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SummaryStructural detailsExperimental detailsFunctional detailsSequence NeighborHistoryDownloads

6B5B

Cryo-EM structure of the NAIP5-NLRC4-flagellin inflammasome

Functional Information from GO Data
ChainGOidnamespacecontents
A0000166molecular_functionnucleotide binding
A0002376biological_processimmune system process
A0005515molecular_functionprotein binding
A0005524molecular_functionATP binding
A0006915biological_processapoptotic process
A0006954biological_processinflammatory response
A0010804biological_processnegative regulation of tumor necrosis factor-mediated signaling pathway
A0016045biological_processdetection of bacterium
A0032731biological_processpositive regulation of interleukin-1 beta production
A0042742biological_processdefense response to bacterium
A0042981biological_processregulation of apoptotic process
A0043027molecular_functioncysteine-type endopeptidase inhibitor activity involved in apoptotic process
A0043066biological_processnegative regulation of apoptotic process
A0045087biological_processinnate immune response
A0046330biological_processpositive regulation of JNK cascade
A0046718biological_processsymbiont entry into host cell
A0046872molecular_functionmetal ion binding
A0050829biological_processdefense response to Gram-negative bacterium
A0070269biological_processpyroptotic inflammatory response
A0072557cellular_componentIPAF inflammasome complex
A0120283molecular_functionprotein serine/threonine kinase binding
B0000166molecular_functionnucleotide binding
B0002218biological_processactivation of innate immune response
B0002376biological_processimmune system process
B0005515molecular_functionprotein binding
B0005524molecular_functionATP binding
B0005829cellular_componentcytosol
B0005886cellular_componentplasma membrane
B0006915biological_processapoptotic process
B0006954biological_processinflammatory response
B0010954biological_processpositive regulation of protein processing
B0016045biological_processdetection of bacterium
B0032731biological_processpositive regulation of interleukin-1 beta production
B0042742biological_processdefense response to bacterium
B0042802molecular_functionidentical protein binding
B0042803molecular_functionprotein homodimerization activity
B0042981biological_processregulation of apoptotic process
B0043065biological_processpositive regulation of apoptotic process
B0045087biological_processinnate immune response
B0051260biological_processprotein homooligomerization
B0061133molecular_functionendopeptidase activator activity
B0061702cellular_componentcanonical inflammasome complex
B0070269biological_processpyroptotic inflammatory response
B0072557cellular_componentIPAF inflammasome complex
B0089720molecular_functioncaspase binding
C0000166molecular_functionnucleotide binding
C0002218biological_processactivation of innate immune response
C0002376biological_processimmune system process
C0005515molecular_functionprotein binding
C0005524molecular_functionATP binding
C0005829cellular_componentcytosol
C0005886cellular_componentplasma membrane
C0006915biological_processapoptotic process
C0006954biological_processinflammatory response
C0010954biological_processpositive regulation of protein processing
C0016045biological_processdetection of bacterium
C0032731biological_processpositive regulation of interleukin-1 beta production
C0042742biological_processdefense response to bacterium
C0042802molecular_functionidentical protein binding
C0042803molecular_functionprotein homodimerization activity
C0042981biological_processregulation of apoptotic process
C0043065biological_processpositive regulation of apoptotic process
C0045087biological_processinnate immune response
C0051260biological_processprotein homooligomerization
C0061133molecular_functionendopeptidase activator activity
C0061702cellular_componentcanonical inflammasome complex
C0070269biological_processpyroptotic inflammatory response
C0072557cellular_componentIPAF inflammasome complex
C0089720molecular_functioncaspase binding
F0005198molecular_functionstructural molecule activity
F0005576cellular_componentextracellular region
F0009288cellular_componentbacterial-type flagellum
Functional Information from PROSITE/UniProt
site_idPS01282
Number of Residues69
DetailsBIR_REPEAT_1 BIR repeat. EeaRlesfed.WpfyahgtsprvlsaAGFvFtgkrDtvqCfsCggslgnWeegddpwkeHakwfPkCefL
ChainResidueDetails
AGLU159-LEU227
AGLU278-LEU345
Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues68
DetailsRepeat: {"description":"BIR 2"}
ChainResidueDetails
site_idSWS_FT_FI2
Number of Residues67
DetailsRepeat: {"description":"BIR 3"}
ChainResidueDetails
site_idSWS_FT_FI3
Number of Residues921
DetailsDomain: {"description":"NACHT","evidences":[{"source":"PROSITE-ProRule","id":"PRU00136","evidenceCode":"ECO:0000255"}]}
ChainResidueDetails
site_idSWS_FT_FI4
Number of Residues4
DetailsBinding site: {"evidences":[{"source":"PROSITE-ProRule","id":"PRU00029","evidenceCode":"ECO:0000255"}]}
ChainResidueDetails
site_idSWS_FT_FI5
Number of Residues5
DetailsBinding site: {"evidences":[{"source":"PubMed","id":"29182158","evidenceCode":"ECO:0000305"},{"source":"PDB","id":"5YUD","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails
site_idSWS_FT_FI6
Number of Residues40
DetailsRepeat: {"description":"LRR 1","evidences":[{"source":"PubMed","id":"23765277","evidenceCode":"ECO:0000269"}]}
ChainResidueDetails
site_idSWS_FT_FI7
Number of Residues46
DetailsRepeat: {"description":"LRR 2","evidences":[{"source":"PubMed","id":"23765277","evidenceCode":"ECO:0000269"}]}
ChainResidueDetails
site_idSWS_FT_FI8
Number of Residues46
DetailsRepeat: {"description":"LRR 3","evidences":[{"source":"PubMed","id":"23765277","evidenceCode":"ECO:0000269"}]}
ChainResidueDetails
site_idSWS_FT_FI9
Number of Residues46
DetailsRepeat: {"description":"LRR 4","evidences":[{"source":"PubMed","id":"23765277","evidenceCode":"ECO:0000269"}]}
ChainResidueDetails
site_idSWS_FT_FI10
Number of Residues50
DetailsRepeat: {"description":"LRR 5","evidences":[{"source":"PubMed","id":"23765277","evidenceCode":"ECO:0000269"}]}
ChainResidueDetails
site_idSWS_FT_FI11
Number of Residues46
DetailsRepeat: {"description":"LRR 6","evidences":[{"source":"PubMed","id":"23765277","evidenceCode":"ECO:0000269"}]}
ChainResidueDetails
site_idSWS_FT_FI12
Number of Residues44
DetailsRepeat: {"description":"LRR 7","evidences":[{"source":"PubMed","id":"23765277","evidenceCode":"ECO:0000269"}]}
ChainResidueDetails
site_idSWS_FT_FI13
Number of Residues48
DetailsRepeat: {"description":"LRR 8","evidences":[{"source":"PubMed","id":"23765277","evidenceCode":"ECO:0000269"}]}
ChainResidueDetails
site_idSWS_FT_FI14
Number of Residues44
DetailsRepeat: {"description":"LRR 9","evidences":[{"source":"PubMed","id":"23765277","evidenceCode":"ECO:0000269"}]}
ChainResidueDetails
site_idSWS_FT_FI15
Number of Residues54
DetailsRepeat: {"description":"LRR 10","evidences":[{"source":"PubMed","id":"23765277","evidenceCode":"ECO:0000269"}]}
ChainResidueDetails
site_idSWS_FT_FI16
Number of Residues40
DetailsRepeat: {"description":"LRR 11","evidences":[{"source":"PubMed","id":"23765277","evidenceCode":"ECO:0000269"}]}
ChainResidueDetails
site_idSWS_FT_FI17
Number of Residues44
DetailsRepeat: {"description":"LRR 12","evidences":[{"source":"PubMed","id":"23765277","evidenceCode":"ECO:0000269"}]}
ChainResidueDetails
site_idSWS_FT_FI18
Number of Residues406
DetailsRegion: {"description":"Nucleotide-binding domain (NBD)"}
ChainResidueDetails
site_idSWS_FT_FI19
Number of Residues214
DetailsRegion: {"description":"Winged-helix domain (WHD)"}
ChainResidueDetails
site_idSWS_FT_FI20
Number of Residues14
DetailsBinding site: {"evidences":[{"source":"PubMed","id":"23765277","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"4KXF","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails
site_idSWS_FT_FI21
Number of Residues2
DetailsModified residue: {"description":"Phosphoserine","evidences":[{"source":"PubMed","id":"22885697","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"23765277","evidenceCode":"ECO:0000269"}]}
ChainResidueDetails

242842

PDB entries from 2025-10-08

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