5Y4H

Human SIRT3 in complex with halistanol sulfate

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0017136	molecular_function	NAD-dependent histone deacetylase activity
A	0051287	molecular_function	NAD binding
A	0070403	molecular_function	NAD+ binding

Functional Information from PDB Data

site_id	AC1
Number of Residues	4
Details	binding site for residue ZN A 501

Chain	Residue
A	CYS256
A	CYS259
A	CYS280
A	CYS283

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site_id	AC2
Number of Residues	10
Details	binding site for residue 8QF A 502

Chain	Residue
A	GLN300
A	ARG301
A	ARG301
A	VAL307
A	HOH601
A	LEU223
A	ARG224
A	SER242
A	LYS243
A	PRO299

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Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	1
Details	MOD_RES: N6-acetyllysine => ECO:0000269|PubMed:16788062

Chain	Residue	Details
B	ALY5

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site_id	SWS_FT_FI2
Number of Residues	4
Details	BINDING: BINDING => ECO:0000269|PubMed:23897466

Chain	Residue	Details
A	GLY145
A	GLN228
A	GLY319
A	ASN344

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site_id	SWS_FT_FI3
Number of Residues	4
Details	BINDING: BINDING => ECO:0000269|PubMed:19535340, ECO:0000269|PubMed:23897466

Chain	Residue	Details
A	CYS256
A	CYS259
A	CYS280
A	CYS283

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site_id	SWS_FT_FI4
Number of Residues	1
Details	MOD_RES: N6-succinyllysine => ECO:0000250|UniProtKB:Q8R104

Chain	Residue	Details
A	LYS122

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