6AUI
Human ribonucleotide reductase large subunit (alpha) with dATP and CDP
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0000731 | biological_process | DNA synthesis involved in DNA repair |
| A | 0004748 | molecular_function | ribonucleoside-diphosphate reductase activity, thioredoxin disulfide as acceptor |
| A | 0005515 | molecular_function | protein binding |
| A | 0005524 | molecular_function | ATP binding |
| A | 0005634 | cellular_component | nucleus |
| A | 0005737 | cellular_component | cytoplasm |
| A | 0005739 | cellular_component | mitochondrion |
| A | 0005829 | cellular_component | cytosol |
| A | 0005971 | cellular_component | ribonucleoside-diphosphate reductase complex |
| A | 0006264 | biological_process | mitochondrial DNA replication |
| A | 0006281 | biological_process | DNA repair |
| A | 0009185 | biological_process | ribonucleoside diphosphate metabolic process |
| A | 0009263 | biological_process | deoxyribonucleotide biosynthetic process |
| A | 0009265 | biological_process | 2'-deoxyribonucleotide biosynthetic process |
| A | 0010971 | biological_process | positive regulation of G2/M transition of mitotic cell cycle |
| A | 0042802 | molecular_function | identical protein binding |
| A | 0051290 | biological_process | protein heterotetramerization |
| A | 0061731 | molecular_function | ribonucleoside-diphosphate reductase activity |
| A | 0070318 | biological_process | positive regulation of G0 to G1 transition |
| A | 0097718 | molecular_function | disordered domain specific binding |
| A | 1900087 | biological_process | positive regulation of G1/S transition of mitotic cell cycle |
| B | 0000731 | biological_process | DNA synthesis involved in DNA repair |
| B | 0004748 | molecular_function | ribonucleoside-diphosphate reductase activity, thioredoxin disulfide as acceptor |
| B | 0005515 | molecular_function | protein binding |
| B | 0005524 | molecular_function | ATP binding |
| B | 0005634 | cellular_component | nucleus |
| B | 0005737 | cellular_component | cytoplasm |
| B | 0005739 | cellular_component | mitochondrion |
| B | 0005829 | cellular_component | cytosol |
| B | 0005971 | cellular_component | ribonucleoside-diphosphate reductase complex |
| B | 0006264 | biological_process | mitochondrial DNA replication |
| B | 0006281 | biological_process | DNA repair |
| B | 0009185 | biological_process | ribonucleoside diphosphate metabolic process |
| B | 0009263 | biological_process | deoxyribonucleotide biosynthetic process |
| B | 0009265 | biological_process | 2'-deoxyribonucleotide biosynthetic process |
| B | 0010971 | biological_process | positive regulation of G2/M transition of mitotic cell cycle |
| B | 0042802 | molecular_function | identical protein binding |
| B | 0051290 | biological_process | protein heterotetramerization |
| B | 0061731 | molecular_function | ribonucleoside-diphosphate reductase activity |
| B | 0070318 | biological_process | positive regulation of G0 to G1 transition |
| B | 0097718 | molecular_function | disordered domain specific binding |
| B | 1900087 | biological_process | positive regulation of G1/S transition of mitotic cell cycle |
| C | 0000731 | biological_process | DNA synthesis involved in DNA repair |
| C | 0004748 | molecular_function | ribonucleoside-diphosphate reductase activity, thioredoxin disulfide as acceptor |
| C | 0005515 | molecular_function | protein binding |
| C | 0005524 | molecular_function | ATP binding |
| C | 0005634 | cellular_component | nucleus |
| C | 0005737 | cellular_component | cytoplasm |
| C | 0005739 | cellular_component | mitochondrion |
| C | 0005829 | cellular_component | cytosol |
| C | 0005971 | cellular_component | ribonucleoside-diphosphate reductase complex |
| C | 0006264 | biological_process | mitochondrial DNA replication |
| C | 0006281 | biological_process | DNA repair |
| C | 0009185 | biological_process | ribonucleoside diphosphate metabolic process |
| C | 0009263 | biological_process | deoxyribonucleotide biosynthetic process |
| C | 0009265 | biological_process | 2'-deoxyribonucleotide biosynthetic process |
| C | 0010971 | biological_process | positive regulation of G2/M transition of mitotic cell cycle |
| C | 0042802 | molecular_function | identical protein binding |
| C | 0051290 | biological_process | protein heterotetramerization |
| C | 0061731 | molecular_function | ribonucleoside-diphosphate reductase activity |
| C | 0070318 | biological_process | positive regulation of G0 to G1 transition |
| C | 0097718 | molecular_function | disordered domain specific binding |
| C | 1900087 | biological_process | positive regulation of G1/S transition of mitotic cell cycle |
| D | 0000731 | biological_process | DNA synthesis involved in DNA repair |
| D | 0004748 | molecular_function | ribonucleoside-diphosphate reductase activity, thioredoxin disulfide as acceptor |
| D | 0005515 | molecular_function | protein binding |
| D | 0005524 | molecular_function | ATP binding |
| D | 0005634 | cellular_component | nucleus |
| D | 0005737 | cellular_component | cytoplasm |
| D | 0005739 | cellular_component | mitochondrion |
| D | 0005829 | cellular_component | cytosol |
| D | 0005971 | cellular_component | ribonucleoside-diphosphate reductase complex |
| D | 0006264 | biological_process | mitochondrial DNA replication |
| D | 0006281 | biological_process | DNA repair |
| D | 0009185 | biological_process | ribonucleoside diphosphate metabolic process |
| D | 0009263 | biological_process | deoxyribonucleotide biosynthetic process |
| D | 0009265 | biological_process | 2'-deoxyribonucleotide biosynthetic process |
| D | 0010971 | biological_process | positive regulation of G2/M transition of mitotic cell cycle |
| D | 0042802 | molecular_function | identical protein binding |
| D | 0051290 | biological_process | protein heterotetramerization |
| D | 0061731 | molecular_function | ribonucleoside-diphosphate reductase activity |
| D | 0070318 | biological_process | positive regulation of G0 to G1 transition |
| D | 0097718 | molecular_function | disordered domain specific binding |
| D | 1900087 | biological_process | positive regulation of G1/S transition of mitotic cell cycle |
| E | 0000731 | biological_process | DNA synthesis involved in DNA repair |
| E | 0004748 | molecular_function | ribonucleoside-diphosphate reductase activity, thioredoxin disulfide as acceptor |
| E | 0005515 | molecular_function | protein binding |
| E | 0005524 | molecular_function | ATP binding |
| E | 0005634 | cellular_component | nucleus |
| E | 0005737 | cellular_component | cytoplasm |
| E | 0005739 | cellular_component | mitochondrion |
| E | 0005829 | cellular_component | cytosol |
| E | 0005971 | cellular_component | ribonucleoside-diphosphate reductase complex |
| E | 0006264 | biological_process | mitochondrial DNA replication |
| E | 0006281 | biological_process | DNA repair |
| E | 0009185 | biological_process | ribonucleoside diphosphate metabolic process |
| E | 0009263 | biological_process | deoxyribonucleotide biosynthetic process |
| E | 0009265 | biological_process | 2'-deoxyribonucleotide biosynthetic process |
| E | 0010971 | biological_process | positive regulation of G2/M transition of mitotic cell cycle |
| E | 0042802 | molecular_function | identical protein binding |
| E | 0051290 | biological_process | protein heterotetramerization |
| E | 0061731 | molecular_function | ribonucleoside-diphosphate reductase activity |
| E | 0070318 | biological_process | positive regulation of G0 to G1 transition |
| E | 0097718 | molecular_function | disordered domain specific binding |
| E | 1900087 | biological_process | positive regulation of G1/S transition of mitotic cell cycle |
| F | 0000731 | biological_process | DNA synthesis involved in DNA repair |
| F | 0004748 | molecular_function | ribonucleoside-diphosphate reductase activity, thioredoxin disulfide as acceptor |
| F | 0005515 | molecular_function | protein binding |
| F | 0005524 | molecular_function | ATP binding |
| F | 0005634 | cellular_component | nucleus |
| F | 0005737 | cellular_component | cytoplasm |
| F | 0005739 | cellular_component | mitochondrion |
| F | 0005829 | cellular_component | cytosol |
| F | 0005971 | cellular_component | ribonucleoside-diphosphate reductase complex |
| F | 0006264 | biological_process | mitochondrial DNA replication |
| F | 0006281 | biological_process | DNA repair |
| F | 0009185 | biological_process | ribonucleoside diphosphate metabolic process |
| F | 0009263 | biological_process | deoxyribonucleotide biosynthetic process |
| F | 0009265 | biological_process | 2'-deoxyribonucleotide biosynthetic process |
| F | 0010971 | biological_process | positive regulation of G2/M transition of mitotic cell cycle |
| F | 0042802 | molecular_function | identical protein binding |
| F | 0051290 | biological_process | protein heterotetramerization |
| F | 0061731 | molecular_function | ribonucleoside-diphosphate reductase activity |
| F | 0070318 | biological_process | positive regulation of G0 to G1 transition |
| F | 0097718 | molecular_function | disordered domain specific binding |
| F | 1900087 | biological_process | positive regulation of G1/S transition of mitotic cell cycle |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 15 |
| Details | binding site for residue DTP A 801 |
| Chain | Residue |
| A | VAL3 |
| A | ASP57 |
| A | LYS88 |
| A | MG802 |
| A | HOH902 |
| A | HOH905 |
| A | HOH906 |
| A | LYS5 |
| A | ARG6 |
| A | GLU11 |
| A | ARG12 |
| A | VAL13 |
| A | MET14 |
| A | ARG21 |
| A | THR53 |
| site_id | AC2 |
| Number of Residues | 4 |
| Details | binding site for residue MG A 802 |
| Chain | Residue |
| A | DTP801 |
| A | HOH902 |
| A | HOH905 |
| A | HOH906 |
| site_id | AC3 |
| Number of Residues | 13 |
| Details | binding site for residue DTP A 803 |
| Chain | Residue |
| A | ASP226 |
| A | SER227 |
| A | ARG256 |
| A | ILE262 |
| A | ALA263 |
| A | GLY264 |
| A | MG804 |
| A | HOH901 |
| A | HOH903 |
| A | HOH904 |
| B | LYS243 |
| B | ASP287 |
| B | GLY289 |
| site_id | AC4 |
| Number of Residues | 4 |
| Details | binding site for residue MG A 804 |
| Chain | Residue |
| A | DTP803 |
| A | HOH901 |
| A | HOH903 |
| A | HOH904 |
| site_id | AC5 |
| Number of Residues | 15 |
| Details | binding site for residue CDP A 805 |
| Chain | Residue |
| A | SER202 |
| A | SER217 |
| A | CYS218 |
| A | GLY247 |
| A | GLN288 |
| A | ARG293 |
| A | ASN427 |
| A | CYS429 |
| A | GLU431 |
| A | LEU446 |
| A | PRO603 |
| A | THR604 |
| A | ALA605 |
| A | SER606 |
| A | THR607 |
| site_id | AC6 |
| Number of Residues | 16 |
| Details | binding site for residue DTP B 801 |
| Chain | Residue |
| B | VAL3 |
| B | LYS5 |
| B | ARG6 |
| B | GLU11 |
| B | ARG12 |
| B | VAL13 |
| B | MET14 |
| B | ARG21 |
| B | THR53 |
| B | LEU56 |
| B | ASP57 |
| B | LYS88 |
| B | MG802 |
| B | HOH902 |
| B | HOH904 |
| B | HOH905 |
| site_id | AC7 |
| Number of Residues | 4 |
| Details | binding site for residue MG B 802 |
| Chain | Residue |
| B | DTP801 |
| B | HOH902 |
| B | HOH904 |
| B | HOH905 |
| site_id | AC8 |
| Number of Residues | 12 |
| Details | binding site for residue DTP B 803 |
| Chain | Residue |
| A | LYS243 |
| A | ASP287 |
| A | GLY289 |
| B | ASP226 |
| B | SER227 |
| B | ARG256 |
| B | ALA263 |
| B | GLY264 |
| B | MG804 |
| B | HOH901 |
| B | HOH903 |
| B | HOH906 |
| site_id | AC9 |
| Number of Residues | 4 |
| Details | binding site for residue MG B 804 |
| Chain | Residue |
| B | DTP803 |
| B | HOH901 |
| B | HOH903 |
| B | HOH906 |
| site_id | AD1 |
| Number of Residues | 15 |
| Details | binding site for residue CDP B 805 |
| Chain | Residue |
| B | ALA605 |
| B | SER606 |
| B | THR607 |
| B | SER202 |
| B | SER217 |
| B | CYS218 |
| B | GLY247 |
| B | GLN288 |
| B | ARG293 |
| B | ASN427 |
| B | CYS429 |
| B | GLU431 |
| B | LEU446 |
| B | PRO603 |
| B | THR604 |
| site_id | AD2 |
| Number of Residues | 16 |
| Details | binding site for residue DTP C 801 |
| Chain | Residue |
| C | VAL3 |
| C | LYS5 |
| C | ARG6 |
| C | GLU11 |
| C | ARG12 |
| C | VAL13 |
| C | MET14 |
| C | ARG21 |
| C | THR53 |
| C | LEU56 |
| C | ASP57 |
| C | LYS88 |
| C | MG802 |
| C | HOH902 |
| C | HOH905 |
| C | HOH906 |
| site_id | AD3 |
| Number of Residues | 4 |
| Details | binding site for residue MG C 802 |
| Chain | Residue |
| C | DTP801 |
| C | HOH902 |
| C | HOH905 |
| C | HOH906 |
| site_id | AD4 |
| Number of Residues | 13 |
| Details | binding site for residue DTP C 803 |
| Chain | Residue |
| C | ASP226 |
| C | SER227 |
| C | ILE228 |
| C | ARG256 |
| C | ALA263 |
| C | GLY264 |
| C | MG804 |
| C | HOH901 |
| C | HOH903 |
| C | HOH904 |
| D | LYS243 |
| D | ASP287 |
| D | GLY289 |
| site_id | AD5 |
| Number of Residues | 4 |
| Details | binding site for residue MG C 804 |
| Chain | Residue |
| C | DTP803 |
| C | HOH901 |
| C | HOH903 |
| C | HOH904 |
| site_id | AD6 |
| Number of Residues | 15 |
| Details | binding site for residue CDP C 805 |
| Chain | Residue |
| C | SER202 |
| C | SER217 |
| C | CYS218 |
| C | GLY247 |
| C | GLN288 |
| C | ARG293 |
| C | ASN427 |
| C | CYS429 |
| C | GLU431 |
| C | LEU446 |
| C | PRO603 |
| C | THR604 |
| C | ALA605 |
| C | SER606 |
| C | THR607 |
| site_id | AD7 |
| Number of Residues | 16 |
| Details | binding site for residue DTP D 801 |
| Chain | Residue |
| D | VAL3 |
| D | LYS5 |
| D | ARG6 |
| D | ARG12 |
| D | VAL13 |
| D | MET14 |
| D | ILE18 |
| D | ARG21 |
| D | THR53 |
| D | LEU56 |
| D | ASP57 |
| D | LYS88 |
| D | MG802 |
| D | HOH902 |
| D | HOH905 |
| D | HOH906 |
| site_id | AD8 |
| Number of Residues | 4 |
| Details | binding site for residue MG D 802 |
| Chain | Residue |
| D | DTP801 |
| D | HOH902 |
| D | HOH905 |
| D | HOH906 |
| site_id | AD9 |
| Number of Residues | 12 |
| Details | binding site for residue DTP D 803 |
| Chain | Residue |
| C | LYS243 |
| C | ASP287 |
| C | GLY289 |
| D | ASP226 |
| D | SER227 |
| D | ARG256 |
| D | ALA263 |
| D | GLY264 |
| D | MG804 |
| D | HOH901 |
| D | HOH903 |
| D | HOH904 |
| site_id | AE1 |
| Number of Residues | 4 |
| Details | binding site for residue MG D 804 |
| Chain | Residue |
| D | DTP803 |
| D | HOH901 |
| D | HOH903 |
| D | HOH904 |
| site_id | AE2 |
| Number of Residues | 15 |
| Details | binding site for residue CDP D 805 |
| Chain | Residue |
| D | SER202 |
| D | SER217 |
| D | CYS218 |
| D | GLY247 |
| D | GLN288 |
| D | ARG293 |
| D | ASN427 |
| D | CYS429 |
| D | GLU431 |
| D | LEU446 |
| D | PRO603 |
| D | THR604 |
| D | ALA605 |
| D | SER606 |
| D | THR607 |
| site_id | AE3 |
| Number of Residues | 15 |
| Details | binding site for residue DTP E 801 |
| Chain | Residue |
| E | VAL3 |
| E | LYS5 |
| E | ARG6 |
| E | GLU11 |
| E | ARG12 |
| E | VAL13 |
| E | MET14 |
| E | ARG21 |
| E | THR53 |
| E | ASP57 |
| E | LYS88 |
| E | MG802 |
| E | HOH902 |
| E | HOH903 |
| E | HOH906 |
| site_id | AE4 |
| Number of Residues | 4 |
| Details | binding site for residue MG E 802 |
| Chain | Residue |
| E | DTP801 |
| E | HOH902 |
| E | HOH903 |
| E | HOH906 |
| site_id | AE5 |
| Number of Residues | 13 |
| Details | binding site for residue DTP E 803 |
| Chain | Residue |
| E | ASP226 |
| E | SER227 |
| E | ARG256 |
| E | ILE262 |
| E | ALA263 |
| E | GLY264 |
| E | MG804 |
| E | HOH901 |
| E | HOH904 |
| E | HOH905 |
| F | LYS243 |
| F | ASP287 |
| F | GLY289 |
| site_id | AE6 |
| Number of Residues | 4 |
| Details | binding site for residue MG E 804 |
| Chain | Residue |
| E | DTP803 |
| E | HOH901 |
| E | HOH904 |
| E | HOH905 |
| site_id | AE7 |
| Number of Residues | 14 |
| Details | binding site for residue CDP E 805 |
| Chain | Residue |
| E | SER202 |
| E | SER217 |
| E | GLY247 |
| E | GLN288 |
| E | ARG293 |
| E | ASN427 |
| E | CYS429 |
| E | GLU431 |
| E | LEU446 |
| E | PRO603 |
| E | THR604 |
| E | ALA605 |
| E | SER606 |
| E | THR607 |
| site_id | AE8 |
| Number of Residues | 15 |
| Details | binding site for residue DTP F 801 |
| Chain | Residue |
| F | VAL3 |
| F | LYS5 |
| F | ARG6 |
| F | ARG12 |
| F | VAL13 |
| F | MET14 |
| F | ARG21 |
| F | THR53 |
| F | LEU56 |
| F | ASP57 |
| F | LYS88 |
| F | MG802 |
| F | HOH903 |
| F | HOH904 |
| F | HOH906 |
| site_id | AE9 |
| Number of Residues | 4 |
| Details | binding site for residue MG F 802 |
| Chain | Residue |
| F | DTP801 |
| F | HOH903 |
| F | HOH904 |
| F | HOH906 |
| site_id | AF1 |
| Number of Residues | 14 |
| Details | binding site for residue DTP F 803 |
| Chain | Residue |
| E | LYS243 |
| E | ASP287 |
| E | GLY289 |
| F | ASP226 |
| F | SER227 |
| F | ARG256 |
| F | TYR261 |
| F | ILE262 |
| F | ALA263 |
| F | GLY264 |
| F | MG804 |
| F | HOH901 |
| F | HOH902 |
| F | HOH905 |
| site_id | AF2 |
| Number of Residues | 4 |
| Details | binding site for residue MG F 804 |
| Chain | Residue |
| F | DTP803 |
| F | HOH901 |
| F | HOH902 |
| F | HOH905 |
| site_id | AF3 |
| Number of Residues | 15 |
| Details | binding site for residue CDP F 805 |
| Chain | Residue |
| F | SER202 |
| F | SER217 |
| F | CYS218 |
| F | GLY247 |
| F | GLN288 |
| F | ARG293 |
| F | ASN427 |
| F | CYS429 |
| F | GLU431 |
| F | LEU446 |
| F | PRO603 |
| F | THR604 |
| F | ALA605 |
| F | SER606 |
| F | THR607 |
Functional Information from PROSITE/UniProt
| site_id | PS00089 |
| Number of Residues | 23 |
| Details | RIBORED_LARGE Ribonucleotide reductase large subunit signature. WkvLkekiakyGIRNsllIApmP |
| Chain | Residue | Details |
| A | TRP581-PRO603 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 546 |
| Details | Domain: {"description":"ATP-cone","evidences":[{"source":"PROSITE-ProRule","id":"PRU00492","evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI2 |
| Number of Residues | 12 |
| Details | Active site: {"description":"Proton acceptor","evidences":[{"evidenceCode":"ECO:0000250"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI3 |
| Number of Residues | 6 |
| Details | Active site: {"description":"Cysteine radical intermediate","evidences":[{"evidenceCode":"ECO:0000250"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI4 |
| Number of Residues | 84 |
| Details | Binding site: {"evidences":[{"source":"PDB","id":"3HNE","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI5 |
| Number of Residues | 42 |
| Details | Binding site: {"evidences":[{"source":"PDB","id":"3HND","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI6 |
| Number of Residues | 12 |
| Details | Site: {"description":"Important for hydrogen atom transfer","evidences":[{"evidenceCode":"ECO:0000250"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI7 |
| Number of Residues | 12 |
| Details | Site: {"description":"Important for electron transfer","evidences":[{"evidenceCode":"ECO:0000250"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI8 |
| Number of Residues | 12 |
| Details | Modified residue: {"description":"N6-acetyllysine","evidences":[{"source":"PubMed","id":"19608861","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
