6BYN

Crystal structure of WDR5-Mb(S4) monobody complex

Functional Information from GO Data

Chain	GOid	namespace	contents
W	0000122	biological_process	negative regulation of transcription by RNA polymerase II
W	0000123	cellular_component	histone acetyltransferase complex
W	0001501	biological_process	skeletal system development
W	0005515	molecular_function	protein binding
W	0005634	cellular_component	nucleus
W	0005654	cellular_component	nucleoplasm
W	0006094	biological_process	gluconeogenesis
W	0006325	biological_process	chromatin organization
W	0006355	biological_process	regulation of DNA-templated transcription
W	0006357	biological_process	regulation of transcription by RNA polymerase II
W	0035064	molecular_function	methylated histone binding
W	0035097	cellular_component	histone methyltransferase complex
W	0042393	molecular_function	histone binding
W	0042800	molecular_function	histone H3K4 methyltransferase activity
W	0044545	cellular_component	NSL complex
W	0044665	cellular_component	MLL1/2 complex
W	0044666	cellular_component	MLL3/4 complex
W	0045722	biological_process	positive regulation of gluconeogenesis
W	0045815	biological_process	transcription initiation-coupled chromatin remodeling
W	0045893	biological_process	positive regulation of DNA-templated transcription
W	0045995	biological_process	regulation of embryonic development
W	0048188	cellular_component	Set1C/COMPASS complex
W	0051302	biological_process	regulation of cell division
W	0051726	biological_process	regulation of cell cycle
W	0071339	cellular_component	MLL1 complex
W	0072686	cellular_component	mitotic spindle
W	0090043	biological_process	regulation of tubulin deacetylation
W	0140672	cellular_component	ATAC complex

Functional Information from PROSITE/UniProt

site_id	PS00678
Number of Residues	15
Details	WD_REPEATS_1 Trp-Asp (WD) repeats signature. LVSAsdDkTLKIWDV

Chain	Residue	Details
W	LEU102-VAL116
W	ILE144-VAL158
W	ILE186-THR200
W	ILE274-LEU288

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site_id	PS00687
Number of Residues	8
Details	ALDEHYDE_DEHYDR_GLU Aldehyde dehydrogenases glutamic acid active site. GETGGNSP

Chain	Residue	Details
M	GLY37-PRO44

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Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	4
Details	SITE: Important for interaction with histone H3

Chain	Residue	Details
W	ASP107
W	PHE133
W	PHE263
W	GLU322

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site_id	SWS_FT_FI2
Number of Residues	1
Details	MOD_RES: N6-acetyllysine => ECO:0007744|PubMed:19608861

Chain	Residue	Details
W	LYS112

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site_id	SWS_FT_FI3
Number of Residues	2
Details	CROSSLNK: Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2) => ECO:0007744|PubMed:28112733

Chain	Residue	Details
W	LYS46

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