6CRN

Structure of the USP15 deubiquitinase domain in complex with a high-affinity first-generation Ubv

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0004843	molecular_function	cysteine-type deubiquitinase activity
A	0016579	biological_process	protein deubiquitination
B	0004843	molecular_function	cysteine-type deubiquitinase activity
B	0016579	biological_process	protein deubiquitination
C	0004843	molecular_function	cysteine-type deubiquitinase activity
C	0016579	biological_process	protein deubiquitination
D	0004843	molecular_function	cysteine-type deubiquitinase activity
D	0016579	biological_process	protein deubiquitination

Functional Information from PDB Data

site_id	AC1
Number of Residues	4
Details	binding site for residue ZN A 700

Chain	Residue
A	CYS448
A	CYS451
A	CYS499
A	CYS502

---

site_id	AC2
Number of Residues	4
Details	binding site for residue ZN B 701

Chain	Residue
B	CYS448
B	CYS451
B	CYS499
B	CYS502

---

site_id	AC3
Number of Residues	4
Details	binding site for residue ZN C 701

Chain	Residue
C	CYS451
C	CYS499
C	CYS502
C	CYS448

---

site_id	AC4
Number of Residues	4
Details	binding site for residue ZN D 701

Chain	Residue
D	CYS448
D	CYS451
D	CYS499
D	CYS502

---

Functional Information from PROSITE/UniProt

site_id	PS00972
Number of Residues	16
Details	USP_1 Ubiquitin specific protease (USP) domain signature 1. GLsnlGNtCFMNSaIQ

Chain	Residue	Details
A	GLY290-GLN305

---

site_id	PS00973
Number of Residues	18
Details	USP_2 Ubiquitin specific protease (USP) domain signature 2. YnLiAVsnHyGgmgg..GHY

Chain	Residue	Details
A	TYR565-TYR582

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	4
Details	ACT_SITE: Nucleophile => ECO:0000255|PROSITE-ProRule:PRU01035, ECO:0000305|PubMed:19553310, ECO:0000305|PubMed:21947082, ECO:0000305|PubMed:22344298, ECO:0000305|PubMed:24852371, ECO:0000305|PubMed:27368102, ECO:0000305|PubMed:33093067

Chain	Residue	Details
A	CYS298
B	CYS298
C	CYS298
D	CYS298

---

site_id	SWS_FT_FI2
Number of Residues	4
Details	ACT_SITE: Proton acceptor => ECO:0000255|PROSITE-ProRule:PRU10092, ECO:0000255|PROSITE-ProRule:PRU10093

Chain	Residue	Details
A	HIS581
B	HIS581
C	HIS581
D	HIS581

---

site_id	SWS_FT_FI3
Number of Residues	4
Details	MOD_RES: Phosphothreonine => ECO:0000250|UniProtKB:Q8R5H1

Chain	Residue	Details
A	VAL602
B	VAL602
C	VAL602
D	VAL602

---