6ACI
Crystal structure of EPEC effector NleB in complex with FADD death domain
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0005515 | molecular_function | protein binding |
| A | 0005576 | cellular_component | extracellular region |
| A | 0016740 | molecular_function | transferase activity |
| A | 0016757 | molecular_function | glycosyltransferase activity |
| A | 0030145 | molecular_function | manganese ion binding |
| A | 0030430 | cellular_component | host cell cytoplasm |
| A | 0046872 | molecular_function | metal ion binding |
| A | 0052041 | biological_process | symbiont-mediated suppression of host programmed cell death |
| A | 0085034 | biological_process | symbiont-mediated suppression of host NF-kappaB cascade |
| A | 0090729 | molecular_function | toxin activity |
| A | 0106362 | molecular_function | protein-arginine N-acetylglucosaminyltransferase activity |
| H | 0007165 | biological_process | signal transduction |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 23 |
| Details | binding site for residue UDP A 401 |
| Chain | Residue |
| A | GLN48 |
| A | ASP223 |
| A | ASN320 |
| A | SER322 |
| A | SER327 |
| A | SER328 |
| A | TRP329 |
| A | MN402 |
| A | HOH521 |
| A | HOH543 |
| A | HOH548 |
| A | TRP49 |
| A | HOH579 |
| A | HOH608 |
| A | HOH633 |
| A | HOH662 |
| A | PHE50 |
| A | TYR72 |
| A | PHE185 |
| A | ARG189 |
| A | TYR219 |
| A | ASP221 |
| A | ALA222 |
| site_id | AC2 |
| Number of Residues | 5 |
| Details | binding site for residue MN A 402 |
| Chain | Residue |
| A | ASP223 |
| A | ASN320 |
| A | SER322 |
| A | UDP401 |
| A | HOH543 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 2 |
| Details | Motif: {"description":"DXD motif","evidences":[{"evidenceCode":"ECO:0000305"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI2 |
| Number of Residues | 1 |
| Details | Active site: {"description":"Proton acceptor","evidences":[{"source":"PubMed","id":"30979585","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI3 |
| Number of Residues | 9 |
| Details | Binding site: {"evidences":[{"source":"PubMed","id":"30979585","evidenceCode":"ECO:0000305"},{"source":"PDB","id":"6ACI","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI4 |
| Number of Residues | 2 |
| Details | Binding site: {"evidences":[{"source":"PubMed","id":"30979585","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"6ACI","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI5 |
| Number of Residues | 3 |
| Details | Glycosylation: {"description":"N-beta-linked (GlcNAc) arginine; by autocatalysis","evidences":[{"source":"PubMed","id":"32432056","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI6 |
| Number of Residues | 84 |
| Details | Domain: {"description":"Death","evidences":[{"source":"PROSITE-ProRule","id":"PRU00064","evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI7 |
| Number of Residues | 1 |
| Details | Glycosylation: {"description":"(Microbial infection) N-beta-linked (GlcNAc) arginine","evidences":[{"source":"PubMed","id":"24025841","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"28860194","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"30979585","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"23955153","evidenceCode":"ECO:0000305"},{"source":"PDB","id":"6ACI","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
