6AM0

Crystal structure of K. lactis Edc1-Dcp1-Dcp2-Edc3 decapping complex with synthetic cap substrate analog

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0000184	biological_process	nuclear-transcribed mRNA catabolic process, nonsense-mediated decay
A	0000290	biological_process	deadenylation-dependent decapping of nuclear-transcribed mRNA
A	0003723	molecular_function	RNA binding
A	0016787	molecular_function	hydrolase activity
A	0030145	molecular_function	manganese ion binding
A	0140933	molecular_function	5'-(N(7)-methylguanosine 5'-triphospho)-[mRNA] hydrolase activity
B	0000290	biological_process	deadenylation-dependent decapping of nuclear-transcribed mRNA
B	0000932	cellular_component	P-body
B	0003729	molecular_function	mRNA binding
B	0005515	molecular_function	protein binding
B	0008047	molecular_function	enzyme activator activity
B	0031087	biological_process	deadenylation-independent decapping of nuclear-transcribed mRNA
B	0043085	biological_process	positive regulation of catalytic activity
B	0043229	cellular_component	intracellular organelle
D	0003723	molecular_function	RNA binding
E	0000184	biological_process	nuclear-transcribed mRNA catabolic process, nonsense-mediated decay
E	0000290	biological_process	deadenylation-dependent decapping of nuclear-transcribed mRNA
E	0003723	molecular_function	RNA binding
E	0016787	molecular_function	hydrolase activity
E	0030145	molecular_function	manganese ion binding
E	0140933	molecular_function	5'-(N(7)-methylguanosine 5'-triphospho)-[mRNA] hydrolase activity
F	0000290	biological_process	deadenylation-dependent decapping of nuclear-transcribed mRNA
F	0000932	cellular_component	P-body
F	0003729	molecular_function	mRNA binding
F	0005515	molecular_function	protein binding
F	0008047	molecular_function	enzyme activator activity
F	0031087	biological_process	deadenylation-independent decapping of nuclear-transcribed mRNA
F	0043085	biological_process	positive regulation of catalytic activity
F	0043229	cellular_component	intracellular organelle
H	0003723	molecular_function	RNA binding

Functional Information from PDB Data

site_id	AC1
Number of Residues	3
Details	binding site for residue MG A 301

Chain	Residue
A	LYS134
A	GLU148
A	6VQ302

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site_id	AC2
Number of Residues	12
Details	binding site for residue 6VQ A 302

Chain	Residue
A	LYS134
A	HIS194
A	LYS195
A	ASN196
A	PHE223
A	MG301
A	TRP49
A	THR52
A	ASP53
A	LYS126
A	HIS127
A	ARG132

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site_id	AC3
Number of Residues	11
Details	binding site for residue 6VQ E 301

Chain	Residue
E	TRP49
E	ASP53
E	LYS100
E	HIS127
E	ARG132
E	LYS134
E	GLU151
E	LYS174
E	ASN196
E	GLU197
E	PHE223

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