6CRN
Structure of the USP15 deubiquitinase domain in complex with a high-affinity first-generation Ubv
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0004843 | molecular_function | cysteine-type deubiquitinase activity |
| A | 0016579 | biological_process | protein deubiquitination |
| B | 0004843 | molecular_function | cysteine-type deubiquitinase activity |
| B | 0016579 | biological_process | protein deubiquitination |
| C | 0004843 | molecular_function | cysteine-type deubiquitinase activity |
| C | 0016579 | biological_process | protein deubiquitination |
| D | 0004843 | molecular_function | cysteine-type deubiquitinase activity |
| D | 0016579 | biological_process | protein deubiquitination |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 4 |
| Details | binding site for residue ZN A 700 |
| Chain | Residue |
| A | CYS448 |
| A | CYS451 |
| A | CYS499 |
| A | CYS502 |
| site_id | AC2 |
| Number of Residues | 4 |
| Details | binding site for residue ZN B 701 |
| Chain | Residue |
| B | CYS448 |
| B | CYS451 |
| B | CYS499 |
| B | CYS502 |
| site_id | AC3 |
| Number of Residues | 4 |
| Details | binding site for residue ZN C 701 |
| Chain | Residue |
| C | CYS451 |
| C | CYS499 |
| C | CYS502 |
| C | CYS448 |
| site_id | AC4 |
| Number of Residues | 4 |
| Details | binding site for residue ZN D 701 |
| Chain | Residue |
| D | CYS448 |
| D | CYS451 |
| D | CYS499 |
| D | CYS502 |
Functional Information from PROSITE/UniProt
| site_id | PS00972 |
| Number of Residues | 16 |
| Details | USP_1 Ubiquitin specific protease (USP) domain signature 1. GLsnlGNtCFMNSaIQ |
| Chain | Residue | Details |
| A | GLY290-GLN305 |
| site_id | PS00973 |
| Number of Residues | 18 |
| Details | USP_2 Ubiquitin specific protease (USP) domain signature 2. YnLiAVsnHyGgmgg..GHY |
| Chain | Residue | Details |
| A | TYR565-TYR582 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 4 |
| Details | Active site: {"description":"Nucleophile","evidences":[{"source":"PROSITE-ProRule","id":"PRU01035","evidenceCode":"ECO:0000255"},{"source":"PubMed","id":"19553310","evidenceCode":"ECO:0000305"},{"source":"PubMed","id":"21947082","evidenceCode":"ECO:0000305"},{"source":"PubMed","id":"22344298","evidenceCode":"ECO:0000305"},{"source":"PubMed","id":"24852371","evidenceCode":"ECO:0000305"},{"source":"PubMed","id":"27368102","evidenceCode":"ECO:0000305"},{"source":"PubMed","id":"33093067","evidenceCode":"ECO:0000305"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI2 |
| Number of Residues | 4 |
| Details | Active site: {"description":"Proton acceptor","evidences":[{"source":"PROSITE-ProRule","id":"PRU10092","evidenceCode":"ECO:0000255"},{"source":"PROSITE-ProRule","id":"PRU10093","evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
