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6B9X

Crystal structure of Ragulator

Functional Information from GO Data
ChainGOidnamespacecontents
A0001558biological_processregulation of cell growth
A0001919biological_processregulation of receptor recycling
A0005085molecular_functionguanyl-nucleotide exchange factor activity
A0005515molecular_functionprotein binding
A0005764cellular_componentlysosome
A0005765cellular_componentlysosomal membrane
A0005768cellular_componentendosome
A0005886cellular_componentplasma membrane
A0007032biological_processendosome organization
A0007040biological_processlysosome organization
A0008104biological_processprotein localization
A0010874biological_processregulation of cholesterol efflux
A0016020cellular_componentmembrane
A0016197biological_processendosomal transport
A0031669biological_processcellular response to nutrient levels
A0031902cellular_componentlate endosome membrane
A0032008biological_processpositive regulation of TOR signaling
A0032418biological_processlysosome localization
A0035577cellular_componentazurophil granule membrane
A0035579cellular_componentspecific granule membrane
A0038202biological_processTORC1 signaling
A0042632biological_processcholesterol homeostasis
A0043410biological_processpositive regulation of MAPK cascade
A0043495molecular_functionprotein-membrane adaptor activity
A0045121cellular_componentmembrane raft
A0051020molecular_functionGTPase binding
A0060090molecular_functionmolecular adaptor activity
A0060620biological_processregulation of cholesterol import
A0070062cellular_componentextracellular exosome
A0071230biological_processcellular response to amino acid stimulus
A0071986cellular_componentRagulator complex
A0072657biological_processprotein localization to membrane
A0101003cellular_componentficolin-1-rich granule membrane
A0150032biological_processpositive regulation of protein localization to lysosome
A1904263biological_processpositive regulation of TORC1 signaling
A1990877cellular_componentFNIP-folliculin RagC/D GAP
B0001558biological_processregulation of cell growth
B0005085molecular_functionguanyl-nucleotide exchange factor activity
B0005515molecular_functionprotein binding
B0005764cellular_componentlysosome
B0005765cellular_componentlysosomal membrane
B0005768cellular_componentendosome
B0005770cellular_componentlate endosome
B0005886cellular_componentplasma membrane
B0008104biological_processprotein localization
B0010008cellular_componentendosome membrane
B0010761biological_processfibroblast migration
B0016020cellular_componentmembrane
B0031902cellular_componentlate endosome membrane
B0032008biological_processpositive regulation of TOR signaling
B0035579cellular_componentspecific granule membrane
B0038202biological_processTORC1 signaling
B0043410biological_processpositive regulation of MAPK cascade
B0060090molecular_functionmolecular adaptor activity
B0070821cellular_componenttertiary granule membrane
B0071230biological_processcellular response to amino acid stimulus
B0071986cellular_componentRagulator complex
B0150116biological_processregulation of cell-substrate junction organization
B1902414biological_processprotein localization to cell junction
B1904263biological_processpositive regulation of TORC1 signaling
B1990877cellular_componentFNIP-folliculin RagC/D GAP
C0005085molecular_functionguanyl-nucleotide exchange factor activity
C0005515molecular_functionprotein binding
C0005765cellular_componentlysosomal membrane
C0005768cellular_componentendosome
C0005770cellular_componentlate endosome
C0005886cellular_componentplasma membrane
C0005925cellular_componentfocal adhesion
C0008104biological_processprotein localization
C0010008cellular_componentendosome membrane
C0016020cellular_componentmembrane
C0019209molecular_functionkinase activator activity
C0031902cellular_componentlate endosome membrane
C0032006biological_processregulation of TOR signaling
C0032008biological_processpositive regulation of TOR signaling
C0035579cellular_componentspecific granule membrane
C0038202biological_processTORC1 signaling
C0043410biological_processpositive regulation of MAPK cascade
C0060090molecular_functionmolecular adaptor activity
C0070062cellular_componentextracellular exosome
C0070821cellular_componenttertiary granule membrane
C0071230biological_processcellular response to amino acid stimulus
C0071986cellular_componentRagulator complex
C1902414biological_processprotein localization to cell junction
C1904263biological_processpositive regulation of TORC1 signaling
C1990877cellular_componentFNIP-folliculin RagC/D GAP
D0005085molecular_functionguanyl-nucleotide exchange factor activity
D0005515molecular_functionprotein binding
D0005764cellular_componentlysosome
D0005765cellular_componentlysosomal membrane
D0008361biological_processregulation of cell size
D0031902cellular_componentlate endosome membrane
D0032008biological_processpositive regulation of TOR signaling
D0038202biological_processTORC1 signaling
D0043231cellular_componentintracellular membrane-bounded organelle
D0060090molecular_functionmolecular adaptor activity
D0061462biological_processprotein localization to lysosome
D0071230biological_processcellular response to amino acid stimulus
D0071986cellular_componentRagulator complex
D1904263biological_processpositive regulation of TORC1 signaling
D1990877cellular_componentFNIP-folliculin RagC/D GAP
E0005085molecular_functionguanyl-nucleotide exchange factor activity
E0005515molecular_functionprotein binding
E0005737cellular_componentcytoplasm
E0005764cellular_componentlysosome
E0005765cellular_componentlysosomal membrane
E0005829cellular_componentcytosol
E0008361biological_processregulation of cell size
E0009615biological_processresponse to virus
E0010628biological_processpositive regulation of gene expression
E0019079biological_processviral genome replication
E0031902cellular_componentlate endosome membrane
E0032008biological_processpositive regulation of TOR signaling
E0032757biological_processpositive regulation of interleukin-8 production
E0032991cellular_componentprotein-containing complex
E0038202biological_processTORC1 signaling
E0043066biological_processnegative regulation of apoptotic process
E0043123biological_processpositive regulation of canonical NF-kappaB signal transduction
E0043154biological_processnegative regulation of cysteine-type endopeptidase activity involved in apoptotic process
E0051092biological_processpositive regulation of NF-kappaB transcription factor activity
E0060090molecular_functionmolecular adaptor activity
E0061462biological_processprotein localization to lysosome
E0071230biological_processcellular response to amino acid stimulus
E0071986cellular_componentRagulator complex
E1900182biological_processpositive regulation of protein localization to nucleus
E1904263biological_processpositive regulation of TORC1 signaling
E1905636biological_processpositive regulation of RNA polymerase II regulatory region sequence-specific DNA binding
E1990877cellular_componentFNIP-folliculin RagC/D GAP
Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues1
DetailsMOD_RES: N-acetylmethionine => ECO:0000269|Ref.8, ECO:0007744|PubMed:19413330, ECO:0007744|PubMed:25944712
ChainResidueDetails
EMET1

site_idSWS_FT_FI2
Number of Residues1
DetailsMOD_RES: N-acetylthreonine; in Ragulator complex protein LAMTOR4, N-terminally processed => ECO:0007744|PubMed:19413330, ECO:0007744|PubMed:22814378, ECO:0007744|PubMed:25944712
ChainResidueDetails
DTHR2
ASER56
ASER98
ASER141

site_idSWS_FT_FI3
Number of Residues1
DetailsMOD_RES: Phosphoserine; by PKA => ECO:0000269|PubMed:31314152
ChainResidueDetails
DSER67

site_idSWS_FT_FI4
Number of Residues2
DetailsLIPID: S-palmitoyl cysteine => ECO:0000269|PubMed:31001086, ECO:0000269|PubMed:34999170, ECO:0000269|PubMed:35893977
ChainResidueDetails
ACYS3
ACYS4

site_idSWS_FT_FI5
Number of Residues3
DetailsCROSSLNK: Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin) => ECO:0000269|PubMed:36476874
ChainResidueDetails
ALYS20
ALYS31
ALYS60

site_idSWS_FT_FI6
Number of Residues3
DetailsCROSSLNK: Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin) => ECO:0000250|UniProtKB:Q9CQ22
ChainResidueDetails
ALYS103
ALYS104

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PDB entries from 2024-07-24

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