6A5S

Structure of 14-3-3 gamma in complex with TFEB 14-3-3 binding motif

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0003723	molecular_function	RNA binding
A	0005080	molecular_function	protein kinase C binding
A	0005159	molecular_function	insulin-like growth factor receptor binding
A	0005515	molecular_function	protein binding
A	0005737	cellular_component	cytoplasm
A	0005829	cellular_component	cytosol
A	0005925	cellular_component	focal adhesion
A	0006469	biological_process	negative regulation of protein kinase activity
A	0006605	biological_process	protein targeting
A	0007165	biological_process	signal transduction
A	0008426	molecular_function	protein kinase C inhibitor activity
A	0009966	biological_process	regulation of signal transduction
A	0016020	cellular_component	membrane
A	0019904	molecular_function	protein domain specific binding
A	0030971	molecular_function	receptor tyrosine kinase binding
A	0031982	cellular_component	vesicle
A	0032869	biological_process	cellular response to insulin stimulus
A	0042149	biological_process	cellular response to glucose starvation
A	0042802	molecular_function	identical protein binding
A	0045202	cellular_component	synapse
A	0045664	biological_process	regulation of neuron differentiation
A	0048167	biological_process	regulation of synaptic plasticity
A	0050815	molecular_function	phosphoserine residue binding
A	0070062	cellular_component	extracellular exosome
A	0098793	cellular_component	presynapse
A	0140311	molecular_function	protein sequestering activity
A	1904262	biological_process	negative regulation of TORC1 signaling
B	0003723	molecular_function	RNA binding
B	0005080	molecular_function	protein kinase C binding
B	0005159	molecular_function	insulin-like growth factor receptor binding
B	0005515	molecular_function	protein binding
B	0005737	cellular_component	cytoplasm
B	0005829	cellular_component	cytosol
B	0005925	cellular_component	focal adhesion
B	0006469	biological_process	negative regulation of protein kinase activity
B	0006605	biological_process	protein targeting
B	0007165	biological_process	signal transduction
B	0008426	molecular_function	protein kinase C inhibitor activity
B	0009966	biological_process	regulation of signal transduction
B	0016020	cellular_component	membrane
B	0019904	molecular_function	protein domain specific binding
B	0030971	molecular_function	receptor tyrosine kinase binding
B	0031982	cellular_component	vesicle
B	0032869	biological_process	cellular response to insulin stimulus
B	0042149	biological_process	cellular response to glucose starvation
B	0042802	molecular_function	identical protein binding
B	0045202	cellular_component	synapse
B	0045664	biological_process	regulation of neuron differentiation
B	0048167	biological_process	regulation of synaptic plasticity
B	0050815	molecular_function	phosphoserine residue binding
B	0070062	cellular_component	extracellular exosome
B	0098793	cellular_component	presynapse
B	0140311	molecular_function	protein sequestering activity
B	1904262	biological_process	negative regulation of TORC1 signaling
D	0003723	molecular_function	RNA binding
D	0005080	molecular_function	protein kinase C binding
D	0005159	molecular_function	insulin-like growth factor receptor binding
D	0005515	molecular_function	protein binding
D	0005737	cellular_component	cytoplasm
D	0005829	cellular_component	cytosol
D	0005925	cellular_component	focal adhesion
D	0006469	biological_process	negative regulation of protein kinase activity
D	0006605	biological_process	protein targeting
D	0007165	biological_process	signal transduction
D	0008426	molecular_function	protein kinase C inhibitor activity
D	0009966	biological_process	regulation of signal transduction
D	0016020	cellular_component	membrane
D	0019904	molecular_function	protein domain specific binding
D	0030971	molecular_function	receptor tyrosine kinase binding
D	0031982	cellular_component	vesicle
D	0032869	biological_process	cellular response to insulin stimulus
D	0042149	biological_process	cellular response to glucose starvation
D	0042802	molecular_function	identical protein binding
D	0045202	cellular_component	synapse
D	0045664	biological_process	regulation of neuron differentiation
D	0048167	biological_process	regulation of synaptic plasticity
D	0050815	molecular_function	phosphoserine residue binding
D	0070062	cellular_component	extracellular exosome
D	0098793	cellular_component	presynapse
D	0140311	molecular_function	protein sequestering activity
D	1904262	biological_process	negative regulation of TORC1 signaling
G	0003723	molecular_function	RNA binding
G	0005080	molecular_function	protein kinase C binding
G	0005159	molecular_function	insulin-like growth factor receptor binding
G	0005515	molecular_function	protein binding
G	0005737	cellular_component	cytoplasm
G	0005829	cellular_component	cytosol
G	0005925	cellular_component	focal adhesion
G	0006469	biological_process	negative regulation of protein kinase activity
G	0006605	biological_process	protein targeting
G	0007165	biological_process	signal transduction
G	0008426	molecular_function	protein kinase C inhibitor activity
G	0009966	biological_process	regulation of signal transduction
G	0016020	cellular_component	membrane
G	0019904	molecular_function	protein domain specific binding
G	0030971	molecular_function	receptor tyrosine kinase binding
G	0031982	cellular_component	vesicle
G	0032869	biological_process	cellular response to insulin stimulus
G	0042149	biological_process	cellular response to glucose starvation
G	0042802	molecular_function	identical protein binding
G	0045202	cellular_component	synapse
G	0045664	biological_process	regulation of neuron differentiation
G	0048167	biological_process	regulation of synaptic plasticity
G	0050815	molecular_function	phosphoserine residue binding
G	0070062	cellular_component	extracellular exosome
G	0098793	cellular_component	presynapse
G	0140311	molecular_function	protein sequestering activity
G	1904262	biological_process	negative regulation of TORC1 signaling

Functional Information from PDB Data

site_id	AC1
Number of Residues	3
Details	binding site for residue NA A 301

Chain	Residue
A	LYS120
A	HOH409
G	HOH370

---

site_id	AC2
Number of Residues	5
Details	binding site for residue MG B 301

Chain	Residue
B	ASP202
B	ASP203
B	ALA204
B	ILE205
B	ALA206

---

site_id	AC3
Number of Residues	13
Details	binding site for Ligand residues SEP C 6 through CYS C 7 bound to SER C 5

Chain	Residue
B	ARG57
B	ARG132
B	TYR133
B	GLY174
B	LEU177
B	ASN178
B	LEU225
C	SER5
C	PRO8
C	HOH102
C	HOH103
C	HOH105
B	LYS50

---

site_id	AC4
Number of Residues	16
Details	binding site for Ligand residues SEP E 6 through CYS E 7 bound to SER E 5

Chain	Residue
A	LYS50
A	ARG57
A	ARG132
A	TYR133
A	GLY174
A	LEU177
A	ASN178
A	LEU225
A	HOH413
E	SER5
E	PRO8
E	ALA9
E	HOH102
E	HOH103
E	HOH105
E	HOH108

---

site_id	AC5
Number of Residues	13
Details	binding site for Ligand residues SEP F 6 through CYS F 7 bound to SER F 5

Chain	Residue
D	LYS50
D	ARG57
D	ARG132
D	TYR133
D	GLY174
D	LEU177
D	ASN178
F	SER5
F	PRO8
F	ALA9
F	HOH102
F	HOH104
F	HOH108

---

site_id	AC6
Number of Residues	13
Details	binding site for Ligand residues SEP H 6 through CYS H 7 bound to SER H 5

Chain	Residue
G	LYS50
G	ARG57
G	ARG132
G	TYR133
G	GLY174
G	LEU177
G	ASN178
H	SER5
H	PRO8
H	HOH101
H	HOH103
H	HOH106
H	HOH107

---

Functional Information from PROSITE/UniProt

site_id	PS00796
Number of Residues	11
Details	1433_1 14-3-3 proteins signature 1. RNLLSVAYKNV

Chain	Residue	Details
A	ARG42-VAL52

---

site_id	PS00797
Number of Residues	20
Details	1433_2 14-3-3 proteins signature 2. YKDSTLIMQLLRDNLTLWTS

Chain	Residue	Details
A	TYR216-SER235

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	8
Details	SITE: Interaction with phosphoserine on interacting protein => ECO:0000269|PubMed:17085597

Chain	Residue	Details
A	ARG57
A	ARG132
B	ARG57
B	ARG132
D	ARG57
D	ARG132
G	ARG57
G	ARG132

---

site_id	SWS_FT_FI2
Number of Residues	4
Details	MOD_RES: N-acetylmethionine; in 14-3-3 protein gamma; alternate; partial => ECO:0000269|Ref.7

Chain	Residue	Details
A	MET1
B	MET1
D	MET1
G	MET1

---

site_id	SWS_FT_FI3
Number of Residues	4
Details	MOD_RES: N-acetylvaline; partial => ECO:0000269|PubMed:14534293, ECO:0000269|Ref.7, ECO:0000269|Ref.9, ECO:0007744|PubMed:19413330

Chain	Residue	Details
A	VAL2
B	VAL2
D	VAL2
G	VAL2

---

site_id	SWS_FT_FI4
Number of Residues	4
Details	MOD_RES: Phosphoserine => ECO:0007744|PubMed:23186163

Chain	Residue	Details
B	SER71
D	SER71
G	SER71
A	SER71

---

site_id	SWS_FT_FI5
Number of Residues	4
Details	MOD_RES: Phosphotyrosine => ECO:0000250|UniProtKB:P61983

Chain	Residue	Details
A	TYR133
B	TYR133
D	TYR133
G	TYR133

---

site_id	SWS_FT_FI6
Number of Residues	4
Details	MOD_RES: Phosphothreonine => ECO:0000269|Ref.7

Chain	Residue	Details
B	THR145
D	THR145
G	THR145
A	THR145

---

site_id	SWS_FT_FI7
Number of Residues	4
Details	MOD_RES: Phosphoserine => ECO:0000250|UniProtKB:P61983

Chain	Residue	Details
A	SER215
B	SER215
D	SER215
G	SER215

---

site_id	SWS_FT_FI8
Number of Residues	4
Details	MOD_RES: Phosphothreonine => ECO:0007744|PubMed:24275569

Chain	Residue	Details
A	THR234
B	THR234
D	THR234
G	THR234

---

site_id	SWS_FT_FI9
Number of Residues	4
Details	MOD_RES: Phosphoserine => ECO:0007744|PubMed:24275569

Chain	Residue	Details
A	SER235
B	SER235
D	SER235
G	SER235

---