5ZBQ
The Crystal Structure of human neuropeptide Y Y1 receptor with UR-MK299
Functional Information from GO Data
Chain | GOid | namespace | contents |
A | 0001601 | molecular_function | peptide YY receptor activity |
A | 0001602 | molecular_function | pancreatic polypeptide receptor activity |
A | 0003151 | biological_process | outflow tract morphogenesis |
A | 0003796 | molecular_function | lysozyme activity |
A | 0004930 | molecular_function | G protein-coupled receptor activity |
A | 0004983 | molecular_function | neuropeptide Y receptor activity |
A | 0005515 | molecular_function | protein binding |
A | 0005886 | cellular_component | plasma membrane |
A | 0006006 | biological_process | glucose metabolic process |
A | 0007186 | biological_process | G protein-coupled receptor signaling pathway |
A | 0007187 | biological_process | G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger |
A | 0007193 | biological_process | adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway |
A | 0007218 | biological_process | neuropeptide signaling pathway |
A | 0007626 | biological_process | locomotory behavior |
A | 0007631 | biological_process | feeding behavior |
A | 0008188 | molecular_function | neuropeptide receptor activity |
A | 0008217 | biological_process | regulation of blood pressure |
A | 0009253 | biological_process | peptidoglycan catabolic process |
A | 0016020 | cellular_component | membrane |
A | 0016798 | molecular_function | hydrolase activity, acting on glycosyl bonds |
A | 0016998 | biological_process | cell wall macromolecule catabolic process |
A | 0019233 | biological_process | sensory perception of pain |
A | 0030430 | cellular_component | host cell cytoplasm |
A | 0031640 | biological_process | killing of cells of another organism |
A | 0040014 | biological_process | regulation of multicellular organism growth |
A | 0042742 | biological_process | defense response to bacterium |
A | 0042923 | molecular_function | neuropeptide binding |
A | 0043005 | cellular_component | neuron projection |
A | 0044659 | biological_process | viral release from host cell by cytolysis |
Functional Information from PDB Data
site_id | AC1 |
Number of Residues | 13 |
Details | binding site for residue 9AO A 1301 |
Chain | Residue |
A | PRO117 |
A | ASN283 |
A | PHE286 |
A | ASP287 |
A | PHE302 |
A | GLN120 |
A | CYS121 |
A | ILE124 |
A | PHE173 |
A | THR212 |
A | GLN219 |
A | THR280 |
A | PHE282 |
Functional Information from PROSITE/UniProt
site_id | PS00237 |
Number of Residues | 17 |
Details | G_PROTEIN_RECEP_F1_1 G-protein coupled receptors family 1 signature. VSIwSLVLIAVERHQlI |
Chain | Residue | Details |
A | VAL126-ILE142 |
Functional Information from SwissProt/UniProt
site_id | SWS_FT_FI1 |
Number of Residues | 20 |
Details | TRANSMEM: Helical; Name=1 => ECO:0000255 |
Chain | Residue | Details |
A | LEU45-ILE65 |
site_id | SWS_FT_FI2 |
Number of Residues | 53 |
Details | TOPO_DOM: Cytoplasmic => ECO:0000255 |
Chain | Residue | Details |
A | LEU66-ASN76 | |
A | ARG138-HIS154 | |
A | LYS233-ARG260 |
site_id | SWS_FT_FI3 |
Number of Residues | 20 |
Details | TRANSMEM: Helical; Name=2 => ECO:0000255 |
Chain | Residue | Details |
A | ILE77-THR97 |
site_id | SWS_FT_FI4 |
Number of Residues | 70 |
Details | TOPO_DOM: Extracellular => ECO:0000255 |
Chain | Residue | Details |
A | PHE98-ASN116 | |
A | TYR176-TYR211 | |
A | PHE282-ASN299 |
site_id | SWS_FT_FI5 |
Number of Residues | 20 |
Details | TRANSMEM: Helical; Name=3 => ECO:0000255 |
Chain | Residue | Details |
A | PRO117-GLU137 |
site_id | SWS_FT_FI6 |
Number of Residues | 20 |
Details | TRANSMEM: Helical; Name=4 => ECO:0000255 |
Chain | Residue | Details |
A | ALA155-ILE175 |
site_id | SWS_FT_FI7 |
Number of Residues | 20 |
Details | TRANSMEM: Helical; Name=5 => ECO:0000255 |
Chain | Residue | Details |
A | THR212-PHE232 |
site_id | SWS_FT_FI8 |
Number of Residues | 20 |
Details | TRANSMEM: Helical; Name=6 => ECO:0000255 |
Chain | Residue | Details |
A | ILE261-ILE281 |
site_id | SWS_FT_FI9 |
Number of Residues | 20 |
Details | TRANSMEM: Helical; Name=7 => ECO:0000255 |
Chain | Residue | Details |
A | LEU300-TYR320 |
site_id | SWS_FT_FI10 |
Number of Residues | 1 |
Details | LIPID: S-palmitoyl cysteine => ECO:0000255 |
Chain | Residue | Details |
A | CYS338 |
site_id | SWS_FT_FI11 |
Number of Residues | 3 |
Details | CARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000255 |
Chain | Residue | Details |
A | ASN2 | |
A | ASN11 | |
A | ASN17 |
site_id | SWS_FT_FI12 |
Number of Residues | 1 |
Details | ACT_SITE: Proton donor/acceptor => ECO:0000255|HAMAP-Rule:MF_04110, ECO:0000269|PubMed:3382407, ECO:0000269|PubMed:7831309, ECO:0000269|PubMed:8266098 |
Chain | Residue | Details |
A | GLU1010 |
site_id | SWS_FT_FI13 |
Number of Residues | 1 |
Details | ACT_SITE: Proton donor/acceptor => ECO:0000255|HAMAP-Rule:MF_04110, ECO:0000269|PubMed:1892846, ECO:0000269|PubMed:3382407, ECO:0000269|PubMed:7831309, ECO:0000269|PubMed:8266098 |
Chain | Residue | Details |
A | ASP1019 |
site_id | SWS_FT_FI14 |
Number of Residues | 2 |
Details | BINDING: BINDING => ECO:0000269|PubMed:8266098 |
Chain | Residue | Details |
A | LEU1031 | |
A | PHE1103 |
site_id | SWS_FT_FI15 |
Number of Residues | 2 |
Details | BINDING: BINDING => ECO:0000303|PubMed:7831309 |
Chain | Residue | Details |
A | SER1116 | |
A | ASN1131 |
Catalytic Information from CSA
site_id | MCSA1 |
Number of Residues | 2 |
Details | M-CSA 921 |
Chain | Residue | Details |
A | GLU1010 | proton shuttle (general acid/base) |
A | ASP1019 | covalent catalysis |