6CNN

Cryo-EM structure of the human SK4/calmodulin channel complex in the Ca2+ bound state I

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0002376	biological_process	immune system process
A	0005267	molecular_function	potassium channel activity
A	0005515	molecular_function	protein binding
A	0005516	molecular_function	calmodulin binding
A	0005829	cellular_component	cytosol
A	0005886	cellular_component	plasma membrane
A	0006813	biological_process	potassium ion transport
A	0006816	biological_process	calcium ion transport
A	0006884	biological_process	cell volume homeostasis
A	0006952	biological_process	defense response
A	0008076	cellular_component	voltage-gated potassium channel complex
A	0015269	molecular_function	calcium-activated potassium channel activity
A	0016020	cellular_component	membrane
A	0016286	molecular_function	small conductance calcium-activated potassium channel activity
A	0019903	molecular_function	protein phosphatase binding
A	0022894	molecular_function	intermediate conductance calcium-activated potassium channel activity
A	0030322	biological_process	stabilization of membrane potential
A	0031982	cellular_component	vesicle
A	0032587	cellular_component	ruffle membrane
A	0034220	biological_process	monoatomic ion transmembrane transport
A	0042803	molecular_function	protein homodimerization activity
A	0042995	cellular_component	cell projection
A	0043005	cellular_component	neuron projection
A	0043025	cellular_component	neuronal cell body
A	0044351	biological_process	macropinocytosis
A	0045332	biological_process	phospholipid translocation
A	0046541	biological_process	saliva secretion
A	0050714	biological_process	positive regulation of protein secretion
A	0050862	biological_process	positive regulation of T cell receptor signaling pathway
A	0051289	biological_process	protein homotetramerization
A	0051649	biological_process	establishment of localization in cell
A	0071805	biological_process	potassium ion transmembrane transport
A	1901381	biological_process	positive regulation of potassium ion transmembrane transport
A	1905664	biological_process	regulation of calcium ion import across plasma membrane
B	0002376	biological_process	immune system process
B	0005267	molecular_function	potassium channel activity
B	0005515	molecular_function	protein binding
B	0005516	molecular_function	calmodulin binding
B	0005829	cellular_component	cytosol
B	0005886	cellular_component	plasma membrane
B	0006813	biological_process	potassium ion transport
B	0006816	biological_process	calcium ion transport
B	0006884	biological_process	cell volume homeostasis
B	0006952	biological_process	defense response
B	0008076	cellular_component	voltage-gated potassium channel complex
B	0015269	molecular_function	calcium-activated potassium channel activity
B	0016020	cellular_component	membrane
B	0016286	molecular_function	small conductance calcium-activated potassium channel activity
B	0019903	molecular_function	protein phosphatase binding
B	0022894	molecular_function	intermediate conductance calcium-activated potassium channel activity
B	0030322	biological_process	stabilization of membrane potential
B	0031982	cellular_component	vesicle
B	0032587	cellular_component	ruffle membrane
B	0034220	biological_process	monoatomic ion transmembrane transport
B	0042803	molecular_function	protein homodimerization activity
B	0042995	cellular_component	cell projection
B	0043005	cellular_component	neuron projection
B	0043025	cellular_component	neuronal cell body
B	0044351	biological_process	macropinocytosis
B	0045332	biological_process	phospholipid translocation
B	0046541	biological_process	saliva secretion
B	0050714	biological_process	positive regulation of protein secretion
B	0050862	biological_process	positive regulation of T cell receptor signaling pathway
B	0051289	biological_process	protein homotetramerization
B	0051649	biological_process	establishment of localization in cell
B	0071805	biological_process	potassium ion transmembrane transport
B	1901381	biological_process	positive regulation of potassium ion transmembrane transport
B	1905664	biological_process	regulation of calcium ion import across plasma membrane
C	0002376	biological_process	immune system process
C	0005267	molecular_function	potassium channel activity
C	0005515	molecular_function	protein binding
C	0005516	molecular_function	calmodulin binding
C	0005829	cellular_component	cytosol
C	0005886	cellular_component	plasma membrane
C	0006813	biological_process	potassium ion transport
C	0006816	biological_process	calcium ion transport
C	0006884	biological_process	cell volume homeostasis
C	0006952	biological_process	defense response
C	0008076	cellular_component	voltage-gated potassium channel complex
C	0015269	molecular_function	calcium-activated potassium channel activity
C	0016020	cellular_component	membrane
C	0016286	molecular_function	small conductance calcium-activated potassium channel activity
C	0019903	molecular_function	protein phosphatase binding
C	0022894	molecular_function	intermediate conductance calcium-activated potassium channel activity
C	0030322	biological_process	stabilization of membrane potential
C	0031982	cellular_component	vesicle
C	0032587	cellular_component	ruffle membrane
C	0034220	biological_process	monoatomic ion transmembrane transport
C	0042803	molecular_function	protein homodimerization activity
C	0042995	cellular_component	cell projection
C	0043005	cellular_component	neuron projection
C	0043025	cellular_component	neuronal cell body
C	0044351	biological_process	macropinocytosis
C	0045332	biological_process	phospholipid translocation
C	0046541	biological_process	saliva secretion
C	0050714	biological_process	positive regulation of protein secretion
C	0050862	biological_process	positive regulation of T cell receptor signaling pathway
C	0051289	biological_process	protein homotetramerization
C	0051649	biological_process	establishment of localization in cell
C	0071805	biological_process	potassium ion transmembrane transport
C	1901381	biological_process	positive regulation of potassium ion transmembrane transport
C	1905664	biological_process	regulation of calcium ion import across plasma membrane
D	0002376	biological_process	immune system process
D	0005267	molecular_function	potassium channel activity
D	0005515	molecular_function	protein binding
D	0005516	molecular_function	calmodulin binding
D	0005829	cellular_component	cytosol
D	0005886	cellular_component	plasma membrane
D	0006813	biological_process	potassium ion transport
D	0006816	biological_process	calcium ion transport
D	0006884	biological_process	cell volume homeostasis
D	0006952	biological_process	defense response
D	0008076	cellular_component	voltage-gated potassium channel complex
D	0015269	molecular_function	calcium-activated potassium channel activity
D	0016020	cellular_component	membrane
D	0016286	molecular_function	small conductance calcium-activated potassium channel activity
D	0019903	molecular_function	protein phosphatase binding
D	0022894	molecular_function	intermediate conductance calcium-activated potassium channel activity
D	0030322	biological_process	stabilization of membrane potential
D	0031982	cellular_component	vesicle
D	0032587	cellular_component	ruffle membrane
D	0034220	biological_process	monoatomic ion transmembrane transport
D	0042803	molecular_function	protein homodimerization activity
D	0042995	cellular_component	cell projection
D	0043005	cellular_component	neuron projection
D	0043025	cellular_component	neuronal cell body
D	0044351	biological_process	macropinocytosis
D	0045332	biological_process	phospholipid translocation
D	0046541	biological_process	saliva secretion
D	0050714	biological_process	positive regulation of protein secretion
D	0050862	biological_process	positive regulation of T cell receptor signaling pathway
D	0051289	biological_process	protein homotetramerization
D	0051649	biological_process	establishment of localization in cell
D	0071805	biological_process	potassium ion transmembrane transport
D	1901381	biological_process	positive regulation of potassium ion transmembrane transport
D	1905664	biological_process	regulation of calcium ion import across plasma membrane
E	0000086	biological_process	G2/M transition of mitotic cell cycle
E	0000922	cellular_component	spindle pole
E	0002027	biological_process	regulation of heart rate
E	0005509	molecular_function	calcium ion binding
E	0005513	biological_process	detection of calcium ion
E	0005515	molecular_function	protein binding
E	0005576	cellular_component	extracellular region
E	0005634	cellular_component	nucleus
E	0005654	cellular_component	nucleoplasm
E	0005737	cellular_component	cytoplasm
E	0005813	cellular_component	centrosome
E	0005819	cellular_component	spindle
E	0005829	cellular_component	cytosol
E	0005856	cellular_component	cytoskeleton
E	0005876	cellular_component	spindle microtubule
E	0005886	cellular_component	plasma membrane
E	0007186	biological_process	G protein-coupled receptor signaling pathway
E	0008076	cellular_component	voltage-gated potassium channel complex
E	0010800	biological_process	positive regulation of peptidyl-threonine phosphorylation
E	0010801	biological_process	negative regulation of peptidyl-threonine phosphorylation
E	0010856	molecular_function	adenylate cyclase activator activity
E	0010880	biological_process	regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum
E	0010881	biological_process	regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion
E	0016020	cellular_component	membrane
E	0016240	biological_process	autophagosome membrane docking
E	0019855	molecular_function	calcium channel inhibitor activity
E	0019901	molecular_function	protein kinase binding
E	0021762	biological_process	substantia nigra development
E	0030017	cellular_component	sarcomere
E	0031432	molecular_function	titin binding
E	0031514	cellular_component	motile cilium
E	0031954	biological_process	positive regulation of protein autophosphorylation
E	0031982	cellular_component	vesicle
E	0032465	biological_process	regulation of cytokinesis
E	0032991	cellular_component	protein-containing complex
E	0034704	cellular_component	calcium channel complex
E	0035458	biological_process	cellular response to interferon-beta
E	0043209	cellular_component	myelin sheath
E	0043539	molecular_function	protein serine/threonine kinase activator activity
E	0044305	cellular_component	calyx of Held
E	0044325	molecular_function	transmembrane transporter binding
E	0046427	biological_process	positive regulation of receptor signaling pathway via JAK-STAT
E	0046872	molecular_function	metal ion binding
E	0048306	molecular_function	calcium-dependent protein binding
E	0050848	biological_process	regulation of calcium-mediated signaling
E	0051592	biological_process	response to calcium ion
E	0055117	biological_process	regulation of cardiac muscle contraction
E	0060314	biological_process	regulation of ryanodine-sensitive calcium-release channel activity
E	0060315	biological_process	negative regulation of ryanodine-sensitive calcium-release channel activity
E	0060316	biological_process	positive regulation of ryanodine-sensitive calcium-release channel activity
E	0071346	biological_process	cellular response to type II interferon
E	0071902	biological_process	positive regulation of protein serine/threonine kinase activity
E	0072542	molecular_function	protein phosphatase activator activity
E	0097225	cellular_component	sperm midpiece
E	0097720	biological_process	calcineurin-mediated signaling
E	0098901	biological_process	regulation of cardiac muscle cell action potential
E	0099523	cellular_component	presynaptic cytosol
E	0140056	biological_process	organelle localization by membrane tethering
E	0140238	biological_process	presynaptic endocytosis
E	1901842	biological_process	negative regulation of high voltage-gated calcium channel activity
E	1901844	biological_process	regulation of cell communication by electrical coupling involved in cardiac conduction
E	1902494	cellular_component	catalytic complex
E	1905913	biological_process	negative regulation of calcium ion export across plasma membrane
E	1990456	biological_process	mitochondrion-endoplasmic reticulum membrane tethering
F	0000086	biological_process	G2/M transition of mitotic cell cycle
F	0000922	cellular_component	spindle pole
F	0002027	biological_process	regulation of heart rate
F	0005509	molecular_function	calcium ion binding
F	0005513	biological_process	detection of calcium ion
F	0005515	molecular_function	protein binding
F	0005576	cellular_component	extracellular region
F	0005634	cellular_component	nucleus
F	0005654	cellular_component	nucleoplasm
F	0005737	cellular_component	cytoplasm
F	0005813	cellular_component	centrosome
F	0005819	cellular_component	spindle
F	0005829	cellular_component	cytosol
F	0005856	cellular_component	cytoskeleton
F	0005876	cellular_component	spindle microtubule
F	0005886	cellular_component	plasma membrane
F	0007186	biological_process	G protein-coupled receptor signaling pathway
F	0008076	cellular_component	voltage-gated potassium channel complex
F	0010800	biological_process	positive regulation of peptidyl-threonine phosphorylation
F	0010801	biological_process	negative regulation of peptidyl-threonine phosphorylation
F	0010856	molecular_function	adenylate cyclase activator activity
F	0010880	biological_process	regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum
F	0010881	biological_process	regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion
F	0016020	cellular_component	membrane
F	0016240	biological_process	autophagosome membrane docking
F	0019855	molecular_function	calcium channel inhibitor activity
F	0019901	molecular_function	protein kinase binding
F	0021762	biological_process	substantia nigra development
F	0030017	cellular_component	sarcomere
F	0031432	molecular_function	titin binding
F	0031514	cellular_component	motile cilium
F	0031954	biological_process	positive regulation of protein autophosphorylation
F	0031982	cellular_component	vesicle
F	0032465	biological_process	regulation of cytokinesis
F	0032991	cellular_component	protein-containing complex
F	0034704	cellular_component	calcium channel complex
F	0035458	biological_process	cellular response to interferon-beta
F	0043209	cellular_component	myelin sheath
F	0043539	molecular_function	protein serine/threonine kinase activator activity
F	0044305	cellular_component	calyx of Held
F	0044325	molecular_function	transmembrane transporter binding
F	0046427	biological_process	positive regulation of receptor signaling pathway via JAK-STAT
F	0046872	molecular_function	metal ion binding
F	0048306	molecular_function	calcium-dependent protein binding
F	0050848	biological_process	regulation of calcium-mediated signaling
F	0051592	biological_process	response to calcium ion
F	0055117	biological_process	regulation of cardiac muscle contraction
F	0060314	biological_process	regulation of ryanodine-sensitive calcium-release channel activity
F	0060315	biological_process	negative regulation of ryanodine-sensitive calcium-release channel activity
F	0060316	biological_process	positive regulation of ryanodine-sensitive calcium-release channel activity
F	0071346	biological_process	cellular response to type II interferon
F	0071902	biological_process	positive regulation of protein serine/threonine kinase activity
F	0072542	molecular_function	protein phosphatase activator activity
F	0097225	cellular_component	sperm midpiece
F	0097720	biological_process	calcineurin-mediated signaling
F	0098901	biological_process	regulation of cardiac muscle cell action potential
F	0099523	cellular_component	presynaptic cytosol
F	0140056	biological_process	organelle localization by membrane tethering
F	0140238	biological_process	presynaptic endocytosis
F	1901842	biological_process	negative regulation of high voltage-gated calcium channel activity
F	1901844	biological_process	regulation of cell communication by electrical coupling involved in cardiac conduction
F	1902494	cellular_component	catalytic complex
F	1905913	biological_process	negative regulation of calcium ion export across plasma membrane
F	1990456	biological_process	mitochondrion-endoplasmic reticulum membrane tethering
G	0000086	biological_process	G2/M transition of mitotic cell cycle
G	0000922	cellular_component	spindle pole
G	0002027	biological_process	regulation of heart rate
G	0005509	molecular_function	calcium ion binding
G	0005513	biological_process	detection of calcium ion
G	0005515	molecular_function	protein binding
G	0005576	cellular_component	extracellular region
G	0005634	cellular_component	nucleus
G	0005654	cellular_component	nucleoplasm
G	0005737	cellular_component	cytoplasm
G	0005813	cellular_component	centrosome
G	0005819	cellular_component	spindle
G	0005829	cellular_component	cytosol
G	0005856	cellular_component	cytoskeleton
G	0005876	cellular_component	spindle microtubule
G	0005886	cellular_component	plasma membrane
G	0007186	biological_process	G protein-coupled receptor signaling pathway
G	0008076	cellular_component	voltage-gated potassium channel complex
G	0010800	biological_process	positive regulation of peptidyl-threonine phosphorylation
G	0010801	biological_process	negative regulation of peptidyl-threonine phosphorylation
G	0010856	molecular_function	adenylate cyclase activator activity
G	0010880	biological_process	regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum
G	0010881	biological_process	regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion
G	0016020	cellular_component	membrane
G	0016240	biological_process	autophagosome membrane docking
G	0019855	molecular_function	calcium channel inhibitor activity
G	0019901	molecular_function	protein kinase binding
G	0021762	biological_process	substantia nigra development
G	0030017	cellular_component	sarcomere
G	0031432	molecular_function	titin binding
G	0031514	cellular_component	motile cilium
G	0031954	biological_process	positive regulation of protein autophosphorylation
G	0031982	cellular_component	vesicle
G	0032465	biological_process	regulation of cytokinesis
G	0032991	cellular_component	protein-containing complex
G	0034704	cellular_component	calcium channel complex
G	0035458	biological_process	cellular response to interferon-beta
G	0043209	cellular_component	myelin sheath
G	0043539	molecular_function	protein serine/threonine kinase activator activity
G	0044305	cellular_component	calyx of Held
G	0044325	molecular_function	transmembrane transporter binding
G	0046427	biological_process	positive regulation of receptor signaling pathway via JAK-STAT
G	0046872	molecular_function	metal ion binding
G	0048306	molecular_function	calcium-dependent protein binding
G	0050848	biological_process	regulation of calcium-mediated signaling
G	0051592	biological_process	response to calcium ion
G	0055117	biological_process	regulation of cardiac muscle contraction
G	0060314	biological_process	regulation of ryanodine-sensitive calcium-release channel activity
G	0060315	biological_process	negative regulation of ryanodine-sensitive calcium-release channel activity
G	0060316	biological_process	positive regulation of ryanodine-sensitive calcium-release channel activity
G	0071346	biological_process	cellular response to type II interferon
G	0071902	biological_process	positive regulation of protein serine/threonine kinase activity
G	0072542	molecular_function	protein phosphatase activator activity
G	0097225	cellular_component	sperm midpiece
G	0097720	biological_process	calcineurin-mediated signaling
G	0098901	biological_process	regulation of cardiac muscle cell action potential
G	0099523	cellular_component	presynaptic cytosol
G	0140056	biological_process	organelle localization by membrane tethering
G	0140238	biological_process	presynaptic endocytosis
G	1901842	biological_process	negative regulation of high voltage-gated calcium channel activity
G	1901844	biological_process	regulation of cell communication by electrical coupling involved in cardiac conduction
G	1902494	cellular_component	catalytic complex
G	1905913	biological_process	negative regulation of calcium ion export across plasma membrane
G	1990456	biological_process	mitochondrion-endoplasmic reticulum membrane tethering
H	0000086	biological_process	G2/M transition of mitotic cell cycle
H	0000922	cellular_component	spindle pole
H	0002027	biological_process	regulation of heart rate
H	0005509	molecular_function	calcium ion binding
H	0005513	biological_process	detection of calcium ion
H	0005515	molecular_function	protein binding
H	0005576	cellular_component	extracellular region
H	0005634	cellular_component	nucleus
H	0005654	cellular_component	nucleoplasm
H	0005737	cellular_component	cytoplasm
H	0005813	cellular_component	centrosome
H	0005819	cellular_component	spindle
H	0005829	cellular_component	cytosol
H	0005856	cellular_component	cytoskeleton
H	0005876	cellular_component	spindle microtubule
H	0005886	cellular_component	plasma membrane
H	0007186	biological_process	G protein-coupled receptor signaling pathway
H	0008076	cellular_component	voltage-gated potassium channel complex
H	0010800	biological_process	positive regulation of peptidyl-threonine phosphorylation
H	0010801	biological_process	negative regulation of peptidyl-threonine phosphorylation
H	0010856	molecular_function	adenylate cyclase activator activity
H	0010880	biological_process	regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum
H	0010881	biological_process	regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion
H	0016020	cellular_component	membrane
H	0016240	biological_process	autophagosome membrane docking
H	0019855	molecular_function	calcium channel inhibitor activity
H	0019901	molecular_function	protein kinase binding
H	0021762	biological_process	substantia nigra development
H	0030017	cellular_component	sarcomere
H	0031432	molecular_function	titin binding
H	0031514	cellular_component	motile cilium
H	0031954	biological_process	positive regulation of protein autophosphorylation
H	0031982	cellular_component	vesicle
H	0032465	biological_process	regulation of cytokinesis
H	0032991	cellular_component	protein-containing complex
H	0034704	cellular_component	calcium channel complex
H	0035458	biological_process	cellular response to interferon-beta
H	0043209	cellular_component	myelin sheath
H	0043539	molecular_function	protein serine/threonine kinase activator activity
H	0044305	cellular_component	calyx of Held
H	0044325	molecular_function	transmembrane transporter binding
H	0046427	biological_process	positive regulation of receptor signaling pathway via JAK-STAT
H	0046872	molecular_function	metal ion binding
H	0048306	molecular_function	calcium-dependent protein binding
H	0050848	biological_process	regulation of calcium-mediated signaling
H	0051592	biological_process	response to calcium ion
H	0055117	biological_process	regulation of cardiac muscle contraction
H	0060314	biological_process	regulation of ryanodine-sensitive calcium-release channel activity
H	0060315	biological_process	negative regulation of ryanodine-sensitive calcium-release channel activity
H	0060316	biological_process	positive regulation of ryanodine-sensitive calcium-release channel activity
H	0071346	biological_process	cellular response to type II interferon
H	0071902	biological_process	positive regulation of protein serine/threonine kinase activity
H	0072542	molecular_function	protein phosphatase activator activity
H	0097225	cellular_component	sperm midpiece
H	0097720	biological_process	calcineurin-mediated signaling
H	0098901	biological_process	regulation of cardiac muscle cell action potential
H	0099523	cellular_component	presynaptic cytosol
H	0140056	biological_process	organelle localization by membrane tethering
H	0140238	biological_process	presynaptic endocytosis
H	1901842	biological_process	negative regulation of high voltage-gated calcium channel activity
H	1901844	biological_process	regulation of cell communication by electrical coupling involved in cardiac conduction
H	1902494	cellular_component	catalytic complex
H	1905913	biological_process	negative regulation of calcium ion export across plasma membrane
H	1990456	biological_process	mitochondrion-endoplasmic reticulum membrane tethering

Functional Information from PDB Data

site_id	AC1
Number of Residues	9
Details	binding site for residue K A 1001

Chain	Residue
A	GLY252
A	TYR253
A	K1002
B	GLY252
B	TYR253
C	GLY252
C	TYR253
D	GLY252
D	TYR253

---

site_id	AC2
Number of Residues	10
Details	binding site for residue K A 1002

Chain	Residue
A	ILE251
A	GLY252
A	K1001
A	K1003
B	ILE251
B	GLY252
C	ILE251
C	GLY252
D	ILE251
D	GLY252

---

site_id	AC3
Number of Residues	10
Details	binding site for residue K A 1003

Chain	Residue
A	THR250
A	ILE251
A	K1002
A	K1004
B	THR250
B	ILE251
C	THR250
C	ILE251
D	THR250
D	ILE251

---

site_id	AC4
Number of Residues	5
Details	binding site for residue K A 1004

Chain	Residue
A	THR250
A	K1003
B	THR250
C	THR250
D	THR250

---

site_id	AC5
Number of Residues	3
Details	binding site for residue POV A 1101

Chain	Residue
D	HIS236
D	SER238
D	LEU241

---

site_id	AC6
Number of Residues	6
Details	binding site for residue LMT A 1104

Chain	Residue
A	PHE144
A	LEU145
A	GLY146
A	ALA150
A	ALA226
A	TRP262

---

site_id	AC7
Number of Residues	3
Details	binding site for residue POV B 1101

Chain	Residue
A	HIS236
A	SER238
A	LEU241

---

site_id	AC8
Number of Residues	6
Details	binding site for residue LMT B 1104

Chain	Residue
B	PHE144
B	LEU145
B	GLY146
B	ALA150
B	ALA226
B	TRP262

---

site_id	AC9
Number of Residues	3
Details	binding site for residue POV C 1101

Chain	Residue
B	HIS236
B	SER238
B	LEU241

---

site_id	AD1
Number of Residues	6
Details	binding site for residue LMT C 1104

Chain	Residue
C	PHE144
C	LEU145
C	GLY146
C	ALA150
C	ALA226
C	TRP262

---

site_id	AD2
Number of Residues	3
Details	binding site for residue POV D 1101

Chain	Residue
C	HIS236
C	SER238
C	LEU241

---

site_id	AD3
Number of Residues	6
Details	binding site for residue LMT D 1104

Chain	Residue
D	PHE144
D	LEU145
D	GLY146
D	ALA150
D	ALA226
D	TRP262

---

site_id	AD4
Number of Residues	5
Details	binding site for residue CA E 201

Chain	Residue
E	ASP20
E	ASP22
E	ASP24
E	THR26
E	GLU31

---

site_id	AD5
Number of Residues	5
Details	binding site for residue CA E 202

Chain	Residue
E	ASP56
E	ASP58
E	ASN60
E	THR62
E	GLU67

---

site_id	AD6
Number of Residues	5
Details	binding site for residue CA E 203

Chain	Residue
E	ASP93
E	ASP95
E	ASN97
E	TYR99
E	GLU104

---

site_id	AD7
Number of Residues	5
Details	binding site for residue CA F 201

Chain	Residue
F	ASP20
F	ASP22
F	ASP24
F	THR26
F	GLU31

---

site_id	AD8
Number of Residues	5
Details	binding site for residue CA F 202

Chain	Residue
F	ASP56
F	ASP58
F	ASN60
F	THR62
F	GLU67

---

site_id	AD9
Number of Residues	5
Details	binding site for residue CA F 203

Chain	Residue
F	GLU104
F	ASP93
F	ASP95
F	ASN97
F	TYR99

---

site_id	AE1
Number of Residues	5
Details	binding site for residue CA G 201

Chain	Residue
G	ASP20
G	ASP22
G	ASP24
G	THR26
G	GLU31

---

site_id	AE2
Number of Residues	5
Details	binding site for residue CA G 202

Chain	Residue
G	ASP56
G	ASP58
G	ASN60
G	THR62
G	GLU67

---

site_id	AE3
Number of Residues	5
Details	binding site for residue CA G 203

Chain	Residue
G	ASP93
G	ASP95
G	ASN97
G	TYR99
G	GLU104

---

site_id	AE4
Number of Residues	5
Details	binding site for residue CA H 201

Chain	Residue
H	ASP20
H	ASP22
H	ASP24
H	THR26
H	GLU31

---

site_id	AE5
Number of Residues	5
Details	binding site for residue CA H 202

Chain	Residue
H	ASP56
H	ASP58
H	ASN60
H	THR62
H	GLU67

---

site_id	AE6
Number of Residues	5
Details	binding site for residue CA H 203

Chain	Residue
H	ASP93
H	ASP95
H	ASN97
H	TYR99
H	GLU104

---

Functional Information from PROSITE/UniProt

site_id	PS00018
Number of Residues	13
Details	EF_HAND_1 EF-hand calcium-binding domain. DKDGDGTITtkEL

Chain	Residue	Details
E	ASP20-LEU32
E	ASP56-PHE68
E	ASP93-LEU105
E	ASP129-PHE141

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	40
Details	BINDING: BINDING => ECO:0000255|PROSITE-ProRule:PRU00448, ECO:0000269|PubMed:1474585, ECO:0000269|PubMed:25441029, ECO:0000269|PubMed:27564677, ECO:0007744|PDB:1CLL, ECO:0007744|PDB:4UMO, ECO:0007744|PDB:4V0C, ECO:0007744|PDB:5J03

Chain	Residue	Details
E	ASP20
E	GLU67
F	ASP20
F	ASP22
F	ASP24
F	THR26
F	GLU31
F	ASP56
F	ASP58
F	ASN60
F	THR62
E	ASP22
F	GLU67
G	ASP20
G	ASP22
G	ASP24
G	THR26
G	GLU31
G	ASP56
G	ASP58
G	ASN60
G	THR62
E	ASP24
G	GLU67
H	ASP20
H	ASP22
H	ASP24
H	THR26
H	GLU31
H	ASP56
H	ASP58
H	ASN60
H	THR62
E	THR26
H	GLU67
E	GLU31
E	ASP56
E	ASP58
E	ASN60
E	THR62

---

site_id	SWS_FT_FI2
Number of Residues	20
Details	BINDING: BINDING => ECO:0000255|PROSITE-ProRule:PRU00448, ECO:0000269|PubMed:1474585, ECO:0000269|PubMed:27564677, ECO:0000269|PubMed:29724949, ECO:0007744|PDB:1CLL, ECO:0007744|PDB:5J03, ECO:0007744|PDB:6CNN, ECO:0007744|PDB:6CNO

Chain	Residue	Details
E	ASP93
F	GLU104
G	ASP93
G	ASP95
G	ASN97
G	TYR99
G	GLU104
H	ASP93
H	ASP95
H	ASN97
H	TYR99
E	ASP95
H	GLU104
E	ASN97
E	TYR99
E	GLU104
F	ASP93
F	ASP95
F	ASN97
F	TYR99

---

site_id	SWS_FT_FI3
Number of Residues	20
Details	BINDING: BINDING => ECO:0000255|PROSITE-ProRule:PRU00448, ECO:0000269|PubMed:1474585, ECO:0000269|PubMed:27564677, ECO:0007744|PDB:1CLL, ECO:0007744|PDB:5J03

Chain	Residue	Details
E	ASP129
F	GLU140
G	ASP129
G	ASP131
G	ASP133
G	GLN135
G	GLU140
H	ASP129
H	ASP131
H	ASP133
H	GLN135
E	ASP131
H	GLU140
E	ASP133
E	GLN135
E	GLU140
F	ASP129
F	ASP131
F	ASP133
F	GLN135

---

site_id	SWS_FT_FI4
Number of Residues	4
Details	MOD_RES: N-acetylalanine => ECO:0000269|PubMed:7093203, ECO:0000269|Ref.7, ECO:0007744|PubMed:19413330, ECO:0007744|PubMed:22223895, ECO:0007744|PubMed:22814378, ECO:0007744|PubMed:25944712

Chain	Residue	Details
E	ALA1
F	ALA1
G	ALA1
H	ALA1

---

site_id	SWS_FT_FI5
Number of Residues	4
Details	MOD_RES: N6-acetyllysine; alternate => ECO:0007744|PubMed:19608861

Chain	Residue	Details
E	LYS21
F	LYS21
G	LYS21
H	LYS21

---

site_id	SWS_FT_FI6
Number of Residues	4
Details	MOD_RES: Phosphothreonine; by CaMK4 => ECO:0000250|UniProtKB:P0DP29

Chain	Residue	Details
E	THR44
F	THR44
G	THR44
H	THR44

---

site_id	SWS_FT_FI7
Number of Residues	4
Details	MOD_RES: Phosphoserine => ECO:0007744|PubMed:23186163

Chain	Residue	Details
E	SER81
F	SER81
G	SER81
H	SER81

---

site_id	SWS_FT_FI8
Number of Residues	4
Details	MOD_RES: N6-acetyllysine => ECO:0007744|PubMed:19608861

Chain	Residue	Details
E	LYS94
F	LYS94
G	LYS94
H	LYS94

---

site_id	SWS_FT_FI9
Number of Residues	4
Details	MOD_RES: Phosphotyrosine => ECO:0007744|PubMed:18669648, ECO:0007744|PubMed:19690332

Chain	Residue	Details
E	TYR99
F	TYR99
G	TYR99
H	TYR99

---

site_id	SWS_FT_FI10
Number of Residues	4
Details	MOD_RES: Phosphoserine => ECO:0007744|PubMed:21406692, ECO:0007744|PubMed:23186163, ECO:0007744|PubMed:24275569

Chain	Residue	Details
E	SER101
F	SER101
G	SER101
H	SER101

---

site_id	SWS_FT_FI11
Number of Residues	4
Details	MOD_RES: Phosphothreonine => ECO:0007744|PubMed:24275569

Chain	Residue	Details
E	THR110
F	THR110
G	THR110
H	THR110

---

site_id	SWS_FT_FI12
Number of Residues	4
Details	MOD_RES: N6-methyllysine; alternate => ECO:0007744|PubMed:24129315

Chain	Residue	Details
E	LYS115
F	LYS115
G	LYS115
H	LYS115

---

site_id	SWS_FT_FI13
Number of Residues	4
Details	MOD_RES: Phosphotyrosine => ECO:0007744|PubMed:19690332

Chain	Residue	Details
E	TYR138
F	TYR138
G	TYR138
H	TYR138

---

site_id	SWS_FT_FI14
Number of Residues	8
Details	CROSSLNK: Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin); alternate => ECO:0000250|UniProtKB:P62157

Chain	Residue	Details
E	LYS21
F	LYS21
G	LYS21
H	LYS21

---