5Z62

Structure of human cytochrome c oxidase

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0001666	biological_process	response to hypoxia
A	0004129	molecular_function	cytochrome-c oxidase activity
A	0005515	molecular_function	protein binding
A	0005739	cellular_component	mitochondrion
A	0005743	cellular_component	mitochondrial inner membrane
A	0006119	biological_process	oxidative phosphorylation
A	0006123	biological_process	mitochondrial electron transport, cytochrome c to oxygen
A	0006979	biological_process	response to oxidative stress
A	0009060	biological_process	aerobic respiration
A	0015990	biological_process	electron transport coupled proton transport
A	0016020	cellular_component	membrane
A	0020037	molecular_function	heme binding
A	0021549	biological_process	cerebellum development
A	0031966	cellular_component	mitochondrial membrane
A	0045277	cellular_component	respiratory chain complex IV
A	0045333	biological_process	cellular respiration
A	0046688	biological_process	response to copper ion
A	0046872	molecular_function	metal ion binding
A	0051602	biological_process	response to electrical stimulus
B	0001666	biological_process	response to hypoxia
B	0004129	molecular_function	cytochrome-c oxidase activity
B	0005507	molecular_function	copper ion binding
B	0005515	molecular_function	protein binding
B	0005739	cellular_component	mitochondrion
B	0005743	cellular_component	mitochondrial inner membrane
B	0005759	cellular_component	mitochondrial matrix
B	0006123	biological_process	mitochondrial electron transport, cytochrome c to oxygen
B	0007595	biological_process	lactation
B	0016020	cellular_component	membrane
B	0016491	molecular_function	oxidoreductase activity
B	0022900	biological_process	electron transport chain
B	0031966	cellular_component	mitochondrial membrane
B	0042773	biological_process	ATP synthesis coupled electron transport
B	0045277	cellular_component	respiratory chain complex IV
B	0045333	biological_process	cellular respiration
B	0046872	molecular_function	metal ion binding
B	1902600	biological_process	proton transmembrane transport
C	0004129	molecular_function	cytochrome-c oxidase activity
C	0005515	molecular_function	protein binding
C	0005739	cellular_component	mitochondrion
C	0005743	cellular_component	mitochondrial inner membrane
C	0006123	biological_process	mitochondrial electron transport, cytochrome c to oxygen
C	0008535	biological_process	respiratory chain complex IV assembly
C	0009055	molecular_function	electron transfer activity
C	0016020	cellular_component	membrane
C	0019646	biological_process	aerobic electron transport chain
C	0022904	biological_process	respiratory electron transport chain
C	0031966	cellular_component	mitochondrial membrane
C	0045277	cellular_component	respiratory chain complex IV
C	0045333	biological_process	cellular respiration
C	1902600	biological_process	proton transmembrane transport
D	0006123	biological_process	mitochondrial electron transport, cytochrome c to oxygen
D	0045277	cellular_component	respiratory chain complex IV
E	0005743	cellular_component	mitochondrial inner membrane
E	0006123	biological_process	mitochondrial electron transport, cytochrome c to oxygen
E	0045277	cellular_component	respiratory chain complex IV
F	0005740	cellular_component	mitochondrial envelope
F	0006123	biological_process	mitochondrial electron transport, cytochrome c to oxygen
F	0045277	cellular_component	respiratory chain complex IV
G	0005743	cellular_component	mitochondrial inner membrane
H	0004129	molecular_function	cytochrome-c oxidase activity
H	0005739	cellular_component	mitochondrion
H	0005743	cellular_component	mitochondrial inner membrane
H	0006119	biological_process	oxidative phosphorylation
H	0006123	biological_process	mitochondrial electron transport, cytochrome c to oxygen
H	0021762	biological_process	substantia nigra development
H	0031966	cellular_component	mitochondrial membrane
H	0045277	cellular_component	respiratory chain complex IV
H	0045333	biological_process	cellular respiration
H	1902600	biological_process	proton transmembrane transport
I	0005515	molecular_function	protein binding
I	0005739	cellular_component	mitochondrion
I	0005743	cellular_component	mitochondrial inner membrane
I	0005758	cellular_component	mitochondrial intermembrane space
I	0006091	biological_process	generation of precursor metabolites and energy
I	0006119	biological_process	oxidative phosphorylation
I	0006123	biological_process	mitochondrial electron transport, cytochrome c to oxygen
I	0031966	cellular_component	mitochondrial membrane
I	0045333	biological_process	cellular respiration
J	0006123	biological_process	mitochondrial electron transport, cytochrome c to oxygen
J	0045277	cellular_component	respiratory chain complex IV
K	0006123	biological_process	mitochondrial electron transport, cytochrome c to oxygen
L	0006123	biological_process	mitochondrial electron transport, cytochrome c to oxygen
L	0045277	cellular_component	respiratory chain complex IV
M	0006123	biological_process	mitochondrial electron transport, cytochrome c to oxygen
M	0045277	cellular_component	respiratory chain complex IV
N	0005515	molecular_function	protein binding
N	0005739	cellular_component	mitochondrion
N	0005743	cellular_component	mitochondrial inner membrane
N	0006120	biological_process	mitochondrial electron transport, NADH to ubiquinone
N	0006123	biological_process	mitochondrial electron transport, cytochrome c to oxygen
N	0008137	molecular_function	NADH dehydrogenase (ubiquinone) activity
N	0031966	cellular_component	mitochondrial membrane
N	0044877	molecular_function	protein-containing complex binding
N	0045277	cellular_component	respiratory chain complex IV
N	0045333	biological_process	cellular respiration
N	1902600	biological_process	proton transmembrane transport

Functional Information from PDB Data

site_id	AC1
Number of Residues	3
Details	binding site for residue CU A 601

Chain	Residue
A	HIS240
A	HIS290
A	HIS291

---

site_id	AC2
Number of Residues	3
Details	binding site for residue MG A 602

Chain	Residue
A	HIS368
A	ASP369
B	GLU198

---

site_id	AC3
Number of Residues	21
Details	binding site for residue HEA A 603

Chain	Residue
A	TYR54
A	VAL58
A	HIS61
A	MET65
A	MET69
A	TRP126
A	TYR371
A	PHE377
A	HIS378
A	LEU381
A	SER382
A	VAL386
A	MET390
A	GLN428
A	ARG438
A	ARG439
A	SER461
A	MET468
A	GLY27
A	THR31
A	ARG38

---

site_id	AC4
Number of Residues	22
Details	binding site for residue HEA A 604

Chain	Residue
A	TRP126
A	TRP236
A	VAL243
A	TYR244
A	HIS290
A	HIS291
A	ILE312
A	ALA313
A	GLY317
A	PHE348
A	GLY352
A	GLY355
A	LEU358
A	ALA359
A	ASP364
A	HIS368
A	HIS376
A	PHE377
A	VAL380
A	LEU381
A	ARG438
B	PRO69

---

site_id	AC5
Number of Residues	11
Details	binding site for residue PEE A 605

Chain	Residue
A	PHE94
A	PRO95
A	ARG96
A	MET97
A	LEU159
C	HIS9
C	TRP57
C	TRP58
C	GLY82
C	PHE86
C	PEE301

---

site_id	AC6
Number of Residues	6
Details	binding site for residue CU B 301

Chain	Residue
B	HIS161
B	CYS196
B	GLU198
B	CYS200
B	MET207
B	CU302

---

site_id	AC7
Number of Residues	6
Details	binding site for residue CU B 302

Chain	Residue
B	HIS161
B	CYS196
B	CYS200
B	HIS204
B	MET207
B	CU301

---

site_id	AC8
Number of Residues	20
Details	binding site for residue PEE C 301

Chain	Residue
A	PEE605
C	TRP58
C	THR62
C	SER65
C	THR66
C	HIS71
C	PHE86
C	GLU90
C	PHE93
C	HIS207
C	THR213
C	PHE214
C	ILE217
C	ARG221
C	HIS226
C	HIS231
C	HIS232
C	PHE233
C	GLY234
C	PEE302

---

site_id	AC9
Number of Residues	14
Details	binding site for residue PEE C 302

Chain	Residue
C	PHE203
C	PEE301
G	TRP86
G	THR92
G	LEU93
G	PHE94
G	ASN100
C	TYR181
C	SER184
C	PHE186
C	THR187
C	ILE188
C	PHE198
C	GLY202

---

site_id	AD1
Number of Residues	14
Details	binding site for residue CDL C 303

Chain	Residue
A	TRP288
A	ASP298
A	THR301
A	PHE305
C	PHE92
C	PHE98
C	TRP99
C	TYR102
C	HIS103
C	ALA107
N	LEU36
N	ALA37
N	ASN40
N	ASP42

---

site_id	AD2
Number of Residues	5
Details	binding site for residue ZN F 201

Chain	Residue
F	CYS91
F	CYS93
F	CYS113
F	CYS116
F	ALA118

---

Functional Information from PROSITE/UniProt

site_id	PS00077
Number of Residues	56
Details	COX1_CUB Heme-copper oxidase catalytic subunit, copper B binding region signature. WFFGHPeVyililpgfgmishivtyysgkkepfgymgmvwammsigflgfivwa.HH

Chain	Residue	Details
A	TRP236-HIS291

---

site_id	PS00078
Number of Residues	49
Details	COX2 CO II and nitrous oxide reductase dinuclear copper centers signature. VlHswavptlglktdaipgrlnqttftatrpgvyygq......CseiCganHsfM

Chain	Residue	Details
B	VAL159-MET207

---

site_id	PS00848
Number of Residues	23
Details	COX5B_1 Cytochrome c oxidase subunit Vb, zinc binding region signature. VVWfwlhkgeaqrCprCGahYKL

Chain	Residue	Details
F	VAL100-LEU122

---

site_id	PS01329
Number of Residues	18
Details	COX6A Cytochrome c oxidase subunit VIa signature. IRtKpFpWGDGnHTlFhN

Chain	Residue	Details
G	ILE79-ASN96

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	22
Details	TRANSMEM: Helical => ECO:0000269|PubMed:30030519

Chain	Residue	Details
N	LEU15-ALA37
F	CYS93
F	CYS113
F	CYS116
A	HIS328-SER335
A	SER401-ASP406
A	LYS479-SER513

---

site_id	SWS_FT_FI2
Number of Residues	43
Details	TOPO_DOM: Mitochondrial intermembrane => ECO:0000269|PubMed:30030519

Chain	Residue	Details
N	LEU38-PHE81
F	LYS86
F	LYS121
C	TYR257-SER261

---

site_id	SWS_FT_FI3
Number of Residues	1
Details	MOD_RES: N6-acetyllysine => ECO:0000250|UniProtKB:Q62425

Chain	Residue	Details
N	LYS10
D	LYS60
A	ARG213-ASP227
A	VAL287-ASP298
A	LEU358-THR370
A	SER434-ALA446

---

site_id	SWS_FT_FI4
Number of Residues	1
Details	MOD_RES: Phosphoserine => ECO:0007744|PubMed:23186163

Chain	Residue	Details
N	SER66
C	GLU153-ASN155
C	MET224-HIS232

---

site_id	SWS_FT_FI5
Number of Residues	2
Details	MOD_RES: Phosphoserine => ECO:0000250|UniProtKB:P10888

Chain	Residue	Details
D	SER56
D	SER58
B	GLU198
B	CYS200
B	HIS204
B	MET207

---

site_id	SWS_FT_FI6
Number of Residues	1
Details	MOD_RES: N6-acetyllysine => ECO:0000250|UniProtKB:P19783

Chain	Residue	Details
D	LYS67

---

site_id	SWS_FT_FI7
Number of Residues	27
Details	TRANSMEM: Helical; Name=V => ECO:0000250|UniProtKB:P00415

Chain	Residue	Details
C	ARG156-GLU183

---

site_id	SWS_FT_FI8
Number of Residues	32
Details	TRANSMEM: Helical; Name=VI => ECO:0000250|UniProtKB:P00415

Chain	Residue	Details
C	GLY191-LEU223

---

site_id	SWS_FT_FI9
Number of Residues	23
Details	TRANSMEM: Helical; Name=VII => ECO:0000250|UniProtKB:P00415

Chain	Residue	Details
C	PHE233-ILE256

---

site_id	SWS_FT_FI10
Number of Residues	28
Details	TRANSMEM: Helical; Name=VIII => ECO:0000250|UniProtKB:P00396

Chain	Residue	Details
A	VAL299-LEU327

---

site_id	SWS_FT_FI11
Number of Residues	21
Details	TRANSMEM: Helical; Name=IX => ECO:0000250|UniProtKB:P00396

Chain	Residue	Details
A	ALA336-VAL357

---

site_id	SWS_FT_FI12
Number of Residues	29
Details	TRANSMEM: Helical; Name=X => ECO:0000250|UniProtKB:P00396

Chain	Residue	Details
A	TYR371-PHE400

---

site_id	SWS_FT_FI13
Number of Residues	26
Details	TRANSMEM: Helical; Name=XI => ECO:0000250|UniProtKB:P00396

Chain	Residue	Details
A	GLN407-LEU433

---

site_id	SWS_FT_FI14
Number of Residues	31
Details	TRANSMEM: Helical; Name=XII => ECO:0000250|UniProtKB:P00396

Chain	Residue	Details
A	TYR447-SER478

---

site_id	SWS_FT_FI15
Number of Residues	2
Details	BINDING: BINDING => ECO:0000250|UniProtKB:P00401

Chain	Residue	Details
A	GLU40
A	GLY45

---

site_id	SWS_FT_FI16
Number of Residues	3
Details	BINDING: axial binding residue => ECO:0000269|PubMed:30030519

Chain	Residue	Details
A	HIS61
A	HIS376
A	HIS378

---

site_id	SWS_FT_FI17
Number of Residues	5
Details	BINDING: BINDING => ECO:0000269|PubMed:30030519

Chain	Residue	Details
A	HIS240
A	HIS290
A	HIS291
A	HIS368
A	ASP369

---

site_id	SWS_FT_FI18
Number of Residues	1
Details	BINDING: BINDING => ECO:0000250|UniProtKB:P00396

Chain	Residue	Details
A	TYR244

---

site_id	SWS_FT_FI19
Number of Residues	2
Details	CROSSLNK: 1'-histidyl-3'-tyrosine (His-Tyr) => ECO:0000250|UniProtKB:P00396

Chain	Residue	Details
A	HIS240
A	TYR244

---