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6B5B

Cryo-EM structure of the NAIP5-NLRC4-flagellin inflammasome

Functional Information from GO Data
ChainGOidnamespacecontents
A0000166molecular_functionnucleotide binding
A0002376biological_processimmune system process
A0005515molecular_functionprotein binding
A0005524molecular_functionATP binding
A0006915biological_processapoptotic process
A0006954biological_processinflammatory response
A0016045biological_processdetection of bacterium
A0032731biological_processpositive regulation of interleukin-1 beta production
A0042742biological_processdefense response to bacterium
A0043027molecular_functioncysteine-type endopeptidase inhibitor activity involved in apoptotic process
A0043066biological_processnegative regulation of apoptotic process
A0045087biological_processinnate immune response
A0046718biological_processsymbiont entry into host cell
A0046872molecular_functionmetal ion binding
A0050829biological_processdefense response to Gram-negative bacterium
A0070269biological_processpyroptotic inflammatory response
A0072557cellular_componentIPAF inflammasome complex
B0000166molecular_functionnucleotide binding
B0002218biological_processactivation of innate immune response
B0002376biological_processimmune system process
B0005515molecular_functionprotein binding
B0005524molecular_functionATP binding
B0005737cellular_componentcytoplasm
B0005829cellular_componentcytosol
B0005886cellular_componentplasma membrane
B0006915biological_processapoptotic process
B0006954biological_processinflammatory response
B0010954biological_processpositive regulation of protein processing
B0016045biological_processdetection of bacterium
B0032731biological_processpositive regulation of interleukin-1 beta production
B0042742biological_processdefense response to bacterium
B0042802molecular_functionidentical protein binding
B0042803molecular_functionprotein homodimerization activity
B0042981biological_processregulation of apoptotic process
B0043065biological_processpositive regulation of apoptotic process
B0043231cellular_componentintracellular membrane-bounded organelle
B0045087biological_processinnate immune response
B0051260biological_processprotein homooligomerization
B0061133molecular_functionendopeptidase activator activity
B0061702cellular_componentcanonical inflammasome complex
B0070269biological_processpyroptotic inflammatory response
B0072557cellular_componentIPAF inflammasome complex
B0089720molecular_functioncaspase binding
C0000166molecular_functionnucleotide binding
C0002218biological_processactivation of innate immune response
C0002376biological_processimmune system process
C0005515molecular_functionprotein binding
C0005524molecular_functionATP binding
C0005737cellular_componentcytoplasm
C0005829cellular_componentcytosol
C0005886cellular_componentplasma membrane
C0006915biological_processapoptotic process
C0006954biological_processinflammatory response
C0010954biological_processpositive regulation of protein processing
C0016045biological_processdetection of bacterium
C0032731biological_processpositive regulation of interleukin-1 beta production
C0042742biological_processdefense response to bacterium
C0042802molecular_functionidentical protein binding
C0042803molecular_functionprotein homodimerization activity
C0042981biological_processregulation of apoptotic process
C0043065biological_processpositive regulation of apoptotic process
C0043231cellular_componentintracellular membrane-bounded organelle
C0045087biological_processinnate immune response
C0051260biological_processprotein homooligomerization
C0061133molecular_functionendopeptidase activator activity
C0061702cellular_componentcanonical inflammasome complex
C0070269biological_processpyroptotic inflammatory response
C0072557cellular_componentIPAF inflammasome complex
C0089720molecular_functioncaspase binding
F0005198molecular_functionstructural molecule activity
F0005576cellular_componentextracellular region
F0009288cellular_componentbacterial-type flagellum
Functional Information from PROSITE/UniProt
site_idPS01282
Number of Residues69
DetailsBIR_REPEAT_1 BIR repeat. EeaRlesfed.WpfyahgtsprvlsaAGFvFtgkrDtvqCfsCggslgnWeegddpwkeHakwfPkCefL
ChainResidueDetails
AGLU159-LEU227
AGLU278-LEU345

Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues6
DetailsBINDING: BINDING => ECO:0000269|PubMed:23765277, ECO:0007744|PDB:4KXF
ChainResidueDetails
BTHR135
BGLY172
BHIS443
CTHR135
CGLY172
CHIS443

site_idSWS_FT_FI2
Number of Residues2
DetailsMOD_RES: Phosphoserine => ECO:0000269|PubMed:22885697, ECO:0000269|PubMed:23765277
ChainResidueDetails
BSER533
CSER533

237735

PDB entries from 2025-06-18

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