5XTZ

Crystal structure of GAS41 YEATS bound to H3K27ac peptide

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0006355	biological_process	regulation of DNA-templated transcription
B	0006355	biological_process	regulation of DNA-templated transcription
C	0006355	biological_process	regulation of DNA-templated transcription
D	0006355	biological_process	regulation of DNA-templated transcription

Functional Information from PDB Data

site_id	AC1
Number of Residues	4
Details	binding site for residue ACT A 201

Chain	Residue
A	SER123
A	ASN126
B	GLU87
B	HOH203

---

site_id	AC2
Number of Residues	5
Details	binding site for residue ACT A 202

Chain	Residue
A	PHE121
A	GLN122
A	SER123
A	ASN126
A	HOH313

---

site_id	AC3
Number of Residues	13
Details	binding site for Di-peptide ARG E 26 and ALY E 27

Chain	Residue
A	HIS71
A	SER73
A	TYR74
A	GLY92
A	TRP93
A	GLY94
A	GLU95
A	PHE96
B	ASP140
E	ALA24
E	ALA25
E	SER28
E	HOH101

---

site_id	AC4
Number of Residues	11
Details	binding site for Di-peptide ALY E 27 and SER E 28

Chain	Residue
A	HIS71
A	SER73
A	TYR74
A	GLY92
A	TRP93
A	GLY94
A	GLU95
A	PHE121
B	GLN145
E	ARG26
E	ALA29

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	16
Details	Region: {"description":"Diacetylated histone H3 binding","evidences":[{"source":"PubMed","id":"29900004","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"30071723","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"5VNB","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5XTZ","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI2
Number of Residues	4
Details	Site: {"description":"Interacts with diacetylated histone H3","evidences":[{"source":"PubMed","id":"29900004","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"30071723","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"5VNB","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5XTZ","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI3
Number of Residues	6
Details	Cross-link: {"description":"Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)","evidences":[{"source":"PubMed","id":"28112733","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI4
Number of Residues	1
Details	Modified residue: {"description":"N6-methyllysine; alternate","evidences":[{"source":"PubMed","id":"17194708","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI5
Number of Residues	1
Details	Modified residue: {"description":"Citrulline","evidences":[{"source":"PubMed","id":"16567635","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---