6AEI

Cryo-EM structure of the receptor-activated TRPC5 ion channel

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0005216	molecular_function	monoatomic ion channel activity
A	0005262	molecular_function	calcium channel activity
A	0006811	biological_process	monoatomic ion transport
A	0016020	cellular_component	membrane
A	0055085	biological_process	transmembrane transport
A	0070588	biological_process	calcium ion transmembrane transport
B	0005216	molecular_function	monoatomic ion channel activity
B	0005262	molecular_function	calcium channel activity
B	0006811	biological_process	monoatomic ion transport
B	0016020	cellular_component	membrane
B	0055085	biological_process	transmembrane transport
B	0070588	biological_process	calcium ion transmembrane transport
C	0005216	molecular_function	monoatomic ion channel activity
C	0005262	molecular_function	calcium channel activity
C	0006811	biological_process	monoatomic ion transport
C	0016020	cellular_component	membrane
C	0055085	biological_process	transmembrane transport
C	0070588	biological_process	calcium ion transmembrane transport
D	0005216	molecular_function	monoatomic ion channel activity
D	0005262	molecular_function	calcium channel activity
D	0006811	biological_process	monoatomic ion transport
D	0016020	cellular_component	membrane
D	0055085	biological_process	transmembrane transport
D	0070588	biological_process	calcium ion transmembrane transport

Functional Information from PDB Data

site_id	AC1
Number of Residues	4
Details	binding site for residue NA A 802

Chain	Residue
A	GLU418
A	GLU421
A	ASN436
A	ASP439

---

site_id	AC2
Number of Residues	11
Details	binding site for residue Y01 A 803

Chain	Residue
A	PHE497
A	ALA499
A	ASN500
D	PHE522
D	LEU526
D	LEU529
A	TRP315
A	TYR316
A	TRP322
A	PHE364
A	LEU496

---

site_id	AC3
Number of Residues	11
Details	binding site for residue LPP A 804

Chain	Residue
A	LEU514
A	TYR524
A	LEU528
A	GLN573
A	PHE576
A	TRP577
D	PHE599
D	ALA602
D	THR603
D	THR607
D	VAL610

---

site_id	AC4
Number of Residues	4
Details	binding site for residue NA B 801

Chain	Residue
B	GLU418
B	GLU421
B	ASN436
B	ASP439

---

site_id	AC5
Number of Residues	10
Details	binding site for residue Y01 B 802

Chain	Residue
A	PHE522
A	LEU526
A	LEU529
B	TRP315
B	TYR316
B	TRP322
B	PHE364
B	LEU496
B	PHE497
B	ASN500

---

site_id	AC6
Number of Residues	12
Details	binding site for residue LPP B 803

Chain	Residue
A	PHE599
A	ALA602
A	THR603
A	THR607
A	VAL610
A	ILE611
B	LEU514
B	TYR524
B	GLN573
B	PHE576
B	TRP577
B	LEU617

---

site_id	AC7
Number of Residues	4
Details	binding site for residue NA C 801

Chain	Residue
C	GLU418
C	GLU421
C	ASN436
C	ASP439

---

site_id	AC8
Number of Residues	10
Details	binding site for residue Y01 C 802

Chain	Residue
B	PHE522
B	LEU529
C	TRP315
C	TYR316
C	TRP322
C	PHE364
C	LEU496
C	PHE497
C	ALA499
C	ASN500

---

site_id	AC9
Number of Residues	11
Details	binding site for residue LPP C 803

Chain	Residue
B	PHE599
B	ALA602
B	THR603
B	THR607
B	VAL610
B	VAL615
C	LEU514
C	TYR524
C	GLN573
C	PHE576
C	TRP577

---

site_id	AD1
Number of Residues	4
Details	binding site for residue NA D 801

Chain	Residue
D	GLU418
D	GLU421
D	ASN436
D	ASP439

---

site_id	AD2
Number of Residues	9
Details	binding site for residue Y01 D 802

Chain	Residue
C	PHE522
C	LEU529
D	TRP315
D	TYR316
D	TRP322
D	PHE364
D	LEU496
D	PHE497
D	ASN500

---

site_id	AD3
Number of Residues	11
Details	binding site for residue LPP D 803

Chain	Residue
D	TRP577
D	LEU617
C	PHE599
C	ALA602
C	THR603
C	THR607
C	VAL610
D	LEU514
D	TYR524
D	GLN573
D	PHE576

---

Functional Information from PROSITE/UniProt

site_id	PS00962
Number of Residues	12
Details	RIBOSOMAL_S2_1 Ribosomal protein S2 signature 1. LiSLFTANSHLG

Chain	Residue	Details
A	LEU493-GLY504

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	136
Details	Intramembrane: {"description":"Discontinuously helical; Name=Pre-S1","evidences":[{"source":"UniProtKB","id":"Q9UL62","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI2
Number of Residues	116
Details	Topological domain: {"description":"Cytoplasmic","evidences":[{"source":"UniProtKB","id":"Q9UL62","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI3
Number of Residues	80
Details	Transmembrane: {"description":"Helical; Name=S1","evidences":[{"source":"UniProtKB","id":"Q9UL62","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI4
Number of Residues	56
Details	Transmembrane: {"description":"Helical; Name=S2","evidences":[{"source":"UniProtKB","id":"Q9UL62","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI5
Number of Residues	80
Details	Transmembrane: {"description":"Helical; Name=S3","evidences":[{"source":"UniProtKB","id":"Q9UL62","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI6
Number of Residues	352
Details	Topological domain: {"description":"Extracellular","evidences":[{"source":"UniProtKB","id":"Q9UL62","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI7
Number of Residues	80
Details	Transmembrane: {"description":"Helical; Name=S4","evidences":[{"source":"UniProtKB","id":"Q9UL62","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI8
Number of Residues	88
Details	Transmembrane: {"description":"Helical; Name=S5","evidences":[{"source":"UniProtKB","id":"Q9UL62","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI9
Number of Residues	80
Details	Transmembrane: {"description":"Helical; Name=S6","evidences":[{"source":"UniProtKB","id":"Q9UL62","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI10
Number of Residues	120
Details	Repeat: {"description":"ANK 1","evidences":[{"source":"UniProtKB","id":"Q9UL62","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI11
Number of Residues	112
Details	Repeat: {"description":"ANK 2","evidences":[{"source":"UniProtKB","id":"Q9UL62","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI12
Number of Residues	116
Details	Repeat: {"description":"ANK 4","evidences":[{"source":"UniProtKB","id":"Q9UL62","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI13
Number of Residues	20
Details	Binding site: {"evidences":[{"source":"UniProtKB","id":"Q9UL62","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI14
Number of Residues	4
Details	Glycosylation: {"description":"N-linked (GlcNAc...) asparagine","evidences":[{"evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---