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SummaryStructural detailsExperimental detailsFunctional detailsSequence NeighborHistoryDownloads

6BYR

Structures of the PKA RI alpha holoenzyme with the FLHCC driver J-PKAc alpha or native PKAc alpha

Functional Information from GO Data
ChainGOidnamespacecontents
A0000166molecular_functionnucleotide binding
A0000287molecular_functionmagnesium ion binding
A0001669cellular_componentacrosomal vesicle
A0002027biological_processregulation of heart rate
A0003091biological_processrenal water homeostasis
A0004672molecular_functionprotein kinase activity
A0004674molecular_functionprotein serine/threonine kinase activity
A0004691molecular_functioncAMP-dependent protein kinase activity
A0004712molecular_functionprotein serine/threonine/tyrosine kinase activity
A0005515molecular_functionprotein binding
A0005524molecular_functionATP binding
A0005634cellular_componentnucleus
A0005654cellular_componentnucleoplasm
A0005737cellular_componentcytoplasm
A0005739cellular_componentmitochondrion
A0005759cellular_componentmitochondrial matrix
A0005811cellular_componentlipid droplet
A0005813cellular_componentcentrosome
A0005829cellular_componentcytosol
A0005886cellular_componentplasma membrane
A0005930cellular_componentaxoneme
A0005952cellular_componentcAMP-dependent protein kinase complex
A0006338biological_processchromatin remodeling
A0006397biological_processmRNA processing
A0006468biological_processprotein phosphorylation
A0007189biological_processadenylate cyclase-activating G protein-coupled receptor signaling pathway
A0007193biological_processadenylate cyclase-inhibiting G protein-coupled receptor signaling pathway
A0010881biological_processregulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion
A0010898biological_processpositive regulation of triglyceride catabolic process
A0016020cellular_componentmembrane
A0016241biological_processregulation of macroautophagy
A0016301molecular_functionkinase activity
A0016607cellular_componentnuclear speck
A0016740molecular_functiontransferase activity
A0019221biological_processcytokine-mediated signaling pathway
A0019870molecular_functionpotassium channel inhibitor activity
A0019901molecular_functionprotein kinase binding
A0019904molecular_functionprotein domain specific binding
A0030007biological_processintracellular potassium ion homeostasis
A0030145molecular_functionmanganese ion binding
A0031410cellular_componentcytoplasmic vesicle
A0031514cellular_componentmotile cilium
A0031594cellular_componentneuromuscular junction
A0032024biological_processpositive regulation of insulin secretion
A0032703biological_processnegative regulation of interleukin-2 production
A0034237molecular_functionprotein kinase A regulatory subunit binding
A0034380biological_processhigh-density lipoprotein particle assembly
A0034605biological_processcellular response to heat
A0034704cellular_componentcalcium channel complex
A0035694biological_processmitochondrial protein catabolic process
A0036126cellular_componentsperm flagellum
A0044853cellular_componentplasma membrane raft
A0045542biological_processpositive regulation of cholesterol biosynthetic process
A0045667biological_processregulation of osteoblast differentiation
A0045722biological_processpositive regulation of gluconeogenesis
A0045820biological_processnegative regulation of glycolytic process
A0048240biological_processsperm capacitation
A0048471cellular_componentperinuclear region of cytoplasm
A0050766biological_processpositive regulation of phagocytosis
A0050850biological_processpositive regulation of calcium-mediated signaling
A0051726biological_processregulation of cell cycle
A0055117biological_processregulation of cardiac muscle contraction
A0061136biological_processregulation of proteasomal protein catabolic process
A0070062cellular_componentextracellular exosome
A0070507biological_processregulation of microtubule cytoskeleton organization
A0071333biological_processcellular response to glucose stimulus
A0071377biological_processcellular response to glucagon stimulus
A0071872biological_processcellular response to epinephrine stimulus
A0086064biological_processcell communication by electrical coupling involved in cardiac conduction
A0097546cellular_componentciliary base
A0097700biological_processvascular endothelial cell response to laminar fluid shear stress
A0098794cellular_componentpostsynapse
A0098978cellular_componentglutamatergic synapse
A0099103molecular_functionchannel activator activity
A0099170biological_processpostsynaptic modulation of chemical synaptic transmission
A0106310molecular_functionprotein serine kinase activity
A0120186biological_processnegative regulation of protein localization to chromatin
A0140198molecular_functionhistone H1-4S35 kinase activity
A1903779biological_processregulation of cardiac conduction
A1904262biological_processnegative regulation of TORC1 signaling
A1904539biological_processnegative regulation of glycolytic process through fructose-6-phosphate
A2000810biological_processregulation of bicellular tight junction assembly
B0000166molecular_functionnucleotide binding
B0001772cellular_componentimmunological synapse
B0001932biological_processregulation of protein phosphorylation
B0004862molecular_functioncAMP-dependent protein kinase inhibitor activity
B0005515molecular_functionprotein binding
B0005737cellular_componentcytoplasm
B0005771cellular_componentmultivesicular body
B0005813cellular_componentcentrosome
B0005829cellular_componentcytosol
B0005886cellular_componentplasma membrane
B0005930cellular_componentaxoneme
B0005952cellular_componentcAMP-dependent protein kinase complex
B0007189biological_processadenylate cyclase-activating G protein-coupled receptor signaling pathway
B0008603molecular_functioncAMP-dependent protein kinase regulator activity
B0019904molecular_functionprotein domain specific binding
B0030291molecular_functionprotein serine/threonine kinase inhibitor activity
B0030552molecular_functioncAMP binding
B0031588cellular_componentnucleotide-activated protein kinase complex
B0031594cellular_componentneuromuscular junction
B0031625molecular_functionubiquitin protein ligase binding
B0032991cellular_componentprotein-containing complex
B0034236molecular_functionprotein kinase A catalytic subunit binding
B0042802molecular_functionidentical protein binding
B0044853cellular_componentplasma membrane raft
B0045202cellular_componentsynapse
B0046007biological_processnegative regulation of activated T cell proliferation
B0071377biological_processcellular response to glucagon stimulus
B0098978cellular_componentglutamatergic synapse
B0120212cellular_componentsperm head-tail coupling apparatus
B0141162biological_processnegative regulation of cAMP/PKA signal transduction
C0000166molecular_functionnucleotide binding
C0000287molecular_functionmagnesium ion binding
C0001669cellular_componentacrosomal vesicle
C0002027biological_processregulation of heart rate
C0003091biological_processrenal water homeostasis
C0004672molecular_functionprotein kinase activity
C0004674molecular_functionprotein serine/threonine kinase activity
C0004691molecular_functioncAMP-dependent protein kinase activity
C0004712molecular_functionprotein serine/threonine/tyrosine kinase activity
C0005515molecular_functionprotein binding
C0005524molecular_functionATP binding
C0005634cellular_componentnucleus
C0005654cellular_componentnucleoplasm
C0005737cellular_componentcytoplasm
C0005739cellular_componentmitochondrion
C0005759cellular_componentmitochondrial matrix
C0005811cellular_componentlipid droplet
C0005813cellular_componentcentrosome
C0005829cellular_componentcytosol
C0005886cellular_componentplasma membrane
C0005930cellular_componentaxoneme
C0005952cellular_componentcAMP-dependent protein kinase complex
C0006338biological_processchromatin remodeling
C0006397biological_processmRNA processing
C0006468biological_processprotein phosphorylation
C0007189biological_processadenylate cyclase-activating G protein-coupled receptor signaling pathway
C0007193biological_processadenylate cyclase-inhibiting G protein-coupled receptor signaling pathway
C0010881biological_processregulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion
C0010898biological_processpositive regulation of triglyceride catabolic process
C0016020cellular_componentmembrane
C0016241biological_processregulation of macroautophagy
C0016301molecular_functionkinase activity
C0016607cellular_componentnuclear speck
C0016740molecular_functiontransferase activity
C0019221biological_processcytokine-mediated signaling pathway
C0019870molecular_functionpotassium channel inhibitor activity
C0019901molecular_functionprotein kinase binding
C0019904molecular_functionprotein domain specific binding
C0030007biological_processintracellular potassium ion homeostasis
C0030145molecular_functionmanganese ion binding
C0031410cellular_componentcytoplasmic vesicle
C0031514cellular_componentmotile cilium
C0031594cellular_componentneuromuscular junction
C0032024biological_processpositive regulation of insulin secretion
C0032703biological_processnegative regulation of interleukin-2 production
C0034237molecular_functionprotein kinase A regulatory subunit binding
C0034380biological_processhigh-density lipoprotein particle assembly
C0034605biological_processcellular response to heat
C0034704cellular_componentcalcium channel complex
C0035694biological_processmitochondrial protein catabolic process
C0036126cellular_componentsperm flagellum
C0044853cellular_componentplasma membrane raft
C0045542biological_processpositive regulation of cholesterol biosynthetic process
C0045667biological_processregulation of osteoblast differentiation
C0045722biological_processpositive regulation of gluconeogenesis
C0045820biological_processnegative regulation of glycolytic process
C0048240biological_processsperm capacitation
C0048471cellular_componentperinuclear region of cytoplasm
C0050766biological_processpositive regulation of phagocytosis
C0050850biological_processpositive regulation of calcium-mediated signaling
C0051726biological_processregulation of cell cycle
C0055117biological_processregulation of cardiac muscle contraction
C0061136biological_processregulation of proteasomal protein catabolic process
C0070062cellular_componentextracellular exosome
C0070507biological_processregulation of microtubule cytoskeleton organization
C0071333biological_processcellular response to glucose stimulus
C0071377biological_processcellular response to glucagon stimulus
C0071872biological_processcellular response to epinephrine stimulus
C0086064biological_processcell communication by electrical coupling involved in cardiac conduction
C0097546cellular_componentciliary base
C0097700biological_processvascular endothelial cell response to laminar fluid shear stress
C0098794cellular_componentpostsynapse
C0098978cellular_componentglutamatergic synapse
C0099103molecular_functionchannel activator activity
C0099170biological_processpostsynaptic modulation of chemical synaptic transmission
C0106310molecular_functionprotein serine kinase activity
C0120186biological_processnegative regulation of protein localization to chromatin
C0140198molecular_functionhistone H1-4S35 kinase activity
C1903779biological_processregulation of cardiac conduction
C1904262biological_processnegative regulation of TORC1 signaling
C1904539biological_processnegative regulation of glycolytic process through fructose-6-phosphate
C2000810biological_processregulation of bicellular tight junction assembly
D0000166molecular_functionnucleotide binding
D0001772cellular_componentimmunological synapse
D0001932biological_processregulation of protein phosphorylation
D0004862molecular_functioncAMP-dependent protein kinase inhibitor activity
D0005515molecular_functionprotein binding
D0005737cellular_componentcytoplasm
D0005771cellular_componentmultivesicular body
D0005813cellular_componentcentrosome
D0005829cellular_componentcytosol
D0005886cellular_componentplasma membrane
D0005930cellular_componentaxoneme
D0005952cellular_componentcAMP-dependent protein kinase complex
D0007189biological_processadenylate cyclase-activating G protein-coupled receptor signaling pathway
D0008603molecular_functioncAMP-dependent protein kinase regulator activity
D0019904molecular_functionprotein domain specific binding
D0030291molecular_functionprotein serine/threonine kinase inhibitor activity
D0030552molecular_functioncAMP binding
D0031588cellular_componentnucleotide-activated protein kinase complex
D0031594cellular_componentneuromuscular junction
D0031625molecular_functionubiquitin protein ligase binding
D0032991cellular_componentprotein-containing complex
D0034236molecular_functionprotein kinase A catalytic subunit binding
D0042802molecular_functionidentical protein binding
D0044853cellular_componentplasma membrane raft
D0045202cellular_componentsynapse
D0046007biological_processnegative regulation of activated T cell proliferation
D0071377biological_processcellular response to glucagon stimulus
D0098978cellular_componentglutamatergic synapse
D0120212cellular_componentsperm head-tail coupling apparatus
D0141162biological_processnegative regulation of cAMP/PKA signal transduction
Functional Information from PDB Data
site_idAC1
Number of Residues22
Detailsbinding site for residue ATP A 501
ChainResidue
AGLY105
AVAL178
AGLU182
ALYS223
AGLU225
AASN226
ALEU228
ATHR238
AASP239
APHE382
AMG502
AGLY107
AMG503
BARG94
BALA97
ASER108
APHE109
AVAL112
AALA125
ALYS127
AMET175
AGLU176
site_idAC2
Number of Residues3
Detailsbinding site for residue MG A 502
ChainResidue
AASP221
AASP239
AATP501
site_idAC3
Number of Residues3
Detailsbinding site for residue MG A 503
ChainResidue
AASN226
AASP239
AATP501
site_idAC4
Number of Residues21
Detailsbinding site for residue ATP C 501
ChainResidue
CGLY105
CGLY107
CSER108
CPHE109
CGLY110
CVAL112
CALA125
CLYS127
CMET175
CVAL178
CGLU182
CLYS223
CGLU225
CASN226
CLEU228
CASP239
CPHE382
CMG502
CMG503
DARG94
DALA97
site_idAC5
Number of Residues3
Detailsbinding site for residue MG C 502
ChainResidue
CASP221
CASP239
CATP501
site_idAC6
Number of Residues3
Detailsbinding site for residue MG C 503
ChainResidue
CASN226
CASP239
CATP501
Functional Information from PROSITE/UniProt
site_idPS00107
Number of Residues24
DetailsPROTEIN_KINASE_ATP Protein kinases ATP-binding region signature. LGTGSFGRVMlVkhketgnh..........YAMK
ChainResidueDetails
ALEU104-LYS127
site_idPS00108
Number of Residues13
DetailsPROTEIN_KINASE_ST Serine/Threonine protein kinases active-site signature. LiYrDLKpeNLLI
ChainResidueDetails
ALEU217-ILE229
site_idPS00636
Number of Residues20
DetailsDNAJ_1 Nt-dnaJ domain signature. FKeIAeaYDvLsDprkREIF
ChainResidueDetails
APHE44-PHE63
site_idPS00888
Number of Residues17
DetailsCNMP_BINDING_1 Cyclic nucleotide-binding domain signature 1. VIqQGDeGDnFYVIdqG
ChainResidueDetails
BVAL162-GLY178
BILE280-GLY296
site_idPS00889
Number of Residues18
DetailsCNMP_BINDING_2 Cyclic nucleotide-binding domain signature 2. FGElALiygtp......RAAtVkA
ChainResidueDetails
BPHE198-ALA215
BPHE322-ALA339
Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues2
DetailsActive site: {"description":"Proton acceptor","evidences":[{"source":"PROSITE-ProRule","id":"PRU00159","evidenceCode":"ECO:0000255"},{"source":"PROSITE-ProRule","id":"PRU10027","evidenceCode":"ECO:0000255"}]}
ChainResidueDetails
site_idSWS_FT_FI2
Number of Residues510
DetailsBinding site: {}
ChainResidueDetails
site_idSWS_FT_FI3
Number of Residues20
DetailsBinding site: {"evidences":[{"source":"PROSITE-ProRule","id":"PRU00159","evidenceCode":"ECO:0000255"}]}
ChainResidueDetails
site_idSWS_FT_FI4
Number of Residues2
DetailsModified residue: {"description":"Phosphothreonine","evidences":[{"source":"PubMed","id":"18691976","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails
site_idSWS_FT_FI5
Number of Residues2
DetailsModified residue: {"description":"Phosphoserine","evidences":[{"source":"UniProtKB","id":"P05132","evidenceCode":"ECO:0000250"}]}
ChainResidueDetails
site_idSWS_FT_FI6
Number of Residues2
DetailsModified residue: {"description":"Phosphothreonine","evidences":[{"source":"PubMed","id":"12372837","evidenceCode":"ECO:0000269"}]}
ChainResidueDetails
site_idSWS_FT_FI7
Number of Residues2
DetailsModified residue: {"description":"Phosphothreonine; by PDPK1","evidences":[{"source":"PubMed","id":"12372837","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"16765046","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"20137943","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"20481595","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"20732331","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"21774789","evidenceCode":"ECO:0000269"},{"source":"Reference","evidenceCode":"ECO:0000269","citation":{"citationType":"submission","publicationDate":"JUL-2010","submissionDatabase":"PDB data bank","title":"Experimental active site mapping as a starting point to fragment-based lead discovery.","authors":["Behnen J.","Koester H.","Ritschel T.","Neudert G.","Heine A.","Klebe G."]}}]}
ChainResidueDetails
site_idSWS_FT_FI8
Number of Residues2
DetailsModified residue: {"description":"Phosphotyrosine","evidences":[{"source":"UniProtKB","id":"P05132","evidenceCode":"ECO:0000250"}]}
ChainResidueDetails
site_idSWS_FT_FI9
Number of Residues2
DetailsModified residue: {"description":"Phosphoserine","evidences":[{"source":"PubMed","id":"16765046","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"20137943","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"20481595","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"20732331","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"21774789","evidenceCode":"ECO:0000269"},{"source":"Reference","evidenceCode":"ECO:0000269","citation":{"citationType":"submission","publicationDate":"JUL-2010","submissionDatabase":"PDB data bank","title":"Experimental active site mapping as a starting point to fragment-based lead discovery.","authors":["Behnen J.","Koester H.","Ritschel T.","Neudert G.","Heine A.","Klebe G."]}},{"source":"PubMed","id":"18691976","evidenceCode":"ECO:0007744"},{"source":"PubMed","id":"19690332","evidenceCode":"ECO:0007744"},{"source":"PubMed","id":"24275569","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails
site_idSWS_FT_FI10
Number of Residues136
DetailsDomain: {"description":"J","evidences":[{"source":"PROSITE-ProRule","id":"PRU00286","evidenceCode":"ECO:0000255"}]}
ChainResidueDetails
site_idSWS_FT_FI11
Number of Residues8
DetailsMotif: {"description":"Pseudophosphorylation motif"}
ChainResidueDetails
site_idSWS_FT_FI12
Number of Residues2
DetailsModified residue: {"description":"Phosphoserine","evidences":[{"source":"UniProtKB","id":"Q9DBC7","evidenceCode":"ECO:0000250"}]}
ChainResidueDetails
site_idSWS_FT_FI13
Number of Residues2
DetailsModified residue: {"description":"Phosphoserine","evidences":[{"source":"UniProtKB","id":"P09456","evidenceCode":"ECO:0000250"}]}
ChainResidueDetails

246704

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