6B92
Crystal Structure of the N-terminal domain of human METTL16 in complex with SAH
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0008168 | molecular_function | methyltransferase activity |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 2 |
| Details | binding site for residue EDO A 301 |
| Chain | Residue |
| A | SER6 |
| A | LYS14 |
| site_id | AC2 |
| Number of Residues | 2 |
| Details | binding site for residue EDO A 302 |
| Chain | Residue |
| A | ARG12 |
| A | LYS16 |
| site_id | AC3 |
| Number of Residues | 7 |
| Details | binding site for residue EDO A 303 |
| Chain | Residue |
| A | GLU274 |
| A | PHE275 |
| A | LYS5 |
| A | SER6 |
| A | MET7 |
| A | HIS8 |
| A | THR273 |
| site_id | AC4 |
| Number of Residues | 2 |
| Details | binding site for residue EDO A 304 |
| Chain | Residue |
| A | ARG41 |
| A | HOH512 |
| site_id | AC5 |
| Number of Residues | 19 |
| Details | binding site for residue SAH A 305 |
| Chain | Residue |
| A | LEU75 |
| A | ARG82 |
| A | GLY110 |
| A | GLY112 |
| A | THR132 |
| A | GLU133 |
| A | VAL134 |
| A | ASP135 |
| A | CYS138 |
| A | THR164 |
| A | ASN184 |
| A | PRO185 |
| A | PRO186 |
| A | PHE227 |
| A | HOH404 |
| A | HOH420 |
| A | HOH433 |
| A | HOH438 |
| A | HOH502 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 13 |
| Details | Region: {"description":"RNA-binding","evidences":[{"source":"PubMed","id":"30197297","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"6DU4","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6DU5","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI2 |
| Number of Residues | 4 |
| Details | Region: {"description":"K-loop","evidences":[{"source":"PubMed","id":"30197297","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI3 |
| Number of Residues | 3 |
| Details | Binding site: {"evidences":[{"source":"PubMed","id":"29593291","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"30197299","evidenceCode":"ECO:0000269"},{"source":"Reference","evidenceCode":"ECO:0000269","citation":{"citationType":"submission","publicationDate":"JUN-2006","submissionDatabase":"PDB data bank","title":"The crystal structure of human methyltransferase 10 domain-containing protein.","authoringGroup":["Structural genomics consortium (SGC)"]}},{"source":"PDB","id":"2H00","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6B92","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6GFK","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6GFN","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI4 |
| Number of Residues | 2 |
| Details | Binding site: {"evidences":[{"source":"PubMed","id":"30197299","evidenceCode":"ECO:0000269"},{"source":"Reference","evidenceCode":"ECO:0000269","citation":{"citationType":"submission","publicationDate":"JUN-2006","submissionDatabase":"PDB data bank","title":"The crystal structure of human methyltransferase 10 domain-containing protein.","authoringGroup":["Structural genomics consortium (SGC)"]}},{"source":"PDB","id":"2H00","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6GFK","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6GFN","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI5 |
| Number of Residues | 1 |
| Details | Binding site: {"evidences":[{"source":"PubMed","id":"30197299","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"6GFN","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
