Summary Structural details Experimental details Functional details Sequence Neighbor History Downloads

6A4B

Structure of TREX2 in complex with a duplex DNA with 2 nucleotide 3'-overhang

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0000287	molecular_function	magnesium ion binding
A	0003676	molecular_function	nucleic acid binding
A	0003677	molecular_function	DNA binding
A	0004518	molecular_function	nuclease activity
A	0004527	molecular_function	exonuclease activity
A	0005634	cellular_component	nucleus
A	0005737	cellular_component	cytoplasm
A	0006259	biological_process	DNA metabolic process
A	0006281	biological_process	DNA repair
A	0006308	biological_process	DNA catabolic process
A	0006974	biological_process	DNA damage response
A	0008296	molecular_function	3'-5'-DNA exonuclease activity
A	0008311	molecular_function	double-stranded DNA 3'-5' DNA exonuclease activity
A	0008408	molecular_function	3'-5' exonuclease activity
A	0016787	molecular_function	hydrolase activity
A	0042803	molecular_function	protein homodimerization activity
A	0046872	molecular_function	metal ion binding
A	0060090	molecular_function	molecular adaptor activity
B	0000287	molecular_function	magnesium ion binding
B	0003676	molecular_function	nucleic acid binding
B	0003677	molecular_function	DNA binding
B	0004518	molecular_function	nuclease activity
B	0004527	molecular_function	exonuclease activity
B	0005634	cellular_component	nucleus
B	0005737	cellular_component	cytoplasm
B	0006259	biological_process	DNA metabolic process
B	0006281	biological_process	DNA repair
B	0006308	biological_process	DNA catabolic process
B	0006974	biological_process	DNA damage response
B	0008296	molecular_function	3'-5'-DNA exonuclease activity
B	0008311	molecular_function	double-stranded DNA 3'-5' DNA exonuclease activity
B	0008408	molecular_function	3'-5' exonuclease activity
B	0016787	molecular_function	hydrolase activity
B	0042803	molecular_function	protein homodimerization activity
B	0046872	molecular_function	metal ion binding
B	0060090	molecular_function	molecular adaptor activity
C	0000287	molecular_function	magnesium ion binding
C	0003676	molecular_function	nucleic acid binding
C	0003677	molecular_function	DNA binding
C	0004518	molecular_function	nuclease activity
C	0004527	molecular_function	exonuclease activity
C	0005634	cellular_component	nucleus
C	0005737	cellular_component	cytoplasm
C	0006259	biological_process	DNA metabolic process
C	0006281	biological_process	DNA repair
C	0006308	biological_process	DNA catabolic process
C	0006974	biological_process	DNA damage response
C	0008296	molecular_function	3'-5'-DNA exonuclease activity
C	0008311	molecular_function	double-stranded DNA 3'-5' DNA exonuclease activity
C	0008408	molecular_function	3'-5' exonuclease activity
C	0016787	molecular_function	hydrolase activity
C	0042803	molecular_function	protein homodimerization activity
C	0046872	molecular_function	metal ion binding
C	0060090	molecular_function	molecular adaptor activity
D	0000287	molecular_function	magnesium ion binding
D	0003676	molecular_function	nucleic acid binding
D	0003677	molecular_function	DNA binding
D	0004518	molecular_function	nuclease activity
D	0004527	molecular_function	exonuclease activity
D	0005634	cellular_component	nucleus
D	0005737	cellular_component	cytoplasm
D	0006259	biological_process	DNA metabolic process
D	0006281	biological_process	DNA repair
D	0006308	biological_process	DNA catabolic process
D	0006974	biological_process	DNA damage response
D	0008296	molecular_function	3'-5'-DNA exonuclease activity
D	0008311	molecular_function	double-stranded DNA 3'-5' DNA exonuclease activity
D	0008408	molecular_function	3'-5' exonuclease activity
D	0016787	molecular_function	hydrolase activity
D	0042803	molecular_function	protein homodimerization activity
D	0046872	molecular_function	metal ion binding
D	0060090	molecular_function	molecular adaptor activity
E	0000287	molecular_function	magnesium ion binding
E	0003676	molecular_function	nucleic acid binding
E	0003677	molecular_function	DNA binding
E	0004518	molecular_function	nuclease activity
E	0004527	molecular_function	exonuclease activity
E	0005634	cellular_component	nucleus
E	0005737	cellular_component	cytoplasm
E	0006259	biological_process	DNA metabolic process
E	0006281	biological_process	DNA repair
E	0006308	biological_process	DNA catabolic process
E	0006974	biological_process	DNA damage response
E	0008296	molecular_function	3'-5'-DNA exonuclease activity
E	0008311	molecular_function	double-stranded DNA 3'-5' DNA exonuclease activity
E	0008408	molecular_function	3'-5' exonuclease activity
E	0016787	molecular_function	hydrolase activity
E	0042803	molecular_function	protein homodimerization activity
E	0046872	molecular_function	metal ion binding
E	0060090	molecular_function	molecular adaptor activity
F	0000287	molecular_function	magnesium ion binding
F	0003676	molecular_function	nucleic acid binding
F	0003677	molecular_function	DNA binding
F	0004518	molecular_function	nuclease activity
F	0004527	molecular_function	exonuclease activity
F	0005634	cellular_component	nucleus
F	0005737	cellular_component	cytoplasm
F	0006259	biological_process	DNA metabolic process
F	0006281	biological_process	DNA repair
F	0006308	biological_process	DNA catabolic process
F	0006974	biological_process	DNA damage response
F	0008296	molecular_function	3'-5'-DNA exonuclease activity
F	0008311	molecular_function	double-stranded DNA 3'-5' DNA exonuclease activity
F	0008408	molecular_function	3'-5' exonuclease activity
F	0016787	molecular_function	hydrolase activity
F	0042803	molecular_function	protein homodimerization activity
F	0046872	molecular_function	metal ion binding
F	0060090	molecular_function	molecular adaptor activity

Functional Information from PDB Data

site_id	AC1
Number of Residues	4
Details	binding site for residue MG A 301

Chain	Residue
A	ASP14
A	ASP123
H	DT17
H	DT18

site_id	AC2
Number of Residues	4
Details	binding site for residue MG A 302

Chain	Residue
A	ASP14
A	GLU16
A	ASP193
H	DT18

site_id	AC3
Number of Residues	4
Details	binding site for residue MG B 301

Chain	Residue
B	GLU16
B	ASP193
G	DT18
B	ASP14

site_id	AC4
Number of Residues	4
Details	binding site for residue MG C 301

Chain	Residue
C	ASP14
C	GLU16
C	ASP193
I	DT18

site_id	AC5
Number of Residues	5
Details	binding site for residue MG D 301

Chain	Residue
D	ASP14
D	LEU15
D	ASP123
J	DT17
J	DT18

site_id	AC6
Number of Residues	4
Details	binding site for residue MG E 301

Chain	Residue
E	ASP14
E	ASP123
K	DT17
K	DT18

site_id	AC7
Number of Residues	4
Details	binding site for residue MG E 302

Chain	Residue
E	ASP14
E	GLU16
E	ASP193
K	DT18

site_id	AC8
Number of Residues	4
Details	binding site for residue MG F 301

Chain	Residue
F	ASP14
F	GLU16
F	ASP193
L	DT18

site_id	AC9
Number of Residues	3
Details	binding site for residue MG G 101

Chain	Residue
B	ASP14
G	DT17
G	DT18

site_id	AD1
Number of Residues	4
Details	binding site for residue MG I 101

Chain	Residue
C	ASP14
C	ASP123
I	DT17
I	DT18

site_id	AD2
Number of Residues	3
Details	binding site for residue MG L 101

Chain	Residue
F	ASP14
L	DT17
L	DT18

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	30
Details	Binding site: {"evidences":[{"evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

site_id	SWS_FT_FI2
Number of Residues	4
Details	Active site: {"description":"Proton donor/acceptor","evidences":[{"evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

		Sequence (fasta)
		PDBx/mmCIF
		PDBML format (no-atom)
		PDB format (full)
		Validation report (PDF)
		EDMap 2fo-fc (MTZ)