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6C02

Human ectonucleotide pyrophosphatase / phosphodiesterase 3 (ENPP3, NPP3, CD203c), inactive (T205A), N594S, with alpha,beta-methylene-ATP (AMPCPP)

Functional Information from GO Data
ChainGOidnamespacecontents
A0002276biological_processbasophil activation involved in immune response
A0003676molecular_functionnucleic acid binding
A0004081molecular_functionbis(5'-nucleosyl)-tetraphosphatase (asymmetrical) activity
A0004528molecular_functionphosphodiesterase I activity
A0005509molecular_functioncalcium ion binding
A0005576cellular_componentextracellular region
A0005886cellular_componentplasma membrane
A0006220biological_processpyrimidine nucleotide metabolic process
A0006796biological_processphosphate-containing compound metabolic process
A0008270molecular_functionzinc ion binding
A0009143biological_processnucleoside triphosphate catabolic process
A0009897cellular_componentexternal side of plasma membrane
A0016324cellular_componentapical plasma membrane
A0016787molecular_functionhydrolase activity
A0030505biological_processinorganic diphosphate transport
A0033007biological_processnegative regulation of mast cell activation involved in immune response
A0034432molecular_functionbis(5'-adenosyl)-pentaphosphatase activity
A0036219molecular_functionGTP diphosphatase activity
A0036221molecular_functionUTP diphosphatase activity
A0046034biological_processATP metabolic process
A0046872molecular_functionmetal ion binding
A0047429molecular_functionnucleoside triphosphate diphosphatase activity
A0047693molecular_functionATP diphosphatase activity
A0047710molecular_functionbis(5'-adenosyl)-triphosphatase activity
A0048471cellular_componentperinuclear region of cytoplasm
A0050728biological_processnegative regulation of inflammatory response
A0055062biological_processphosphate ion homeostasis
A0070062cellular_componentextracellular exosome
A0070667biological_processnegative regulation of mast cell proliferation
B0002276biological_processbasophil activation involved in immune response
B0003676molecular_functionnucleic acid binding
B0004081molecular_functionbis(5'-nucleosyl)-tetraphosphatase (asymmetrical) activity
B0004528molecular_functionphosphodiesterase I activity
B0005509molecular_functioncalcium ion binding
B0005576cellular_componentextracellular region
B0005886cellular_componentplasma membrane
B0006220biological_processpyrimidine nucleotide metabolic process
B0006796biological_processphosphate-containing compound metabolic process
B0008270molecular_functionzinc ion binding
B0009143biological_processnucleoside triphosphate catabolic process
B0009897cellular_componentexternal side of plasma membrane
B0016324cellular_componentapical plasma membrane
B0016787molecular_functionhydrolase activity
B0030505biological_processinorganic diphosphate transport
B0033007biological_processnegative regulation of mast cell activation involved in immune response
B0034432molecular_functionbis(5'-adenosyl)-pentaphosphatase activity
B0036219molecular_functionGTP diphosphatase activity
B0036221molecular_functionUTP diphosphatase activity
B0046034biological_processATP metabolic process
B0046872molecular_functionmetal ion binding
B0047429molecular_functionnucleoside triphosphate diphosphatase activity
B0047693molecular_functionATP diphosphatase activity
B0047710molecular_functionbis(5'-adenosyl)-triphosphatase activity
B0048471cellular_componentperinuclear region of cytoplasm
B0050728biological_processnegative regulation of inflammatory response
B0055062biological_processphosphate ion homeostasis
B0070062cellular_componentextracellular exosome
B0070667biological_processnegative regulation of mast cell proliferation
Functional Information from PROSITE/UniProt
site_idPS00524
Number of Residues21
DetailsSMB_1 Somatomedin B domain (SMB) signature. CrCdvaCkdrgd.CCwDFedtC
ChainResidueDetails
ACYS69-CYS89
ACYS113-CYS133

Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues2
DetailsACT_SITE: Nucleophile => ECO:0000305|PubMed:29717535
ChainResidueDetails
AALA205
BALA205

site_idSWS_FT_FI2
Number of Residues22
DetailsBINDING: BINDING => ECO:0000269|PubMed:29717535, ECO:0007744|PDB:6C01, ECO:0007744|PDB:6C02
ChainResidueDetails
AASP167
AHIS758
AASP760
BASP167
BASP325
BHIS329
BASP372
BHIS373
BHIS483
BASP752
BASN754
AASP325
BASP756
BHIS758
BASP760
AHIS329
AASP372
AHIS373
AHIS483
AASP752
AASN754
AASP756

site_idSWS_FT_FI3
Number of Residues8
DetailsBINDING: BINDING => ECO:0000305|PubMed:29717535, ECO:0007744|PDB:6C02
ChainResidueDetails
ALYS204
AASN226
AGLU275
ATYR289
BLYS204
BASN226
BGLU275
BTYR289

site_idSWS_FT_FI4
Number of Residues2
DetailsBINDING: BINDING => ECO:0000269|PubMed:29717535, ECO:0007744|PDB:6C01
ChainResidueDetails
AALA205
BALA205

site_idSWS_FT_FI5
Number of Residues14
DetailsCARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000269|PubMed:29717535, ECO:0007744|PDB:6C02
ChainResidueDetails
AASN236
BASN290
BASN426
BASN533
BASN699
BASN789
AASN279
AASN290
AASN426
AASN533
AASN699
AASN789
BASN236
BASN279

site_idSWS_FT_FI6
Number of Residues4
DetailsCARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000269|PubMed:29717535, ECO:0007744|PDB:6C01
ChainResidueDetails
AASN582
ASER594
BASN582
BSER594

site_idSWS_FT_FI7
Number of Residues2
DetailsCARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000305|PubMed:29717535
ChainResidueDetails
AASN687
BASN687

226707

PDB entries from 2024-10-30

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