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5XJC

Cryo-EM structure of the human spliceosome just prior to exon ligation at 3.6 angstrom

This is a non-PDB format compatible entry.
Functional Information from GO Data
ChainGOidnamespacecontents
A0000244biological_processspliceosomal tri-snRNP complex assembly
A0000375biological_processRNA splicing, via transesterification reactions
A0000398biological_processmRNA splicing, via spliceosome
A0003723molecular_functionRNA binding
A0005515molecular_functionprotein binding
A0005634cellular_componentnucleus
A0005654cellular_componentnucleoplasm
A0005681cellular_componentspliceosomal complex
A0005682cellular_componentU5 snRNP
A0006397biological_processmRNA processing
A0008233molecular_functionpeptidase activity
A0008237molecular_functionmetallopeptidase activity
A0008380biological_processRNA splicing
A0016020cellular_componentmembrane
A0016607cellular_componentnuclear speck
A0017070molecular_functionU6 snRNA binding
A0030532cellular_componentsmall nuclear ribonucleoprotein complex
A0030619molecular_functionU1 snRNA binding
A0030620molecular_functionU2 snRNA binding
A0030623molecular_functionU5 snRNA binding
A0046540cellular_componentU4/U6 x U5 tri-snRNP complex
A0070530molecular_functionK63-linked polyubiquitin modification-dependent protein binding
A0071005cellular_componentU2-type precatalytic spliceosome
A0071006cellular_componentU2-type catalytic step 1 spliceosome
A0071007cellular_componentU2-type catalytic step 2 spliceosome
A0071013cellular_componentcatalytic step 2 spliceosome
A0071222biological_processcellular response to lipopolysaccharide
A0071356biological_processcellular response to tumor necrosis factor
A0097157molecular_functionpre-mRNA intronic binding
A0140492molecular_functionmetal-dependent deubiquitinase activity
C0000398biological_processmRNA splicing, via spliceosome
C0003723molecular_functionRNA binding
C0003924molecular_functionGTPase activity
C0005515molecular_functionprotein binding
C0005525molecular_functionGTP binding
C0005634cellular_componentnucleus
C0005654cellular_componentnucleoplasm
C0005681cellular_componentspliceosomal complex
C0005829cellular_componentcytosol
C0006397biological_processmRNA processing
C0008380biological_processRNA splicing
C0015030cellular_componentCajal body
C0016020cellular_componentmembrane
C0016607cellular_componentnuclear speck
C0030623molecular_functionU5 snRNA binding
C0042220biological_processresponse to cocaine
C0043231cellular_componentintracellular membrane-bounded organelle
C0046540cellular_componentU4/U6 x U5 tri-snRNP complex
C0071005cellular_componentU2-type precatalytic spliceosome
C0071007cellular_componentU2-type catalytic step 2 spliceosome
C0071013cellular_componentcatalytic step 2 spliceosome
C0071466biological_processcellular response to xenobiotic stimulus
D0000354biological_processcis assembly of pre-catalytic spliceosome
D0000388biological_processspliceosome conformational change to release U4 (or U4atac) and U1 (or U11)
D0000398biological_processmRNA splicing, via spliceosome
D0001649biological_processosteoblast differentiation
D0003676molecular_functionnucleic acid binding
D0003689molecular_functionDNA clamp loader activity
D0003723molecular_functionRNA binding
D0003724molecular_functionRNA helicase activity
D0004386molecular_functionhelicase activity
D0005515molecular_functionprotein binding
D0005524molecular_functionATP binding
D0005634cellular_componentnucleus
D0005654cellular_componentnucleoplasm
D0005681cellular_componentspliceosomal complex
D0005682cellular_componentU5 snRNP
D0006338biological_processchromatin remodeling
D0006397biological_processmRNA processing
D0008380biological_processRNA splicing
D0016020cellular_componentmembrane
D0016787molecular_functionhydrolase activity
D0016887molecular_functionATP hydrolysis activity
D0042802molecular_functionidentical protein binding
D0046540cellular_componentU4/U6 x U5 tri-snRNP complex
D0061775molecular_functioncohesin loader activity
D0071005cellular_componentU2-type precatalytic spliceosome
D0071006cellular_componentU2-type catalytic step 1 spliceosome
D0071013cellular_componentcatalytic step 2 spliceosome
D0140584molecular_functionchromatin extrusion motor activity
D0140588biological_processchromatin looping
D0140665molecular_functionATP-dependent H3-H4 histone complex chaperone activity
D0140849molecular_functionATP-dependent H2AZ histone chaperone activity
E0000375biological_processRNA splicing, via transesterification reactions
E0000398biological_processmRNA splicing, via spliceosome
E0003723molecular_functionRNA binding
E0005515molecular_functionprotein binding
E0005634cellular_componentnucleus
E0005654cellular_componentnucleoplasm
E0005681cellular_componentspliceosomal complex
E0005682cellular_componentU5 snRNP
E0005732cellular_componentsno(s)RNA-containing ribonucleoprotein complex
E0005829cellular_componentcytosol
E0006396biological_processRNA processing
E0006397biological_processmRNA processing
E0008380biological_processRNA splicing
E0016607cellular_componentnuclear speck
E0046540cellular_componentU4/U6 x U5 tri-snRNP complex
E0071007cellular_componentU2-type catalytic step 2 spliceosome
E0071013cellular_componentcatalytic step 2 spliceosome
I0000349biological_processgeneration of catalytic spliceosome for first transesterification step
I0000398biological_processmRNA splicing, via spliceosome
I0000974cellular_componentPrp19 complex
I0001824biological_processblastocyst development
I0005515molecular_functionprotein binding
I0005634cellular_componentnucleus
I0005654cellular_componentnucleoplasm
I0005681cellular_componentspliceosomal complex
I0006281biological_processDNA repair
I0006283biological_processtranscription-coupled nucleotide-excision repair
I0006351biological_processDNA-templated transcription
I0006396biological_processRNA processing
I0006397biological_processmRNA processing
I0008380biological_processRNA splicing
I0016020cellular_componentmembrane
I0043231cellular_componentintracellular membrane-bounded organelle
I0071007cellular_componentU2-type catalytic step 2 spliceosome
I0071013cellular_componentcatalytic step 2 spliceosome
I0071014cellular_componentpost-mRNA release spliceosomal complex
J0000245biological_processspliceosomal complex assembly
J0000398biological_processmRNA splicing, via spliceosome
J0000974cellular_componentPrp19 complex
J0003723molecular_functionRNA binding
J0005515molecular_functionprotein binding
J0005634cellular_componentnucleus
J0005654cellular_componentnucleoplasm
J0005681cellular_componentspliceosomal complex
J0006396biological_processRNA processing
J0006397biological_processmRNA processing
J0008380biological_processRNA splicing
J0016607cellular_componentnuclear speck
J0071007cellular_componentU2-type catalytic step 2 spliceosome
J0071013cellular_componentcatalytic step 2 spliceosome
J0071014cellular_componentpost-mRNA release spliceosomal complex
K0000375biological_processRNA splicing, via transesterification reactions
K0000380biological_processalternative mRNA splicing, via spliceosome
K0000398biological_processmRNA splicing, via spliceosome
K0000974cellular_componentPrp19 complex
K0001541biological_processovarian follicle development
K0005515molecular_functionprotein binding
K0005634cellular_componentnucleus
K0005654cellular_componentnucleoplasm
K0005662cellular_componentDNA replication factor A complex
K0005681cellular_componentspliceosomal complex
K0005730cellular_componentnucleolus
K0005813cellular_componentcentrosome
K0006397biological_processmRNA processing
K0008380biological_processRNA splicing
K0016607cellular_componentnuclear speck
K0030163biological_processprotein catabolic process
K0048477biological_processoogenesis
K0048599biological_processoocyte development
K0051225biological_processspindle assembly
K0071007cellular_componentU2-type catalytic step 2 spliceosome
K0071013cellular_componentcatalytic step 2 spliceosome
L0000077biological_processDNA damage checkpoint signaling
L0000398biological_processmRNA splicing, via spliceosome
L0000974cellular_componentPrp19 complex
L0000977molecular_functionRNA polymerase II transcription regulatory region sequence-specific DNA binding
L0000981molecular_functionDNA-binding transcription factor activity, RNA polymerase II-specific
L0001228molecular_functionDNA-binding transcription activator activity, RNA polymerase II-specific
L0003677molecular_functionDNA binding
L0003723molecular_functionRNA binding
L0005515molecular_functionprotein binding
L0005634cellular_componentnucleus
L0005654cellular_componentnucleoplasm
L0005662cellular_componentDNA replication factor A complex
L0005681cellular_componentspliceosomal complex
L0005737cellular_componentcytoplasm
L0006281biological_processDNA repair
L0006357biological_processregulation of transcription by RNA polymerase II
L0006397biological_processmRNA processing
L0008380biological_processRNA splicing
L0016020cellular_componentmembrane
L0016607cellular_componentnuclear speck
L0042802molecular_functionidentical protein binding
L0045944biological_processpositive regulation of transcription by RNA polymerase II
L0071007cellular_componentU2-type catalytic step 2 spliceosome
L0071013cellular_componentcatalytic step 2 spliceosome
L0071987molecular_functionWD40-repeat domain binding
M0000398biological_processmRNA splicing, via spliceosome
M0000974cellular_componentPrp19 complex
M0001701biological_processin utero embryonic development
M0003723molecular_functionRNA binding
M0005515molecular_functionprotein binding
M0005634cellular_componentnucleus
M0005654cellular_componentnucleoplasm
M0005681cellular_componentspliceosomal complex
M0006397biological_processmRNA processing
M0007095biological_processmitotic G2 DNA damage checkpoint signaling
M0007369biological_processgastrulation
M0008284biological_processpositive regulation of cell population proliferation
M0008380biological_processRNA splicing
M0016607cellular_componentnuclear speck
M0048568biological_processembryonic organ development
M0071007cellular_componentU2-type catalytic step 2 spliceosome
M0071013cellular_componentcatalytic step 2 spliceosome
M0071014cellular_componentpost-mRNA release spliceosomal complex
N0000398biological_processmRNA splicing, via spliceosome
N0000785cellular_componentchromatin
N0005515molecular_functionprotein binding
N0005634cellular_componentnucleus
N0005654cellular_componentnucleoplasm
N0005681cellular_componentspliceosomal complex
N0006397biological_processmRNA processing
N0008380biological_processRNA splicing
N0016922molecular_functionnuclear receptor binding
N0030374molecular_functionnuclear receptor coactivator activity
N0045893biological_processpositive regulation of DNA-templated transcription
N0071007cellular_componentU2-type catalytic step 2 spliceosome
N2000825biological_processpositive regulation of androgen receptor activity
O0000398biological_processmRNA splicing, via spliceosome
O0000974cellular_componentPrp19 complex
O0003676molecular_functionnucleic acid binding
O0003723molecular_functionRNA binding
O0005515molecular_functionprotein binding
O0005634cellular_componentnucleus
O0005654cellular_componentnucleoplasm
O0005681cellular_componentspliceosomal complex
O0005737cellular_componentcytoplasm
O0006397biological_processmRNA processing
O0008380biological_processRNA splicing
O0017070molecular_functionU6 snRNA binding
O0033120biological_processpositive regulation of RNA splicing
O0036002molecular_functionpre-mRNA binding
O0042307biological_processpositive regulation of protein import into nucleus
O0045292biological_processmRNA cis splicing, via spliceosome
O0046827biological_processpositive regulation of protein export from nucleus
O0046872molecular_functionmetal ion binding
O0048306molecular_functioncalcium-dependent protein binding
O0071006cellular_componentU2-type catalytic step 1 spliceosome
O0071007cellular_componentU2-type catalytic step 2 spliceosome
O0071013cellular_componentcatalytic step 2 spliceosome
O0071466biological_processcellular response to xenobiotic stimulus
P0000398biological_processmRNA splicing, via spliceosome
P0000974cellular_componentPrp19 complex
P0003723molecular_functionRNA binding
P0005515molecular_functionprotein binding
P0005634cellular_componentnucleus
P0005654cellular_componentnucleoplasm
P0005681cellular_componentspliceosomal complex
P0005739cellular_componentmitochondrion
P0006397biological_processmRNA processing
P0008380biological_processRNA splicing
P0016607cellular_componentnuclear speck
P0045292biological_processmRNA cis splicing, via spliceosome
P0071007cellular_componentU2-type catalytic step 2 spliceosome
P0071013cellular_componentcatalytic step 2 spliceosome
Q0000398biological_processmRNA splicing, via spliceosome
Q0003689molecular_functionDNA clamp loader activity
Q0003723molecular_functionRNA binding
Q0003724molecular_functionRNA helicase activity
Q0003727molecular_functionsingle-stranded RNA binding
Q0003729molecular_functionmRNA binding
Q0004386molecular_functionhelicase activity
Q0005515molecular_functionprotein binding
Q0005524molecular_functionATP binding
Q0005634cellular_componentnucleus
Q0005654cellular_componentnucleoplasm
Q0005681cellular_componentspliceosomal complex
Q0006338biological_processchromatin remodeling
Q0006397biological_processmRNA processing
Q0008380biological_processRNA splicing
Q0016020cellular_componentmembrane
Q0016787molecular_functionhydrolase activity
Q0016887molecular_functionATP hydrolysis activity
Q0034458molecular_function3'-5' RNA helicase activity
Q0061775molecular_functioncohesin loader activity
Q0071007cellular_componentU2-type catalytic step 2 spliceosome
Q0071013cellular_componentcatalytic step 2 spliceosome
Q0140584molecular_functionchromatin extrusion motor activity
Q0140588biological_processchromatin looping
Q0140665molecular_functionATP-dependent H3-H4 histone complex chaperone activity
Q0140849molecular_functionATP-dependent H2AZ histone chaperone activity
R0000122biological_processnegative regulation of transcription by RNA polymerase II
R0000398biological_processmRNA splicing, via spliceosome
R0003713molecular_functiontranscription coactivator activity
R0003714molecular_functiontranscription corepressor activity
R0003723molecular_functionRNA binding
R0005112molecular_functionNotch binding
R0005515molecular_functionprotein binding
R0005634cellular_componentnucleus
R0005654cellular_componentnucleoplasm
R0005681cellular_componentspliceosomal complex
R0006357biological_processregulation of transcription by RNA polymerase II
R0006397biological_processmRNA processing
R0008024cellular_componentcyclin/CDK positive transcription elongation factor complex
R0008380biological_processRNA splicing
R0016363cellular_componentnuclear matrix
R0016604cellular_componentnuclear body
R0016607cellular_componentnuclear speck
R0016922molecular_functionnuclear receptor binding
R0019899molecular_functionenzyme binding
R0030511biological_processpositive regulation of transforming growth factor beta receptor signaling pathway
R0042771biological_processintrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator
R0042809molecular_functionnuclear vitamin D receptor binding
R0042974molecular_functionnuclear retinoic acid receptor binding
R0043923biological_processpositive regulation by host of viral transcription
R0045892biological_processnegative regulation of DNA-templated transcription
R0045944biological_processpositive regulation of transcription by RNA polymerase II
R0046332molecular_functionSMAD binding
R0048026biological_processpositive regulation of mRNA splicing, via spliceosome
R0048384biological_processretinoic acid receptor signaling pathway
R0048385biological_processregulation of retinoic acid receptor signaling pathway
R0050681molecular_functionnuclear androgen receptor binding
R0050769biological_processpositive regulation of neurogenesis
R0070562biological_processregulation of vitamin D receptor signaling pathway
R0070564biological_processpositive regulation of vitamin D receptor signaling pathway
R0071007cellular_componentU2-type catalytic step 2 spliceosome
R0071013cellular_componentcatalytic step 2 spliceosome
R0071300biological_processcellular response to retinoic acid
S0000398biological_processmRNA splicing, via spliceosome
S0000413biological_processprotein peptidyl-prolyl isomerization
S0003755molecular_functionpeptidyl-prolyl cis-trans isomerase activity
S0005515molecular_functionprotein binding
S0005634cellular_componentnucleus
S0005654cellular_componentnucleoplasm
S0005681cellular_componentspliceosomal complex
S0006357biological_processregulation of transcription by RNA polymerase II
S0006397biological_processmRNA processing
S0006457biological_processprotein folding
S0008380biological_processRNA splicing
S0071007cellular_componentU2-type catalytic step 2 spliceosome
S0071013cellular_componentcatalytic step 2 spliceosome
S0097718molecular_functiondisordered domain specific binding
S0140839molecular_functionRNA polymerase II CTD heptapeptide repeat P3 isomerase activity
S0140840molecular_functionRNA polymerase II CTD heptapeptide repeat P6 isomerase activity
S1990403biological_processembryonic brain development
T0000398biological_processmRNA splicing, via spliceosome
T0000974cellular_componentPrp19 complex
T0001650cellular_componentfibrillar center
T0005515molecular_functionprotein binding
T0005634cellular_componentnucleus
T0005654cellular_componentnucleoplasm
T0005662cellular_componentDNA replication factor A complex
T0005681cellular_componentspliceosomal complex
T0006397biological_processmRNA processing
T0008380biological_processRNA splicing
T0016607cellular_componentnuclear speck
T0031965cellular_componentnuclear membrane
T0034504biological_processprotein localization to nucleus
T0071007cellular_componentU2-type catalytic step 2 spliceosome
T0071013cellular_componentcatalytic step 2 spliceosome
T1900087biological_processpositive regulation of G1/S transition of mitotic cell cycle
U0000398biological_processmRNA splicing, via spliceosome
U0003723molecular_functionRNA binding
U0003729molecular_functionmRNA binding
U0005515molecular_functionprotein binding
U0005634cellular_componentnucleus
U0005654cellular_componentnucleoplasm
U0005681cellular_componentspliceosomal complex
U0006397biological_processmRNA processing
U0008380biological_processRNA splicing
U0015030cellular_componentCajal body
U0016607cellular_componentnuclear speck
U0070742molecular_functionC2H2 zinc finger domain binding
U0071005cellular_componentU2-type precatalytic spliceosome
U0071007cellular_componentU2-type catalytic step 2 spliceosome
U0071013cellular_componentcatalytic step 2 spliceosome
V0000398biological_processmRNA splicing, via spliceosome
V0003723molecular_functionRNA binding
V0005515molecular_functionprotein binding
V0005634cellular_componentnucleus
V0005654cellular_componentnucleoplasm
V0005681cellular_componentspliceosomal complex
V0005829cellular_componentcytosol
V0006397biological_processmRNA processing
V0008380biological_processRNA splicing
V0016607cellular_componentnuclear speck
V0048024biological_processregulation of mRNA splicing, via spliceosome
V0071005cellular_componentU2-type precatalytic spliceosome
V0071006cellular_componentU2-type catalytic step 1 spliceosome
V0071007cellular_componentU2-type catalytic step 2 spliceosome
V0071013cellular_componentcatalytic step 2 spliceosome
W0000398biological_processmRNA splicing, via spliceosome
W0003723molecular_functionRNA binding
W0003729molecular_functionmRNA binding
W0005515molecular_functionprotein binding
W0005634cellular_componentnucleus
W0005654cellular_componentnucleoplasm
W0005681cellular_componentspliceosomal complex
W0006397biological_processmRNA processing
W0008380biological_processRNA splicing
W0016607cellular_componentnuclear speck
W0071007cellular_componentU2-type catalytic step 2 spliceosome
W0071013cellular_componentcatalytic step 2 spliceosome
W1990403biological_processembryonic brain development
X0003014biological_processrenal system process
X0003725molecular_functiondouble-stranded RNA binding
X0004860molecular_functionprotein kinase inhibitor activity
X0005515molecular_functionprotein binding
X0005634cellular_componentnucleus
X0005654cellular_componentnucleoplasm
X0005681cellular_componentspliceosomal complex
X0005730cellular_componentnucleolus
X0006397biological_processmRNA processing
X0006469biological_processnegative regulation of protein kinase activity
X0008380biological_processRNA splicing
X0019901molecular_functionprotein kinase binding
X0042326biological_processnegative regulation of phosphorylation
X0070062cellular_componentextracellular exosome
Y0000398biological_processmRNA splicing, via spliceosome
Y0003676molecular_functionnucleic acid binding
Y0003689molecular_functionDNA clamp loader activity
Y0003723molecular_functionRNA binding
Y0003724molecular_functionRNA helicase activity
Y0004386molecular_functionhelicase activity
Y0005515molecular_functionprotein binding
Y0005524molecular_functionATP binding
Y0005634cellular_componentnucleus
Y0005654cellular_componentnucleoplasm
Y0005681cellular_componentspliceosomal complex
Y0005829cellular_componentcytosol
Y0006338biological_processchromatin remodeling
Y0006396biological_processRNA processing
Y0006397biological_processmRNA processing
Y0008186molecular_functionATP-dependent activity, acting on RNA
Y0008380biological_processRNA splicing
Y0016604cellular_componentnuclear body
Y0016787molecular_functionhydrolase activity
Y0016887molecular_functionATP hydrolysis activity
Y0042802molecular_functionidentical protein binding
Y0061775molecular_functioncohesin loader activity
Y0071007cellular_componentU2-type catalytic step 2 spliceosome
Y0071013cellular_componentcatalytic step 2 spliceosome
Y0140584molecular_functionchromatin extrusion motor activity
Y0140588biological_processchromatin looping
Y0140665molecular_functionATP-dependent H3-H4 histone complex chaperone activity
Y0140849molecular_functionATP-dependent H2AZ histone chaperone activity
Z0000375biological_processRNA splicing, via transesterification reactions
Z0000380biological_processalternative mRNA splicing, via spliceosome
Z0000386molecular_functionsecond spliceosomal transesterification activity
Z0000389biological_processmRNA 3'-splice site recognition
Z0000398biological_processmRNA splicing, via spliceosome
Z0005515molecular_functionprotein binding
Z0005634cellular_componentnucleus
Z0005654cellular_componentnucleoplasm
Z0005681cellular_componentspliceosomal complex
Z0005737cellular_componentcytoplasm
Z0005829cellular_componentcytosol
Z0006397biological_processmRNA processing
Z0006886biological_processintracellular protein transport
Z0008270molecular_functionzinc ion binding
Z0008380biological_processRNA splicing
Z0016020cellular_componentmembrane
Z0016607cellular_componentnuclear speck
Z0030532cellular_componentsmall nuclear ribonucleoprotein complex
Z0030628molecular_functionpre-mRNA 3'-splice site binding
Z0034605biological_processcellular response to heat
Z0043231cellular_componentintracellular membrane-bounded organelle
Z0046872molecular_functionmetal ion binding
Z0071013cellular_componentcatalytic step 2 spliceosome
a0000243cellular_componentcommitment complex
a0000387biological_processspliceosomal snRNP assembly
a0000398biological_processmRNA splicing, via spliceosome
a0003723molecular_functionRNA binding
a0005515molecular_functionprotein binding
a0005634cellular_componentnucleus
a0005654cellular_componentnucleoplasm
a0005681cellular_componentspliceosomal complex
a0005682cellular_componentU5 snRNP
a0005683cellular_componentU7 snRNP
a0005684cellular_componentU2-type spliceosomal complex
a0005685cellular_componentU1 snRNP
a0005686cellular_componentU2 snRNP
a0005687cellular_componentU4 snRNP
a0005689cellular_componentU12-type spliceosomal complex
a0005697cellular_componenttelomerase holoenzyme complex
a0005737cellular_componentcytoplasm
a0005829cellular_componentcytosol
a0006396biological_processRNA processing
a0006397biological_processmRNA processing
a0006479biological_processprotein methylation
a0008380biological_processRNA splicing
a0016604cellular_componentnuclear body
a0019899molecular_functionenzyme binding
a0030532cellular_componentsmall nuclear ribonucleoprotein complex
a0034709cellular_componentmethylosome
a0034715cellular_componentpICln-Sm protein complex
a0034719cellular_componentSMN-Sm protein complex
a0036261biological_process7-methylguanosine cap hypermethylation
a0046540cellular_componentU4/U6 x U5 tri-snRNP complex
a0070034molecular_functiontelomerase RNA binding
a0071005cellular_componentU2-type precatalytic spliceosome
a0071007cellular_componentU2-type catalytic step 2 spliceosome
a0071011cellular_componentprecatalytic spliceosome
a0071013cellular_componentcatalytic step 2 spliceosome
a0071208molecular_functionhistone pre-mRNA DCP binding
a0071209molecular_functionU7 snRNA binding
a0097526cellular_componentspliceosomal tri-snRNP complex
a1903241biological_processU2-type prespliceosome assembly
b0000387biological_processspliceosomal snRNP assembly
b0000398biological_processmRNA splicing, via spliceosome
b0003723molecular_functionRNA binding
b0005515molecular_functionprotein binding
b0005634cellular_componentnucleus
b0005654cellular_componentnucleoplasm
b0005681cellular_componentspliceosomal complex
b0005682cellular_componentU5 snRNP
b0005683cellular_componentU7 snRNP
b0005684cellular_componentU2-type spliceosomal complex
b0005685cellular_componentU1 snRNP
b0005686cellular_componentU2 snRNP
b0005687cellular_componentU4 snRNP
b0005689cellular_componentU12-type spliceosomal complex
b0005697cellular_componenttelomerase holoenzyme complex
b0005737cellular_componentcytoplasm
b0005829cellular_componentcytosol
b0006397biological_processmRNA processing
b0006479biological_processprotein methylation
b0008380biological_processRNA splicing
b0030532cellular_componentsmall nuclear ribonucleoprotein complex
b0034709cellular_componentmethylosome
b0034719cellular_componentSMN-Sm protein complex
b0036261biological_process7-methylguanosine cap hypermethylation
b0046540cellular_componentU4/U6 x U5 tri-snRNP complex
b0070034molecular_functiontelomerase RNA binding
b0070990molecular_functionsnRNP binding
b0071004cellular_componentU2-type prespliceosome
b0071005cellular_componentU2-type precatalytic spliceosome
b0071007cellular_componentU2-type catalytic step 2 spliceosome
b0071013cellular_componentcatalytic step 2 spliceosome
b0071204cellular_componenthistone pre-mRNA 3'end processing complex
b0071208molecular_functionhistone pre-mRNA DCP binding
b1903241biological_processU2-type prespliceosome assembly
b1990446molecular_functionU1 snRNP binding
b1990447molecular_functionU2 snRNP binding
c0000243cellular_componentcommitment complex
c0000245biological_processspliceosomal complex assembly
c0000387biological_processspliceosomal snRNP assembly
c0000398biological_processmRNA splicing, via spliceosome
c0003723molecular_functionRNA binding
c0005515molecular_functionprotein binding
c0005634cellular_componentnucleus
c0005654cellular_componentnucleoplasm
c0005681cellular_componentspliceosomal complex
c0005682cellular_componentU5 snRNP
c0005684cellular_componentU2-type spliceosomal complex
c0005685cellular_componentU1 snRNP
c0005686cellular_componentU2 snRNP
c0005687cellular_componentU4 snRNP
c0005689cellular_componentU12-type spliceosomal complex
c0005737cellular_componentcytoplasm
c0005829cellular_componentcytosol
c0006396biological_processRNA processing
c0006397biological_processmRNA processing
c0008380biological_processRNA splicing
c0030532cellular_componentsmall nuclear ribonucleoprotein complex
c0034709cellular_componentmethylosome
c0034715cellular_componentpICln-Sm protein complex
c0034719cellular_componentSMN-Sm protein complex
c0036261biological_process7-methylguanosine cap hypermethylation
c0046540cellular_componentU4/U6 x U5 tri-snRNP complex
c0071005cellular_componentU2-type precatalytic spliceosome
c0071007cellular_componentU2-type catalytic step 2 spliceosome
c0071011cellular_componentprecatalytic spliceosome
c0071013cellular_componentcatalytic step 2 spliceosome
c0097526cellular_componentspliceosomal tri-snRNP complex
c1903241biological_processU2-type prespliceosome assembly
c1990446molecular_functionU1 snRNP binding
d0000245biological_processspliceosomal complex assembly
d0000387biological_processspliceosomal snRNP assembly
d0000398biological_processmRNA splicing, via spliceosome
d0003723molecular_functionRNA binding
d0005515molecular_functionprotein binding
d0005634cellular_componentnucleus
d0005654cellular_componentnucleoplasm
d0005681cellular_componentspliceosomal complex
d0005682cellular_componentU5 snRNP
d0005684cellular_componentU2-type spliceosomal complex
d0005685cellular_componentU1 snRNP
d0005686cellular_componentU2 snRNP
d0005687cellular_componentU4 snRNP
d0005689cellular_componentU12-type spliceosomal complex
d0005737cellular_componentcytoplasm
d0005829cellular_componentcytosol
d0006397biological_processmRNA processing
d0008380biological_processRNA splicing
d0030532cellular_componentsmall nuclear ribonucleoprotein complex
d0034709cellular_componentmethylosome
d0034715cellular_componentpICln-Sm protein complex
d0034719cellular_componentSMN-Sm protein complex
d0036261biological_process7-methylguanosine cap hypermethylation
d0046540cellular_componentU4/U6 x U5 tri-snRNP complex
d0070062cellular_componentextracellular exosome
d0071005cellular_componentU2-type precatalytic spliceosome
d0071007cellular_componentU2-type catalytic step 2 spliceosome
d0071011cellular_componentprecatalytic spliceosome
d0071013cellular_componentcatalytic step 2 spliceosome
d1903241biological_processU2-type prespliceosome assembly
e0000245biological_processspliceosomal complex assembly
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e0005737cellular_componentcytoplasm
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e0034709cellular_componentmethylosome
e0034715cellular_componentpICln-Sm protein complex
e0034719cellular_componentSMN-Sm protein complex
e0036261biological_process7-methylguanosine cap hypermethylation
e0046540cellular_componentU4/U6 x U5 tri-snRNP complex
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e0071013cellular_componentcatalytic step 2 spliceosome
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g0071005cellular_componentU2-type precatalytic spliceosome
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h0000243cellular_componentcommitment complex
h0000387biological_processspliceosomal snRNP assembly
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h0003723molecular_functionRNA binding
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h0005654cellular_componentnucleoplasm
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h0005683cellular_componentU7 snRNP
h0005684cellular_componentU2-type spliceosomal complex
h0005685cellular_componentU1 snRNP
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h0005687cellular_componentU4 snRNP
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h0005829cellular_componentcytosol
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h0008380biological_processRNA splicing
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h0071011cellular_componentprecatalytic spliceosome
h0071013cellular_componentcatalytic step 2 spliceosome
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h1903241biological_processU2-type prespliceosome assembly
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i0005684cellular_componentU2-type spliceosomal complex
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m0000398biological_processmRNA splicing, via spliceosome
m0003723molecular_functionRNA binding
m0005515molecular_functionprotein binding
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m0005654cellular_componentnucleoplasm
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m0005683cellular_componentU7 snRNP
m0005684cellular_componentU2-type spliceosomal complex
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m0005687cellular_componentU4 snRNP
m0005689cellular_componentU12-type spliceosomal complex
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m0008380biological_processRNA splicing
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m0034709cellular_componentmethylosome
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m0034719cellular_componentSMN-Sm protein complex
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m0071005cellular_componentU2-type precatalytic spliceosome
m0071007cellular_componentU2-type catalytic step 2 spliceosome
m0071013cellular_componentcatalytic step 2 spliceosome
m0120114cellular_componentSm-like protein family complex
m1903241biological_processU2-type prespliceosome assembly
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n0008380biological_processRNA splicing
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p0001650cellular_componentfibrillar center
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p0003723molecular_functionRNA binding
p0005515molecular_functionprotein binding
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p0008380biological_processRNA splicing
p0016607cellular_componentnuclear speck
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p0071005cellular_componentU2-type precatalytic spliceosome
p0071007cellular_componentU2-type catalytic step 2 spliceosome
p0071013cellular_componentcatalytic step 2 spliceosome
p1903241biological_processU2-type prespliceosome assembly
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q0000244biological_processspliceosomal tri-snRNP complex assembly
q0000245biological_processspliceosomal complex assembly
q0000398biological_processmRNA splicing, via spliceosome
q0000974cellular_componentPrp19 complex
q0001833biological_processinner cell mass cell proliferation
q0004842molecular_functionubiquitin-protein transferase activity
q0005515molecular_functionprotein binding
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q0005654cellular_componentnucleoplasm
q0005662cellular_componentDNA replication factor A complex
q0005681cellular_componentspliceosomal complex
q0005737cellular_componentcytoplasm
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r0005654cellular_componentnucleoplasm
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r0005681cellular_componentspliceosomal complex
r0005737cellular_componentcytoplasm
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r0005856cellular_componentcytoskeleton
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r0006303biological_processdouble-strand break repair via nonhomologous end joining
r0006397biological_processmRNA processing
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r0008380biological_processRNA splicing
r0008610biological_processlipid biosynthetic process
r0010498biological_processproteasomal protein catabolic process
r0016020cellular_componentmembrane
r0016567biological_processprotein ubiquitination
r0016607cellular_componentnuclear speck
r0016740molecular_functiontransferase activity
r0034450molecular_functionubiquitin-ubiquitin ligase activity
r0035861cellular_componentsite of double-strand break
r0042802molecular_functionidentical protein binding
r0048026biological_processpositive regulation of mRNA splicing, via spliceosome
r0061630molecular_functionubiquitin protein ligase activity
r0070534biological_processprotein K63-linked ubiquitination
r0071006cellular_componentU2-type catalytic step 1 spliceosome
r0071007cellular_componentU2-type catalytic step 2 spliceosome
r0071013cellular_componentcatalytic step 2 spliceosome
s0000077biological_processDNA damage checkpoint signaling
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s0000244biological_processspliceosomal tri-snRNP complex assembly
s0000245biological_processspliceosomal complex assembly
s0000398biological_processmRNA splicing, via spliceosome
s0000974cellular_componentPrp19 complex
s0001833biological_processinner cell mass cell proliferation
s0004842molecular_functionubiquitin-protein transferase activity
s0005515molecular_functionprotein binding
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s0005654cellular_componentnucleoplasm
s0005662cellular_componentDNA replication factor A complex
s0005681cellular_componentspliceosomal complex
s0005737cellular_componentcytoplasm
s0005811cellular_componentlipid droplet
s0005819cellular_componentspindle
s0005856cellular_componentcytoskeleton
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s0006303biological_processdouble-strand break repair via nonhomologous end joining
s0006397biological_processmRNA processing
s0008104biological_processprotein localization
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s0008610biological_processlipid biosynthetic process
s0010498biological_processproteasomal protein catabolic process
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s0016607cellular_componentnuclear speck
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s0061630molecular_functionubiquitin protein ligase activity
s0070534biological_processprotein K63-linked ubiquitination
s0071006cellular_componentU2-type catalytic step 1 spliceosome
s0071007cellular_componentU2-type catalytic step 2 spliceosome
s0071013cellular_componentcatalytic step 2 spliceosome
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t0000244biological_processspliceosomal tri-snRNP complex assembly
t0000245biological_processspliceosomal complex assembly
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t0000974cellular_componentPrp19 complex
t0001833biological_processinner cell mass cell proliferation
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t0005654cellular_componentnucleoplasm
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t0005681cellular_componentspliceosomal complex
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t0008610biological_processlipid biosynthetic process
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t0048026biological_processpositive regulation of mRNA splicing, via spliceosome
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t0070534biological_processprotein K63-linked ubiquitination
t0071006cellular_componentU2-type catalytic step 1 spliceosome
t0071007cellular_componentU2-type catalytic step 2 spliceosome
t0071013cellular_componentcatalytic step 2 spliceosome
u0000184biological_processnuclear-transcribed mRNA catabolic process, nonsense-mediated decay
u0000398biological_processmRNA splicing, via spliceosome
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u0005737cellular_componentcytoplasm
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u0030425cellular_componentdendrite
u0035145cellular_componentexon-exon junction complex
u0035368molecular_functionselenocysteine insertion sequence binding
u0035613molecular_functionRNA stem-loop binding
u0035640biological_processexploration behavior
u0043021molecular_functionribonucleoprotein complex binding
u0043025cellular_componentneuronal cell body
u0045727biological_processpositive regulation of translation
u0048701biological_processembryonic cranial skeleton morphogenesis
u0051028biological_processmRNA transport
u0061775molecular_functioncohesin loader activity
u0071006cellular_componentU2-type catalytic step 1 spliceosome
u0071013cellular_componentcatalytic step 2 spliceosome
u0072715biological_processcellular response to selenite ion
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u0099578biological_processregulation of translation at postsynapse, modulating synaptic transmission
u0140584molecular_functionchromatin extrusion motor activity
u0140588biological_processchromatin looping
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u0140849molecular_functionATP-dependent H2AZ histone chaperone activity
u1904570biological_processnegative regulation of selenocysteine incorporation
u1990416biological_processcellular response to brain-derived neurotrophic factor stimulus
u1990904cellular_componentribonucleoprotein complex
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v0000398biological_processmRNA splicing, via spliceosome
v0003723molecular_functionRNA binding
v0005515molecular_functionprotein binding
v0005634cellular_componentnucleus
v0005654cellular_componentnucleoplasm
v0005681cellular_componentspliceosomal complex
v0005829cellular_componentcytosol
v0006397biological_processmRNA processing
v0006406biological_processmRNA export from nucleus
v0008380biological_processRNA splicing
v0035145cellular_componentexon-exon junction complex
v0043025cellular_componentneuronal cell body
v0050684biological_processregulation of mRNA processing
v0051028biological_processmRNA transport
v0071005cellular_componentU2-type precatalytic spliceosome
v0071006cellular_componentU2-type catalytic step 1 spliceosome
v0071013cellular_componentcatalytic step 2 spliceosome
v1990501cellular_componentexon-exon junction subcomplex mago-y14
v2000622biological_processregulation of nuclear-transcribed mRNA catabolic process, nonsense-mediated decay
w0000184biological_processnuclear-transcribed mRNA catabolic process, nonsense-mediated decay
w0000381biological_processregulation of alternative mRNA splicing, via spliceosome
w0000398biological_processmRNA splicing, via spliceosome
w0003676molecular_functionnucleic acid binding
w0003723molecular_functionRNA binding
w0003729molecular_functionmRNA binding
w0005515molecular_functionprotein binding
w0005634cellular_componentnucleus
w0005654cellular_componentnucleoplasm
w0005681cellular_componentspliceosomal complex
w0005737cellular_componentcytoplasm
w0005829cellular_componentcytosol
w0006396biological_processRNA processing
w0006397biological_processmRNA processing
w0006406biological_processmRNA export from nucleus
w0006417biological_processregulation of translation
w0008380biological_processRNA splicing
w0016607cellular_componentnuclear speck
w0030425cellular_componentdendrite
w0035145cellular_componentexon-exon junction complex
w0043025cellular_componentneuronal cell body
w0050684biological_processregulation of mRNA processing
w0051028biological_processmRNA transport
w0071006cellular_componentU2-type catalytic step 1 spliceosome
w0071013cellular_componentcatalytic step 2 spliceosome
w1990501cellular_componentexon-exon junction subcomplex mago-y14
w2000622biological_processregulation of nuclear-transcribed mRNA catabolic process, nonsense-mediated decay
x0000184biological_processnuclear-transcribed mRNA catabolic process, nonsense-mediated decay
x0000398biological_processmRNA splicing, via spliceosome
x0003723molecular_functionRNA binding
x0003729molecular_functionmRNA binding
x0005515molecular_functionprotein binding
x0005634cellular_componentnucleus
x0005654cellular_componentnucleoplasm
x0005681cellular_componentspliceosomal complex
x0005737cellular_componentcytoplasm
x0005829cellular_componentcytosol
x0006397biological_processmRNA processing
x0006406biological_processmRNA export from nucleus
x0006417biological_processregulation of translation
x0008298biological_processintracellular mRNA localization
x0008380biological_processRNA splicing
x0010494cellular_componentcytoplasmic stress granule
x0016607cellular_componentnuclear speck
x0019899molecular_functionenzyme binding
x0030425cellular_componentdendrite
x0031625molecular_functionubiquitin protein ligase binding
x0031965cellular_componentnuclear membrane
x0035145cellular_componentexon-exon junction complex
x0042802molecular_functionidentical protein binding
x0042995cellular_componentcell projection
x0048471cellular_componentperinuclear region of cytoplasm
x0051028biological_processmRNA transport
x0071006cellular_componentU2-type catalytic step 1 spliceosome
x1990904cellular_componentribonucleoprotein complex
x2000622biological_processregulation of nuclear-transcribed mRNA catabolic process, nonsense-mediated decay
Functional Information from PDB Data
site_idAC1
Number of Residues10
Detailsbinding site for residue IHP A 3000
ChainResidue
AARG163
ZARG167
ALYS442
AHIS584
ALYS609
AHIS610
ATYR613
ALYS623
AGLY624
ZLYS166

site_idAC2
Number of Residues17
Detailsbinding site for residue GTP C 1500
ChainResidue
APRO335
CLEU138
CHIS139
CGLY141
CLYS142
CTHR143
CCYS144
CGLY180
CPRO206
CGLY207
CLYS259
CASP261
CARG262
CSER311
CSER312
CGLN313
CMG1501

site_idAC3
Number of Residues2
Detailsbinding site for residue MG C 1501
ChainResidue
CTHR143
CGTP1500

site_idAC4
Number of Residues8
Detailsbinding site for residue ADP D 2201
ChainResidue
DTHR480
DGLN485
DGLY508
DLYS509
DTHR510
DASP615
DGLU616
DASN820

site_idAC5
Number of Residues11
Detailsbinding site for residue ADP D 2202
ChainResidue
DPHE1325
DPHE1327
DGLN1332
DGLY1353
DSER1354
DGLY1355
DLYS1356
DTHR1357
DGLU1455
DPRO1694
DMG2203

site_idAC6
Number of Residues3
Detailsbinding site for residue MG D 2203
ChainResidue
DTHR1357
DASP1454
DADP2202

site_idAC7
Number of Residues3
Detailsbinding site for residue MG F 200
ChainResidue
FG72
FU74
GG-1

site_idAC8
Number of Residues3
Detailsbinding site for residue MG F 201
ChainResidue
FA53
FG54
FU74

site_idAC9
Number of Residues1
Detailsbinding site for residue MG F 202
ChainResidue
FG75

site_idAD1
Number of Residues1
Detailsbinding site for residue MG F 203
ChainResidue
FG75

site_idAD2
Number of Residues3
Detailsbinding site for residue MG F 204
ChainResidue
FG54
FC55
FG71

site_idAD3
Number of Residues2
Detailsbinding site for residue MG F 205
ChainResidue
FA48
FA50

site_idAD4
Number of Residues4
Detailsbinding site for residue ZN N 201
ChainResidue
NCYS105
NCYS117
NCYS119
NCYS134

site_idAD5
Number of Residues4
Detailsbinding site for residue ZN N 202
ChainResidue
NCYS101
NCYS102
NCYS105
NCYS137

site_idAD6
Number of Residues4
Detailsbinding site for residue ZN N 203
ChainResidue
NCYS101
NCYS119
NCYS139
NCYS142

site_idAD7
Number of Residues5
Detailsbinding site for residue ZN O 501
ChainResidue
OCYS24
OCYS27
OCYS81
OTHR83
OCYS84

site_idAD8
Number of Residues4
Detailsbinding site for residue ZN O 502
ChainResidue
OCYS45
OCYS48
OCYS71
OCYS74

site_idAD9
Number of Residues4
Detailsbinding site for residue ZN O 503
ChainResidue
OCYS165
OCYS173
OCYS179
OHIS183

site_idAE1
Number of Residues14
Detailsbinding site for residue ATP Q 1501
ChainResidue
QASP831
QARG1138
QLEU1157
QMG1502
QILE800
QGLN801
QPHE802
QTHR803
QGLN806
QPRO825
QGLY826
QGLY828
QLYS829
QTHR830

site_idAE2
Number of Residues3
Detailsbinding site for residue MG Q 1502
ChainResidue
QTHR830
QGLN861
QATP1501

site_idAE3
Number of Residues4
Detailsbinding site for residue ZN Z 601
ChainResidue
ZCYS120
ZCYS123
ZHIS128
ZCYS133

site_idAE4
Number of Residues3
Detailsbinding site for residue MG u 701
ChainResidue
uTHR89
uASP187
uATP702

site_idAE5
Number of Residues17
Detailsbinding site for residue ATP u 702
ChainResidue
uPHE58
uLYS60
uGLN65
uSER84
uGLY85
uTHR86
uGLY87
uLYS88
uTHR89
uALA90
uGLU188
uGLY340
uASP342
uARG367
uARG370
uTYR371
uMG701

Functional Information from PROSITE/UniProt
site_idPS00039
Number of Residues9
DetailsDEAD_ATP_HELICASE DEAD-box subfamily ATP-dependent helicases signature. VLDEADEmL
ChainResidueDetails
uVAL185-LEU193

site_idPS00170
Number of Residues18
DetailsCSA_PPIASE_1 Cyclophilin-type peptidyl-prolyl cis-trans isomerase signature. YngTkFHRIIkdFMiQGG
ChainResidueDetails
STYR48-GLY65

site_idPS00211
Number of Residues15
DetailsABC_TRANSPORTER_1 ABC transporters family signature. VSKGQRVKVKVLSFT
ChainResidueDetails
YVAL313-THR327

site_idPS00678
Number of Residues15
DetailsWD_REPEATS_1 Trp-Asp (WD) repeats signature. LLSCsmDcKIKLWEV
ChainResidueDetails
WLEU304-VAL318
ELEU81-VAL95
ELEU124-SER138
EVAL167-ILE181
EILE208-LEU222
EILE300-THR314
qLEU407-LEU421
TLEU303-VAL317
TILE345-LEU359

site_idPS00690
Number of Residues10
DetailsDEAH_ATP_HELICASE DEAH-box subfamily ATP-dependent helicases signature. AiIMLDEAHE
ChainResidueDetails
YALA680-GLU689

site_idPS00997
Number of Residues23
DetailsG10_1 G10 protein signature 1. LCClRCiqtrDtNfgtnCiCRVP
ChainResidueDetails
NLEU100-PRO122

site_idPS00998
Number of Residues10
DetailsG10_2 G10 protein signature 2. CtHCGCRGCS
ChainResidueDetails
NCYS134-SER143

Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues1
DetailsMOD_RES: Phosphoserine => ECO:0000250|UniProtKB:Q8K3W3
ChainResidueDetails
xSER35
uGLN65
uGLY85
uASP342
uARG367
SLYS125

site_idSWS_FT_FI2
Number of Residues1
DetailsMOD_RES: Phosphoserine => ECO:0007744|PubMed:21406692, ECO:0007744|PubMed:23186163, ECO:0007744|PubMed:24275569
ChainResidueDetails
xSER117
qLYS261
rLYS122
rLYS261
sLYS122
sLYS261
tLYS122
tLYS261

site_idSWS_FT_FI3
Number of Residues1
DetailsMOD_RES: Phosphoserine => ECO:0007744|PubMed:18669648, ECO:0007744|PubMed:19369195, ECO:0007744|PubMed:21406692, ECO:0007744|PubMed:23186163, ECO:0007744|PubMed:24275569
ChainResidueDetails
xSER148
qLYS244
rLYS179
rLYS244
sLYS179
sLYS244
tLYS179
tLYS244

site_idSWS_FT_FI4
Number of Residues1
DetailsMOD_RES: Phosphoserine => ECO:0007744|PubMed:21406692, ECO:0007744|PubMed:23186163
ChainResidueDetails
xSER265
oSER255
dLYS8
kLYS6
kLYS8

site_idSWS_FT_FI5
Number of Residues1
DetailsMOD_RES: Phosphothreonine => ECO:0007744|PubMed:24275569
ChainResidueDetails
xTHR357
USER1460
USER1462
USER1482
USER1483
USER1501
USER1621
USER1893
USER2343
USER2394
USER2453
USER222
USER454
USER484
USER486
USER875
USER1336
USER1368
USER1421

site_idSWS_FT_FI6
Number of Residues1
DetailsMOD_RES: Phosphoserine => ECO:0007744|PubMed:17081983, ECO:0007744|PubMed:21406692, ECO:0007744|PubMed:23186163
ChainResidueDetails
xSER363
RLYS416
RLYS441
RLYS452
oLYS221
ZLYS408
RLYS141
RLYS158
RLYS258
RLYS286
RLYS339
RLYS344

site_idSWS_FT_FI7
Number of Residues1
DetailsMOD_RES: Phosphoserine => ECO:0007744|PubMed:17081983, ECO:0007744|PubMed:21406692
ChainResidueDetails
xSER373
USER994
USER1014

site_idSWS_FT_FI8
Number of Residues1
DetailsMOD_RES: Phosphoserine => ECO:0007744|PubMed:18669648
ChainResidueDetails
xSER477
USER1179
USER2581

site_idSWS_FT_FI9
Number of Residues2
DetailsMOD_RES: N6-acetyllysine => ECO:0007744|PubMed:19608861
ChainResidueDetails
uLYS296
uLYS321
USER1152

site_idSWS_FT_FI10
Number of Residues1
DetailsCROSSLNK: Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2) => ECO:0007744|PubMed:25218447, ECO:0007744|PubMed:25755297, ECO:0007744|PubMed:25772364, ECO:0007744|PubMed:28112733
ChainResidueDetails
uLYS19
USER857
USER952
USER1318
USER1401
USER2100

site_idSWS_FT_FI11
Number of Residues3
DetailsCROSSLNK: Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2) => ECO:0007744|PubMed:28112733
ChainResidueDetails
USER323
uLYS314
uLYS382

site_idSWS_FT_FI12
Number of Residues2
DetailsCROSSLNK: Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2) => ECO:0000250|UniProtKB:P60842
ChainResidueDetails
uLYS152
uLYS374

site_idSWS_FT_FI13
Number of Residues4
DetailsMOD_RES: Phosphoserine => ECO:0007744|PubMed:19690332
ChainResidueDetails
USER357
USER358
USER846
USER1214

site_idSWS_FT_FI14
Number of Residues3
DetailsMOD_RES: Phosphothreonine => ECO:0007744|PubMed:19690332
ChainResidueDetails
UTHR359
UTHR1106
UTHR2381

site_idSWS_FT_FI15
Number of Residues1
DetailsMOD_RES: Phosphothreonine => ECO:0007744|PubMed:16964243, ECO:0007744|PubMed:19690332, ECO:0007744|PubMed:20068231, ECO:0007744|PubMed:23186163
ChainResidueDetails
UTHR367
LLYS487

site_idSWS_FT_FI16
Number of Residues1
DetailsMOD_RES: Phosphoserine => ECO:0007744|PubMed:16964243, ECO:0007744|PubMed:17525332, ECO:0007744|PubMed:18669648, ECO:0007744|PubMed:19690332, ECO:0007744|PubMed:20068231, ECO:0007744|PubMed:21406692, ECO:0007744|PubMed:23186163, ECO:0007744|PubMed:24275569
ChainResidueDetails
USER377

site_idSWS_FT_FI17
Number of Residues2
DetailsMOD_RES: Phosphothreonine => ECO:0007744|PubMed:24275569
ChainResidueDetails
UTHR383
UTHR384

site_idSWS_FT_FI18
Number of Residues1
DetailsMOD_RES: Phosphoserine => ECO:0007744|PubMed:18669648, ECO:0007744|PubMed:23186163, ECO:0007744|PubMed:24275569
ChainResidueDetails
USER387

site_idSWS_FT_FI19
Number of Residues3
DetailsMOD_RES: Phosphoserine => ECO:0007744|PubMed:24275569
ChainResidueDetails
USER395
USER935
USER1311

site_idSWS_FT_FI20
Number of Residues1
DetailsMOD_RES: Phosphoserine => ECO:0007744|PubMed:18669648, ECO:0007744|PubMed:21406692, ECO:0007744|PubMed:24275569
ChainResidueDetails
USER398

site_idSWS_FT_FI21
Number of Residues2
DetailsMOD_RES: Phosphoserine => ECO:0007744|PubMed:21406692, ECO:0007744|PubMed:24275569
ChainResidueDetails
USER404
USER408

site_idSWS_FT_FI22
Number of Residues3
DetailsMOD_RES: Phosphoserine => ECO:0007744|PubMed:20068231, ECO:0007744|PubMed:21406692, ECO:0007744|PubMed:23186163, ECO:0007744|PubMed:24275569
ChainResidueDetails
USER424
USER1124
USER2702

site_idSWS_FT_FI23
Number of Residues12
DetailsMOD_RES: Phosphoserine => ECO:0007744|PubMed:18669648, ECO:0007744|PubMed:23186163
ChainResidueDetails
USER435
USER2121
USER2675
USER2677
USER780
USER864
USER1064
USER1112
USER1537
USER1539
USER1541
USER1876

site_idSWS_FT_FI24
Number of Residues24
DetailsMOD_RES: Phosphoserine => ECO:0007744|PubMed:23186163
ChainResidueDetails
USER436
USER704
USER706
USER992
USER1198
USER1227
USER1254
USER1257
USER1258
USER2018
USER2030
USER437
USER2042
USER2310
USER2368
USER2376
USER2740
USER506
USER508
USER510
USER534
USER536
USER543
USER702

site_idSWS_FT_FI25
Number of Residues2
DetailsMOD_RES: Phosphoserine => ECO:0007744|PubMed:17081983, ECO:0007744|PubMed:18669648, ECO:0007744|PubMed:20068231, ECO:0007744|PubMed:21406692, ECO:0007744|PubMed:23186163, ECO:0007744|PubMed:24275569
ChainResidueDetails
USER440
USER1188

site_idSWS_FT_FI26
Number of Residues5
DetailsMOD_RES: Phosphoserine => ECO:0007744|PubMed:18669648, ECO:0007744|PubMed:20068231, ECO:0007744|PubMed:21406692, ECO:0007744|PubMed:23186163
ChainResidueDetails
USER778
USER2123
USER2398
USER2407
USER2692

site_idSWS_FT_FI27
Number of Residues3
DetailsMOD_RES: Phosphoserine => ECO:0007744|PubMed:18669648, ECO:0007744|PubMed:21406692
ChainResidueDetails
USER783
USER1522
USER1970

site_idSWS_FT_FI28
Number of Residues12
DetailsMOD_RES: Phosphoserine => ECO:0000250|UniProtKB:Q8BTI8
ChainResidueDetails
USER854
USER1423
USER1616
USER1620
USER1024
USER1042
USER1266
USER1270
USER1271
USER1348
USER1383
USER1384

site_idSWS_FT_FI29
Number of Residues1
DetailsMOD_RES: Phosphothreonine => ECO:0000250|UniProtKB:Q8BTI8
ChainResidueDetails
UTHR856

site_idSWS_FT_FI30
Number of Residues1
DetailsMOD_RES: Phosphothreonine => ECO:0007744|PubMed:18669648, ECO:0007744|PubMed:19690332, ECO:0007744|PubMed:20068231, ECO:0007744|PubMed:23186163, ECO:0007744|PubMed:24275569
ChainResidueDetails
UTHR866

site_idSWS_FT_FI31
Number of Residues1
DetailsMOD_RES: Phosphoserine => ECO:0007744|PubMed:16964243, ECO:0007744|PubMed:20068231
ChainResidueDetails
USER871

site_idSWS_FT_FI32
Number of Residues1
DetailsMOD_RES: Phosphoserine => ECO:0007744|PubMed:16964243, ECO:0007744|PubMed:19690332, ECO:0007744|PubMed:20068231, ECO:0007744|PubMed:21406692, ECO:0007744|PubMed:23186163
ChainResidueDetails
USER876

site_idSWS_FT_FI33
Number of Residues24
DetailsMOD_RES: Phosphoserine => ECO:0007744|PubMed:21406692
ChainResidueDetails
USER908
USER1582
USER1598
USER1600
USER1601
USER1658
USER1727
USER1729
USER1731
USER1732
USER1818
USER1129
USER1822
USER1884
USER2090
USER2415
USER2429
USER1424
USER1517
USER1519
USER1521
USER1577
USER1579
USER1581

site_idSWS_FT_FI34
Number of Residues1
DetailsMOD_RES: Phosphoserine => ECO:0007744|PubMed:18669648, ECO:0007744|PubMed:20068231, ECO:0007744|PubMed:23186163
ChainResidueDetails
USER950

site_idSWS_FT_FI35
Number of Residues1
DetailsMOD_RES: Phosphoserine => ECO:0007744|PubMed:16964243, ECO:0007744|PubMed:18669648, ECO:0007744|PubMed:19690332, ECO:0007744|PubMed:23186163
ChainResidueDetails
USER954

site_idSWS_FT_FI36
Number of Residues12
DetailsMOD_RES: Phosphoserine => ECO:0007744|PubMed:18669648
ChainResidueDetails
USER957
USER1946
USER1958
USER2118
USER968
USER970
USER972
USER1032
USER1451
USER1691
USER1693
USER1923

site_idSWS_FT_FI37
Number of Residues18
DetailsMOD_RES: Phosphoserine => ECO:0007744|PubMed:20068231, ECO:0007744|PubMed:21406692
ChainResidueDetails
USER973
USER1975
USER1984
USER1987
USER1996
USER1999
USER2008
USER2011
USER2664
USER2706
USER1497
USER1502
USER1762
USER1764
USER1890
USER1916
USER1919
USER1972

site_idSWS_FT_FI38
Number of Residues5
DetailsMOD_RES: Phosphoserine => ECO:0007744|PubMed:18669648, ECO:0007744|PubMed:20068231, ECO:0007744|PubMed:21406692
ChainResidueDetails
USER974
USER1415
USER1925
USER1948
USER1960

site_idSWS_FT_FI39
Number of Residues7
DetailsMOD_RES: Phosphothreonine => ECO:0007744|PubMed:21406692
ChainResidueDetails
UTHR977
UTHR1043
UTHR1931
UTHR1954
UTHR1966
UTHR1978
UTHR2092

site_idSWS_FT_FI40
Number of Residues1
DetailsMOD_RES: Phosphothreonine => ECO:0007744|PubMed:18669648, ECO:0007744|PubMed:20068231, ECO:0007744|PubMed:23186163, ECO:0007744|PubMed:24275569
ChainResidueDetails
UTHR983

site_idSWS_FT_FI41
Number of Residues2
DetailsMOD_RES: Phosphotyrosine => ECO:0007744|PubMed:24275569
ChainResidueDetails
UTYR996
UTYR1049

site_idSWS_FT_FI42
Number of Residues1
DetailsMOD_RES: Phosphothreonine => ECO:0007744|PubMed:17081983, ECO:0007744|PubMed:18669648, ECO:0007744|PubMed:19690332, ECO:0007744|PubMed:20068231, ECO:0007744|PubMed:21406692, ECO:0007744|PubMed:23186163, ECO:0007744|PubMed:24275569
ChainResidueDetails
UTHR1003

site_idSWS_FT_FI43
Number of Residues1
DetailsMOD_RES: Phosphoserine => ECO:0007744|PubMed:23186163, ECO:0007744|PubMed:24275569
ChainResidueDetails
USER1010

site_idSWS_FT_FI44
Number of Residues2
DetailsMOD_RES: Phosphoserine => ECO:0007744|PubMed:18669648, ECO:0007744|PubMed:20068231
ChainResidueDetails
USER1028
USER2690

site_idSWS_FT_FI45
Number of Residues7
DetailsMOD_RES: Phosphoserine => ECO:0007744|PubMed:18669648, ECO:0007744|PubMed:21406692, ECO:0007744|PubMed:23186163
ChainResidueDetails
USER1069
USER1444
USER1542
USER1552
USER1694
USER1878
USER2412

site_idSWS_FT_FI46
Number of Residues2
DetailsMOD_RES: Phosphoserine => ECO:0007744|PubMed:16964243, ECO:0007744|PubMed:18669648
ChainResidueDetails
USER1072
USER1073

site_idSWS_FT_FI47
Number of Residues2
DetailsMOD_RES: Phosphoserine => ECO:0007744|PubMed:18669648, ECO:0007744|PubMed:19690332, ECO:0007744|PubMed:20068231, ECO:0007744|PubMed:21406692
ChainResidueDetails
USER1099
USER1101

site_idSWS_FT_FI48
Number of Residues1
DetailsMOD_RES: Phosphoserine => ECO:0007744|PubMed:16964243, ECO:0007744|PubMed:18669648, ECO:0007744|PubMed:19690332
ChainResidueDetails
USER1102

site_idSWS_FT_FI49
Number of Residues3
DetailsMOD_RES: Phosphoserine => ECO:0007744|PubMed:18669648, ECO:0007744|PubMed:19690332, ECO:0007744|PubMed:20068231, ECO:0007744|PubMed:21406692, ECO:0007744|PubMed:23186163
ChainResidueDetails
USER1103
USER1404
USER2132

site_idSWS_FT_FI50
Number of Residues3
DetailsMOD_RES: Phosphoserine => ECO:0007744|PubMed:20068231, ECO:0007744|PubMed:23186163
ChainResidueDetails
USER1122
USER1857
USER2335

site_idSWS_FT_FI51
Number of Residues1
DetailsMOD_RES: Phosphoserine => ECO:0007744|PubMed:17081983, ECO:0007744|PubMed:20068231, ECO:0007744|PubMed:21406692, ECO:0007744|PubMed:23186163, ECO:0007744|PubMed:24275569
ChainResidueDetails
USER1132

site_idSWS_FT_FI52
Number of Residues2
DetailsMOD_RES: Phosphothreonine => ECO:0007744|PubMed:18669648, ECO:0007744|PubMed:23186163
ChainResidueDetails
UTHR1208
UTHR1880

site_idSWS_FT_FI53
Number of Residues1
DetailsMOD_RES: Phosphoserine => ECO:0007744|PubMed:20068231, ECO:0007744|PubMed:21406692, ECO:0007744|PubMed:24275569
ChainResidueDetails
USER1219

site_idSWS_FT_FI54
Number of Residues2
DetailsMOD_RES: Phosphoserine => ECO:0007744|PubMed:18669648, ECO:0007744|PubMed:19690332, ECO:0007744|PubMed:20068231, ECO:0007744|PubMed:21406692, ECO:0007744|PubMed:23186163, ECO:0007744|PubMed:24275569
ChainResidueDetails
USER1320
USER1387

site_idSWS_FT_FI55
Number of Residues1
DetailsMOD_RES: Phosphoserine => ECO:0007744|PubMed:18669648, ECO:0007744|PubMed:19690332, ECO:0007744|PubMed:20068231, ECO:0007744|PubMed:23186163, ECO:0007744|PubMed:24275569
ChainResidueDetails
USER1326

site_idSWS_FT_FI56
Number of Residues1
DetailsMOD_RES: Phosphoserine => ECO:0007744|PubMed:17081983, ECO:0007744|PubMed:18669648, ECO:0007744|PubMed:19690332, ECO:0007744|PubMed:20068231, ECO:0007744|PubMed:21406692, ECO:0007744|PubMed:23186163, ECO:0007744|PubMed:24275569
ChainResidueDetails
USER1329

site_idSWS_FT_FI57
Number of Residues1
DetailsMOD_RES: Phosphoserine => ECO:0007744|PubMed:19690332, ECO:0007744|PubMed:21406692, ECO:0007744|PubMed:23186163
ChainResidueDetails
USER1382

site_idSWS_FT_FI58
Number of Residues1
DetailsMOD_RES: Phosphoserine => ECO:0007744|PubMed:19690332, ECO:0007744|PubMed:23186163
ChainResidueDetails
USER1403

site_idSWS_FT_FI59
Number of Residues1
DetailsMOD_RES: Phosphothreonine => ECO:0007744|PubMed:18669648, ECO:0007744|PubMed:20068231, ECO:0007744|PubMed:21406692, ECO:0007744|PubMed:23186163
ChainResidueDetails
UTHR1413

site_idSWS_FT_FI60
Number of Residues1
DetailsMOD_RES: Phosphothreonine => ECO:0007744|PubMed:20068231, ECO:0007744|PubMed:23186163
ChainResidueDetails
UTHR1434

site_idSWS_FT_FI61
Number of Residues5
DetailsMOD_RES: Phosphothreonine => ECO:0007744|PubMed:18669648
ChainResidueDetails
UTHR1453
UTHR1472
UTHR1511
UTHR1698
UTHR2144

site_idSWS_FT_FI62
Number of Residues5
DetailsMOD_RES: Phosphoserine => ECO:0007744|PubMed:21406692, ECO:0007744|PubMed:23186163
ChainResidueDetails
USER1458
USER1648
USER2020
USER2032
USER2067

site_idSWS_FT_FI63
Number of Residues9
DetailsMOD_RES: Phosphoserine => ECO:0007744|PubMed:20068231, ECO:0007744|PubMed:21406692, ECO:0007744|PubMed:23186163
ChainResidueDetails
USER1463
USER1499
USER1854
USER2044
USER2046
USER2071
USER2426
USER2684
USER2688

site_idSWS_FT_FI64
Number of Residues1
DetailsMOD_RES: Phosphothreonine => ECO:0007744|PubMed:17081983, ECO:0007744|PubMed:20068231, ECO:0007744|PubMed:23186163
ChainResidueDetails
UTHR1492

site_idSWS_FT_FI65
Number of Residues1
DetailsMOD_RES: Phosphothreonine => ECO:0007744|PubMed:17924679, ECO:0007744|PubMed:18669648, ECO:0007744|PubMed:23186163
ChainResidueDetails
UTHR1531

site_idSWS_FT_FI66
Number of Residues3
DetailsMOD_RES: Phosphothreonine => ECO:0007744|PubMed:18669648, ECO:0007744|PubMed:20068231, ECO:0007744|PubMed:21406692
ChainResidueDetails
UTHR1927
UTHR1950
UTHR1962

site_idSWS_FT_FI67
Number of Residues2
DetailsMOD_RES: Phosphothreonine => ECO:0007744|PubMed:21406692, ECO:0007744|PubMed:23186163
ChainResidueDetails
UTHR2022
UTHR2034

site_idSWS_FT_FI68
Number of Residues1
DetailsMOD_RES: Phosphothreonine => ECO:0007744|PubMed:20068231, ECO:0007744|PubMed:21406692, ECO:0007744|PubMed:23186163
ChainResidueDetails
UTHR2069

site_idSWS_FT_FI69
Number of Residues1
DetailsMOD_RES: Phosphoserine => ECO:0007744|PubMed:18669648, ECO:0007744|PubMed:19690332, ECO:0007744|PubMed:20068231, ECO:0007744|PubMed:23186163
ChainResidueDetails
USER2102

site_idSWS_FT_FI70
Number of Residues1
DetailsMOD_RES: Phosphothreonine => ECO:0007744|PubMed:18669648, ECO:0007744|PubMed:19690332, ECO:0007744|PubMed:20068231, ECO:0007744|PubMed:21406692, ECO:0007744|PubMed:23186163
ChainResidueDetails
UTHR2104

site_idSWS_FT_FI71
Number of Residues7
DetailsMOD_RES: Omega-N-methylarginine => ECO:0007744|PubMed:24129315
ChainResidueDetails
UARG2194
UARG2207
UARG2231
UARG2246
UARG2274
UARG2288
UARG2342

site_idSWS_FT_FI72
Number of Residues1
DetailsMOD_RES: Phosphoserine => ECO:0007744|PubMed:16964243, ECO:0007744|PubMed:18220336, ECO:0007744|PubMed:18669648, ECO:0007744|PubMed:19690332, ECO:0007744|PubMed:20068231, ECO:0007744|PubMed:21406692, ECO:0007744|PubMed:23186163, ECO:0007744|PubMed:24275569
ChainResidueDetails
USER2272

site_idSWS_FT_FI73
Number of Residues1
DetailsMOD_RES: Phosphothreonine => ECO:0007744|PubMed:18669648, ECO:0007744|PubMed:19690332, ECO:0007744|PubMed:20068231, ECO:0007744|PubMed:23186163
ChainResidueDetails
UTHR2289

site_idSWS_FT_FI74
Number of Residues1
DetailsMOD_RES: Phosphothreonine => ECO:0007744|PubMed:16964243
ChainResidueDetails
UTHR2291

site_idSWS_FT_FI75
Number of Residues1
DetailsMOD_RES: Phosphothreonine => ECO:0007744|PubMed:18669648, ECO:0007744|PubMed:20068231
ChainResidueDetails
UTHR2302

site_idSWS_FT_FI76
Number of Residues1
DetailsMOD_RES: Phosphothreonine => ECO:0007744|PubMed:16964243, ECO:0007744|PubMed:18669648, ECO:0007744|PubMed:19690332, ECO:0007744|PubMed:23186163
ChainResidueDetails
UTHR2316

site_idSWS_FT_FI77
Number of Residues2
DetailsMOD_RES: Phosphothreonine => ECO:0007744|PubMed:18669648, ECO:0007744|PubMed:20068231, ECO:0007744|PubMed:23186163
ChainResidueDetails
UTHR2329
UTHR2409

site_idSWS_FT_FI78
Number of Residues1
DetailsMOD_RES: Phosphoserine => ECO:0007744|PubMed:16964243, ECO:0007744|PubMed:18669648, ECO:0007744|PubMed:19690332, ECO:0007744|PubMed:20068231, ECO:0007744|PubMed:21406692, ECO:0007744|PubMed:24275569
ChainResidueDetails
USER2382

site_idSWS_FT_FI79
Number of Residues1
DetailsMOD_RES: Omega-N-methylarginine; alternate => ECO:0007744|PubMed:24129315
ChainResidueDetails
UARG2384

site_idSWS_FT_FI80
Number of Residues1
DetailsMOD_RES: Phosphoserine => ECO:0007744|PubMed:17525332, ECO:0007744|PubMed:18669648, ECO:0007744|PubMed:19690332, ECO:0007744|PubMed:20068231, ECO:0007744|PubMed:21406692, ECO:0007744|PubMed:23186163
ChainResidueDetails
USER2449

site_idSWS_FT_FI81
Number of Residues1
DetailsMOD_RES: Phosphothreonine => ECO:0007744|PubMed:20068231, ECO:0007744|PubMed:24275569
ChainResidueDetails
UTHR2583

site_idSWS_FT_FI82
Number of Residues2
DetailsMOD_RES: Phosphothreonine => ECO:0007744|PubMed:23186163
ChainResidueDetails
UTHR2599
UTHR2738

site_idSWS_FT_FI83
Number of Residues1
DetailsMOD_RES: Phosphoserine => ECO:0007744|PubMed:16964243, ECO:0007744|PubMed:18669648, ECO:0007744|PubMed:20068231, ECO:0007744|PubMed:21406692, ECO:0007744|PubMed:23186163
ChainResidueDetails
USER2694

site_idSWS_FT_FI84
Number of Residues4
DetailsCROSSLNK: Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2) => ECO:0007744|PubMed:28112733
ChainResidueDetails
ULYS108
ULYS130
ULYS2587

227561

PDB entries from 2024-11-20

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