6AJJ
Crystal structure of mycolic acid transporter MmpL3 from Mycobacterium smegmatis complexed with ICA38
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0003796 | molecular_function | lysozyme activity |
| A | 0003824 | molecular_function | catalytic activity |
| A | 0009253 | biological_process | peptidoglycan catabolic process |
| A | 0016020 | cellular_component | membrane |
| A | 0016787 | molecular_function | hydrolase activity |
| A | 0016798 | molecular_function | hydrolase activity, acting on glycosyl bonds |
| A | 0016998 | biological_process | cell wall macromolecule catabolic process |
| A | 0030430 | cellular_component | host cell cytoplasm |
| A | 0031640 | biological_process | killing of cells of another organism |
| A | 0042742 | biological_process | defense response to bacterium |
| A | 0044659 | biological_process | viral release from host cell by cytolysis |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 8 |
| Details | binding site for residue MHA A 1001 |
| Chain | Residue |
| A | ASP759 |
| A | THR891 |
| A | PRO892 |
| A | ASN893 |
| A | ARG894 |
| A | ILE917 |
| A | LYS918 |
| A | ALA919 |
| site_id | AC2 |
| Number of Residues | 6 |
| Details | binding site for residue MHA A 1002 |
| Chain | Residue |
| A | PHE863 |
| A | THR864 |
| A | ASN865 |
| A | SER866 |
| A | ASN881 |
| A | GLY862 |
| site_id | AC3 |
| Number of Residues | 9 |
| Details | binding site for residue L6T A 1003 |
| Chain | Residue |
| A | GLN40 |
| A | TYR44 |
| A | SER54 |
| A | ASP58 |
| A | ARG63 |
| A | ASP64 |
| A | ASP144 |
| A | THR179 |
| A | PHE240 |
| site_id | AC4 |
| Number of Residues | 6 |
| Details | binding site for residue L6T A 1004 |
| Chain | Residue |
| A | ARG188 |
| A | ALA192 |
| A | ASN621 |
| A | GLY691 |
| A | ALA692 |
| A | PHE695 |
| site_id | AC5 |
| Number of Residues | 7 |
| Details | binding site for residue L6T A 1005 |
| Chain | Residue |
| A | SER67 |
| A | VAL70 |
| A | ASP119 |
| A | VAL122 |
| A | MET125 |
| A | GLY170 |
| A | LEU171 |
| site_id | AC6 |
| Number of Residues | 2 |
| Details | binding site for residue L6T A 1006 |
| Chain | Residue |
| A | THR236 |
| A | TYR317 |
| site_id | AC7 |
| Number of Residues | 5 |
| Details | binding site for residue L6T A 1007 |
| Chain | Residue |
| A | THR285 |
| A | ARG288 |
| A | THR289 |
| A | PHE292 |
| A | ARG653 |
| site_id | AC8 |
| Number of Residues | 10 |
| Details | binding site for residue J9E A 1008 |
| Chain | Residue |
| A | ILE249 |
| A | ILE253 |
| A | PHE260 |
| A | ILE297 |
| A | VAL638 |
| A | GLY641 |
| A | LEU642 |
| A | ASP645 |
| A | TYR646 |
| A | PHE649 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 69 |
| Details | Topological domain: {"description":"Cytoplasmic","evidences":[{"source":"PubMed","id":"30682372","evidenceCode":"ECO:0000305"},{"source":"PubMed","id":"31113875","evidenceCode":"ECO:0000305"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI2 |
| Number of Residues | 240 |
| Details | Transmembrane: {"description":"Helical","evidences":[{"evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI3 |
| Number of Residues | 330 |
| Details | Topological domain: {"description":"Periplasmic","evidences":[{"source":"PubMed","id":"30682372","evidenceCode":"ECO:0000305"},{"source":"PubMed","id":"31113875","evidenceCode":"ECO:0000305"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI4 |
| Number of Residues | 28 |
| Details | Region: {"description":"Disordered","evidences":[{"source":"SAM","id":"MobiDB-lite","evidenceCode":"ECO:0000256"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI5 |
| Number of Residues | 19 |
| Details | Compositional bias: {"description":"Basic and acidic residues","evidences":[{"source":"SAM","id":"MobiDB-lite","evidenceCode":"ECO:0000256"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI6 |
| Number of Residues | 4 |
| Details | Binding site: {"evidences":[{"source":"PubMed","id":"31113875","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"6OR2","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI7 |
| Number of Residues | 1 |
| Details | Binding site: {"evidences":[{"source":"PubMed","id":"30682372","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"6AJG","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI8 |
| Number of Residues | 3 |
| Details | Site: {"description":"Part of the proton-transportation channel","evidences":[{"source":"PubMed","id":"30682372","evidenceCode":"ECO:0000305"},{"source":"PubMed","id":"31113875","evidenceCode":"ECO:0000305"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI9 |
| Number of Residues | 2 |
| Details | Site: {"description":"Part of the proton transportation network","evidences":[{"source":"PubMed","id":"31113875","evidenceCode":"ECO:0000305"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI10 |
| Number of Residues | 1 |
| Details | Site: {"description":"Part of the proton-transportation channel","evidences":[{"source":"PubMed","id":"30682372","evidenceCode":"ECO:0000305"},{"source":"PubMed","id":"31113875","evidenceCode":"ECO:0000305"},{"source":"PubMed","id":"32512002","evidenceCode":"ECO:0000305"}]} |
| Chain | Residue | Details |
