6ACI
Crystal structure of EPEC effector NleB in complex with FADD death domain
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0005515 | molecular_function | protein binding |
| A | 0005576 | cellular_component | extracellular region |
| A | 0016757 | molecular_function | glycosyltransferase activity |
| A | 0030145 | molecular_function | manganese ion binding |
| A | 0030430 | cellular_component | host cell cytoplasm |
| A | 0034054 | biological_process | symbiont-mediated suppression of host defense-related programmed cell death |
| A | 0046872 | molecular_function | metal ion binding |
| A | 0085034 | biological_process | symbiont-mediated suppression of host NF-kappaB cascade |
| A | 0090729 | molecular_function | toxin activity |
| A | 0106362 | molecular_function | protein-arginine N-acetylglucosaminyltransferase activity |
| H | 0007165 | biological_process | signal transduction |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 23 |
| Details | binding site for residue UDP A 401 |
| Chain | Residue |
| A | GLN48 |
| A | ASP223 |
| A | ASN320 |
| A | SER322 |
| A | SER327 |
| A | SER328 |
| A | TRP329 |
| A | MN402 |
| A | HOH521 |
| A | HOH543 |
| A | HOH548 |
| A | TRP49 |
| A | HOH579 |
| A | HOH608 |
| A | HOH633 |
| A | HOH662 |
| A | PHE50 |
| A | TYR72 |
| A | PHE185 |
| A | ARG189 |
| A | TYR219 |
| A | ASP221 |
| A | ALA222 |
| site_id | AC2 |
| Number of Residues | 5 |
| Details | binding site for residue MN A 402 |
| Chain | Residue |
| A | ASP223 |
| A | ASN320 |
| A | SER322 |
| A | UDP401 |
| A | HOH543 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 1 |
| Details | CARBOHYD: (Microbial infection) N-beta-linked (GlcNAc) arginine => ECO:0000269|PubMed:24025841, ECO:0000269|PubMed:28860194, ECO:0000269|PubMed:30979585, ECO:0000305|PubMed:23955153, ECO:0007744|PDB:6ACI |
| Chain | Residue | Details |
| H | ARG117 |
| site_id | SWS_FT_FI2 |
| Number of Residues | 5 |
| Details | BINDING: BINDING => ECO:0000305|PubMed:30979585, ECO:0007744|PDB:6ACI |
| Chain | Residue | Details |
| A | GLN48 | |
| A | TYR72 | |
| A | TYR219 | |
| A | SER322 | |
| A | SER327 |
| site_id | SWS_FT_FI3 |
| Number of Residues | 2 |
| Details | BINDING: BINDING => ECO:0000269|PubMed:30979585, ECO:0007744|PDB:6ACI |
| Chain | Residue | Details |
| A | ASP223 | |
| A | ASN320 |
| site_id | SWS_FT_FI4 |
| Number of Residues | 3 |
| Details | CARBOHYD: N-beta-linked (GlcNAc) arginine; by autocatalysis => ECO:0000269|PubMed:32432056 |
| Chain | Residue | Details |
| A | ARG53 | |
| A | ARG159 | |
| A | ARG293 |
