5Y8M
Mycobacterium tuberculosis 3-Hydroxyisobutyrate dehydrogenase (MtHIBADH) + NAD + (R)-3-hydroxyisobutyrate (R-HIBA)
Functional Information from GO Data
Chain | GOid | namespace | contents |
A | 0006574 | biological_process | valine catabolic process |
A | 0008442 | molecular_function | 3-hydroxyisobutyrate dehydrogenase activity |
A | 0009083 | biological_process | branched-chain amino acid catabolic process |
A | 0016054 | biological_process | organic acid catabolic process |
A | 0016491 | molecular_function | oxidoreductase activity |
A | 0016616 | molecular_function | oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor |
A | 0050661 | molecular_function | NADP binding |
A | 0051287 | molecular_function | NAD binding |
B | 0006574 | biological_process | valine catabolic process |
B | 0008442 | molecular_function | 3-hydroxyisobutyrate dehydrogenase activity |
B | 0009083 | biological_process | branched-chain amino acid catabolic process |
B | 0016054 | biological_process | organic acid catabolic process |
B | 0016491 | molecular_function | oxidoreductase activity |
B | 0016616 | molecular_function | oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor |
B | 0050661 | molecular_function | NADP binding |
B | 0051287 | molecular_function | NAD binding |
Functional Information from PDB Data
site_id | AC1 |
Number of Residues | 9 |
Details | binding site for residue GOL A 301 |
Chain | Residue |
A | HIS25 |
A | VAL26 |
A | VAL27 |
A | GLY44 |
A | THR76 |
A | LEU79 |
A | ALA80 |
A | HOH408 |
A | HOH496 |
site_id | AC2 |
Number of Residues | 9 |
Details | binding site for residue GOL A 302 |
Chain | Residue |
A | MET12 |
A | MET64 |
A | VAL118 |
A | LYS243 |
A | GOL303 |
A | HOH413 |
A | HOH454 |
A | HOH509 |
A | HOH567 |
site_id | AC3 |
Number of Residues | 4 |
Details | binding site for residue GOL A 303 |
Chain | Residue |
A | GLY10 |
A | ASN11 |
A | GOL302 |
A | HOH475 |
site_id | AC4 |
Number of Residues | 7 |
Details | binding site for residue AKR A 304 |
Chain | Residue |
A | ALA58 |
A | ASP59 |
A | ARG83 |
A | PRO84 |
A | ALA85 |
A | THR86 |
A | ARG143 |
site_id | AC5 |
Number of Residues | 11 |
Details | binding site for residue 9ON A 305 |
Chain | Residue |
A | ARG145 |
A | GLU149 |
A | ALA152 |
A | GLY153 |
A | LYS154 |
A | ILE155 |
A | HOH419 |
A | HOH428 |
A | HOH458 |
B | ALA253 |
B | HOH590 |
site_id | AC6 |
Number of Residues | 30 |
Details | binding site for residue NAD B 301 |
Chain | Residue |
B | GLY8 |
B | GLY10 |
B | ASN11 |
B | MET12 |
B | PHE30 |
B | ASP31 |
B | PRO32 |
B | ALA33 |
B | MET64 |
B | LEU65 |
B | PRO66 |
B | VAL70 |
B | THR93 |
B | VAL118 |
B | GLY121 |
B | LYS168 |
B | LEU240 |
B | LYS243 |
B | HOH414 |
B | HOH418 |
B | HOH419 |
B | HOH430 |
B | HOH436 |
B | HOH437 |
B | HOH460 |
B | HOH499 |
B | HOH511 |
B | HOH520 |
B | HOH522 |
B | HOH570 |
site_id | AC7 |
Number of Residues | 6 |
Details | binding site for residue HIU B 302 |
Chain | Residue |
A | ALA274 |
A | ASP275 |
B | SER119 |
B | GLY120 |
B | HOH404 |
B | HOH535 |
site_id | AC8 |
Number of Residues | 9 |
Details | binding site for residue 9ON B 303 |
Chain | Residue |
B | ALA128 |
B | GLU149 |
B | ALA152 |
B | GLY153 |
B | LYS154 |
B | HOH401 |
B | HOH528 |
B | HOH536 |
B | HOH619 |
Functional Information from PROSITE/UniProt
site_id | PS00895 |
Number of Residues | 14 |
Details | 3_HYDROXYISOBUT_DH 3-hydroxyisobutyrate dehydrogenase signature. FLGLGnMGapMSaN |
Chain | Residue | Details |
A | PHE6-ASN19 |
Functional Information from SwissProt/UniProt
site_id | SWS_FT_FI1 |
Number of Residues | 2 |
Details | ACT_SITE: ACT_SITE => ECO:0000250 |
Chain | Residue | Details |
A | LYS168 | |
B | LYS168 |
site_id | SWS_FT_FI2 |
Number of Residues | 6 |
Details | BINDING: BINDING => ECO:0000250 |
Chain | Residue | Details |
A | THR3 | |
A | THR93 | |
A | LYS243 | |
B | THR3 | |
B | THR93 | |
B | LYS243 |