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6AEZ

Crystal structure of human CCL5 trimer

Functional Information from GO Data
ChainGOidnamespacecontents
A0002407biological_processdendritic cell chemotaxis
A0002548biological_processmonocyte chemotaxis
A0002676biological_processregulation of chronic inflammatory response
A0004435molecular_functionphosphatidylinositol phospholipase C activity
A0004672molecular_functionprotein kinase activity
A0005125molecular_functioncytokine activity
A0005515molecular_functionprotein binding
A0005576cellular_componentextracellular region
A0005615cellular_componentextracellular space
A0005737cellular_componentcytoplasm
A0006816biological_processcalcium ion transport
A0006874biological_processintracellular calcium ion homeostasis
A0006887biological_processexocytosis
A0006935biological_processchemotaxis
A0006954biological_processinflammatory response
A0006955biological_processimmune response
A0007159biological_processleukocyte cell-cell adhesion
A0007186biological_processG protein-coupled receptor signaling pathway
A0007267biological_processcell-cell signaling
A0008009molecular_functionchemokine activity
A0009615biological_processresponse to virus
A0009636biological_processresponse to toxic substance
A0010536biological_processpositive regulation of activation of Janus kinase activity
A0010759biological_processpositive regulation of macrophage chemotaxis
A0010820biological_processpositive regulation of T cell chemotaxis
A0014911biological_processpositive regulation of smooth muscle cell migration
A0016004molecular_functionphospholipase activator activity
A0030298molecular_functionreceptor signaling protein tyrosine kinase activator activity
A0030335biological_processpositive regulation of cell migration
A0030593biological_processneutrophil chemotaxis
A0031328biological_processpositive regulation of cellular biosynthetic process
A0031584biological_processactivation of phospholipase D activity
A0031726molecular_functionCCR1 chemokine receptor binding
A0031729molecular_functionCCR4 chemokine receptor binding
A0031730molecular_functionCCR5 chemokine receptor binding
A0033634biological_processpositive regulation of cell-cell adhesion mediated by integrin
A0034097biological_processresponse to cytokine
A0034112biological_processpositive regulation of homotypic cell-cell adhesion
A0034612biological_processresponse to tumor necrosis factor
A0042056molecular_functionchemoattractant activity
A0042102biological_processpositive regulation of T cell proliferation
A0042119biological_processneutrophil activation
A0042327biological_processpositive regulation of phosphorylation
A0042379molecular_functionchemokine receptor binding
A0042531biological_processpositive regulation of tyrosine phosphorylation of STAT protein
A0042802molecular_functionidentical protein binding
A0042803molecular_functionprotein homodimerization activity
A0043621molecular_functionobsolete protein self-association
A0043922biological_processnegative regulation by host of viral transcription
A0044344biological_processcellular response to fibroblast growth factor stimulus
A0045070biological_processpositive regulation of viral genome replication
A0045071biological_processnegative regulation of viral genome replication
A0045089biological_processpositive regulation of innate immune response
A0045744biological_processnegative regulation of G protein-coupled receptor signaling pathway
A0045785biological_processpositive regulation of cell adhesion
A0045948biological_processpositive regulation of translational initiation
A0046427biological_processpositive regulation of receptor signaling pathway via JAK-STAT
A0046817molecular_functionchemokine receptor antagonist activity
A0048020molecular_functionCCR chemokine receptor binding
A0048245biological_processeosinophil chemotaxis
A0048246biological_processmacrophage chemotaxis
A0048247biological_processlymphocyte chemotaxis
A0048661biological_processpositive regulation of smooth muscle cell proliferation
A0050673biological_processepithelial cell proliferation
A0050679biological_processpositive regulation of epithelial cell proliferation
A0050796biological_processregulation of insulin secretion
A0050863biological_processregulation of T cell activation
A0050918biological_processpositive chemotaxis
A0051897biological_processpositive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction
A0051928biological_processpositive regulation of calcium ion transport
A0070098biological_processchemokine-mediated signaling pathway
A0070100biological_processnegative regulation of chemokine-mediated signaling pathway
A0070233biological_processnegative regulation of T cell apoptotic process
A0070234biological_processpositive regulation of T cell apoptotic process
A0070374biological_processpositive regulation of ERK1 and ERK2 cascade
A0071346biological_processcellular response to type II interferon
A0071347biological_processcellular response to interleukin-1
A0071356biological_processcellular response to tumor necrosis factor
A0090026biological_processpositive regulation of monocyte chemotaxis
A0098586biological_processcellular response to virus
A2000110biological_processnegative regulation of macrophage apoptotic process
A2000406biological_processpositive regulation of T cell migration
A2000503biological_processpositive regulation of natural killer cell chemotaxis
B0002407biological_processdendritic cell chemotaxis
B0002548biological_processmonocyte chemotaxis
B0002676biological_processregulation of chronic inflammatory response
B0004435molecular_functionphosphatidylinositol phospholipase C activity
B0004672molecular_functionprotein kinase activity
B0005125molecular_functioncytokine activity
B0005515molecular_functionprotein binding
B0005576cellular_componentextracellular region
B0005615cellular_componentextracellular space
B0005737cellular_componentcytoplasm
B0006816biological_processcalcium ion transport
B0006874biological_processintracellular calcium ion homeostasis
B0006887biological_processexocytosis
B0006935biological_processchemotaxis
B0006954biological_processinflammatory response
B0006955biological_processimmune response
B0007159biological_processleukocyte cell-cell adhesion
B0007186biological_processG protein-coupled receptor signaling pathway
B0007267biological_processcell-cell signaling
B0008009molecular_functionchemokine activity
B0009615biological_processresponse to virus
B0009636biological_processresponse to toxic substance
B0010536biological_processpositive regulation of activation of Janus kinase activity
B0010759biological_processpositive regulation of macrophage chemotaxis
B0010820biological_processpositive regulation of T cell chemotaxis
B0014911biological_processpositive regulation of smooth muscle cell migration
B0016004molecular_functionphospholipase activator activity
B0030298molecular_functionreceptor signaling protein tyrosine kinase activator activity
B0030335biological_processpositive regulation of cell migration
B0030593biological_processneutrophil chemotaxis
B0031328biological_processpositive regulation of cellular biosynthetic process
B0031584biological_processactivation of phospholipase D activity
B0031726molecular_functionCCR1 chemokine receptor binding
B0031729molecular_functionCCR4 chemokine receptor binding
B0031730molecular_functionCCR5 chemokine receptor binding
B0033634biological_processpositive regulation of cell-cell adhesion mediated by integrin
B0034097biological_processresponse to cytokine
B0034112biological_processpositive regulation of homotypic cell-cell adhesion
B0034612biological_processresponse to tumor necrosis factor
B0042056molecular_functionchemoattractant activity
B0042102biological_processpositive regulation of T cell proliferation
B0042119biological_processneutrophil activation
B0042327biological_processpositive regulation of phosphorylation
B0042379molecular_functionchemokine receptor binding
B0042531biological_processpositive regulation of tyrosine phosphorylation of STAT protein
B0042802molecular_functionidentical protein binding
B0042803molecular_functionprotein homodimerization activity
B0043621molecular_functionobsolete protein self-association
B0043922biological_processnegative regulation by host of viral transcription
B0044344biological_processcellular response to fibroblast growth factor stimulus
B0045070biological_processpositive regulation of viral genome replication
B0045071biological_processnegative regulation of viral genome replication
B0045089biological_processpositive regulation of innate immune response
B0045744biological_processnegative regulation of G protein-coupled receptor signaling pathway
B0045785biological_processpositive regulation of cell adhesion
B0045948biological_processpositive regulation of translational initiation
B0046427biological_processpositive regulation of receptor signaling pathway via JAK-STAT
B0046817molecular_functionchemokine receptor antagonist activity
B0048020molecular_functionCCR chemokine receptor binding
B0048245biological_processeosinophil chemotaxis
B0048246biological_processmacrophage chemotaxis
B0048247biological_processlymphocyte chemotaxis
B0048661biological_processpositive regulation of smooth muscle cell proliferation
B0050673biological_processepithelial cell proliferation
B0050679biological_processpositive regulation of epithelial cell proliferation
B0050796biological_processregulation of insulin secretion
B0050863biological_processregulation of T cell activation
B0050918biological_processpositive chemotaxis
B0051897biological_processpositive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction
B0051928biological_processpositive regulation of calcium ion transport
B0070098biological_processchemokine-mediated signaling pathway
B0070100biological_processnegative regulation of chemokine-mediated signaling pathway
B0070233biological_processnegative regulation of T cell apoptotic process
B0070234biological_processpositive regulation of T cell apoptotic process
B0070374biological_processpositive regulation of ERK1 and ERK2 cascade
B0071346biological_processcellular response to type II interferon
B0071347biological_processcellular response to interleukin-1
B0071356biological_processcellular response to tumor necrosis factor
B0090026biological_processpositive regulation of monocyte chemotaxis
B0098586biological_processcellular response to virus
B2000110biological_processnegative regulation of macrophage apoptotic process
B2000406biological_processpositive regulation of T cell migration
B2000503biological_processpositive regulation of natural killer cell chemotaxis
C0002407biological_processdendritic cell chemotaxis
C0002548biological_processmonocyte chemotaxis
C0002676biological_processregulation of chronic inflammatory response
C0004435molecular_functionphosphatidylinositol phospholipase C activity
C0004672molecular_functionprotein kinase activity
C0005125molecular_functioncytokine activity
C0005515molecular_functionprotein binding
C0005576cellular_componentextracellular region
C0005615cellular_componentextracellular space
C0005737cellular_componentcytoplasm
C0006816biological_processcalcium ion transport
C0006874biological_processintracellular calcium ion homeostasis
C0006887biological_processexocytosis
C0006935biological_processchemotaxis
C0006954biological_processinflammatory response
C0006955biological_processimmune response
C0007159biological_processleukocyte cell-cell adhesion
C0007186biological_processG protein-coupled receptor signaling pathway
C0007267biological_processcell-cell signaling
C0008009molecular_functionchemokine activity
C0009615biological_processresponse to virus
C0009636biological_processresponse to toxic substance
C0010536biological_processpositive regulation of activation of Janus kinase activity
C0010759biological_processpositive regulation of macrophage chemotaxis
C0010820biological_processpositive regulation of T cell chemotaxis
C0014911biological_processpositive regulation of smooth muscle cell migration
C0016004molecular_functionphospholipase activator activity
C0030298molecular_functionreceptor signaling protein tyrosine kinase activator activity
C0030335biological_processpositive regulation of cell migration
C0030593biological_processneutrophil chemotaxis
C0031328biological_processpositive regulation of cellular biosynthetic process
C0031584biological_processactivation of phospholipase D activity
C0031726molecular_functionCCR1 chemokine receptor binding
C0031729molecular_functionCCR4 chemokine receptor binding
C0031730molecular_functionCCR5 chemokine receptor binding
C0033634biological_processpositive regulation of cell-cell adhesion mediated by integrin
C0034097biological_processresponse to cytokine
C0034112biological_processpositive regulation of homotypic cell-cell adhesion
C0034612biological_processresponse to tumor necrosis factor
C0042056molecular_functionchemoattractant activity
C0042102biological_processpositive regulation of T cell proliferation
C0042119biological_processneutrophil activation
C0042327biological_processpositive regulation of phosphorylation
C0042379molecular_functionchemokine receptor binding
C0042531biological_processpositive regulation of tyrosine phosphorylation of STAT protein
C0042802molecular_functionidentical protein binding
C0042803molecular_functionprotein homodimerization activity
C0043621molecular_functionobsolete protein self-association
C0043922biological_processnegative regulation by host of viral transcription
C0044344biological_processcellular response to fibroblast growth factor stimulus
C0045070biological_processpositive regulation of viral genome replication
C0045071biological_processnegative regulation of viral genome replication
C0045089biological_processpositive regulation of innate immune response
C0045744biological_processnegative regulation of G protein-coupled receptor signaling pathway
C0045785biological_processpositive regulation of cell adhesion
C0045948biological_processpositive regulation of translational initiation
C0046427biological_processpositive regulation of receptor signaling pathway via JAK-STAT
C0046817molecular_functionchemokine receptor antagonist activity
C0048020molecular_functionCCR chemokine receptor binding
C0048245biological_processeosinophil chemotaxis
C0048246biological_processmacrophage chemotaxis
C0048247biological_processlymphocyte chemotaxis
C0048661biological_processpositive regulation of smooth muscle cell proliferation
C0050673biological_processepithelial cell proliferation
C0050679biological_processpositive regulation of epithelial cell proliferation
C0050796biological_processregulation of insulin secretion
C0050863biological_processregulation of T cell activation
C0050918biological_processpositive chemotaxis
C0051897biological_processpositive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction
C0051928biological_processpositive regulation of calcium ion transport
C0070098biological_processchemokine-mediated signaling pathway
C0070100biological_processnegative regulation of chemokine-mediated signaling pathway
C0070233biological_processnegative regulation of T cell apoptotic process
C0070234biological_processpositive regulation of T cell apoptotic process
C0070374biological_processpositive regulation of ERK1 and ERK2 cascade
C0071346biological_processcellular response to type II interferon
C0071347biological_processcellular response to interleukin-1
C0071356biological_processcellular response to tumor necrosis factor
C0090026biological_processpositive regulation of monocyte chemotaxis
C0098586biological_processcellular response to virus
C2000110biological_processnegative regulation of macrophage apoptotic process
C2000406biological_processpositive regulation of T cell migration
C2000503biological_processpositive regulation of natural killer cell chemotaxis
Functional Information from PDB Data
site_idAC1
Number of Residues6
Detailsbinding site for residue SO4 A 101
ChainResidue
AHIS24
ATHR44
AARG45
ALYS46
AARG48
AHOH201

site_idAC2
Number of Residues3
Detailsbinding site for residue SO4 A 102
ChainResidue
ALYS56
ALYS57
AHOH202

site_idAC3
Number of Residues3
Detailsbinding site for residue SO4 B 101
ChainResidue
BLYS57
BARG60
BSO4103

site_idAC4
Number of Residues5
Detailsbinding site for residue SO4 B 102
ChainResidue
BHIS24
BTHR44
BARG45
BLYS46
BARG48

site_idAC5
Number of Residues5
Detailsbinding site for residue SO4 B 103
ChainResidue
AGLU55
BLYS56
BLYS57
BSO4101
BHOH213

site_idAC6
Number of Residues3
Detailsbinding site for residue SO4 C 101
ChainResidue
CLYS56
CLYS57
CHOH203

Functional Information from PROSITE/UniProt
site_idPS00472
Number of Residues42
DetailsSMALL_CYTOKINES_CC Small cytokines (intercrine/chemokine) C-C subfamily signature. CCFayiarp..LprahIkeYfytsgk..Csnp.AVVFvtrknrqv.CA
ChainResidueDetails
ACYS11-ALA52
BCYS11-ALA52

Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues1
DetailsSITE: Cleavage; by DPP4
ChainResidueDetails
BPRO3
CPRO3

site_idSWS_FT_FI2
Number of Residues1
DetailsMOD_RES: Methionine sulfoxide => ECO:0000269|PubMed:1380064
ChainResidueDetails
BMET68
CMET68

site_idSWS_FT_FI3
Number of Residues2
DetailsCARBOHYD: O-linked (GalNAc...) serine; partial => ECO:0000269|PubMed:1380064
ChainResidueDetails
BSER5
BSER6
CSER5
CSER6

218853

PDB entries from 2024-04-24

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