6C02
Human ectonucleotide pyrophosphatase / phosphodiesterase 3 (ENPP3, NPP3, CD203c), inactive (T205A), N594S, with alpha,beta-methylene-ATP (AMPCPP)
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B (A, B) | Ectonucleotide pyrophosphatase/phosphodiesterase family member 3 | polymer | 838 | 96454.4 | 2 | UniProt (O14638) Pfam (PF01033) Pfam (PF01663) | Homo sapiens (Human) | E-NPP 3,Phosphodiesterase I beta,PD-Ibeta,Phosphodiesterase I/nucleotide pyrophosphatase 3 |
| 2 | C, F, J, L, M (C, F, J, L, M) | 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose | branched | 424.4 | 5 | In PDB GlyTouCan (G42666HT) | |||
| 3 | D, K (D, K) | beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose | branched | 586.5 | 2 | In PDB GlyTouCan (G15407YE) | |||
| 4 | E, G, N (E, G, N) | 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-[alpha-L-fucopyranose-(1-6)]2-acetamido-2-deoxy-beta-D-glucopyranose | branched | 570.5 | 3 | In PDB GlyTouCan (G21290RB) | |||
| 5 | H, I (H, I) | alpha-L-fucopyranose-(1-6)-2-acetamido-2-deoxy-beta-D-glucopyranose | branched | 367.3 | 2 | In PDB GlyTouCan (G86851RC) | |||
| 6 | O, P, Y, Z (A, B) | ZINC ION | non-polymer | 65.4 | 4 | Chemie (ZN) | |||
| 7 | AA, Q (B, A) | CALCIUM ION | non-polymer | 40.1 | 2 | Chemie (CA) | |||
| 8 | BA, R (B, A) | SODIUM ION | non-polymer | 23.0 | 2 | Chemie (NA) | |||
| 9 | S, T, U (A) | CHLORIDE ION | non-polymer | 35.5 | 3 | Chemie (CL) | |||
| 10 | CA, DA, V, W (B, A) | SULFATE ION | non-polymer | 96.1 | 4 | Chemie (SO4) | |||
| 11 | EA, X (B, A) | DIPHOSPHOMETHYLPHOSPHONIC ACID ADENOSYL ESTER | non-polymer | 505.2 | 2 | Chemie (APC) | |||
| 12 | FA, GA (A, B) | water | water | 18.0 | 1305 | Chemie (HOH) |
Sequence modifications
A, B: 48 - 875 (UniProt: O14638)
| PDB | External Database | Details |
|---|---|---|
| Asp 38 | - | expression tag |
| Arg 39 | - | expression tag |
| His 40 | - | expression tag |
| His 41 | - | expression tag |
| His 42 | - | expression tag |
| His 43 | - | expression tag |
| His 44 | - | expression tag |
| His 45 | - | expression tag |
| Lys 46 | - | expression tag |
| Leu 47 | - | expression tag |
| Ala 205 | Thr 205 | engineered mutation |
| Ser 594 | Asn 594 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 2 |
| Total formula weight | 192908.8 | |
| Branched | Number of molecules | 12 |
| Total formula weight | 5741.4 | |
| Non-Polymers* | Number of molecules | 17 |
| Total formula weight | 1888.8 | |
| All* | Total formula weight | 200539.0 |
