6B4J

Crystal structure of human Gle1 CTD-Nup42 GBM-DDX19B(AMPPNP) complex

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0005643	cellular_component	nuclear pore
A	0016973	biological_process	poly(A)+ mRNA export from nucleus
B	0005643	cellular_component	nuclear pore
B	0016973	biological_process	poly(A)+ mRNA export from nucleus
E	0003676	molecular_function	nucleic acid binding
E	0003724	molecular_function	RNA helicase activity
E	0005524	molecular_function	ATP binding
F	0003676	molecular_function	nucleic acid binding
F	0003724	molecular_function	RNA helicase activity
F	0005524	molecular_function	ATP binding

Functional Information from PDB Data

site_id	AC1
Number of Residues	2
Details	binding site for residue PO4 B 701

Chain	Residue
A	HIS681
B	SER693

---

site_id	AC2
Number of Residues	3
Details	binding site for residue PO4 B 702

Chain	Residue
A	SER693
B	LYS677
B	HIS681

---

site_id	AC3
Number of Residues	4
Details	binding site for residue PO4 E 501

Chain	Residue
E	ARG67
E	ARG299
E	GLY396
E	ARG429

---

site_id	AC4
Number of Residues	5
Details	binding site for residue PO4 E 502

Chain	Residue
E	ARG199
E	THR217
E	PRO218
E	GLY219
E	THR220

---

site_id	AC5
Number of Residues	5
Details	binding site for residue MG E 503

Chain	Residue
E	LYS64
E	THR145
E	ASP242
E	GLU243
E	ANP504

---

site_id	AC6
Number of Residues	16
Details	binding site for residue ANP E 504

Chain	Residue
E	LYS64
E	SER68
E	ASN69
E	LEU70
E	PHE112
E	ARG114
E	SER116
E	GLN119
E	SER140
E	GLY141
E	GLY143
E	LYS144
E	THR145
E	ALA146
E	GLU243
E	MG503

---

site_id	AC7
Number of Residues	5
Details	binding site for residue PO4 F 501

Chain	Residue
F	ARG299
F	ARG395
F	GLY396
F	HIS425
F	ARG429

---

site_id	AC8
Number of Residues	5
Details	binding site for residue PO4 F 502

Chain	Residue
F	ARG199
F	THR217
F	PRO218
F	GLY219
F	THR220

---

site_id	AC9
Number of Residues	4
Details	binding site for residue MG F 503

Chain	Residue
F	LYS64
F	THR145
F	ASP242
F	ANP504

---

site_id	AD1
Number of Residues	15
Details	binding site for residue ANP F 504

Chain	Residue
F	LYS64
F	ARG67
F	ASN69
F	LEU70
F	PHE112
F	ARG114
F	GLN119
F	SER140
F	GLY141
F	GLY143
F	LYS144
F	THR145
F	ALA146
F	GLU243
F	MG503

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	78
Details	Region: {"description":"Mediates the shuttling between the nucleus and the cytoplasm"}

Chain

Residue

Details

---

site_id	SWS_FT_FI2
Number of Residues	84
Details	Region: {"description":"Interaction with NUP42","evidences":[{"source":"PubMed","id":"16000379","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI3
Number of Residues	340
Details	Domain: {"description":"Helicase ATP-binding","evidences":[{"source":"PROSITE-ProRule","id":"PRU00541","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI4
Number of Residues	336
Details	Domain: {"description":"Helicase C-terminal","evidences":[{"source":"PROSITE-ProRule","id":"PRU00542","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI5
Number of Residues	26
Details	Region: {"description":"N-terminal helix"}

Chain

Residue

Details

---

site_id	SWS_FT_FI6
Number of Residues	356
Details	Region: {"description":"C-terminal lobe"}

Chain

Residue

Details

---

site_id	SWS_FT_FI7
Number of Residues	56
Details	Motif: {"description":"Q motif"}

Chain

Residue

Details

---

site_id	SWS_FT_FI8
Number of Residues	6
Details	Motif: {"description":"DEAD box"}

Chain

Residue

Details

---

site_id	SWS_FT_FI9
Number of Residues	20
Details	Binding site: {}

Chain

Residue

Details

---