6A46
Structure of TREX2 in complex with a nucleotide (dCMP)
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0000287 | molecular_function | magnesium ion binding |
| A | 0003676 | molecular_function | nucleic acid binding |
| A | 0004527 | molecular_function | exonuclease activity |
| A | 0005634 | cellular_component | nucleus |
| A | 0005737 | cellular_component | cytoplasm |
| A | 0006259 | biological_process | DNA metabolic process |
| A | 0006281 | biological_process | DNA repair |
| A | 0006308 | biological_process | DNA catabolic process |
| A | 0008296 | molecular_function | 3'-5'-DNA exonuclease activity |
| A | 0008311 | molecular_function | double-stranded DNA 3'-5' DNA exonuclease activity |
| A | 0008408 | molecular_function | 3'-5' exonuclease activity |
| A | 0042803 | molecular_function | protein homodimerization activity |
| A | 0046872 | molecular_function | metal ion binding |
| B | 0000287 | molecular_function | magnesium ion binding |
| B | 0003676 | molecular_function | nucleic acid binding |
| B | 0004527 | molecular_function | exonuclease activity |
| B | 0005634 | cellular_component | nucleus |
| B | 0005737 | cellular_component | cytoplasm |
| B | 0006259 | biological_process | DNA metabolic process |
| B | 0006281 | biological_process | DNA repair |
| B | 0006308 | biological_process | DNA catabolic process |
| B | 0008296 | molecular_function | 3'-5'-DNA exonuclease activity |
| B | 0008311 | molecular_function | double-stranded DNA 3'-5' DNA exonuclease activity |
| B | 0008408 | molecular_function | 3'-5' exonuclease activity |
| B | 0042803 | molecular_function | protein homodimerization activity |
| B | 0046872 | molecular_function | metal ion binding |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 7 |
| Details | binding site for residue MG A 301 |
| Chain | Residue |
| A | ASP14 |
| A | MG302 |
| A | DCM303 |
| A | HOH407 |
| A | HOH412 |
| A | HOH430 |
| A | HOH457 |
| site_id | AC2 |
| Number of Residues | 5 |
| Details | binding site for residue MG A 302 |
| Chain | Residue |
| A | ASP193 |
| A | MG301 |
| A | DCM303 |
| A | ASP14 |
| A | GLU16 |
| site_id | AC3 |
| Number of Residues | 16 |
| Details | binding site for residue DCM A 303 |
| Chain | Residue |
| A | LEU15 |
| A | GLU16 |
| A | ALA17 |
| A | LEU20 |
| A | LYS73 |
| A | ILE77 |
| A | THR78 |
| A | TYR122 |
| A | HIS188 |
| A | ASP193 |
| A | MG301 |
| A | MG302 |
| A | HOH414 |
| A | HOH430 |
| A | HOH431 |
| A | HOH457 |
| site_id | AC4 |
| Number of Residues | 1 |
| Details | binding site for residue CA A 304 |
| Chain | Residue |
| A | LEU172 |
| site_id | AC5 |
| Number of Residues | 15 |
| Details | binding site for residue DCM B 301 |
| Chain | Residue |
| B | ASP14 |
| B | LEU15 |
| B | GLU16 |
| B | ALA17 |
| B | GLY19 |
| B | LEU20 |
| B | LYS73 |
| B | THR78 |
| B | TYR122 |
| B | HIS188 |
| B | ASP193 |
| B | MG302 |
| B | MG303 |
| B | HOH409 |
| B | HOH414 |
| site_id | AC6 |
| Number of Residues | 7 |
| Details | binding site for residue MG B 302 |
| Chain | Residue |
| B | ASP14 |
| B | ASP123 |
| B | DCM301 |
| B | HOH401 |
| B | HOH404 |
| B | HOH409 |
| B | HOH414 |
| site_id | AC7 |
| Number of Residues | 4 |
| Details | binding site for residue MG B 303 |
| Chain | Residue |
| B | ASP14 |
| B | GLU16 |
| B | ASP193 |
| B | DCM301 |
| site_id | AC8 |
| Number of Residues | 4 |
| Details | binding site for residue CA B 304 |
| Chain | Residue |
| B | ASN94 |
| B | GLY95 |
| B | ALA96 |
| B | ARG99 |
| site_id | AC9 |
| Number of Residues | 2 |
| Details | binding site for residue CA B 305 |
| Chain | Residue |
| B | HIS177 |
| B | HIS221 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 2 |
| Details | ACT_SITE: Proton donor/acceptor => ECO:0000250 |
| Chain | Residue | Details |
| A | HIS188 | |
| B | HIS188 |
| site_id | SWS_FT_FI2 |
| Number of Residues | 8 |
| Details | BINDING: BINDING => ECO:0000250 |
| Chain | Residue | Details |
| A | ASP14 | |
| A | GLU16 | |
| A | TYR122 | |
| A | ASP193 | |
| B | ASP14 | |
| B | GLU16 | |
| B | TYR122 | |
| B | ASP193 |
