5YE4

Crystal structure of the complex of di-acetylated histone H4 and 1A9D7 Fab fragment

Functional Information from PDB Data

site_id	AC1
Number of Residues	4
Details	binding site for residue ZN A 301

Chain	Residue
A	HIS162
B	ASP166
B	HOH517
B	HOH552

---

site_id	AC2
Number of Residues	4
Details	binding site for residue ZN A 302

Chain	Residue
A	GLU16
A	HOH547
A	HOH564
D	HOH565

---

site_id	AC3
Number of Residues	3
Details	binding site for residue ZN A 303

Chain	Residue
A	HOH451
A	HOH546
A	GLU89

---

site_id	AC4
Number of Residues	2
Details	binding site for residue ZN A 304

Chain	Residue
A	ASP31
B	ASP150

---

site_id	AC5
Number of Residues	4
Details	binding site for residue ZN A 305

Chain	Residue
A	GLU10
A	LYS19
A	HOH430
A	HOH530

---

site_id	AC6
Number of Residues	2
Details	binding site for residue ZN A 306

Chain	Residue
A	ASP62
B	ASP1

---

site_id	AC7
Number of Residues	4
Details	binding site for residue ZN A 307

Chain	Residue
A	GLN39
A	HOH489
B	HIS38
B	HOH557

---

site_id	AC8
Number of Residues	3
Details	binding site for residue ZN B 301

Chain	Residue
B	HIS197
B	HOH548
B	HOH561

---

site_id	AC9
Number of Residues	2
Details	binding site for residue ZN B 302

Chain	Residue
B	ASP92
B	HOH498

---

site_id	AD1
Number of Residues	3
Details	binding site for residue ZN B 303

Chain	Residue
B	ASP1
B	HOH405
B	HOH467

---

site_id	AD2
Number of Residues	3
Details	binding site for residue ZN B 304

Chain	Residue
B	ASP70
B	ZN305
B	HOH500

---

site_id	AD3
Number of Residues	3
Details	binding site for residue ZN B 305

Chain	Residue
B	ASP70
B	ZN304
B	HOH455

---

site_id	AD4
Number of Residues	2
Details	binding site for residue ZN B 306

Chain	Residue
B	ASP142
B	HOH556

---

site_id	AD5
Number of Residues	5
Details	binding site for residue ZN B 307

Chain	Residue
A	GLU54
A	HOH425
B	GLU184
B	ARG187
B	HIS188

---

site_id	AD6
Number of Residues	4
Details	binding site for residue ZN C 301

Chain	Residue
C	HIS162
D	ASN137
D	ZN301
D	ZN302

---

site_id	AD7
Number of Residues	4
Details	binding site for residue ZN C 302

Chain	Residue
C	ASP31
C	GLU89
C	HOH510
C	HOH515

---

site_id	AD8
Number of Residues	4
Details	binding site for residue ZN D 301

Chain	Residue
C	HIS162
C	ZN301
D	ASP166
D	ZN305

---

site_id	AD9
Number of Residues	4
Details	binding site for residue ZN D 302

Chain	Residue
C	HIS162
C	ZN301
C	HOH547
D	ASN137

---

site_id	AE1
Number of Residues	4
Details	binding site for residue ZN D 303

Chain	Residue
D	HIS188
D	HOH410
D	HOH560
D	HOH575

---

site_id	AE2
Number of Residues	5
Details	binding site for residue ZN D 304

Chain	Residue
D	HIS197
D	HOH414
D	HOH568
D	HOH578
D	HOH586

---

site_id	AE3
Number of Residues	4
Details	binding site for residue ZN D 305

Chain	Residue
D	ASP166
D	ZN301
D	HOH564
D	HOH593

---

site_id	AE4
Number of Residues	5
Details	binding site for residue ZN D 306

Chain	Residue
D	ASP92
D	HOH407
D	HOH427
D	HOH471
F	HOH109

---

site_id	AE5
Number of Residues	2
Details	binding site for residue ZN D 307

Chain	Residue
D	ASP1
D	HOH437

---

site_id	AE6
Number of Residues	3
Details	binding site for residue ZN D 308

Chain	Residue
D	ASP142
D	HOH416
D	HOH447

---

site_id	AE7
Number of Residues	1
Details	binding site for residue ZN D 309

Chain	Residue
D	GLU79

---

site_id	AE8
Number of Residues	3
Details	binding site for residue ZN D 310

Chain	Residue
D	LYS148
D	GLU194
D	HOH569

---

site_id	AE9
Number of Residues	13
Details	binding site for Di-peptide GLY E 4 and ALY E 5

Chain	Residue
E	HOH104
A	HIS35
A	ARG98
A	ASP99
A	HOH454
B	TYR49
B	TYR91
B	ARG95
B	HOH428
E	GLY2
E	ARG3
E	GLY6
E	HOH103

---

site_id	AF1
Number of Residues	13
Details	binding site for Di-peptide ALY E 5 and GLY E 6

Chain	Residue
A	HIS35
A	ARG98
A	ASP99
B	TYR49
B	TYR91
B	ARG95
B	HOH428
E	ARG3
E	GLY4
E	GLY7
E	ALY8
E	HOH103
E	HOH104

---

site_id	AF2
Number of Residues	10
Details	binding site for Di-peptide GLY E 7 and ALY E 8

Chain	Residue
A	ILE2
A	TYR27
A	TYR32
A	ARG98
A	ASP99
A	TYR100
B	TYR49
B	GLN55
E	GLY6
E	GLY9

---

site_id	AF3
Number of Residues	9
Details	binding site for Di-peptide ALY E 8 and GLY E 9

Chain	Residue
A	ILE2
A	TYR27
A	TYR32
A	ARG98
A	ASP99
A	TYR100
B	GLN55
E	GLY6
E	GLY7

---

site_id	AF4
Number of Residues	14
Details	binding site for Di-peptide GLY F 4 and ALY F 5

Chain	Residue
C	HIS35
C	ARG98
C	ASP99
D	TYR49
D	TYR91
D	ARG95
F	GLY2
F	ARG3
F	GLY6
F	HOH103
F	HOH104
F	HOH106
F	HOH107
F	HOH108

---

site_id	AF5
Number of Residues	13
Details	binding site for Di-peptide ALY F 5 and GLY F 6

Chain	Residue
C	HIS35
C	ARG98
C	ASP99
D	TYR49
D	TYR91
D	ARG95
F	ARG3
F	GLY4
F	GLY7
F	ALY8
F	HOH103
F	HOH107
F	HOH108

---

site_id	AF6
Number of Residues	9
Details	binding site for Di-peptide GLY F 7 and ALY F 8

Chain	Residue
C	ILE2
C	TYR27
C	ARG98
C	ASP99
C	TYR100
D	TYR49
D	GLN55
F	GLY6
F	GLY9

---

site_id	AF7
Number of Residues	10
Details	binding site for Di-peptide ALY F 8 and GLY F 9

Chain	Residue
C	ILE2
C	TYR27
C	ARG98
C	ASP99
C	TYR100
D	GLN55
D	PRO56
F	GLY6
F	GLY7
F	HOH105

---

Functional Information from PROSITE/UniProt

site_id	PS00290
Number of Residues	7
Details	IG_MHC Immunoglobulins and major histocompatibility complex proteins signature. YTCEATH

Chain	Residue	Details
B	TYR191-HIS197

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	2
Details	Modified residue: {"description":"Symmetric dimethylarginine; by PRMT5 and PRMT7; alternate","evidences":[{"source":"UniProtKB","id":"P62806","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

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