5ZBZ

Crystal structure of the DEAD domain of Human eIF4A with sanguinarine

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0003676	molecular_function	nucleic acid binding
A	0003724	molecular_function	RNA helicase activity
A	0005524	molecular_function	ATP binding

Functional Information from PDB Data

site_id	AC1
Number of Residues	10
Details	binding site for residue SAU A 301

Chain	Residue
A	TYR50
A	HOH481
A	TYR50
A	GLY51
A	PHE52
A	GLY79
A	THR80
A	GLY81
A	GLN115
A	MLI302

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site_id	AC2
Number of Residues	12
Details	binding site for residue MLI A 302

Chain	Residue
A	SER78
A	GLY79
A	THR80
A	GLY81
A	MLY82
A	THR83
A	GLN115
A	SAU301
A	HOH426
A	HOH445
A	HOH448
A	HOH502

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Functional Information from PROSITE/UniProt

site_id	PS00039
Number of Residues	9
Details	DEAD_ATP_HELICASE DEAD-box subfamily ATP-dependent helicases signature. VLDEADEmL

Chain	Residue	Details
A	VAL180-LEU188

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Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	3
Details	Motif: {"description":"DEAD box"}

Chain

Residue

Details

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site_id	SWS_FT_FI2
Number of Residues	2
Details	Modified residue: {"description":"N6-acetyllysine","evidences":[{"source":"PubMed","id":"19608861","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

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site_id	SWS_FT_FI3
Number of Residues	1
Details	Modified residue: {"description":"Phosphothreonine","evidences":[{"source":"PubMed","id":"23186163","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

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site_id	SWS_FT_FI4
Number of Residues	1
Details	Modified residue: {"description":"N6-acetyllysine","evidences":[{"source":"UniProtKB","id":"P60843","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

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site_id	SWS_FT_FI5
Number of Residues	2
Details	Cross-link: {"description":"Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)","evidences":[{"source":"PubMed","id":"28112733","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

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