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6AXF

Structure of RasGRP2 in complex with Rap1B

Functional Information from GO Data
ChainGOidnamespacecontents
A0005085molecular_functionguanyl-nucleotide exchange factor activity
A0007264biological_processsmall GTPase-mediated signal transduction
B0003924molecular_functionGTPase activity
B0003925molecular_functionG protein activity
B0005515molecular_functionprotein binding
B0005525molecular_functionGTP binding
B0005737cellular_componentcytoplasm
B0005811cellular_componentlipid droplet
B0005829cellular_componentcytosol
B0005886cellular_componentplasma membrane
B0005911cellular_componentcell-cell junction
B0007165biological_processsignal transduction
B0007264biological_processsmall GTPase-mediated signal transduction
B0008283biological_processcell population proliferation
B0016020cellular_componentmembrane
B0016787molecular_functionhydrolase activity
B0017156biological_processcalcium-ion regulated exocytosis
B0019003molecular_functionGDP binding
B0030033biological_processmicrovillus assembly
B0032486biological_processRap protein signal transduction
B0033625biological_processpositive regulation of integrin activation
B0035577cellular_componentazurophil granule membrane
B0044877molecular_functionprotein-containing complex binding
B0045121cellular_componentmembrane raft
B0045955biological_processnegative regulation of calcium ion-dependent exocytosis
B0051649biological_processestablishment of localization in cell
B0061028biological_processestablishment of endothelial barrier
B0070062cellular_componentextracellular exosome
B0070161cellular_componentanchoring junction
B0070374biological_processpositive regulation of ERK1 and ERK2 cascade
B0071320biological_processcellular response to cAMP
B0098978cellular_componentglutamatergic synapse
B0099010biological_processmodification of postsynaptic structure
B1901888biological_processregulation of cell junction assembly
B2000114biological_processregulation of establishment of cell polarity
B2000301biological_processnegative regulation of synaptic vesicle exocytosis
C0005085molecular_functionguanyl-nucleotide exchange factor activity
C0007264biological_processsmall GTPase-mediated signal transduction
D0003924molecular_functionGTPase activity
D0003925molecular_functionG protein activity
D0005515molecular_functionprotein binding
D0005525molecular_functionGTP binding
D0005737cellular_componentcytoplasm
D0005811cellular_componentlipid droplet
D0005829cellular_componentcytosol
D0005886cellular_componentplasma membrane
D0005911cellular_componentcell-cell junction
D0007165biological_processsignal transduction
D0007264biological_processsmall GTPase-mediated signal transduction
D0008283biological_processcell population proliferation
D0016020cellular_componentmembrane
D0016787molecular_functionhydrolase activity
D0017156biological_processcalcium-ion regulated exocytosis
D0019003molecular_functionGDP binding
D0030033biological_processmicrovillus assembly
D0032486biological_processRap protein signal transduction
D0033625biological_processpositive regulation of integrin activation
D0035577cellular_componentazurophil granule membrane
D0044877molecular_functionprotein-containing complex binding
D0045121cellular_componentmembrane raft
D0045955biological_processnegative regulation of calcium ion-dependent exocytosis
D0051649biological_processestablishment of localization in cell
D0061028biological_processestablishment of endothelial barrier
D0070062cellular_componentextracellular exosome
D0070161cellular_componentanchoring junction
D0070374biological_processpositive regulation of ERK1 and ERK2 cascade
D0071320biological_processcellular response to cAMP
D0098978cellular_componentglutamatergic synapse
D0099010biological_processmodification of postsynaptic structure
D1901888biological_processregulation of cell junction assembly
D2000114biological_processregulation of establishment of cell polarity
D2000301biological_processnegative regulation of synaptic vesicle exocytosis
E0005085molecular_functionguanyl-nucleotide exchange factor activity
E0007264biological_processsmall GTPase-mediated signal transduction
F0003924molecular_functionGTPase activity
F0003925molecular_functionG protein activity
F0005515molecular_functionprotein binding
F0005525molecular_functionGTP binding
F0005737cellular_componentcytoplasm
F0005811cellular_componentlipid droplet
F0005829cellular_componentcytosol
F0005886cellular_componentplasma membrane
F0005911cellular_componentcell-cell junction
F0007165biological_processsignal transduction
F0007264biological_processsmall GTPase-mediated signal transduction
F0008283biological_processcell population proliferation
F0016020cellular_componentmembrane
F0016787molecular_functionhydrolase activity
F0017156biological_processcalcium-ion regulated exocytosis
F0019003molecular_functionGDP binding
F0030033biological_processmicrovillus assembly
F0032486biological_processRap protein signal transduction
F0033625biological_processpositive regulation of integrin activation
F0035577cellular_componentazurophil granule membrane
F0044877molecular_functionprotein-containing complex binding
F0045121cellular_componentmembrane raft
F0045955biological_processnegative regulation of calcium ion-dependent exocytosis
F0051649biological_processestablishment of localization in cell
F0061028biological_processestablishment of endothelial barrier
F0070062cellular_componentextracellular exosome
F0070161cellular_componentanchoring junction
F0070374biological_processpositive regulation of ERK1 and ERK2 cascade
F0071320biological_processcellular response to cAMP
F0098978cellular_componentglutamatergic synapse
F0099010biological_processmodification of postsynaptic structure
F1901888biological_processregulation of cell junction assembly
F2000114biological_processregulation of establishment of cell polarity
F2000301biological_processnegative regulation of synaptic vesicle exocytosis
G0005085molecular_functionguanyl-nucleotide exchange factor activity
G0007264biological_processsmall GTPase-mediated signal transduction
H0003924molecular_functionGTPase activity
H0003925molecular_functionG protein activity
H0005515molecular_functionprotein binding
H0005525molecular_functionGTP binding
H0005737cellular_componentcytoplasm
H0005811cellular_componentlipid droplet
H0005829cellular_componentcytosol
H0005886cellular_componentplasma membrane
H0005911cellular_componentcell-cell junction
H0007165biological_processsignal transduction
H0007264biological_processsmall GTPase-mediated signal transduction
H0008283biological_processcell population proliferation
H0016020cellular_componentmembrane
H0016787molecular_functionhydrolase activity
H0017156biological_processcalcium-ion regulated exocytosis
H0019003molecular_functionGDP binding
H0030033biological_processmicrovillus assembly
H0032486biological_processRap protein signal transduction
H0033625biological_processpositive regulation of integrin activation
H0035577cellular_componentazurophil granule membrane
H0044877molecular_functionprotein-containing complex binding
H0045121cellular_componentmembrane raft
H0045955biological_processnegative regulation of calcium ion-dependent exocytosis
H0051649biological_processestablishment of localization in cell
H0061028biological_processestablishment of endothelial barrier
H0070062cellular_componentextracellular exosome
H0070161cellular_componentanchoring junction
H0070374biological_processpositive regulation of ERK1 and ERK2 cascade
H0071320biological_processcellular response to cAMP
H0098978cellular_componentglutamatergic synapse
H0099010biological_processmodification of postsynaptic structure
H1901888biological_processregulation of cell junction assembly
H2000114biological_processregulation of establishment of cell polarity
H2000301biological_processnegative regulation of synaptic vesicle exocytosis
I0005085molecular_functionguanyl-nucleotide exchange factor activity
I0007264biological_processsmall GTPase-mediated signal transduction
J0003924molecular_functionGTPase activity
J0003925molecular_functionG protein activity
J0005515molecular_functionprotein binding
J0005525molecular_functionGTP binding
J0005737cellular_componentcytoplasm
J0005811cellular_componentlipid droplet
J0005829cellular_componentcytosol
J0005886cellular_componentplasma membrane
J0005911cellular_componentcell-cell junction
J0007165biological_processsignal transduction
J0007264biological_processsmall GTPase-mediated signal transduction
J0008283biological_processcell population proliferation
J0016020cellular_componentmembrane
J0016787molecular_functionhydrolase activity
J0017156biological_processcalcium-ion regulated exocytosis
J0019003molecular_functionGDP binding
J0030033biological_processmicrovillus assembly
J0032486biological_processRap protein signal transduction
J0033625biological_processpositive regulation of integrin activation
J0035577cellular_componentazurophil granule membrane
J0044877molecular_functionprotein-containing complex binding
J0045121cellular_componentmembrane raft
J0045955biological_processnegative regulation of calcium ion-dependent exocytosis
J0051649biological_processestablishment of localization in cell
J0061028biological_processestablishment of endothelial barrier
J0070062cellular_componentextracellular exosome
J0070161cellular_componentanchoring junction
J0070374biological_processpositive regulation of ERK1 and ERK2 cascade
J0071320biological_processcellular response to cAMP
J0098978cellular_componentglutamatergic synapse
J0099010biological_processmodification of postsynaptic structure
J1901888biological_processregulation of cell junction assembly
J2000114biological_processregulation of establishment of cell polarity
J2000301biological_processnegative regulation of synaptic vesicle exocytosis
K0005085molecular_functionguanyl-nucleotide exchange factor activity
K0007264biological_processsmall GTPase-mediated signal transduction
L0003924molecular_functionGTPase activity
L0003925molecular_functionG protein activity
L0005515molecular_functionprotein binding
L0005525molecular_functionGTP binding
L0005737cellular_componentcytoplasm
L0005811cellular_componentlipid droplet
L0005829cellular_componentcytosol
L0005886cellular_componentplasma membrane
L0005911cellular_componentcell-cell junction
L0007165biological_processsignal transduction
L0007264biological_processsmall GTPase-mediated signal transduction
L0008283biological_processcell population proliferation
L0016020cellular_componentmembrane
L0016787molecular_functionhydrolase activity
L0017156biological_processcalcium-ion regulated exocytosis
L0019003molecular_functionGDP binding
L0030033biological_processmicrovillus assembly
L0032486biological_processRap protein signal transduction
L0033625biological_processpositive regulation of integrin activation
L0035577cellular_componentazurophil granule membrane
L0044877molecular_functionprotein-containing complex binding
L0045121cellular_componentmembrane raft
L0045955biological_processnegative regulation of calcium ion-dependent exocytosis
L0051649biological_processestablishment of localization in cell
L0061028biological_processestablishment of endothelial barrier
L0070062cellular_componentextracellular exosome
L0070161cellular_componentanchoring junction
L0070374biological_processpositive regulation of ERK1 and ERK2 cascade
L0071320biological_processcellular response to cAMP
L0098978cellular_componentglutamatergic synapse
L0099010biological_processmodification of postsynaptic structure
L1901888biological_processregulation of cell junction assembly
L2000114biological_processregulation of establishment of cell polarity
L2000301biological_processnegative regulation of synaptic vesicle exocytosis
M0005085molecular_functionguanyl-nucleotide exchange factor activity
M0007264biological_processsmall GTPase-mediated signal transduction
N0003924molecular_functionGTPase activity
N0003925molecular_functionG protein activity
N0005515molecular_functionprotein binding
N0005525molecular_functionGTP binding
N0005737cellular_componentcytoplasm
N0005811cellular_componentlipid droplet
N0005829cellular_componentcytosol
N0005886cellular_componentplasma membrane
N0005911cellular_componentcell-cell junction
N0007165biological_processsignal transduction
N0007264biological_processsmall GTPase-mediated signal transduction
N0008283biological_processcell population proliferation
N0016020cellular_componentmembrane
N0016787molecular_functionhydrolase activity
N0017156biological_processcalcium-ion regulated exocytosis
N0019003molecular_functionGDP binding
N0030033biological_processmicrovillus assembly
N0032486biological_processRap protein signal transduction
N0033625biological_processpositive regulation of integrin activation
N0035577cellular_componentazurophil granule membrane
N0044877molecular_functionprotein-containing complex binding
N0045121cellular_componentmembrane raft
N0045955biological_processnegative regulation of calcium ion-dependent exocytosis
N0051649biological_processestablishment of localization in cell
N0061028biological_processestablishment of endothelial barrier
N0070062cellular_componentextracellular exosome
N0070161cellular_componentanchoring junction
N0070374biological_processpositive regulation of ERK1 and ERK2 cascade
N0071320biological_processcellular response to cAMP
N0098978cellular_componentglutamatergic synapse
N0099010biological_processmodification of postsynaptic structure
N1901888biological_processregulation of cell junction assembly
N2000114biological_processregulation of establishment of cell polarity
N2000301biological_processnegative regulation of synaptic vesicle exocytosis
O0005085molecular_functionguanyl-nucleotide exchange factor activity
O0007264biological_processsmall GTPase-mediated signal transduction
P0003924molecular_functionGTPase activity
P0003925molecular_functionG protein activity
P0005515molecular_functionprotein binding
P0005525molecular_functionGTP binding
P0005737cellular_componentcytoplasm
P0005811cellular_componentlipid droplet
P0005829cellular_componentcytosol
P0005886cellular_componentplasma membrane
P0005911cellular_componentcell-cell junction
P0007165biological_processsignal transduction
P0007264biological_processsmall GTPase-mediated signal transduction
P0008283biological_processcell population proliferation
P0016020cellular_componentmembrane
P0016787molecular_functionhydrolase activity
P0017156biological_processcalcium-ion regulated exocytosis
P0019003molecular_functionGDP binding
P0030033biological_processmicrovillus assembly
P0032486biological_processRap protein signal transduction
P0033625biological_processpositive regulation of integrin activation
P0035577cellular_componentazurophil granule membrane
P0044877molecular_functionprotein-containing complex binding
P0045121cellular_componentmembrane raft
P0045955biological_processnegative regulation of calcium ion-dependent exocytosis
P0051649biological_processestablishment of localization in cell
P0061028biological_processestablishment of endothelial barrier
P0070062cellular_componentextracellular exosome
P0070161cellular_componentanchoring junction
P0070374biological_processpositive regulation of ERK1 and ERK2 cascade
P0071320biological_processcellular response to cAMP
P0098978cellular_componentglutamatergic synapse
P0099010biological_processmodification of postsynaptic structure
P1901888biological_processregulation of cell junction assembly
P2000114biological_processregulation of establishment of cell polarity
P2000301biological_processnegative regulation of synaptic vesicle exocytosis
Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues32
DetailsBINDING: BINDING => ECO:0000269|PubMed:18309292, ECO:0000269|PubMed:22577140
ChainResidueDetails
BGLY10
FASP57
FASN116
FSER147
HGLY10
HASP57
HASN116
HSER147
JGLY10
JASP57
JASN116
BASP57
JSER147
LGLY10
LASP57
LASN116
LSER147
NGLY10
NASP57
NASN116
NSER147
PGLY10
BASN116
PASP57
PASN116
PSER147
MSER381
MGLN383
MSER388
OLEU377
OGLN379
OSER381
OGLN383
BSER147
OSER388
DGLY10
DASP57
DASN116
DSER147
FGLY10

site_idSWS_FT_FI2
Number of Residues8
DetailsMOD_RES: ADP-ribosylserine; by botulinum toxin => ECO:0000305|PubMed:3141412
ChainResidueDetails
BSER39
GALA54
GLYS55
GALA85
IALA54
ILYS55
IALA85
KALA54
KLYS55
KALA85
MALA54
DSER39
MLYS55
MALA85
OALA54
OLYS55
OALA85
FSER39
HSER39
JSER39
LSER39
NSER39
PSER39
EALA85

224931

PDB entries from 2024-09-11

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