5Z62
Structure of human cytochrome c oxidase
Functional Information from GO Data
Chain | GOid | namespace | contents |
A | 0001666 | biological_process | response to hypoxia |
A | 0004129 | molecular_function | cytochrome-c oxidase activity |
A | 0005515 | molecular_function | protein binding |
A | 0005739 | cellular_component | mitochondrion |
A | 0005743 | cellular_component | mitochondrial inner membrane |
A | 0006119 | biological_process | oxidative phosphorylation |
A | 0006123 | biological_process | mitochondrial electron transport, cytochrome c to oxygen |
A | 0006979 | biological_process | response to oxidative stress |
A | 0009060 | biological_process | aerobic respiration |
A | 0015990 | biological_process | electron transport coupled proton transport |
A | 0016020 | cellular_component | membrane |
A | 0020037 | molecular_function | heme binding |
A | 0021549 | biological_process | cerebellum development |
A | 0031966 | cellular_component | mitochondrial membrane |
A | 0045277 | cellular_component | respiratory chain complex IV |
A | 0045333 | biological_process | cellular respiration |
A | 0046688 | biological_process | response to copper ion |
A | 0046872 | molecular_function | metal ion binding |
A | 0051602 | biological_process | response to electrical stimulus |
B | 0001666 | biological_process | response to hypoxia |
B | 0004129 | molecular_function | cytochrome-c oxidase activity |
B | 0005507 | molecular_function | copper ion binding |
B | 0005515 | molecular_function | protein binding |
B | 0005739 | cellular_component | mitochondrion |
B | 0005743 | cellular_component | mitochondrial inner membrane |
B | 0005759 | cellular_component | mitochondrial matrix |
B | 0006123 | biological_process | mitochondrial electron transport, cytochrome c to oxygen |
B | 0007595 | biological_process | lactation |
B | 0016020 | cellular_component | membrane |
B | 0016491 | molecular_function | oxidoreductase activity |
B | 0022900 | biological_process | electron transport chain |
B | 0031966 | cellular_component | mitochondrial membrane |
B | 0042773 | biological_process | ATP synthesis coupled electron transport |
B | 0045277 | cellular_component | respiratory chain complex IV |
B | 0045333 | biological_process | cellular respiration |
B | 0046872 | molecular_function | metal ion binding |
B | 1902600 | biological_process | proton transmembrane transport |
C | 0004129 | molecular_function | cytochrome-c oxidase activity |
C | 0005515 | molecular_function | protein binding |
C | 0005739 | cellular_component | mitochondrion |
C | 0005743 | cellular_component | mitochondrial inner membrane |
C | 0006123 | biological_process | mitochondrial electron transport, cytochrome c to oxygen |
C | 0008535 | biological_process | respiratory chain complex IV assembly |
C | 0009055 | molecular_function | electron transfer activity |
C | 0016020 | cellular_component | membrane |
C | 0019646 | biological_process | aerobic electron transport chain |
C | 0022904 | biological_process | respiratory electron transport chain |
C | 0031966 | cellular_component | mitochondrial membrane |
C | 0045277 | cellular_component | respiratory chain complex IV |
C | 0045333 | biological_process | cellular respiration |
C | 1902600 | biological_process | proton transmembrane transport |
D | 0006123 | biological_process | mitochondrial electron transport, cytochrome c to oxygen |
D | 0045277 | cellular_component | respiratory chain complex IV |
E | 0005743 | cellular_component | mitochondrial inner membrane |
E | 0006123 | biological_process | mitochondrial electron transport, cytochrome c to oxygen |
E | 0045277 | cellular_component | respiratory chain complex IV |
F | 0005740 | cellular_component | mitochondrial envelope |
F | 0006123 | biological_process | mitochondrial electron transport, cytochrome c to oxygen |
F | 0045277 | cellular_component | respiratory chain complex IV |
G | 0005743 | cellular_component | mitochondrial inner membrane |
H | 0004129 | molecular_function | cytochrome-c oxidase activity |
H | 0005739 | cellular_component | mitochondrion |
H | 0005743 | cellular_component | mitochondrial inner membrane |
H | 0006119 | biological_process | oxidative phosphorylation |
H | 0006123 | biological_process | mitochondrial electron transport, cytochrome c to oxygen |
H | 0021762 | biological_process | substantia nigra development |
H | 0031966 | cellular_component | mitochondrial membrane |
H | 0045277 | cellular_component | respiratory chain complex IV |
H | 0045333 | biological_process | cellular respiration |
H | 1902600 | biological_process | proton transmembrane transport |
I | 0005515 | molecular_function | protein binding |
I | 0005739 | cellular_component | mitochondrion |
I | 0005743 | cellular_component | mitochondrial inner membrane |
I | 0005758 | cellular_component | mitochondrial intermembrane space |
I | 0006091 | biological_process | generation of precursor metabolites and energy |
I | 0006119 | biological_process | oxidative phosphorylation |
I | 0006123 | biological_process | mitochondrial electron transport, cytochrome c to oxygen |
I | 0031966 | cellular_component | mitochondrial membrane |
I | 0045333 | biological_process | cellular respiration |
J | 0006123 | biological_process | mitochondrial electron transport, cytochrome c to oxygen |
J | 0045277 | cellular_component | respiratory chain complex IV |
K | 0006123 | biological_process | mitochondrial electron transport, cytochrome c to oxygen |
L | 0006123 | biological_process | mitochondrial electron transport, cytochrome c to oxygen |
L | 0045277 | cellular_component | respiratory chain complex IV |
M | 0006123 | biological_process | mitochondrial electron transport, cytochrome c to oxygen |
M | 0045277 | cellular_component | respiratory chain complex IV |
N | 0005515 | molecular_function | protein binding |
N | 0005739 | cellular_component | mitochondrion |
N | 0005743 | cellular_component | mitochondrial inner membrane |
N | 0006120 | biological_process | mitochondrial electron transport, NADH to ubiquinone |
N | 0006123 | biological_process | mitochondrial electron transport, cytochrome c to oxygen |
N | 0008137 | molecular_function | NADH dehydrogenase (ubiquinone) activity |
N | 0031966 | cellular_component | mitochondrial membrane |
N | 0044877 | molecular_function | protein-containing complex binding |
N | 0045277 | cellular_component | respiratory chain complex IV |
N | 0045333 | biological_process | cellular respiration |
N | 1902600 | biological_process | proton transmembrane transport |
Functional Information from PDB Data
site_id | AC1 |
Number of Residues | 3 |
Details | binding site for residue CU A 601 |
Chain | Residue |
A | HIS240 |
A | HIS290 |
A | HIS291 |
site_id | AC2 |
Number of Residues | 3 |
Details | binding site for residue MG A 602 |
Chain | Residue |
A | HIS368 |
A | ASP369 |
B | GLU198 |
site_id | AC3 |
Number of Residues | 21 |
Details | binding site for residue HEA A 603 |
Chain | Residue |
A | TYR54 |
A | VAL58 |
A | HIS61 |
A | MET65 |
A | MET69 |
A | TRP126 |
A | TYR371 |
A | PHE377 |
A | HIS378 |
A | LEU381 |
A | SER382 |
A | VAL386 |
A | MET390 |
A | GLN428 |
A | ARG438 |
A | ARG439 |
A | SER461 |
A | MET468 |
A | GLY27 |
A | THR31 |
A | ARG38 |
site_id | AC4 |
Number of Residues | 22 |
Details | binding site for residue HEA A 604 |
Chain | Residue |
A | TRP126 |
A | TRP236 |
A | VAL243 |
A | TYR244 |
A | HIS290 |
A | HIS291 |
A | ILE312 |
A | ALA313 |
A | GLY317 |
A | PHE348 |
A | GLY352 |
A | GLY355 |
A | LEU358 |
A | ALA359 |
A | ASP364 |
A | HIS368 |
A | HIS376 |
A | PHE377 |
A | VAL380 |
A | LEU381 |
A | ARG438 |
B | PRO69 |
site_id | AC5 |
Number of Residues | 11 |
Details | binding site for residue PEE A 605 |
Chain | Residue |
A | PHE94 |
A | PRO95 |
A | ARG96 |
A | MET97 |
A | LEU159 |
C | HIS9 |
C | TRP57 |
C | TRP58 |
C | GLY82 |
C | PHE86 |
C | PEE301 |
site_id | AC6 |
Number of Residues | 6 |
Details | binding site for residue CU B 301 |
Chain | Residue |
B | HIS161 |
B | CYS196 |
B | GLU198 |
B | CYS200 |
B | MET207 |
B | CU302 |
site_id | AC7 |
Number of Residues | 6 |
Details | binding site for residue CU B 302 |
Chain | Residue |
B | HIS161 |
B | CYS196 |
B | CYS200 |
B | HIS204 |
B | MET207 |
B | CU301 |
site_id | AC8 |
Number of Residues | 20 |
Details | binding site for residue PEE C 301 |
Chain | Residue |
A | PEE605 |
C | TRP58 |
C | THR62 |
C | SER65 |
C | THR66 |
C | HIS71 |
C | PHE86 |
C | GLU90 |
C | PHE93 |
C | HIS207 |
C | THR213 |
C | PHE214 |
C | ILE217 |
C | ARG221 |
C | HIS226 |
C | HIS231 |
C | HIS232 |
C | PHE233 |
C | GLY234 |
C | PEE302 |
site_id | AC9 |
Number of Residues | 14 |
Details | binding site for residue PEE C 302 |
Chain | Residue |
C | PHE203 |
C | PEE301 |
G | TRP86 |
G | THR92 |
G | LEU93 |
G | PHE94 |
G | ASN100 |
C | TYR181 |
C | SER184 |
C | PHE186 |
C | THR187 |
C | ILE188 |
C | PHE198 |
C | GLY202 |
site_id | AD1 |
Number of Residues | 14 |
Details | binding site for residue CDL C 303 |
Chain | Residue |
A | TRP288 |
A | ASP298 |
A | THR301 |
A | PHE305 |
C | PHE92 |
C | PHE98 |
C | TRP99 |
C | TYR102 |
C | HIS103 |
C | ALA107 |
N | LEU36 |
N | ALA37 |
N | ASN40 |
N | ASP42 |
site_id | AD2 |
Number of Residues | 5 |
Details | binding site for residue ZN F 201 |
Chain | Residue |
F | CYS91 |
F | CYS93 |
F | CYS113 |
F | CYS116 |
F | ALA118 |
Functional Information from PROSITE/UniProt
site_id | PS00077 |
Number of Residues | 56 |
Details | COX1_CUB Heme-copper oxidase catalytic subunit, copper B binding region signature. WFFGHPeVyililpgfgmishivtyysgkkepfgymgmvwammsigflgfivwa.HH |
Chain | Residue | Details |
A | TRP236-HIS291 |
site_id | PS00078 |
Number of Residues | 49 |
Details | COX2 CO II and nitrous oxide reductase dinuclear copper centers signature. VlHswavptlglktdaipgrlnqttftatrpgvyygq......CseiCganHsfM |
Chain | Residue | Details |
B | VAL159-MET207 |
site_id | PS00848 |
Number of Residues | 23 |
Details | COX5B_1 Cytochrome c oxidase subunit Vb, zinc binding region signature. VVWfwlhkgeaqrCprCGahYKL |
Chain | Residue | Details |
F | VAL100-LEU122 |
site_id | PS01329 |
Number of Residues | 18 |
Details | COX6A Cytochrome c oxidase subunit VIa signature. IRtKpFpWGDGnHTlFhN |
Chain | Residue | Details |
G | ILE79-ASN96 |
Functional Information from SwissProt/UniProt
site_id | SWS_FT_FI1 |
Number of Residues | 22 |
Details | TRANSMEM: Helical => ECO:0000269|PubMed:30030519 |
Chain | Residue | Details |
N | LEU15-ALA37 | |
F | CYS93 | |
F | CYS113 | |
F | CYS116 | |
A | HIS328-SER335 | |
A | SER401-ASP406 | |
A | LYS479-SER513 |
site_id | SWS_FT_FI2 |
Number of Residues | 43 |
Details | TOPO_DOM: Mitochondrial intermembrane => ECO:0000269|PubMed:30030519 |
Chain | Residue | Details |
N | LEU38-PHE81 | |
F | LYS86 | |
F | LYS121 | |
C | TYR257-SER261 |
site_id | SWS_FT_FI3 |
Number of Residues | 1 |
Details | MOD_RES: N6-acetyllysine => ECO:0000250|UniProtKB:Q62425 |
Chain | Residue | Details |
N | LYS10 | |
D | LYS60 | |
A | ARG213-ASP227 | |
A | VAL287-ASP298 | |
A | LEU358-THR370 | |
A | SER434-ALA446 |
site_id | SWS_FT_FI4 |
Number of Residues | 1 |
Details | MOD_RES: Phosphoserine => ECO:0007744|PubMed:23186163 |
Chain | Residue | Details |
N | SER66 | |
C | GLU153-ASN155 | |
C | MET224-HIS232 |
site_id | SWS_FT_FI5 |
Number of Residues | 2 |
Details | MOD_RES: Phosphoserine => ECO:0000250|UniProtKB:P10888 |
Chain | Residue | Details |
D | SER56 | |
D | SER58 | |
B | GLU198 | |
B | CYS200 | |
B | HIS204 | |
B | MET207 |
site_id | SWS_FT_FI6 |
Number of Residues | 1 |
Details | MOD_RES: N6-acetyllysine => ECO:0000250|UniProtKB:P19783 |
Chain | Residue | Details |
D | LYS67 |
site_id | SWS_FT_FI7 |
Number of Residues | 27 |
Details | TRANSMEM: Helical; Name=V => ECO:0000250|UniProtKB:P00415 |
Chain | Residue | Details |
C | ARG156-GLU183 |
site_id | SWS_FT_FI8 |
Number of Residues | 32 |
Details | TRANSMEM: Helical; Name=VI => ECO:0000250|UniProtKB:P00415 |
Chain | Residue | Details |
C | GLY191-LEU223 |
site_id | SWS_FT_FI9 |
Number of Residues | 23 |
Details | TRANSMEM: Helical; Name=VII => ECO:0000250|UniProtKB:P00415 |
Chain | Residue | Details |
C | PHE233-ILE256 |
site_id | SWS_FT_FI10 |
Number of Residues | 28 |
Details | TRANSMEM: Helical; Name=VIII => ECO:0000250|UniProtKB:P00396 |
Chain | Residue | Details |
A | VAL299-LEU327 |
site_id | SWS_FT_FI11 |
Number of Residues | 21 |
Details | TRANSMEM: Helical; Name=IX => ECO:0000250|UniProtKB:P00396 |
Chain | Residue | Details |
A | ALA336-VAL357 |
site_id | SWS_FT_FI12 |
Number of Residues | 29 |
Details | TRANSMEM: Helical; Name=X => ECO:0000250|UniProtKB:P00396 |
Chain | Residue | Details |
A | TYR371-PHE400 |
site_id | SWS_FT_FI13 |
Number of Residues | 26 |
Details | TRANSMEM: Helical; Name=XI => ECO:0000250|UniProtKB:P00396 |
Chain | Residue | Details |
A | GLN407-LEU433 |
site_id | SWS_FT_FI14 |
Number of Residues | 31 |
Details | TRANSMEM: Helical; Name=XII => ECO:0000250|UniProtKB:P00396 |
Chain | Residue | Details |
A | TYR447-SER478 |
site_id | SWS_FT_FI15 |
Number of Residues | 2 |
Details | BINDING: BINDING => ECO:0000250|UniProtKB:P00401 |
Chain | Residue | Details |
A | GLU40 | |
A | GLY45 |
site_id | SWS_FT_FI16 |
Number of Residues | 3 |
Details | BINDING: axial binding residue => ECO:0000269|PubMed:30030519 |
Chain | Residue | Details |
A | HIS61 | |
A | HIS376 | |
A | HIS378 |
site_id | SWS_FT_FI17 |
Number of Residues | 5 |
Details | BINDING: BINDING => ECO:0000269|PubMed:30030519 |
Chain | Residue | Details |
A | HIS240 | |
A | HIS290 | |
A | HIS291 | |
A | HIS368 | |
A | ASP369 |
site_id | SWS_FT_FI18 |
Number of Residues | 1 |
Details | BINDING: BINDING => ECO:0000250|UniProtKB:P00396 |
Chain | Residue | Details |
A | TYR244 |
site_id | SWS_FT_FI19 |
Number of Residues | 2 |
Details | CROSSLNK: 1'-histidyl-3'-tyrosine (His-Tyr) => ECO:0000250|UniProtKB:P00396 |
Chain | Residue | Details |
A | HIS240 | |
A | TYR244 |