5Y8M
Mycobacterium tuberculosis 3-Hydroxyisobutyrate dehydrogenase (MtHIBADH) + NAD + (R)-3-hydroxyisobutyrate (R-HIBA)
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0006574 | biological_process | L-valine catabolic process |
| A | 0008442 | molecular_function | 3-hydroxyisobutyrate dehydrogenase activity |
| A | 0009083 | biological_process | branched-chain amino acid catabolic process |
| A | 0016054 | biological_process | organic acid catabolic process |
| A | 0016491 | molecular_function | oxidoreductase activity |
| A | 0016616 | molecular_function | oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor |
| A | 0050661 | molecular_function | NADP binding |
| A | 0051287 | molecular_function | NAD binding |
| B | 0006574 | biological_process | L-valine catabolic process |
| B | 0008442 | molecular_function | 3-hydroxyisobutyrate dehydrogenase activity |
| B | 0009083 | biological_process | branched-chain amino acid catabolic process |
| B | 0016054 | biological_process | organic acid catabolic process |
| B | 0016491 | molecular_function | oxidoreductase activity |
| B | 0016616 | molecular_function | oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor |
| B | 0050661 | molecular_function | NADP binding |
| B | 0051287 | molecular_function | NAD binding |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 9 |
| Details | binding site for residue GOL A 301 |
| Chain | Residue |
| A | HIS25 |
| A | VAL26 |
| A | VAL27 |
| A | GLY44 |
| A | THR76 |
| A | LEU79 |
| A | ALA80 |
| A | HOH408 |
| A | HOH496 |
| site_id | AC2 |
| Number of Residues | 9 |
| Details | binding site for residue GOL A 302 |
| Chain | Residue |
| A | MET12 |
| A | MET64 |
| A | VAL118 |
| A | LYS243 |
| A | GOL303 |
| A | HOH413 |
| A | HOH454 |
| A | HOH509 |
| A | HOH567 |
| site_id | AC3 |
| Number of Residues | 4 |
| Details | binding site for residue GOL A 303 |
| Chain | Residue |
| A | GLY10 |
| A | ASN11 |
| A | GOL302 |
| A | HOH475 |
| site_id | AC4 |
| Number of Residues | 7 |
| Details | binding site for residue AKR A 304 |
| Chain | Residue |
| A | ALA58 |
| A | ASP59 |
| A | ARG83 |
| A | PRO84 |
| A | ALA85 |
| A | THR86 |
| A | ARG143 |
| site_id | AC5 |
| Number of Residues | 11 |
| Details | binding site for residue 9ON A 305 |
| Chain | Residue |
| A | ARG145 |
| A | GLU149 |
| A | ALA152 |
| A | GLY153 |
| A | LYS154 |
| A | ILE155 |
| A | HOH419 |
| A | HOH428 |
| A | HOH458 |
| B | ALA253 |
| B | HOH590 |
| site_id | AC6 |
| Number of Residues | 30 |
| Details | binding site for residue NAD B 301 |
| Chain | Residue |
| B | GLY8 |
| B | GLY10 |
| B | ASN11 |
| B | MET12 |
| B | PHE30 |
| B | ASP31 |
| B | PRO32 |
| B | ALA33 |
| B | MET64 |
| B | LEU65 |
| B | PRO66 |
| B | VAL70 |
| B | THR93 |
| B | VAL118 |
| B | GLY121 |
| B | LYS168 |
| B | LEU240 |
| B | LYS243 |
| B | HOH414 |
| B | HOH418 |
| B | HOH419 |
| B | HOH430 |
| B | HOH436 |
| B | HOH437 |
| B | HOH460 |
| B | HOH499 |
| B | HOH511 |
| B | HOH520 |
| B | HOH522 |
| B | HOH570 |
| site_id | AC7 |
| Number of Residues | 6 |
| Details | binding site for residue HIU B 302 |
| Chain | Residue |
| A | ALA274 |
| A | ASP275 |
| B | SER119 |
| B | GLY120 |
| B | HOH404 |
| B | HOH535 |
| site_id | AC8 |
| Number of Residues | 9 |
| Details | binding site for residue 9ON B 303 |
| Chain | Residue |
| B | ALA128 |
| B | GLU149 |
| B | ALA152 |
| B | GLY153 |
| B | LYS154 |
| B | HOH401 |
| B | HOH528 |
| B | HOH536 |
| B | HOH619 |
Functional Information from PROSITE/UniProt
| site_id | PS00895 |
| Number of Residues | 14 |
| Details | 3_HYDROXYISOBUT_DH 3-hydroxyisobutyrate dehydrogenase signature. FLGLGnMGapMSaN |
| Chain | Residue | Details |
| A | PHE6-ASN19 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 2 |
| Details | Active site: {"evidences":[{"evidenceCode":"ECO:0000250"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI2 |
| Number of Residues | 60 |
| Details | Binding site: {"evidences":[{"evidenceCode":"ECO:0000250"}]} |
| Chain | Residue | Details |
