6AXF

Structure of RasGRP2 in complex with Rap1B

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0005085	molecular_function	guanyl-nucleotide exchange factor activity
A	0007264	biological_process	small GTPase-mediated signal transduction
B	0000166	molecular_function	nucleotide binding
B	0003924	molecular_function	GTPase activity
B	0003925	molecular_function	G protein activity
B	0005515	molecular_function	protein binding
B	0005525	molecular_function	GTP binding
B	0005811	cellular_component	lipid droplet
B	0005829	cellular_component	cytosol
B	0005886	cellular_component	plasma membrane
B	0005911	cellular_component	cell-cell junction
B	0007165	biological_process	signal transduction
B	0007264	biological_process	small GTPase-mediated signal transduction
B	0008283	biological_process	cell population proliferation
B	0016020	cellular_component	membrane
B	0016787	molecular_function	hydrolase activity
B	0017156	biological_process	calcium-ion regulated exocytosis
B	0019003	molecular_function	GDP binding
B	0032486	biological_process	Rap protein signal transduction
B	0033625	biological_process	positive regulation of integrin activation
B	0035577	cellular_component	azurophil granule membrane
B	0044877	molecular_function	protein-containing complex binding
B	0045121	cellular_component	membrane raft
B	0045955	biological_process	negative regulation of calcium ion-dependent exocytosis
B	0051649	biological_process	establishment of localization in cell
B	0061028	biological_process	establishment of endothelial barrier
B	0070062	cellular_component	extracellular exosome
B	0070161	cellular_component	anchoring junction
B	0070374	biological_process	positive regulation of ERK1 and ERK2 cascade
B	0071320	biological_process	cellular response to cAMP
B	0098978	cellular_component	glutamatergic synapse
B	0099010	biological_process	modification of postsynaptic structure
B	1901888	biological_process	regulation of cell junction assembly
B	2000114	biological_process	regulation of establishment of cell polarity
B	2000301	biological_process	negative regulation of synaptic vesicle exocytosis
C	0005085	molecular_function	guanyl-nucleotide exchange factor activity
C	0007264	biological_process	small GTPase-mediated signal transduction
D	0000166	molecular_function	nucleotide binding
D	0003924	molecular_function	GTPase activity
D	0003925	molecular_function	G protein activity
D	0005515	molecular_function	protein binding
D	0005525	molecular_function	GTP binding
D	0005811	cellular_component	lipid droplet
D	0005829	cellular_component	cytosol
D	0005886	cellular_component	plasma membrane
D	0005911	cellular_component	cell-cell junction
D	0007165	biological_process	signal transduction
D	0007264	biological_process	small GTPase-mediated signal transduction
D	0008283	biological_process	cell population proliferation
D	0016020	cellular_component	membrane
D	0016787	molecular_function	hydrolase activity
D	0017156	biological_process	calcium-ion regulated exocytosis
D	0019003	molecular_function	GDP binding
D	0032486	biological_process	Rap protein signal transduction
D	0033625	biological_process	positive regulation of integrin activation
D	0035577	cellular_component	azurophil granule membrane
D	0044877	molecular_function	protein-containing complex binding
D	0045121	cellular_component	membrane raft
D	0045955	biological_process	negative regulation of calcium ion-dependent exocytosis
D	0051649	biological_process	establishment of localization in cell
D	0061028	biological_process	establishment of endothelial barrier
D	0070062	cellular_component	extracellular exosome
D	0070161	cellular_component	anchoring junction
D	0070374	biological_process	positive regulation of ERK1 and ERK2 cascade
D	0071320	biological_process	cellular response to cAMP
D	0098978	cellular_component	glutamatergic synapse
D	0099010	biological_process	modification of postsynaptic structure
D	1901888	biological_process	regulation of cell junction assembly
D	2000114	biological_process	regulation of establishment of cell polarity
D	2000301	biological_process	negative regulation of synaptic vesicle exocytosis
E	0005085	molecular_function	guanyl-nucleotide exchange factor activity
E	0007264	biological_process	small GTPase-mediated signal transduction
F	0000166	molecular_function	nucleotide binding
F	0003924	molecular_function	GTPase activity
F	0003925	molecular_function	G protein activity
F	0005515	molecular_function	protein binding
F	0005525	molecular_function	GTP binding
F	0005811	cellular_component	lipid droplet
F	0005829	cellular_component	cytosol
F	0005886	cellular_component	plasma membrane
F	0005911	cellular_component	cell-cell junction
F	0007165	biological_process	signal transduction
F	0007264	biological_process	small GTPase-mediated signal transduction
F	0008283	biological_process	cell population proliferation
F	0016020	cellular_component	membrane
F	0016787	molecular_function	hydrolase activity
F	0017156	biological_process	calcium-ion regulated exocytosis
F	0019003	molecular_function	GDP binding
F	0032486	biological_process	Rap protein signal transduction
F	0033625	biological_process	positive regulation of integrin activation
F	0035577	cellular_component	azurophil granule membrane
F	0044877	molecular_function	protein-containing complex binding
F	0045121	cellular_component	membrane raft
F	0045955	biological_process	negative regulation of calcium ion-dependent exocytosis
F	0051649	biological_process	establishment of localization in cell
F	0061028	biological_process	establishment of endothelial barrier
F	0070062	cellular_component	extracellular exosome
F	0070161	cellular_component	anchoring junction
F	0070374	biological_process	positive regulation of ERK1 and ERK2 cascade
F	0071320	biological_process	cellular response to cAMP
F	0098978	cellular_component	glutamatergic synapse
F	0099010	biological_process	modification of postsynaptic structure
F	1901888	biological_process	regulation of cell junction assembly
F	2000114	biological_process	regulation of establishment of cell polarity
F	2000301	biological_process	negative regulation of synaptic vesicle exocytosis
G	0005085	molecular_function	guanyl-nucleotide exchange factor activity
G	0007264	biological_process	small GTPase-mediated signal transduction
H	0000166	molecular_function	nucleotide binding
H	0003924	molecular_function	GTPase activity
H	0003925	molecular_function	G protein activity
H	0005515	molecular_function	protein binding
H	0005525	molecular_function	GTP binding
H	0005811	cellular_component	lipid droplet
H	0005829	cellular_component	cytosol
H	0005886	cellular_component	plasma membrane
H	0005911	cellular_component	cell-cell junction
H	0007165	biological_process	signal transduction
H	0007264	biological_process	small GTPase-mediated signal transduction
H	0008283	biological_process	cell population proliferation
H	0016020	cellular_component	membrane
H	0016787	molecular_function	hydrolase activity
H	0017156	biological_process	calcium-ion regulated exocytosis
H	0019003	molecular_function	GDP binding
H	0032486	biological_process	Rap protein signal transduction
H	0033625	biological_process	positive regulation of integrin activation
H	0035577	cellular_component	azurophil granule membrane
H	0044877	molecular_function	protein-containing complex binding
H	0045121	cellular_component	membrane raft
H	0045955	biological_process	negative regulation of calcium ion-dependent exocytosis
H	0051649	biological_process	establishment of localization in cell
H	0061028	biological_process	establishment of endothelial barrier
H	0070062	cellular_component	extracellular exosome
H	0070161	cellular_component	anchoring junction
H	0070374	biological_process	positive regulation of ERK1 and ERK2 cascade
H	0071320	biological_process	cellular response to cAMP
H	0098978	cellular_component	glutamatergic synapse
H	0099010	biological_process	modification of postsynaptic structure
H	1901888	biological_process	regulation of cell junction assembly
H	2000114	biological_process	regulation of establishment of cell polarity
H	2000301	biological_process	negative regulation of synaptic vesicle exocytosis
I	0005085	molecular_function	guanyl-nucleotide exchange factor activity
I	0007264	biological_process	small GTPase-mediated signal transduction
J	0000166	molecular_function	nucleotide binding
J	0003924	molecular_function	GTPase activity
J	0003925	molecular_function	G protein activity
J	0005515	molecular_function	protein binding
J	0005525	molecular_function	GTP binding
J	0005811	cellular_component	lipid droplet
J	0005829	cellular_component	cytosol
J	0005886	cellular_component	plasma membrane
J	0005911	cellular_component	cell-cell junction
J	0007165	biological_process	signal transduction
J	0007264	biological_process	small GTPase-mediated signal transduction
J	0008283	biological_process	cell population proliferation
J	0016020	cellular_component	membrane
J	0016787	molecular_function	hydrolase activity
J	0017156	biological_process	calcium-ion regulated exocytosis
J	0019003	molecular_function	GDP binding
J	0032486	biological_process	Rap protein signal transduction
J	0033625	biological_process	positive regulation of integrin activation
J	0035577	cellular_component	azurophil granule membrane
J	0044877	molecular_function	protein-containing complex binding
J	0045121	cellular_component	membrane raft
J	0045955	biological_process	negative regulation of calcium ion-dependent exocytosis
J	0051649	biological_process	establishment of localization in cell
J	0061028	biological_process	establishment of endothelial barrier
J	0070062	cellular_component	extracellular exosome
J	0070161	cellular_component	anchoring junction
J	0070374	biological_process	positive regulation of ERK1 and ERK2 cascade
J	0071320	biological_process	cellular response to cAMP
J	0098978	cellular_component	glutamatergic synapse
J	0099010	biological_process	modification of postsynaptic structure
J	1901888	biological_process	regulation of cell junction assembly
J	2000114	biological_process	regulation of establishment of cell polarity
J	2000301	biological_process	negative regulation of synaptic vesicle exocytosis
K	0005085	molecular_function	guanyl-nucleotide exchange factor activity
K	0007264	biological_process	small GTPase-mediated signal transduction
L	0000166	molecular_function	nucleotide binding
L	0003924	molecular_function	GTPase activity
L	0003925	molecular_function	G protein activity
L	0005515	molecular_function	protein binding
L	0005525	molecular_function	GTP binding
L	0005811	cellular_component	lipid droplet
L	0005829	cellular_component	cytosol
L	0005886	cellular_component	plasma membrane
L	0005911	cellular_component	cell-cell junction
L	0007165	biological_process	signal transduction
L	0007264	biological_process	small GTPase-mediated signal transduction
L	0008283	biological_process	cell population proliferation
L	0016020	cellular_component	membrane
L	0016787	molecular_function	hydrolase activity
L	0017156	biological_process	calcium-ion regulated exocytosis
L	0019003	molecular_function	GDP binding
L	0032486	biological_process	Rap protein signal transduction
L	0033625	biological_process	positive regulation of integrin activation
L	0035577	cellular_component	azurophil granule membrane
L	0044877	molecular_function	protein-containing complex binding
L	0045121	cellular_component	membrane raft
L	0045955	biological_process	negative regulation of calcium ion-dependent exocytosis
L	0051649	biological_process	establishment of localization in cell
L	0061028	biological_process	establishment of endothelial barrier
L	0070062	cellular_component	extracellular exosome
L	0070161	cellular_component	anchoring junction
L	0070374	biological_process	positive regulation of ERK1 and ERK2 cascade
L	0071320	biological_process	cellular response to cAMP
L	0098978	cellular_component	glutamatergic synapse
L	0099010	biological_process	modification of postsynaptic structure
L	1901888	biological_process	regulation of cell junction assembly
L	2000114	biological_process	regulation of establishment of cell polarity
L	2000301	biological_process	negative regulation of synaptic vesicle exocytosis
M	0005085	molecular_function	guanyl-nucleotide exchange factor activity
M	0007264	biological_process	small GTPase-mediated signal transduction
N	0000166	molecular_function	nucleotide binding
N	0003924	molecular_function	GTPase activity
N	0003925	molecular_function	G protein activity
N	0005515	molecular_function	protein binding
N	0005525	molecular_function	GTP binding
N	0005811	cellular_component	lipid droplet
N	0005829	cellular_component	cytosol
N	0005886	cellular_component	plasma membrane
N	0005911	cellular_component	cell-cell junction
N	0007165	biological_process	signal transduction
N	0007264	biological_process	small GTPase-mediated signal transduction
N	0008283	biological_process	cell population proliferation
N	0016020	cellular_component	membrane
N	0016787	molecular_function	hydrolase activity
N	0017156	biological_process	calcium-ion regulated exocytosis
N	0019003	molecular_function	GDP binding
N	0032486	biological_process	Rap protein signal transduction
N	0033625	biological_process	positive regulation of integrin activation
N	0035577	cellular_component	azurophil granule membrane
N	0044877	molecular_function	protein-containing complex binding
N	0045121	cellular_component	membrane raft
N	0045955	biological_process	negative regulation of calcium ion-dependent exocytosis
N	0051649	biological_process	establishment of localization in cell
N	0061028	biological_process	establishment of endothelial barrier
N	0070062	cellular_component	extracellular exosome
N	0070161	cellular_component	anchoring junction
N	0070374	biological_process	positive regulation of ERK1 and ERK2 cascade
N	0071320	biological_process	cellular response to cAMP
N	0098978	cellular_component	glutamatergic synapse
N	0099010	biological_process	modification of postsynaptic structure
N	1901888	biological_process	regulation of cell junction assembly
N	2000114	biological_process	regulation of establishment of cell polarity
N	2000301	biological_process	negative regulation of synaptic vesicle exocytosis
O	0005085	molecular_function	guanyl-nucleotide exchange factor activity
O	0007264	biological_process	small GTPase-mediated signal transduction
P	0000166	molecular_function	nucleotide binding
P	0003924	molecular_function	GTPase activity
P	0003925	molecular_function	G protein activity
P	0005515	molecular_function	protein binding
P	0005525	molecular_function	GTP binding
P	0005811	cellular_component	lipid droplet
P	0005829	cellular_component	cytosol
P	0005886	cellular_component	plasma membrane
P	0005911	cellular_component	cell-cell junction
P	0007165	biological_process	signal transduction
P	0007264	biological_process	small GTPase-mediated signal transduction
P	0008283	biological_process	cell population proliferation
P	0016020	cellular_component	membrane
P	0016787	molecular_function	hydrolase activity
P	0017156	biological_process	calcium-ion regulated exocytosis
P	0019003	molecular_function	GDP binding
P	0032486	biological_process	Rap protein signal transduction
P	0033625	biological_process	positive regulation of integrin activation
P	0035577	cellular_component	azurophil granule membrane
P	0044877	molecular_function	protein-containing complex binding
P	0045121	cellular_component	membrane raft
P	0045955	biological_process	negative regulation of calcium ion-dependent exocytosis
P	0051649	biological_process	establishment of localization in cell
P	0061028	biological_process	establishment of endothelial barrier
P	0070062	cellular_component	extracellular exosome
P	0070161	cellular_component	anchoring junction
P	0070374	biological_process	positive regulation of ERK1 and ERK2 cascade
P	0071320	biological_process	cellular response to cAMP
P	0098978	cellular_component	glutamatergic synapse
P	0099010	biological_process	modification of postsynaptic structure
P	1901888	biological_process	regulation of cell junction assembly
P	2000114	biological_process	regulation of establishment of cell polarity
P	2000301	biological_process	negative regulation of synaptic vesicle exocytosis

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	24
Details	Modified residue: {"description":"Phosphoserine","evidences":[{"source":"UniProtKB","id":"Q9QUG9","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI2
Number of Residues	8
Details	Lipidation: {"description":"S-palmitoyl cysteine","evidences":[{"source":"PubMed","id":"10918068","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI3
Number of Residues	1
Details	Lipidation: {"description":"N-myristoyl glycine","evidences":[{"source":"PubMed","id":"10918068","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI4
Number of Residues	336
Details	Region: {"description":"Interaction with KRIT1","evidences":[{"source":"PubMed","id":"22577140","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI5
Number of Residues	64
Details	Motif: {"description":"Effector region","evidences":[{"evidenceCode":"ECO:0000305"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI6
Number of Residues	136
Details	Binding site: {"evidences":[{"source":"PubMed","id":"18309292","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"22577140","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI7
Number of Residues	8
Details	Modified residue: {"description":"ADP-ribosylserine; by botulinum toxin","evidences":[{"source":"PubMed","id":"3141412","evidenceCode":"ECO:0000305"}]}

Chain

Residue

Details

---