5ZQY

Crystal structure of a poly(ADP-ribose) glycohydrolase

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0000287	molecular_function	magnesium ion binding
A	0004553	molecular_function	hydrolase activity, hydrolyzing O-glycosyl compounds
A	0004649	molecular_function	poly(ADP-ribose) glycohydrolase activity
A	0005515	molecular_function	protein binding
A	0005634	cellular_component	nucleus
A	0005654	cellular_component	nucleoplasm
A	0005694	cellular_component	chromosome
A	0005737	cellular_component	cytoplasm
A	0005739	cellular_component	mitochondrion
A	0005759	cellular_component	mitochondrial matrix
A	0006281	biological_process	DNA repair
A	0006287	biological_process	base-excision repair, gap-filling
A	0006974	biological_process	DNA damage response
A	0016787	molecular_function	hydrolase activity
A	0046872	molecular_function	metal ion binding
A	0060546	biological_process	negative regulation of necroptotic process
A	0061463	molecular_function	O-acetyl-ADP-ribose deacetylase activity
A	0071451	biological_process	cellular response to superoxide
A	0090734	cellular_component	site of DNA damage
A	0140290	biological_process	peptidyl-serine ADP-deribosylation
A	0140292	molecular_function	ADP-ribosylserine hydrolase activity

Functional Information from PDB Data

site_id	AC1
Number of Residues	6
Details	binding site for residue MG A 401

Chain	Residue
A	ASP314
A	ASP316
A	THR317
A	AR6403
A	HOH501
A	HOH624

---

site_id	AC2
Number of Residues	7
Details	binding site for residue MG A 402

Chain	Residue
A	ASP316
A	AR6403
A	HOH501
A	HOH648
A	THR76
A	ASP77
A	ASP78

---

site_id	AC3
Number of Residues	30
Details	binding site for residue AR6 A 403

Chain	Residue
A	ASP77
A	GLY115
A	GLY117
A	ALA118
A	GLY119
A	VAL120
A	PHE143
A	GLY147
A	SER148
A	TYR149
A	GLY150
A	ASN151
A	GLY152
A	HIS182
A	ILE271
A	ASP314
A	THR317
A	MG401
A	MG402
A	HOH501
A	HOH506
A	HOH553
A	HOH555
A	HOH598
A	HOH606
A	HOH610
A	HOH611
A	HOH624
A	HOH656
A	HOH718

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	1
Details	Binding site: {"evidences":[{"source":"PubMed","id":"21892188","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"29907568","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"30045870","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"5ZQY","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6D36","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6D3A","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI2
Number of Residues	1
Details	Binding site: {"evidences":[{"source":"PubMed","id":"21892188","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"29907568","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"30045870","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"33894202","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"5ZQY","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6D36","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6D3A","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7L9I","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI3
Number of Residues	8
Details	Binding site: {"evidences":[{"source":"PubMed","id":"29907568","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"30045870","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"5ZQY","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6D36","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6D3A","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI4
Number of Residues	1
Details	Binding site: {"evidences":[{"source":"PubMed","id":"34321462","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"7ARW","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI5
Number of Residues	2
Details	Binding site: {"evidences":[{"source":"PubMed","id":"29907568","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"6D36","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6D3A","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI6
Number of Residues	2
Details	Binding site: {"evidences":[{"source":"PubMed","id":"21892188","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"29907568","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"30045870","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"33894202","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"34321462","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"5ZQY","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6D36","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6D3A","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7AKR","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7AKS","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7ARW","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7L9H","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI7
Number of Residues	1
Details	Binding site: {"evidences":[{"source":"PubMed","id":"21892188","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"29907568","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"30045870","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"33894202","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"5ZQY","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6D36","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6D3A","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7L9H","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI8
Number of Residues	1
Details	Site: {"description":"Glutamate flap","evidences":[{"source":"PubMed","id":"29907568","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"30045870","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI9
Number of Residues	1
Details	Modified residue: {"description":"Phosphothreonine","evidences":[{"source":"PubMed","id":"23186163","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

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