GLN812
A	ILE826
A	GLN859
A	PHE862
A	EDO1004
A	HOH1119
A	HOH1121
A	HOH1181

---

site_id	AC4
Number of Residues	6
Details	binding site for residue EDO A 1004

Chain	Residue
A	PHE830
A	PHE862
A	FKJ1003
A	EDO1005
A	EDO1006
A	HOH1176

---

site_id	AC5
Number of Residues	6
Details	binding site for residue EDO A 1005

Chain	Residue
A	ASN704
A	PHE830
A	EDO1004
A	EDO1006
A	HOH1113
A	HOH1219

---

site_id	AC6
Number of Residues	5
Details	binding site for residue EDO A 1006

Chain	Residue
A	ASP769
A	LEU770
A	EDO1004
A	EDO1005
A	HOH1161

---

site_id	AC7
Number of Residues	8
Details	binding site for residue EDO A 1007

Chain	Residue
A	SER721
A	GLU722
A	HOH1114
A	HOH1228
B	HIS772
B	ARG797
B	LEU798
B	CYS801

---

site_id	AC8
Number of Residues	5
Details	binding site for residue EDO A 1008

Chain	Residue
A	LYS569
A	PHE572
A	GLN733
A	HOH1105
A	HOH1171

---

site_id	AC9
Number of Residues	4
Details	binding site for residue EDO A 1009

Chain	Residue
A	ILE735
A	ASN739
A	TYR754
B	ARG751

---

site_id	AD1
Number of Residues	6
Details	binding site for residue ZN B 1001

Chain	Residue
B	HIS660
B	HIS696
B	ASP697
B	ASP808
B	HOH1110
B	HOH1206

---

site_id	AD2
Number of Residues	6
Details	binding site for residue MG B 1002

Chain	Residue
B	ASP697
B	HOH1104
B	HOH1110
B	HOH1133
B	HOH1134
B	HOH1269

---

site_id	AD3
Number of Residues	15
Details	binding site for residue FKJ B 1003

Chain	Residue
B	TYR655
B	HIS656
B	THR768
B	LEU770
B	THR805
B	ASP808
B	LEU809
B	GLN812
B	ILE826
B	PHE862
B	EDO1006
B	HOH1105
B	HOH1109
B	HOH1122
B	HOH1184

---

site_id	AD4
Number of Residues	4
Details	binding site for residue EDO B 1004

Chain	Residue
B	LEU770
B	EDO1005
B	HOH1107
B	HOH1245

---

site_id	AD5
Number of Residues	6
Details	binding site for residue EDO B 1005

Chain	Residue
B	ASN704
B	PHE830
B	MET848
B	EDO1004
B	EDO1006
B	HOH1210

---

site_id	AD6
Number of Residues	5
Details	binding site for residue EDO B 1006

Chain	Residue
B	ILE866
B	FKJ1003
B	EDO1005
B	HOH1154
B	PHE830

---

site_id	AD7
Number of Residues	6
Details	binding site for residue EDO B 1007

Chain	Residue
A	LYS569
B	ASN599
B	THR604
B	TYR605
B	THR606
B	HOH1135

---

site_id	AD8
Number of Residues	3
Details	binding site for residue EDO B 1008

Chain	Residue
B	PHE777
B	HIS865
B	HOH1112

---

Functional Information from PROSITE/UniProt

site_id	PS00126
Number of Residues	12
Details	PDEASE_I_1 3'5'-cyclic nucleotide phosphodiesterase domain signature. HDLdHrGtnNsF

Chain	Residue	Details
A	HIS696-PHE707

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	2
Details	Active site: {"description":"Proton donor","evidences":[{"source":"UniProtKB","id":"O76083","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI2
Number of Residues	6
Details	Binding site: {"evidences":[{"source":"PubMed","id":"15938621","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"19828435","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"23899287","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"1Z1L","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3IBJ","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3ITM","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3ITU","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4HTX","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4HTZ","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4JIB","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI3
Number of Residues	2
Details	Binding site: {"evidences":[{"source":"PubMed","id":"15938621","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"19828435","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"23899287","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"1Z1L","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3ITM","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3ITU","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4HTX","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4HTZ","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4JIB","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---