Summary Structural details Experimental details Functional details Sequence Neighbor History Downloads

6BWY

DNA substrate selection by APOBEC3G

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0000723	biological_process	telomere maintenance
A	0000781	cellular_component	chromosome, telomeric region
A	0003677	molecular_function	DNA binding
A	0003824	molecular_function	catalytic activity
A	0008270	molecular_function	zinc ion binding
A	0016787	molecular_function	hydrolase activity
B	0000723	biological_process	telomere maintenance
B	0000781	cellular_component	chromosome, telomeric region
B	0003677	molecular_function	DNA binding
B	0003824	molecular_function	catalytic activity
B	0008270	molecular_function	zinc ion binding
B	0016787	molecular_function	hydrolase activity
E	0000723	biological_process	telomere maintenance
E	0000781	cellular_component	chromosome, telomeric region
E	0003677	molecular_function	DNA binding
E	0003824	molecular_function	catalytic activity
E	0008270	molecular_function	zinc ion binding
E	0016787	molecular_function	hydrolase activity
G	0000723	biological_process	telomere maintenance
G	0000781	cellular_component	chromosome, telomeric region
G	0003677	molecular_function	DNA binding
G	0003824	molecular_function	catalytic activity
G	0008270	molecular_function	zinc ion binding
G	0016787	molecular_function	hydrolase activity

Functional Information from PDB Data

site_id	AC1
Number of Residues	1
Details	binding site for residue PO4 I 101

Chain	Residue
I	DG2

site_id	AC2
Number of Residues	2
Details	binding site for residue PO4 C 101

Chain	Residue
C	DG2
G	LYS59

site_id	AC3
Number of Residues	1
Details	binding site for residue PO4 D 101

Chain	Residue
D	DG2

site_id	AC4
Number of Residues	1
Details	binding site for residue PO4 F 101

Chain	Residue
F	DG2

site_id	AC5
Number of Residues	4
Details	binding site for residue ZN A 401

Chain	Residue
A	HIS257
A	GLU259
A	CYS288
A	CYS291

site_id	AC6
Number of Residues	2
Details	binding site for residue PO4 A 402

Chain	Residue
A	LYS144
A	GLN146

site_id	AC7
Number of Residues	1
Details	binding site for residue PO4 A 403

Chain	Residue
A	GLN146

site_id	AC8
Number of Residues	4
Details	binding site for residue PO4 A 404

Chain	Residue
A	LEU45
A	ASN64
A	HIS128
A	GLN129

site_id	AC9
Number of Residues	4
Details	binding site for residue ZN B 401

Chain	Residue
B	HIS257
B	GLU259
B	CYS288
B	CYS291

site_id	AD1
Number of Residues	2
Details	binding site for residue PO4 B 402

Chain	Residue
B	LYS144
B	GLN146

site_id	AD2
Number of Residues	2
Details	binding site for residue PO4 B 403

Chain	Residue
B	GLN129
B	GLN146

site_id	AD3
Number of Residues	4
Details	binding site for residue ZN E 401

Chain	Residue
E	HIS257
E	GLU259
E	CYS288
E	CYS291

site_id	AD4
Number of Residues	2
Details	binding site for residue PO4 E 402

Chain	Residue
E	LYS144
E	GLN146

site_id	AD5
Number of Residues	2
Details	binding site for residue PO4 E 403

Chain	Residue
E	GLN129
E	GLN146

site_id	AD6
Number of Residues	3
Details	binding site for residue PO4 E 404

Chain	Residue
E	LEU45
E	ASN64
E	HIS128

site_id	AD7
Number of Residues	3
Details	binding site for residue ZN G 401

Chain	Residue
G	HIS257
G	CYS288
G	CYS291

site_id	AD8
Number of Residues	2
Details	binding site for residue PO4 G 402

Chain	Residue
G	LYS144
G	GLN146

site_id	AD9
Number of Residues	2
Details	binding site for residue PO4 G 403

Chain	Residue
G	GLN129
G	GLN146

site_id	AE1
Number of Residues	5
Details	binding site for residue PO4 G 404

Chain	Residue
E	ARG213
E	GLY214
E	HIS216
G	LEU171
G	LYS173

Functional Information from PROSITE/UniProt

site_id	PS00903
Number of Residues	39
Details	CYT_DCMP_DEAMINASES_1 Cytidine and deoxycytidylate deaminases zinc-binding region signature. HAElcFLdvipfwkldldqdyrvtcftsws..........PCfs......CaqeM

Chain	Residue	Details
A	HIS257-MET295

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	4
Details	ACT_SITE: Proton donor => ECO:0000255\|PROSITE-ProRule:PRU01083, ECO:0000269\|PubMed:18288108, ECO:0000269\|PubMed:18849968, ECO:0000269\|PubMed:19153609, ECO:0000269\|PubMed:25542899, ECO:0000269\|PubMed:36754086, ECO:0007744\|PDB:4ROV, ECO:0007744\|PDB:4ROW, ECO:0007744\|PDB:8CX0, ECO:0007744\|PDB:8CX1

Chain	Residue	Details
A	GLU259
B	GLU259
E	GLU259
G	GLU259

site_id	SWS_FT_FI2
Number of Residues	12
Details	BINDING: BINDING => ECO:0000269\|PubMed:18288108, ECO:0000269\|PubMed:18849968, ECO:0000269\|PubMed:19153609, ECO:0000269\|PubMed:25542899, ECO:0000269\|PubMed:36754086, ECO:0000269\|PubMed:37419875, ECO:0007744\|PDB:4ROV, ECO:0007744\|PDB:4ROW, ECO:0007744\|PDB:8CX0, ECO:0007744\|PDB:8CX1, ECO:0007744\|PDB:8H0I, ECO:0007744\|PDB:8J62

Chain	Residue	Details
A	HIS257
G	HIS257
G	CYS288
G	CYS291
A	CYS288
A	CYS291
B	HIS257
B	CYS288
B	CYS291
E	HIS257
E	CYS288
E	CYS291

site_id	SWS_FT_FI3
Number of Residues	4
Details	SITE: Interaction with DNA => ECO:0000305

Chain	Residue	Details
A	ASN244
B	ASN244
E	ASN244
G	ASN244

site_id	SWS_FT_FI4
Number of Residues	4
Details	MOD_RES: Phosphothreonine; by PKA and CAMK2 => ECO:0000269\|PubMed:21659520

Chain	Residue	Details
A	THR218
B	THR218
E	THR218
G	THR218

site_id	SWS_FT_FI5
Number of Residues	4
Details	CROSSLNK: (Microbial infection) Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin) => ECO:0000305\|PubMed:23318957, ECO:0000305\|PubMed:31253590

Chain	Residue	Details
A	LYS249
B	LYS249
E	LYS249
G	LYS249

site_id	SWS_FT_FI6
Number of Residues	16
Details	CROSSLNK: (Microbial infection) Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin) => ECO:0000305\|PubMed:19887642, ECO:0000305\|PubMed:23318957, ECO:0000305\|PubMed:31253590

Chain	Residue	Details
E	LYS297
E	LYS303
E	LYS334
G	LYS297
G	LYS303
G	LYS334
A	LYS297
A	LYS303
A	LYS334
B	LYS297
B	LYS303
B	LYS334

site_id	SWS_FT_FI7
Number of Residues	4
Details	CROSSLNK: (Microbial infection) Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin) => ECO:0000305\|PubMed:23318957

Chain	Residue	Details
A	LYS270
B	LYS270
E	LYS270
G	LYS270

site_id	SWS_FT_FI8
Number of Residues	4
Details	CROSSLNK: (Microbial infection) Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin) => ECO:0000305\|PubMed:19887642

Chain	Residue	Details
A	LYS301
B	LYS301
E	LYS301
G	LYS301

		Sequence (fasta)
		PDBx/mmCIF
		PDBML format (no-atom)
		PDB format (full)
		Validation report (PDF)
		EDMap 2fo-fc (MTZ)