6B0U

Crystal structure of acetyltransferase Eis from Mycobacterium tuberculosis in complex with a Lys-containing peptide

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0005576	cellular_component	extracellular region
A	0005829	cellular_component	cytosol
A	0008080	molecular_function	N-acetyltransferase activity
A	0016740	molecular_function	transferase activity
A	0016746	molecular_function	acyltransferase activity
A	0016747	molecular_function	acyltransferase activity, transferring groups other than amino-acyl groups
A	0030649	biological_process	aminoglycoside antibiotic catabolic process
A	0033661	biological_process	effector-mediated defense to host-produced reactive oxygen species
A	0034069	molecular_function	aminoglycoside N-acetyltransferase activity
A	0042802	molecular_function	identical protein binding
A	0043655	cellular_component	host extracellular space
A	0044161	cellular_component	host cell cytoplasmic vesicle
A	0046677	biological_process	response to antibiotic
A	0051701	biological_process	biological process involved in interaction with host
A	0052032	biological_process	symbiont-mediated perturbation of host inflammatory response
A	0052040	biological_process	symbiont-mediated perturbation of host programmed cell death
A	0052041	biological_process	symbiont-mediated suppression of host programmed cell death
A	0052167	biological_process	symbiont-mediated perturbation of host innate immune response
A	0061733	molecular_function	protein-lysine-acetyltransferase activity
A	0097691	cellular_component	bacterial extracellular vesicle
B	0005576	cellular_component	extracellular region
B	0005829	cellular_component	cytosol
B	0008080	molecular_function	N-acetyltransferase activity
B	0016740	molecular_function	transferase activity
B	0016746	molecular_function	acyltransferase activity
B	0016747	molecular_function	acyltransferase activity, transferring groups other than amino-acyl groups
B	0030649	biological_process	aminoglycoside antibiotic catabolic process
B	0033661	biological_process	effector-mediated defense to host-produced reactive oxygen species
B	0034069	molecular_function	aminoglycoside N-acetyltransferase activity
B	0042802	molecular_function	identical protein binding
B	0043655	cellular_component	host extracellular space
B	0044161	cellular_component	host cell cytoplasmic vesicle
B	0046677	biological_process	response to antibiotic
B	0051701	biological_process	biological process involved in interaction with host
B	0052032	biological_process	symbiont-mediated perturbation of host inflammatory response
B	0052040	biological_process	symbiont-mediated perturbation of host programmed cell death
B	0052041	biological_process	symbiont-mediated suppression of host programmed cell death
B	0052167	biological_process	symbiont-mediated perturbation of host innate immune response
B	0061733	molecular_function	protein-lysine-acetyltransferase activity
B	0097691	cellular_component	bacterial extracellular vesicle
C	0005576	cellular_component	extracellular region
C	0005829	cellular_component	cytosol
C	0008080	molecular_function	N-acetyltransferase activity
C	0016740	molecular_function	transferase activity
C	0016746	molecular_function	acyltransferase activity
C	0016747	molecular_function	acyltransferase activity, transferring groups other than amino-acyl groups
C	0030649	biological_process	aminoglycoside antibiotic catabolic process
C	0033661	biological_process	effector-mediated defense to host-produced reactive oxygen species
C	0034069	molecular_function	aminoglycoside N-acetyltransferase activity
C	0042802	molecular_function	identical protein binding
C	0043655	cellular_component	host extracellular space
C	0044161	cellular_component	host cell cytoplasmic vesicle
C	0046677	biological_process	response to antibiotic
C	0051701	biological_process	biological process involved in interaction with host
C	0052032	biological_process	symbiont-mediated perturbation of host inflammatory response
C	0052040	biological_process	symbiont-mediated perturbation of host programmed cell death
C	0052041	biological_process	symbiont-mediated suppression of host programmed cell death
C	0052167	biological_process	symbiont-mediated perturbation of host innate immune response
C	0061733	molecular_function	protein-lysine-acetyltransferase activity
C	0097691	cellular_component	bacterial extracellular vesicle

Functional Information from PDB Data

site_id	AC1
Number of Residues	3
Details	binding site for residue COA A 501

Chain	Residue
A	CYS101
A	TYR126
A	PHE129

---

site_id	AC2
Number of Residues	11
Details	binding site for residue COA A 502

Chain	Residue
A	ARG98
A	ILE125
A	ARG128
A	CYS204
A	SER214
A	VAL87
A	ARG93
A	ARG94
A	GLY95
A	LEU96
A	LEU97

---

site_id	AC3
Number of Residues	7
Details	binding site for residue COA B 501

Chain	Residue
B	VAL87
B	ARG93
B	ARG94
B	GLY95
B	LEU96
B	LEU97
B	ARG98

---

site_id	AC4
Number of Residues	11
Details	binding site for residue COA C 501

Chain	Residue
C	VAL87
C	ARG93
C	ARG94
C	GLY95
C	LEU96
C	LEU97
C	ARG98
C	CYS101
C	TYR126
C	ARG128
C	PHE129

---

site_id	AC5
Number of Residues	5
Details	binding site for residue COA C 502

Chain	Residue
C	LEU200
C	GLU203
C	CYS204
C	SER214
C	SER239

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	3
Details	Active site: {"description":"Proton donor","evidences":[{"source":"PubMed","id":"21628583","evidenceCode":"ECO:0000305"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI2
Number of Residues	3
Details	Active site: {"description":"Proton acceptor; via carboxylate","evidences":[{"source":"PubMed","id":"21628583","evidenceCode":"ECO:0000305"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI3
Number of Residues	9
Details	Binding site: {"evidences":[{"source":"PubMed","id":"22547814","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"21628583","evidenceCode":"ECO:0000305"},{"source":"PDB","id":"3RYO","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI4
Number of Residues	15
Details	Binding site: {"evidences":[{"source":"PubMed","id":"22547814","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"21628583","evidenceCode":"ECO:0000305"},{"source":"PubMed","id":"24106131","evidenceCode":"ECO:0000305"},{"source":"PubMed","id":"27010218","evidenceCode":"ECO:0000305"},{"source":"PDB","id":"3RYO","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---