Summary Structural details Experimental details Functional details Sequence Neighbor History Downloads

6AUI

Human ribonucleotide reductase large subunit (alpha) with dATP and CDP

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0000731	biological_process	DNA synthesis involved in DNA repair
A	0004748	molecular_function	ribonucleoside-diphosphate reductase activity, thioredoxin disulfide as acceptor
A	0005515	molecular_function	protein binding
A	0005524	molecular_function	ATP binding
A	0005635	cellular_component	nuclear envelope
A	0005737	cellular_component	cytoplasm
A	0005739	cellular_component	mitochondrion
A	0005829	cellular_component	cytosol
A	0005971	cellular_component	ribonucleoside-diphosphate reductase complex
A	0006206	biological_process	pyrimidine nucleobase metabolic process
A	0006264	biological_process	mitochondrial DNA replication
A	0006281	biological_process	DNA repair
A	0008584	biological_process	male gonad development
A	0009185	biological_process	ribonucleoside diphosphate metabolic process
A	0009263	biological_process	deoxyribonucleotide biosynthetic process
A	0009265	biological_process	2'-deoxyribonucleotide biosynthetic process
A	0010212	biological_process	response to ionizing radiation
A	0010971	biological_process	positive regulation of G2/M transition of mitotic cell cycle
A	0016491	molecular_function	oxidoreductase activity
A	0017076	molecular_function	purine nucleotide binding
A	0021846	biological_process	cell proliferation in forebrain
A	0042802	molecular_function	identical protein binding
A	0042995	cellular_component	cell projection
A	0043025	cellular_component	neuronal cell body
A	0051290	biological_process	protein heterotetramerization
A	0060041	biological_process	retina development in camera-type eye
A	0061731	molecular_function	ribonucleoside-diphosphate reductase activity
A	0070318	biological_process	positive regulation of G0 to G1 transition
A	0097718	molecular_function	disordered domain specific binding
A	1900087	biological_process	positive regulation of G1/S transition of mitotic cell cycle
B	0000731	biological_process	DNA synthesis involved in DNA repair
B	0004748	molecular_function	ribonucleoside-diphosphate reductase activity, thioredoxin disulfide as acceptor
B	0005515	molecular_function	protein binding
B	0005524	molecular_function	ATP binding
B	0005635	cellular_component	nuclear envelope
B	0005737	cellular_component	cytoplasm
B	0005739	cellular_component	mitochondrion
B	0005829	cellular_component	cytosol
B	0005971	cellular_component	ribonucleoside-diphosphate reductase complex
B	0006206	biological_process	pyrimidine nucleobase metabolic process
B	0006264	biological_process	mitochondrial DNA replication
B	0006281	biological_process	DNA repair
B	0008584	biological_process	male gonad development
B	0009185	biological_process	ribonucleoside diphosphate metabolic process
B	0009263	biological_process	deoxyribonucleotide biosynthetic process
B	0009265	biological_process	2'-deoxyribonucleotide biosynthetic process
B	0010212	biological_process	response to ionizing radiation
B	0010971	biological_process	positive regulation of G2/M transition of mitotic cell cycle
B	0016491	molecular_function	oxidoreductase activity
B	0017076	molecular_function	purine nucleotide binding
B	0021846	biological_process	cell proliferation in forebrain
B	0042802	molecular_function	identical protein binding
B	0042995	cellular_component	cell projection
B	0043025	cellular_component	neuronal cell body
B	0051290	biological_process	protein heterotetramerization
B	0060041	biological_process	retina development in camera-type eye
B	0061731	molecular_function	ribonucleoside-diphosphate reductase activity
B	0070318	biological_process	positive regulation of G0 to G1 transition
B	0097718	molecular_function	disordered domain specific binding
B	1900087	biological_process	positive regulation of G1/S transition of mitotic cell cycle
C	0000731	biological_process	DNA synthesis involved in DNA repair
C	0004748	molecular_function	ribonucleoside-diphosphate reductase activity, thioredoxin disulfide as acceptor
C	0005515	molecular_function	protein binding
C	0005524	molecular_function	ATP binding
C	0005635	cellular_component	nuclear envelope
C	0005737	cellular_component	cytoplasm
C	0005739	cellular_component	mitochondrion
C	0005829	cellular_component	cytosol
C	0005971	cellular_component	ribonucleoside-diphosphate reductase complex
C	0006206	biological_process	pyrimidine nucleobase metabolic process
C	0006264	biological_process	mitochondrial DNA replication
C	0006281	biological_process	DNA repair
C	0008584	biological_process	male gonad development
C	0009185	biological_process	ribonucleoside diphosphate metabolic process
C	0009263	biological_process	deoxyribonucleotide biosynthetic process
C	0009265	biological_process	2'-deoxyribonucleotide biosynthetic process
C	0010212	biological_process	response to ionizing radiation
C	0010971	biological_process	positive regulation of G2/M transition of mitotic cell cycle
C	0016491	molecular_function	oxidoreductase activity
C	0017076	molecular_function	purine nucleotide binding
C	0021846	biological_process	cell proliferation in forebrain
C	0042802	molecular_function	identical protein binding
C	0042995	cellular_component	cell projection
C	0043025	cellular_component	neuronal cell body
C	0051290	biological_process	protein heterotetramerization
C	0060041	biological_process	retina development in camera-type eye
C	0061731	molecular_function	ribonucleoside-diphosphate reductase activity
C	0070318	biological_process	positive regulation of G0 to G1 transition
C	0097718	molecular_function	disordered domain specific binding
C	1900087	biological_process	positive regulation of G1/S transition of mitotic cell cycle
D	0000731	biological_process	DNA synthesis involved in DNA repair
D	0004748	molecular_function	ribonucleoside-diphosphate reductase activity, thioredoxin disulfide as acceptor
D	0005515	molecular_function	protein binding
D	0005524	molecular_function	ATP binding
D	0005635	cellular_component	nuclear envelope
D	0005737	cellular_component	cytoplasm
D	0005739	cellular_component	mitochondrion
D	0005829	cellular_component	cytosol
D	0005971	cellular_component	ribonucleoside-diphosphate reductase complex
D	0006206	biological_process	pyrimidine nucleobase metabolic process
D	0006264	biological_process	mitochondrial DNA replication
D	0006281	biological_process	DNA repair
D	0008584	biological_process	male gonad development
D	0009185	biological_process	ribonucleoside diphosphate metabolic process
D	0009263	biological_process	deoxyribonucleotide biosynthetic process
D	0009265	biological_process	2'-deoxyribonucleotide biosynthetic process
D	0010212	biological_process	response to ionizing radiation
D	0010971	biological_process	positive regulation of G2/M transition of mitotic cell cycle
D	0016491	molecular_function	oxidoreductase activity
D	0017076	molecular_function	purine nucleotide binding
D	0021846	biological_process	cell proliferation in forebrain
D	0042802	molecular_function	identical protein binding
D	0042995	cellular_component	cell projection
D	0043025	cellular_component	neuronal cell body
D	0051290	biological_process	protein heterotetramerization
D	0060041	biological_process	retina development in camera-type eye
D	0061731	molecular_function	ribonucleoside-diphosphate reductase activity
D	0070318	biological_process	positive regulation of G0 to G1 transition
D	0097718	molecular_function	disordered domain specific binding
D	1900087	biological_process	positive regulation of G1/S transition of mitotic cell cycle
E	0000731	biological_process	DNA synthesis involved in DNA repair
E	0004748	molecular_function	ribonucleoside-diphosphate reductase activity, thioredoxin disulfide as acceptor
E	0005515	molecular_function	protein binding
E	0005524	molecular_function	ATP binding
E	0005635	cellular_component	nuclear envelope
E	0005737	cellular_component	cytoplasm
E	0005739	cellular_component	mitochondrion
E	0005829	cellular_component	cytosol
E	0005971	cellular_component	ribonucleoside-diphosphate reductase complex
E	0006206	biological_process	pyrimidine nucleobase metabolic process
E	0006264	biological_process	mitochondrial DNA replication
E	0006281	biological_process	DNA repair
E	0008584	biological_process	male gonad development
E	0009185	biological_process	ribonucleoside diphosphate metabolic process
E	0009263	biological_process	deoxyribonucleotide biosynthetic process
E	0009265	biological_process	2'-deoxyribonucleotide biosynthetic process
E	0010212	biological_process	response to ionizing radiation
E	0010971	biological_process	positive regulation of G2/M transition of mitotic cell cycle
E	0016491	molecular_function	oxidoreductase activity
E	0017076	molecular_function	purine nucleotide binding
E	0021846	biological_process	cell proliferation in forebrain
E	0042802	molecular_function	identical protein binding
E	0042995	cellular_component	cell projection
E	0043025	cellular_component	neuronal cell body
E	0051290	biological_process	protein heterotetramerization
E	0060041	biological_process	retina development in camera-type eye
E	0061731	molecular_function	ribonucleoside-diphosphate reductase activity
E	0070318	biological_process	positive regulation of G0 to G1 transition
E	0097718	molecular_function	disordered domain specific binding
E	1900087	biological_process	positive regulation of G1/S transition of mitotic cell cycle
F	0000731	biological_process	DNA synthesis involved in DNA repair
F	0004748	molecular_function	ribonucleoside-diphosphate reductase activity, thioredoxin disulfide as acceptor
F	0005515	molecular_function	protein binding
F	0005524	molecular_function	ATP binding
F	0005635	cellular_component	nuclear envelope
F	0005737	cellular_component	cytoplasm
F	0005739	cellular_component	mitochondrion
F	0005829	cellular_component	cytosol
F	0005971	cellular_component	ribonucleoside-diphosphate reductase complex
F	0006206	biological_process	pyrimidine nucleobase metabolic process
F	0006264	biological_process	mitochondrial DNA replication
F	0006281	biological_process	DNA repair
F	0008584	biological_process	male gonad development
F	0009185	biological_process	ribonucleoside diphosphate metabolic process
F	0009263	biological_process	deoxyribonucleotide biosynthetic process
F	0009265	biological_process	2'-deoxyribonucleotide biosynthetic process
F	0010212	biological_process	response to ionizing radiation
F	0010971	biological_process	positive regulation of G2/M transition of mitotic cell cycle
F	0016491	molecular_function	oxidoreductase activity
F	0017076	molecular_function	purine nucleotide binding
F	0021846	biological_process	cell proliferation in forebrain
F	0042802	molecular_function	identical protein binding
F	0042995	cellular_component	cell projection
F	0043025	cellular_component	neuronal cell body
F	0051290	biological_process	protein heterotetramerization
F	0060041	biological_process	retina development in camera-type eye
F	0061731	molecular_function	ribonucleoside-diphosphate reductase activity
F	0070318	biological_process	positive regulation of G0 to G1 transition
F	0097718	molecular_function	disordered domain specific binding
F	1900087	biological_process	positive regulation of G1/S transition of mitotic cell cycle

Functional Information from PDB Data

site_id	AC1
Number of Residues	15
Details	binding site for residue DTP A 801

Chain	Residue
A	VAL3
A	ASP57
A	LYS88
A	MG802
A	HOH902
A	HOH905
A	HOH906
A	LYS5
A	ARG6
A	GLU11
A	ARG12
A	VAL13
A	MET14
A	ARG21
A	THR53

site_id	AC2
Number of Residues	4
Details	binding site for residue MG A 802

Chain	Residue
A	DTP801
A	HOH902
A	HOH905
A	HOH906

site_id	AC3
Number of Residues	13
Details	binding site for residue DTP A 803

Chain	Residue
A	ASP226
A	SER227
A	ARG256
A	ILE262
A	ALA263
A	GLY264
A	MG804
A	HOH901
A	HOH903
A	HOH904
B	LYS243
B	ASP287
B	GLY289

site_id	AC4
Number of Residues	4
Details	binding site for residue MG A 804

Chain	Residue
A	DTP803
A	HOH901
A	HOH903
A	HOH904

site_id	AC5
Number of Residues	15
Details	binding site for residue CDP A 805

Chain	Residue
A	SER202
A	SER217
A	CYS218
A	GLY247
A	GLN288
A	ARG293
A	ASN427
A	CYS429
A	GLU431
A	LEU446
A	PRO603
A	THR604
A	ALA605
A	SER606
A	THR607

site_id	AC6
Number of Residues	16
Details	binding site for residue DTP B 801

Chain	Residue
B	VAL3
B	LYS5
B	ARG6
B	GLU11
B	ARG12
B	VAL13
B	MET14
B	ARG21
B	THR53
B	LEU56
B	ASP57
B	LYS88
B	MG802
B	HOH902
B	HOH904
B	HOH905

site_id	AC7
Number of Residues	4
Details	binding site for residue MG B 802

Chain	Residue
B	DTP801
B	HOH902
B	HOH904
B	HOH905

site_id	AC8
Number of Residues	12
Details	binding site for residue DTP B 803

Chain	Residue
A	LYS243
A	ASP287
A	GLY289
B	ASP226
B	SER227
B	ARG256
B	ALA263
B	GLY264
B	MG804
B	HOH901
B	HOH903
B	HOH906

site_id	AC9
Number of Residues	4
Details	binding site for residue MG B 804

Chain	Residue
B	DTP803
B	HOH901
B	HOH903
B	HOH906

site_id	AD1
Number of Residues	15
Details	binding site for residue CDP B 805

Chain	Residue
B	ALA605
B	SER606
B	THR607
B	SER202
B	SER217
B	CYS218
B	GLY247
B	GLN288
B	ARG293
B	ASN427
B	CYS429
B	GLU431
B	LEU446
B	PRO603
B	THR604

site_id	AD2
Number of Residues	16
Details	binding site for residue DTP C 801

Chain	Residue
C	VAL3
C	LYS5
C	ARG6
C	GLU11
C	ARG12
C	VAL13
C	MET14
C	ARG21
C	THR53
C	LEU56
C	ASP57
C	LYS88
C	MG802
C	HOH902
C	HOH905
C	HOH906

site_id	AD3
Number of Residues	4
Details	binding site for residue MG C 802

Chain	Residue
C	DTP801
C	HOH902
C	HOH905
C	HOH906

site_id	AD4
Number of Residues	13
Details	binding site for residue DTP C 803

Chain	Residue
C	ASP226
C	SER227
C	ILE228
C	ARG256
C	ALA263
C	GLY264
C	MG804
C	HOH901
C	HOH903
C	HOH904
D	LYS243
D	ASP287
D	GLY289

site_id	AD5
Number of Residues	4
Details	binding site for residue MG C 804

Chain	Residue
C	DTP803
C	HOH901
C	HOH903
C	HOH904

site_id	AD6
Number of Residues	15
Details	binding site for residue CDP C 805

Chain	Residue
C	SER202
C	SER217
C	CYS218
C	GLY247
C	GLN288
C	ARG293
C	ASN427
C	CYS429
C	GLU431
C	LEU446
C	PRO603
C	THR604
C	ALA605
C	SER606
C	THR607

site_id	AD7
Number of Residues	16
Details	binding site for residue DTP D 801

Chain	Residue
D	VAL3
D	LYS5
D	ARG6
D	ARG12
D	VAL13
D	MET14
D	ILE18
D	ARG21
D	THR53
D	LEU56
D	ASP57
D	LYS88
D	MG802
D	HOH902
D	HOH905
D	HOH906

site_id	AD8
Number of Residues	4
Details	binding site for residue MG D 802

Chain	Residue
D	DTP801
D	HOH902
D	HOH905
D	HOH906

site_id	AD9
Number of Residues	12
Details	binding site for residue DTP D 803

Chain	Residue
C	LYS243
C	ASP287
C	GLY289
D	ASP226
D	SER227
D	ARG256
D	ALA263
D	GLY264
D	MG804
D	HOH901
D	HOH903
D	HOH904

site_id	AE1
Number of Residues	4
Details	binding site for residue MG D 804

Chain	Residue
D	DTP803
D	HOH901
D	HOH903
D	HOH904

site_id	AE2
Number of Residues	15
Details	binding site for residue CDP D 805

Chain	Residue
D	SER202
D	SER217
D	CYS218
D	GLY247
D	GLN288
D	ARG293
D	ASN427
D	CYS429
D	GLU431
D	LEU446
D	PRO603
D	THR604
D	ALA605
D	SER606
D	THR607

site_id	AE3
Number of Residues	15
Details	binding site for residue DTP E 801

Chain	Residue
E	VAL3
E	LYS5
E	ARG6
E	GLU11
E	ARG12
E	VAL13
E	MET14
E	ARG21
E	THR53
E	ASP57
E	LYS88
E	MG802
E	HOH902
E	HOH903
E	HOH906

site_id	AE4
Number of Residues	4
Details	binding site for residue MG E 802

Chain	Residue
E	DTP801
E	HOH902
E	HOH903
E	HOH906

site_id	AE5
Number of Residues	13
Details	binding site for residue DTP E 803

Chain	Residue
E	ASP226
E	SER227
E	ARG256
E	ILE262
E	ALA263
E	GLY264
E	MG804
E	HOH901
E	HOH904
E	HOH905
F	LYS243
F	ASP287
F	GLY289

site_id	AE6
Number of Residues	4
Details	binding site for residue MG E 804

Chain	Residue
E	DTP803
E	HOH901
E	HOH904
E	HOH905

site_id	AE7
Number of Residues	14
Details	binding site for residue CDP E 805

Chain	Residue
E	SER202
E	SER217
E	GLY247
E	GLN288
E	ARG293
E	ASN427
E	CYS429
E	GLU431
E	LEU446
E	PRO603
E	THR604
E	ALA605
E	SER606
E	THR607

site_id	AE8
Number of Residues	15
Details	binding site for residue DTP F 801

Chain	Residue
F	VAL3
F	LYS5
F	ARG6
F	ARG12
F	VAL13
F	MET14
F	ARG21
F	THR53
F	LEU56
F	ASP57
F	LYS88
F	MG802
F	HOH903
F	HOH904
F	HOH906

site_id	AE9
Number of Residues	4
Details	binding site for residue MG F 802

Chain	Residue
F	DTP801
F	HOH903
F	HOH904
F	HOH906

site_id	AF1
Number of Residues	14
Details	binding site for residue DTP F 803

Chain	Residue
E	LYS243
E	ASP287
E	GLY289
F	ASP226
F	SER227
F	ARG256
F	TYR261
F	ILE262
F	ALA263
F	GLY264
F	MG804
F	HOH901
F	HOH902
F	HOH905

site_id	AF2
Number of Residues	4
Details	binding site for residue MG F 804

Chain	Residue
F	DTP803
F	HOH901
F	HOH902
F	HOH905

site_id	AF3
Number of Residues	15
Details	binding site for residue CDP F 805

Chain	Residue
F	SER202
F	SER217
F	CYS218
F	GLY247
F	GLN288
F	ARG293
F	ASN427
F	CYS429
F	GLU431
F	LEU446
F	PRO603
F	THR604
F	ALA605
F	SER606
F	THR607

Functional Information from PROSITE/UniProt

site_id	PS00089
Number of Residues	23
Details	RIBORED_LARGE Ribonucleotide reductase large subunit signature. WkvLkekiakyGIRNsllIApmP

Chain	Residue	Details
A	TRP581-PRO603

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	12
Details	ACT_SITE: Proton acceptor => ECO:0000250

Chain	Residue	Details
A	ASN427
E	GLU431
F	ASN427
F	GLU431
A	GLU431
B	ASN427
B	GLU431
C	ASN427
C	GLU431
D	ASN427
D	GLU431
E	ASN427

site_id	SWS_FT_FI2
Number of Residues	6
Details	ACT_SITE: Cysteine radical intermediate => ECO:0000250

Chain	Residue	Details
A	CYS429
B	CYS429
C	CYS429
D	CYS429
E	CYS429
F	CYS429

site_id	SWS_FT_FI3
Number of Residues	48
Details	BINDING: BINDING => ECO:0007744\|PDB:3HNE

Chain	Residue	Details
A	LYS5
B	GLU11
B	THR53
B	ASP57
B	ASP226
B	LYS243
B	ARG256
B	ALA263
C	LYS5
C	GLU11
C	THR53
A	GLU11
C	ASP57
C	ASP226
C	LYS243
C	ARG256
C	ALA263
D	LYS5
D	GLU11
D	THR53
D	ASP57
D	ASP226
A	THR53
D	LYS243
D	ARG256
D	ALA263
E	LYS5
E	GLU11
E	THR53
E	ASP57
E	ASP226
E	LYS243
E	ARG256
A	ASP57
E	ALA263
F	LYS5
F	GLU11
F	THR53
F	ASP57
F	ASP226
F	LYS243
F	ARG256
F	ALA263
A	ASP226
A	LYS243
A	ARG256
A	ALA263
B	LYS5

site_id	SWS_FT_FI4
Number of Residues	30
Details	BINDING: BINDING => ECO:0007744\|PDB:3HND

Chain	Residue	Details
A	SER202
B	THR604
C	SER202
C	SER217
C	ASN427
C	GLU431
C	THR604
D	SER202
D	SER217
D	ASN427
D	GLU431
A	SER217
D	THR604
E	SER202
E	SER217
E	ASN427
E	GLU431
E	THR604
F	SER202
F	SER217
F	ASN427
F	GLU431
A	ASN427
F	THR604
A	GLU431
A	THR604
B	SER202
B	SER217
B	ASN427
B	GLU431

site_id	SWS_FT_FI5
Number of Residues	12
Details	SITE: Important for hydrogen atom transfer => ECO:0000250

Chain	Residue	Details
A	CYS218
E	CYS444
F	CYS218
F	CYS444
A	CYS444
B	CYS218
B	CYS444
C	CYS218
C	CYS444
D	CYS218
D	CYS444
E	CYS218

site_id	SWS_FT_FI6
Number of Residues	12
Details	SITE: Important for electron transfer => ECO:0000250

Chain	Residue	Details
A	TYR737
E	TYR738
F	TYR737
F	TYR738
A	TYR738
B	TYR737
B	TYR738
C	TYR737
C	TYR738
D	TYR737
D	TYR738
E	TYR737

site_id	SWS_FT_FI7
Number of Residues	12
Details	SITE: Interacts with thioredoxin/glutaredoxin => ECO:0000250

Chain	Residue	Details
A	CYS787
E	CYS790
F	CYS787
F	CYS790
A	CYS790
B	CYS787
B	CYS790
C	CYS787
C	CYS790
D	CYS787
D	CYS790
E	CYS787

site_id	SWS_FT_FI8
Number of Residues	12
Details	MOD_RES: N6-acetyllysine => ECO:0007744\|PubMed:19608861

Chain	Residue	Details
A	LYS17
E	LYS376
F	LYS17
F	LYS376
A	LYS376
B	LYS17
B	LYS376
C	LYS17
C	LYS376
D	LYS17
D	LYS376
E	LYS17

site_id	SWS_FT_FI9
Number of Residues	6
Details	MOD_RES: Phosphothreonine => ECO:0007744\|PubMed:23186163

Chain	Residue	Details
A	THR751
B	THR751
C	THR751
D	THR751
E	THR751
F	THR751

		Sequence (fasta)
		PDBx/mmCIF
		PDBML format (no-atom)
		PDB format (full)
		Validation report (PDF)