6BWY
DNA substrate selection by APOBEC3G
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0000723 | biological_process | telomere maintenance |
| A | 0000781 | cellular_component | chromosome, telomeric region |
| A | 0003677 | molecular_function | DNA binding |
| A | 0003824 | molecular_function | catalytic activity |
| A | 0008270 | molecular_function | zinc ion binding |
| A | 0016787 | molecular_function | hydrolase activity |
| B | 0000723 | biological_process | telomere maintenance |
| B | 0000781 | cellular_component | chromosome, telomeric region |
| B | 0003677 | molecular_function | DNA binding |
| B | 0003824 | molecular_function | catalytic activity |
| B | 0008270 | molecular_function | zinc ion binding |
| B | 0016787 | molecular_function | hydrolase activity |
| E | 0000723 | biological_process | telomere maintenance |
| E | 0000781 | cellular_component | chromosome, telomeric region |
| E | 0003677 | molecular_function | DNA binding |
| E | 0003824 | molecular_function | catalytic activity |
| E | 0008270 | molecular_function | zinc ion binding |
| E | 0016787 | molecular_function | hydrolase activity |
| G | 0000723 | biological_process | telomere maintenance |
| G | 0000781 | cellular_component | chromosome, telomeric region |
| G | 0003677 | molecular_function | DNA binding |
| G | 0003824 | molecular_function | catalytic activity |
| G | 0008270 | molecular_function | zinc ion binding |
| G | 0016787 | molecular_function | hydrolase activity |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 1 |
| Details | binding site for residue PO4 I 101 |
| Chain | Residue |
| I | DG2 |
| site_id | AC2 |
| Number of Residues | 2 |
| Details | binding site for residue PO4 C 101 |
| Chain | Residue |
| C | DG2 |
| G | LYS59 |
| site_id | AC3 |
| Number of Residues | 1 |
| Details | binding site for residue PO4 D 101 |
| Chain | Residue |
| D | DG2 |
| site_id | AC4 |
| Number of Residues | 1 |
| Details | binding site for residue PO4 F 101 |
| Chain | Residue |
| F | DG2 |
| site_id | AC5 |
| Number of Residues | 4 |
| Details | binding site for residue ZN A 401 |
| Chain | Residue |
| A | HIS257 |
| A | GLU259 |
| A | CYS288 |
| A | CYS291 |
| site_id | AC6 |
| Number of Residues | 2 |
| Details | binding site for residue PO4 A 402 |
| Chain | Residue |
| A | LYS144 |
| A | GLN146 |
| site_id | AC7 |
| Number of Residues | 1 |
| Details | binding site for residue PO4 A 403 |
| Chain | Residue |
| A | GLN146 |
| site_id | AC8 |
| Number of Residues | 4 |
| Details | binding site for residue PO4 A 404 |
| Chain | Residue |
| A | LEU45 |
| A | ASN64 |
| A | HIS128 |
| A | GLN129 |
| site_id | AC9 |
| Number of Residues | 4 |
| Details | binding site for residue ZN B 401 |
| Chain | Residue |
| B | HIS257 |
| B | GLU259 |
| B | CYS288 |
| B | CYS291 |
| site_id | AD1 |
| Number of Residues | 2 |
| Details | binding site for residue PO4 B 402 |
| Chain | Residue |
| B | LYS144 |
| B | GLN146 |
| site_id | AD2 |
| Number of Residues | 2 |
| Details | binding site for residue PO4 B 403 |
| Chain | Residue |
| B | GLN129 |
| B | GLN146 |
| site_id | AD3 |
| Number of Residues | 4 |
| Details | binding site for residue ZN E 401 |
| Chain | Residue |
| E | HIS257 |
| E | GLU259 |
| E | CYS288 |
| E | CYS291 |
| site_id | AD4 |
| Number of Residues | 2 |
| Details | binding site for residue PO4 E 402 |
| Chain | Residue |
| E | LYS144 |
| E | GLN146 |
| site_id | AD5 |
| Number of Residues | 2 |
| Details | binding site for residue PO4 E 403 |
| Chain | Residue |
| E | GLN129 |
| E | GLN146 |
| site_id | AD6 |
| Number of Residues | 3 |
| Details | binding site for residue PO4 E 404 |
| Chain | Residue |
| E | LEU45 |
| E | ASN64 |
| E | HIS128 |
| site_id | AD7 |
| Number of Residues | 3 |
| Details | binding site for residue ZN G 401 |
| Chain | Residue |
| G | HIS257 |
| G | CYS288 |
| G | CYS291 |
| site_id | AD8 |
| Number of Residues | 2 |
| Details | binding site for residue PO4 G 402 |
| Chain | Residue |
| G | LYS144 |
| G | GLN146 |
| site_id | AD9 |
| Number of Residues | 2 |
| Details | binding site for residue PO4 G 403 |
| Chain | Residue |
| G | GLN129 |
| G | GLN146 |
| site_id | AE1 |
| Number of Residues | 5 |
| Details | binding site for residue PO4 G 404 |
| Chain | Residue |
| E | ARG213 |
| E | GLY214 |
| E | HIS216 |
| G | LEU171 |
| G | LYS173 |
Functional Information from PROSITE/UniProt
| site_id | PS00903 |
| Number of Residues | 39 |
| Details | CYT_DCMP_DEAMINASES_1 Cytidine and deoxycytidylate deaminases zinc-binding region signature. HAElcFLdvipfwkldldqdyrvtcftsws..........PCfs......CaqeM |
| Chain | Residue | Details |
| A | HIS257-MET295 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 36 |
| Details | Region: {"description":"Interaction with DNA","evidences":[{"evidenceCode":"ECO:0000305"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI2 |
| Number of Residues | 4 |
| Details | Active site: {"description":"Proton donor","evidences":[{"source":"PROSITE-ProRule","id":"PRU01083","evidenceCode":"ECO:0000255"},{"source":"PubMed","id":"18288108","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"18849968","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"19153609","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"25542899","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"36754086","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"4ROV","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4ROW","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8CX0","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8CX1","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI3 |
| Number of Residues | 12 |
| Details | Binding site: {"evidences":[{"source":"PubMed","id":"18288108","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"18849968","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"19153609","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"25542899","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"36754086","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"37419875","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"4ROV","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4ROW","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8CX0","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8CX1","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8H0I","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8J62","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI4 |
| Number of Residues | 4 |
| Details | Site: {"description":"Interaction with DNA","evidences":[{"evidenceCode":"ECO:0000305"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI5 |
| Number of Residues | 4 |
| Details | Modified residue: {"description":"Phosphothreonine; by PKA and CAMK2","evidences":[{"source":"PubMed","id":"21659520","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI6 |
| Number of Residues | 8 |
| Details | Cross-link: {"description":"(Microbial infection) Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin)","evidences":[{"source":"PubMed","id":"23318957","evidenceCode":"ECO:0000305"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI7 |
| Number of Residues | 16 |
| Details | Cross-link: {"description":"(Microbial infection) Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin)","evidences":[{"source":"PubMed","id":"19887642","evidenceCode":"ECO:0000305"},{"source":"PubMed","id":"23318957","evidenceCode":"ECO:0000305"},{"source":"PubMed","id":"31253590","evidenceCode":"ECO:0000305"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI8 |
| Number of Residues | 4 |
| Details | Cross-link: {"description":"(Microbial infection) Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin)","evidences":[{"source":"PubMed","id":"19887642","evidenceCode":"ECO:0000305"}]} |
| Chain | Residue | Details |
