5ZMS

Crystal structure of Zika NS3 protease in complex with 4-guanidinomethyl-phenylacetyl-Lys-Lys-Arg-H

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0004252	molecular_function	serine-type endopeptidase activity
A	0044423	cellular_component	virion component
B	0003723	molecular_function	RNA binding
B	0003724	molecular_function	RNA helicase activity
B	0005524	molecular_function	ATP binding
D	0004252	molecular_function	serine-type endopeptidase activity
D	0044423	cellular_component	virion component
E	0003723	molecular_function	RNA binding
E	0003724	molecular_function	RNA helicase activity
E	0005524	molecular_function	ATP binding
G	0004252	molecular_function	serine-type endopeptidase activity
G	0044423	cellular_component	virion component
H	0003723	molecular_function	RNA binding
H	0003724	molecular_function	RNA helicase activity
H	0005524	molecular_function	ATP binding
J	0004252	molecular_function	serine-type endopeptidase activity
J	0044423	cellular_component	virion component
K	0003723	molecular_function	RNA binding
K	0003724	molecular_function	RNA helicase activity
K	0005524	molecular_function	ATP binding

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	8
Details	ACT_SITE: Charge relay system; for serine protease NS3 activity => ECO:0000255|PROSITE-ProRule:PRU00860

Chain	Residue	Details
B	HIS51
B	ASP75
E	HIS51
E	ASP75
H	HIS51
H	ASP75
K	HIS51
K	ASP75

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site_id	SWS_FT_FI2
Number of Residues	4
Details	ACT_SITE: Charge relay system; for serine protease NS3 activity => ECO:0000255|PROSITE-ProRule:PRU00860, ECO:0000269|PubMed:29526431

Chain	Residue	Details
B	SER135
E	SER135
H	SER135
K	SER135

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