6BBH
The CRAC channel Orai in an unlatched-closed conformation; K163W loss-of-function mutation
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 1848 |
| Details | TRANSMEM: Helical => ECO:0000255 |
| Chain | Residue | Details |
| A | THR164-LEU181 | |
| C | LEU192-ILE212 | |
| C | ALA249-VAL269 | |
| C | ALA278-ILE298 | |
| D | THR164-LEU181 | |
| D | LEU192-ILE212 | |
| D | ALA249-VAL269 | |
| D | ALA278-ILE298 | |
| E | THR164-LEU181 | |
| E | LEU192-ILE212 | |
| E | ALA249-VAL269 | |
| A | LEU192-ILE212 | |
| E | ALA278-ILE298 | |
| F | THR164-LEU181 | |
| F | LEU192-ILE212 | |
| F | ALA249-VAL269 | |
| F | ALA278-ILE298 | |
| G | THR164-LEU181 | |
| G | LEU192-ILE212 | |
| G | ALA249-VAL269 | |
| G | ALA278-ILE298 | |
| H | THR164-LEU181 | |
| A | ALA249-VAL269 | |
| H | LEU192-ILE212 | |
| H | ALA249-VAL269 | |
| H | ALA278-ILE298 | |
| I | THR164-LEU181 | |
| I | LEU192-ILE212 | |
| I | ALA249-VAL269 | |
| I | ALA278-ILE298 | |
| J | THR164-LEU181 | |
| J | LEU192-ILE212 | |
| J | ALA249-VAL269 | |
| A | ALA278-ILE298 | |
| J | ALA278-ILE298 | |
| K | THR164-LEU181 | |
| K | LEU192-ILE212 | |
| K | ALA249-VAL269 | |
| K | ALA278-ILE298 | |
| L | THR164-LEU181 | |
| L | LEU192-ILE212 | |
| L | ALA249-VAL269 | |
| L | ALA278-ILE298 | |
| M | THR164-LEU181 | |
| B | THR164-LEU181 | |
| M | LEU192-ILE212 | |
| M | ALA249-VAL269 | |
| M | ALA278-ILE298 | |
| N | THR164-LEU181 | |
| N | LEU192-ILE212 | |
| N | ALA249-VAL269 | |
| N | ALA278-ILE298 | |
| O | THR164-LEU181 | |
| O | LEU192-ILE212 | |
| O | ALA249-VAL269 | |
| B | LEU192-ILE212 | |
| O | ALA278-ILE298 | |
| P | THR164-LEU181 | |
| P | LEU192-ILE212 | |
| P | ALA249-VAL269 | |
| P | ALA278-ILE298 | |
| Q | THR164-LEU181 | |
| Q | LEU192-ILE212 | |
| Q | ALA249-VAL269 | |
| Q | ALA278-ILE298 | |
| R | THR164-LEU181 | |
| B | ALA249-VAL269 | |
| R | LEU192-ILE212 | |
| R | ALA249-VAL269 | |
| R | ALA278-ILE298 | |
| S | THR164-LEU181 | |
| S | LEU192-ILE212 | |
| S | ALA249-VAL269 | |
| S | ALA278-ILE298 | |
| T | THR164-LEU181 | |
| T | LEU192-ILE212 | |
| T | ALA249-VAL269 | |
| B | ALA278-ILE298 | |
| T | ALA278-ILE298 | |
| U | THR164-LEU181 | |
| U | LEU192-ILE212 | |
| U | ALA249-VAL269 | |
| U | ALA278-ILE298 | |
| V | THR164-LEU181 | |
| V | LEU192-ILE212 | |
| V | ALA249-VAL269 | |
| V | ALA278-ILE298 | |
| W | THR164-LEU181 | |
| C | THR164-LEU181 | |
| W | LEU192-ILE212 | |
| W | ALA249-VAL269 | |
| W | ALA278-ILE298 | |
| X | THR164-LEU181 | |
| X | LEU192-ILE212 | |
| X | ALA249-VAL269 | |
| X | ALA278-ILE298 |
| site_id | SWS_FT_FI2 |
| Number of Residues | 384 |
| Details | TOPO_DOM: Extracellular => ECO:0000255 |
| Chain | Residue | Details |
| A | ASP182-MET191 | |
| E | LYS270-PRO277 | |
| F | ASP182-MET191 | |
| F | LYS270-PRO277 | |
| G | ASP182-MET191 | |
| G | LYS270-PRO277 | |
| H | ASP182-MET191 | |
| H | LYS270-PRO277 | |
| I | ASP182-MET191 | |
| I | LYS270-PRO277 | |
| J | ASP182-MET191 | |
| A | LYS270-PRO277 | |
| J | LYS270-PRO277 | |
| K | ASP182-MET191 | |
| K | LYS270-PRO277 | |
| L | ASP182-MET191 | |
| L | LYS270-PRO277 | |
| M | ASP182-MET191 | |
| M | LYS270-PRO277 | |
| N | ASP182-MET191 | |
| N | LYS270-PRO277 | |
| O | ASP182-MET191 | |
| B | ASP182-MET191 | |
| O | LYS270-PRO277 | |
| P | ASP182-MET191 | |
| P | LYS270-PRO277 | |
| Q | ASP182-MET191 | |
| Q | LYS270-PRO277 | |
| R | ASP182-MET191 | |
| R | LYS270-PRO277 | |
| S | ASP182-MET191 | |
| S | LYS270-PRO277 | |
| T | ASP182-MET191 | |
| B | LYS270-PRO277 | |
| T | LYS270-PRO277 | |
| U | ASP182-MET191 | |
| U | LYS270-PRO277 | |
| V | ASP182-MET191 | |
| V | LYS270-PRO277 | |
| W | ASP182-MET191 | |
| W | LYS270-PRO277 | |
| X | ASP182-MET191 | |
| X | LYS270-PRO277 | |
| C | ASP182-MET191 | |
| C | LYS270-PRO277 | |
| D | ASP182-MET191 | |
| D | LYS270-PRO277 | |
| E | ASP182-MET191 |
| site_id | SWS_FT_FI3 |
| Number of Residues | 840 |
| Details | TOPO_DOM: Cytoplasmic => ECO:0000255 |
| Chain | Residue | Details |
| A | SER213-TRP248 | |
| J | SER213-TRP248 | |
| K | SER213-TRP248 | |
| L | SER213-TRP248 | |
| M | SER213-TRP248 | |
| N | SER213-TRP248 | |
| O | SER213-TRP248 | |
| P | SER213-TRP248 | |
| Q | SER213-TRP248 | |
| R | SER213-TRP248 | |
| S | SER213-TRP248 | |
| B | SER213-TRP248 | |
| T | SER213-TRP248 | |
| U | SER213-TRP248 | |
| V | SER213-TRP248 | |
| W | SER213-TRP248 | |
| X | SER213-TRP248 | |
| C | SER213-TRP248 | |
| D | SER213-TRP248 | |
| E | SER213-TRP248 | |
| F | SER213-TRP248 | |
| G | SER213-TRP248 | |
| H | SER213-TRP248 | |
| I | SER213-TRP248 |
| site_id | SWS_FT_FI4 |
| Number of Residues | 24 |
| Details | SITE: Confers selective permeability to Ca(2+) ions => ECO:0000250|UniProtKB:Q96D31, ECO:0000305|PubMed:16921383 |
| Chain | Residue | Details |
| A | GLU178 | |
| J | GLU178 | |
| K | GLU178 | |
| L | GLU178 | |
| M | GLU178 | |
| N | GLU178 | |
| O | GLU178 | |
| P | GLU178 | |
| Q | GLU178 | |
| R | GLU178 | |
| S | GLU178 | |
| B | GLU178 | |
| T | GLU178 | |
| U | GLU178 | |
| V | GLU178 | |
| W | GLU178 | |
| X | GLU178 | |
| C | GLU178 | |
| D | GLU178 | |
| E | GLU178 | |
| F | GLU178 | |
| G | GLU178 | |
| H | GLU178 | |
| I | GLU178 |
