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5YJ1

Mouse Cereblon thalidomide binding domain complexed with R-form thalidomide

Functional Information from PDB Data
site_idAC1
Number of Residues10
Detailsbinding site for residue 6EL A 501
ChainResidue
AHIS381
e6EL501
ASER382
ATRP383
ATRP389
ATRP403
APHE405
AHOH619
eTHR362
eTRP383

site_idAC2
Number of Residues4
Detailsbinding site for residue ZN A 502
ChainResidue
ACYS326
ACYS329
ACYS394
ACYS397

site_idAC3
Number of Residues6
Detailsbinding site for residue SO4 A 503
ChainResidue
ALYS367
ALYS416
DLYS367
DLYS416
GLYS367
GLYS416

site_idAC4
Number of Residues7
Detailsbinding site for residue SO4 A 504
ChainResidue
ALYS367
ALYS404
ALYS416
AHOH610
AHOH621
GPRO414
GGLN415

site_idAC5
Number of Residues11
Detailsbinding site for residue 6EL D 501
ChainResidue
DHIS381
DSER382
DTRP383
DTRP389
DTRP403
DPHE405
DHOH604
MHIS360
MTHR362
MTRP383
M6EL501

site_idAC6
Number of Residues4
Detailsbinding site for residue ZN D 502
ChainResidue
DCYS326
DCYS329
DCYS394
DCYS397

site_idAC7
Number of Residues7
Detailsbinding site for residue SO4 D 503
ChainResidue
DPRO414
DGLN415
DHOH609
DHOH627
GLYS367
GLYS404
GLYS416

site_idAC8
Number of Residues8
Detailsbinding site for residue SO4 D 504
ChainResidue
APRO414
AGLN415
DLYS367
DLYS404
DLYS416
DHOH606
DHOH616
DHOH618

site_idAC9
Number of Residues10
Detailsbinding site for residue 6EL G 501
ChainResidue
GHIS381
GTRP383
GTRP389
GTRP403
GPHE405
GHOH605
YHIS360
YTHR362
YTRP383
Y6EL501

site_idAD1
Number of Residues4
Detailsbinding site for residue ZN G 502
ChainResidue
GCYS326
GCYS329
GCYS394
GCYS397

site_idAD2
Number of Residues10
Detailsbinding site for residue 6EL J 501
ChainResidue
JHIS381
JSER382
JTRP383
JTRP389
JTRP403
JPHE405
JHOH622
bTHR362
bTRP383
b6EL501

site_idAD3
Number of Residues4
Detailsbinding site for residue ZN J 502
ChainResidue
JCYS326
JCYS329
JCYS394
JCYS397

site_idAD4
Number of Residues6
Detailsbinding site for residue SO4 J 503
ChainResidue
JLYS367
JLYS416
MLYS367
MLYS416
PLYS367
PLYS416

site_idAD5
Number of Residues3
Detailsbinding site for residue SO4 J 504
ChainResidue
JHIS381
JHOH615
bHIS381

site_idAD6
Number of Residues10
Detailsbinding site for residue 6EL M 501
ChainResidue
MTRP383
MTRP389
MTRP403
MPHE405
MHOH743
DTHR362
DTRP383
D6EL501
MHIS381
MSER382

site_idAD7
Number of Residues4
Detailsbinding site for residue ZN M 502
ChainResidue
MCYS326
MCYS329
MCYS394
MCYS397

site_idAD8
Number of Residues9
Detailsbinding site for residue SO4 M 503
ChainResidue
MLYS367
MLYS404
MLYS416
MTRP418
MHOH726
MHOH733
PPRO414
PGLN415
PLYS416

site_idAD9
Number of Residues8
Detailsbinding site for residue SO4 M 504
ChainResidue
JLYS367
JLYS416
JHOH627
MPRO414
MGLN415
MLYS416
MHOH723
MHOH728

site_idAE1
Number of Residues3
Detailsbinding site for residue SO4 M 505
ChainResidue
DHIS381
MHIS381
MHOH701

site_idAE2
Number of Residues10
Detailsbinding site for residue 6EL P 501
ChainResidue
PHIS381
PSER382
PTRP383
PTRP389
PTRP403
PPHE405
PHOH630
VTHR362
VTRP383
V6EL501

site_idAE3
Number of Residues4
Detailsbinding site for residue ZN P 502
ChainResidue
PCYS326
PCYS329
PCYS394
PCYS397

site_idAE4
Number of Residues7
Detailsbinding site for residue SO4 P 503
ChainResidue
JPRO414
JGLN415
JHOH619
PLYS367
PLYS404
PLYS416
PHOH613

site_idAE5
Number of Residues10
Detailsbinding site for residue 6EL S 501
ChainResidue
SHIS381
SSER382
STRP383
STRP389
STRP403
SPHE405
SHOH635
hTHR362
hTRP383
h6EL501

site_idAE6
Number of Residues4
Detailsbinding site for residue ZN S 502
ChainResidue
SCYS326
SCYS329
SCYS394
SCYS397

site_idAE7
Number of Residues7
Detailsbinding site for residue SO4 S 503
ChainResidue
SLYS367
SLYS404
SLYS416
SHOH620
VPRO414
VGLN415
VHOH626

site_idAE8
Number of Residues3
Detailsbinding site for residue SO4 S 504
ChainResidue
SHIS381
SHOH618
hHIS381

site_idAE9
Number of Residues10
Detailsbinding site for residue 6EL V 501
ChainResidue
PTHR362
PTRP383
P6EL501
VHIS381
VSER382
VTRP383
VTRP389
VTRP403
VPHE405
VHOH623

site_idAF1
Number of Residues4
Detailsbinding site for residue ZN V 502
ChainResidue
VCYS326
VCYS329
VCYS394
VCYS397

site_idAF2
Number of Residues6
Detailsbinding site for residue SO4 V 503
ChainResidue
SLYS367
SLYS416
VLYS367
VLYS416
YLYS367
YLYS416

site_idAF3
Number of Residues3
Detailsbinding site for residue SO4 V 504
ChainResidue
PHIS381
VHIS381
VHOH614

site_idAF4
Number of Residues9
Detailsbinding site for residue 6EL Y 501
ChainResidue
GTHR362
GTRP383
G6EL501
YHIS381
YSER382
YTRP383
YTRP389
YTRP403
YPHE405

site_idAF5
Number of Residues4
Detailsbinding site for residue ZN Y 502
ChainResidue
YCYS326
YCYS329
YCYS394
YCYS397

site_idAF6
Number of Residues8
Detailsbinding site for residue SO4 Y 503
ChainResidue
VLYS367
VLYS404
VLYS416
VHOH627
YPRO414
YGLN415
YLYS416
YHOH619

site_idAF7
Number of Residues7
Detailsbinding site for residue SO4 Y 504
ChainResidue
SPRO414
SGLN415
YLYS367
YLYS404
YLYS416
YHOH604
YHOH620

site_idAF8
Number of Residues3
Detailsbinding site for residue SO4 Y 505
ChainResidue
GHIS381
YHIS381
YHOH601

site_idAF9
Number of Residues10
Detailsbinding site for residue 6EL b 501
ChainResidue
JTHR362
JTRP383
J6EL501
bHIS381
bSER382
bTRP383
bTRP389
bTRP403
bPHE405
bHOH619

site_idAG1
Number of Residues4
Detailsbinding site for residue ZN b 502
ChainResidue
bCYS326
bCYS329
bCYS394
bCYS397

site_idAG2
Number of Residues9
Detailsbinding site for residue SO4 b 503
ChainResidue
bPRO414
bGLN415
bHOH623
eLYS367
eLYS404
eLYS416
eHOH609
eHOH625
eHOH627

site_idAG3
Number of Residues8
Detailsbinding site for residue SO4 b 504
ChainResidue
bLYS367
bLYS404
bLYS416
bHOH602
bHOH609
bHOH632
hPRO414
hGLN415

site_idAG4
Number of Residues10
Detailsbinding site for residue 6EL e 501
ChainResidue
ATHR362
ATRP383
A6EL501
eHIS381
eSER382
eTRP383
eTRP389
eTRP403
ePHE405
eHOH629

site_idAG5
Number of Residues4
Detailsbinding site for residue ZN e 502
ChainResidue
eCYS326
eCYS329
eCYS394
eCYS397

site_idAG6
Number of Residues10
Detailsbinding site for residue SO4 e 503
ChainResidue
ePRO414
eGLN415
eLYS416
eHOH603
eHOH617
eHOH636
hLYS367
hLYS404
hLYS416
hHOH615

site_idAG7
Number of Residues3
Detailsbinding site for residue SO4 e 504
ChainResidue
AHIS381
eHIS381
eHOH601

site_idAG8
Number of Residues10
Detailsbinding site for residue 6EL h 501
ChainResidue
STHR362
STRP383
S6EL501
hHIS381
hSER382
hTRP383
hTRP389
hTRP403
hPHE405
hHOH622

site_idAG9
Number of Residues4
Detailsbinding site for residue ZN h 502
ChainResidue
hCYS326
hCYS329
hCYS394
hCYS397

site_idAH1
Number of Residues6
Detailsbinding site for residue SO4 h 503
ChainResidue
bLYS367
bLYS416
eLYS367
eLYS416
hLYS367
hLYS416

site_idAH2
Number of Residues9
Detailsbinding site for residue 6EL k 501
ChainResidue
kHIS381
kSER382
kTRP383
kTRP389
kTRP403
kPHE405
tTHR362
tTRP383
t6EL501

site_idAH3
Number of Residues4
Detailsbinding site for residue ZN k 502
ChainResidue
kCYS326
kCYS329
kCYS394
kCYS397

site_idAH4
Number of Residues3
Detailsbinding site for residue SO4 k 503
ChainResidue
kHIS381
kHOH601
tHIS381

site_idAH5
Number of Residues9
Detailsbinding site for residue SO4 k 504
ChainResidue
kPRO414
kGLN415
kLYS416
kHOH604
kHOH616
nLYS367
nLYS404
nLYS416
nHOH626

site_idAH6
Number of Residues9
Detailsbinding site for residue 6EL n 501
ChainResidue
nHIS381
nSER382
nTRP383
nTRP389
nTRP403
nPHE405
qTHR362
qTRP383
q6EL501

site_idAH7
Number of Residues4
Detailsbinding site for residue ZN n 502
ChainResidue
nCYS326
nCYS329
nCYS394
nCYS397

site_idAH8
Number of Residues8
Detailsbinding site for residue SO4 n 503
ChainResidue
nPRO414
nGLN415
nHOH620
nHOH622
nHOH627
qLYS367
qLYS404
qLYS416

site_idAH9
Number of Residues7
Detailsbinding site for residue SO4 n 504
ChainResidue
kLYS367
kLYS416
kHOH604
nLYS367
nLYS416
qLYS367
qLYS416

site_idAI1
Number of Residues3
Detailsbinding site for residue SO4 n 505
ChainResidue
nHIS381
nHOH602
qHIS381

site_idAI2
Number of Residues10
Detailsbinding site for residue 6EL q 501
ChainResidue
nTHR362
nTRP383
n6EL501
qHIS381
qSER382
qTRP383
qTRP389
qTRP403
qPHE405
qHOH621

site_idAI3
Number of Residues4
Detailsbinding site for residue ZN q 502
ChainResidue
qCYS326
qCYS329
qCYS394
qCYS397

site_idAI4
Number of Residues8
Detailsbinding site for residue SO4 q 503
ChainResidue
kLYS367
kLYS404
kLYS416
kHOH606
kHOH626
kHOH631
qPRO414
qGLN415

site_idAI5
Number of Residues10
Detailsbinding site for residue 6EL t 501
ChainResidue
kHIS360
kTHR362
kTRP383
k6EL501
tHIS381
tTRP383
tTRP389
tTRP403
tPHE405
tHOH607

site_idAI6
Number of Residues4
Detailsbinding site for residue ZN t 502
ChainResidue
tCYS326
tCYS329
tCYS394
tCYS397

site_idAI7
Number of Residues9
Detailsbinding site for residue SO4 t 503
ChainResidue
tLYS367
tLYS404
tPRO414
tGLN415
tLYS416
tLYS416
tHOH614
tHOH616
tHOH622

site_idAI8
Number of Residues6
Detailsbinding site for residue SO4 t 504
ChainResidue
tLYS367
tLYS367
tLYS367
tLYS416
tLYS416
tLYS416

Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues112
DetailsBINDING: BINDING => ECO:0000269|PubMed:25108355
ChainResidueDetails
ACYS326
DHIS381
qCYS329
qHIS381
qTRP383
qTRP389
qCYS394
qCYS397
tCYS326
tCYS329
tHIS381
tTRP383
DTRP383
tTRP389
tCYS394
tCYS397
DTRP389
DCYS394
DCYS397
GCYS326
GCYS329
GHIS381
GTRP383
GTRP389
ACYS329
GCYS394
GCYS397
JCYS326
JCYS329
JHIS381
JTRP383
JTRP389
JCYS394
JCYS397
MCYS326
AHIS381
MCYS329
MHIS381
MTRP383
MTRP389
MCYS394
MCYS397
PCYS326
PCYS329
PHIS381
PTRP383
ATRP383
PTRP389
PCYS394
PCYS397
SCYS326
SCYS329
SHIS381
STRP383
STRP389
SCYS394
SCYS397
ATRP389
VCYS326
VCYS329
VHIS381
VTRP383
VTRP389
VCYS394
VCYS397
YCYS326
YCYS329
YHIS381
ACYS394
YTRP383
YTRP389
YCYS394
YCYS397
bCYS326
bCYS329
bHIS381
bTRP383
bTRP389
bCYS394
ACYS397
bCYS397
eCYS326
eCYS329
eHIS381
eTRP383
eTRP389
eCYS394
eCYS397
hCYS326
hCYS329
DCYS326
hHIS381
hTRP383
hTRP389
hCYS394
hCYS397
kCYS326
kCYS329
kHIS381
kTRP383
kTRP389
DCYS329
kCYS394
kCYS397
nCYS326
nCYS329
nHIS381
nTRP383
nTRP389
nCYS394
nCYS397
qCYS326

226707

PDB entries from 2024-10-30

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