5YO1
Structure of ePepN E298A mutant in complex with Puromycin
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0004177 | molecular_function | aminopeptidase activity |
| A | 0005515 | molecular_function | protein binding |
| A | 0005886 | cellular_component | plasma membrane |
| A | 0006508 | biological_process | proteolysis |
| A | 0008233 | molecular_function | peptidase activity |
| A | 0008237 | molecular_function | metallopeptidase activity |
| A | 0008270 | molecular_function | zinc ion binding |
| A | 0016285 | molecular_function | alanyl aminopeptidase activity |
| A | 0016787 | molecular_function | hydrolase activity |
| A | 0042802 | molecular_function | identical protein binding |
| A | 0046872 | molecular_function | metal ion binding |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 5 |
| Details | binding site for residue ZN A 901 |
| Chain | Residue |
| A | HIS297 |
| A | HIS301 |
| A | GLU320 |
| A | HOH1148 |
| A | HOH1645 |
| site_id | AC2 |
| Number of Residues | 21 |
| Details | binding site for residue PUY A 902 |
| Chain | Residue |
| A | TYR376 |
| A | TYR381 |
| A | GLU382 |
| A | GLY787 |
| A | ARG825 |
| A | PUY903 |
| A | GOL912 |
| A | HOH1023 |
| A | HOH1062 |
| A | HOH1106 |
| A | HOH1120 |
| A | HOH1196 |
| A | HOH1247 |
| A | HOH1270 |
| A | HOH1335 |
| A | HOH1466 |
| A | HOH1486 |
| A | MET260 |
| A | ARG293 |
| A | HIS297 |
| A | ASP327 |
| site_id | AC3 |
| Number of Residues | 16 |
| Details | binding site for residue PUY A 903 |
| Chain | Residue |
| A | TYR275 |
| A | ASP290 |
| A | ARG293 |
| A | GLU382 |
| A | PUY902 |
| A | HOH1019 |
| A | HOH1023 |
| A | HOH1106 |
| A | HOH1208 |
| A | HOH1220 |
| A | HOH1283 |
| A | HOH1335 |
| A | HOH1440 |
| A | HOH1559 |
| A | HOH1627 |
| A | HOH1668 |
| site_id | AC4 |
| Number of Residues | 7 |
| Details | binding site for residue NA A 904 |
| Chain | Residue |
| A | TYR18 |
| A | ARG44 |
| A | SER48 |
| A | ALA50 |
| A | ASN85 |
| A | LEU86 |
| A | HOH1660 |
| site_id | AC5 |
| Number of Residues | 7 |
| Details | binding site for residue GOL A 905 |
| Chain | Residue |
| A | LEU532 |
| A | TRP546 |
| A | ASP566 |
| A | ALA567 |
| A | SER570 |
| A | HOH1017 |
| A | HOH1063 |
| site_id | AC6 |
| Number of Residues | 5 |
| Details | binding site for residue GOL A 906 |
| Chain | Residue |
| A | LEU61 |
| A | GLU671 |
| A | HOH1002 |
| A | HOH1232 |
| A | HOH1624 |
| site_id | AC7 |
| Number of Residues | 11 |
| Details | binding site for residue GOL A 907 |
| Chain | Residue |
| A | SER63 |
| A | VAL64 |
| A | TRP71 |
| A | TRP74 |
| A | ARG669 |
| A | VAL670 |
| A | GLU671 |
| A | GOL914 |
| A | HOH1002 |
| A | HOH1258 |
| A | HOH1415 |
| site_id | AC8 |
| Number of Residues | 9 |
| Details | binding site for residue GOL A 908 |
| Chain | Residue |
| A | ARG641 |
| A | GLU642 |
| A | THR645 |
| A | ARG686 |
| A | PHE690 |
| A | ALA722 |
| A | HOH1155 |
| A | HOH1179 |
| A | HOH1356 |
| site_id | AC9 |
| Number of Residues | 8 |
| Details | binding site for residue GOL A 909 |
| Chain | Residue |
| A | MET555 |
| A | ARG556 |
| A | ARG564 |
| A | ALA598 |
| A | ALA601 |
| A | ASP605 |
| A | ILE608 |
| A | HOH1277 |
| site_id | AD1 |
| Number of Residues | 6 |
| Details | binding site for residue GOL A 910 |
| Chain | Residue |
| A | GLU123 |
| A | ASP312 |
| A | TRP313 |
| A | PHE314 |
| A | HOH1218 |
| A | HOH1397 |
| site_id | AD2 |
| Number of Residues | 11 |
| Details | binding site for residue GOL A 911 |
| Chain | Residue |
| A | THR469 |
| A | LYS478 |
| A | GLN479 |
| A | PRO480 |
| A | HOH1286 |
| A | HOH1341 |
| A | HOH1587 |
| A | HIS11 |
| A | ARG14 |
| A | GLN467 |
| A | ARG468 |
| site_id | AD3 |
| Number of Residues | 11 |
| Details | binding site for residue GOL A 912 |
| Chain | Residue |
| A | GLU355 |
| A | ASN374 |
| A | THR377 |
| A | LEU378 |
| A | GLU828 |
| A | LYS864 |
| A | PUY902 |
| A | HOH1023 |
| A | HOH1062 |
| A | HOH1231 |
| A | HOH1638 |
| site_id | AD4 |
| Number of Residues | 6 |
| Details | binding site for residue GOL A 913 |
| Chain | Residue |
| A | ASP281 |
| A | PHE704 |
| A | LYS738 |
| A | TRP739 |
| A | HOH1027 |
| A | HOH1108 |
| site_id | AD5 |
| Number of Residues | 5 |
| Details | binding site for residue GOL A 914 |
| Chain | Residue |
| A | THR72 |
| A | TRP74 |
| A | VAL670 |
| A | GOL907 |
| A | HOH1365 |
| site_id | AD6 |
| Number of Residues | 5 |
| Details | binding site for residue GOL A 915 |
| Chain | Residue |
| A | ALA101 |
| A | GLN111 |
| A | GLY113 |
| A | HOH1008 |
| A | HOH1561 |
| site_id | AD7 |
| Number of Residues | 3 |
| Details | binding site for residue GOL A 916 |
| Chain | Residue |
| A | ARG53 |
| A | GLU77 |
| A | ALA80 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 1 |
| Details | Active site: {"description":"Proton acceptor","evidences":[{"source":"PubMed","id":"16885166","evidenceCode":"ECO:0000305"},{"source":"PubMed","id":"18416562","evidenceCode":"ECO:0000305"},{"source":"PubMed","id":"19622865","evidenceCode":"ECO:0000305"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI2 |
| Number of Residues | 8 |
| Details | Binding site: {} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI3 |
| Number of Residues | 1 |
| Details | Site: {"description":"Transition state stabilizer","evidences":[{"evidenceCode":"ECO:0000305"}]} |
| Chain | Residue | Details |
