5YOD
Crystal structure of zika virus NS3 protease in complex with a small molecule inhibitor
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0004252 | molecular_function | serine-type endopeptidase activity |
| A | 0044423 | cellular_component | virion component |
| B | 0003723 | molecular_function | RNA binding |
| B | 0003724 | molecular_function | RNA helicase activity |
| B | 0005524 | molecular_function | ATP binding |
| C | 0004252 | molecular_function | serine-type endopeptidase activity |
| C | 0044423 | cellular_component | virion component |
| D | 0003723 | molecular_function | RNA binding |
| D | 0003724 | molecular_function | RNA helicase activity |
| D | 0005524 | molecular_function | ATP binding |
| E | 0004252 | molecular_function | serine-type endopeptidase activity |
| E | 0044423 | cellular_component | virion component |
| F | 0003723 | molecular_function | RNA binding |
| F | 0003724 | molecular_function | RNA helicase activity |
| F | 0005524 | molecular_function | ATP binding |
| G | 0004252 | molecular_function | serine-type endopeptidase activity |
| G | 0044423 | cellular_component | virion component |
| H | 0003723 | molecular_function | RNA binding |
| H | 0003724 | molecular_function | RNA helicase activity |
| H | 0005524 | molecular_function | ATP binding |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 6 |
| Details | binding site for residue BEZ B 201 |
| Chain | Residue |
| B | HIS51 |
| B | TYR130 |
| B | ALA132 |
| B | SER135 |
| B | GLY151 |
| B | TYR161 |
| site_id | AC2 |
| Number of Residues | 7 |
| Details | binding site for residue BEZ F 201 |
| Chain | Residue |
| F | ALA132 |
| F | SER135 |
| F | GLY151 |
| F | TYR161 |
| F | HIS51 |
| F | TYR130 |
| F | PRO131 |
| site_id | AC3 |
| Number of Residues | 12 |
| Details | binding site for Di-peptide BEZ D 201 and SER D 135 |
| Chain | Residue |
| D | GLY37 |
| D | VAL38 |
| D | HIS51 |
| D | TYR130 |
| D | ALA132 |
| D | GLY133 |
| D | THR134 |
| D | GLY136 |
| D | SER137 |
| D | TYR150 |
| D | GLY151 |
| D | TYR161 |
| site_id | AC4 |
| Number of Residues | 14 |
| Details | binding site for Di-peptide BEZ H 201 and SER H 135 |
| Chain | Residue |
| H | GLY37 |
| H | VAL38 |
| H | MET49 |
| H | HIS51 |
| H | TYR130 |
| H | ALA132 |
| H | GLY133 |
| H | THR134 |
| H | GLY136 |
| H | SER137 |
| H | TYR150 |
| H | GLY151 |
| H | TYR161 |
| H | HOH359 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 88 |
| Details | Region: {"description":"Disordered","evidences":[{"source":"PubMed","id":"29080786","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI2 |
| Number of Residues | 8 |
| Details | Active site: {"description":"Charge relay system; for serine protease NS3 activity","evidences":[{"source":"PROSITE-ProRule","id":"PRU00860","evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI3 |
| Number of Residues | 4 |
| Details | Active site: {"description":"Charge relay system; for serine protease NS3 activity","evidences":[{"source":"PROSITE-ProRule","id":"PRU00860","evidenceCode":"ECO:0000255"},{"source":"PubMed","id":"29526431","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
