5XIT

Crystal structure of RNF168 UDM1 in complex with Lys63-linked diubiquitin, form II

Functional Information from PDB Data

site_id	AC1
Number of Residues	1
Details	binding site for residue GOL D 101

Chain	Residue
D	LYS33

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site_id	AC2
Number of Residues	5
Details	binding site for residue PR E 201

Chain	Residue
A	HOH314
A	HOH319
E	HOH306
E	HOH308
H	HOH104

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site_id	AC3
Number of Residues	2
Details	binding site for residue PR E 203

Chain	Residue
A	ARG117
A	ARG118

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site_id	AC4
Number of Residues	1
Details	binding site for residue GOL E 204

Chain	Residue
E	ARG118

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site_id	AC5
Number of Residues	2
Details	binding site for residue GOL A 201

Chain	Residue
A	PRO113
D	THR14

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site_id	AC6
Number of Residues	5
Details	binding site for residue GOL A 202

Chain	Residue
A	GLU119
A	GLU123
B	ASP32
B	LYS33
D	THR9

---

site_id	AC7
Number of Residues	1
Details	binding site for residue GOL A 203

Chain	Residue
A	GLU137

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Functional Information from PROSITE/UniProt

site_id	PS00299
Number of Residues	26
Details	UBIQUITIN_1 Ubiquitin domain signature. KakIqDkegIPpdqQrLIFaGkqleD

Chain	Residue	Details
H	LYS27-ASP52
D	LYS27-ASP52

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Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	4
Details	SITE: Interacts with activating enzyme

Chain	Residue	Details
H	ARG54
H	ARG72
B	ARG54
B	ARG72

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site_id	SWS_FT_FI2
Number of Residues	2
Details	SITE: Essential for function

Chain	Residue	Details
H	HIS68
B	HIS68

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site_id	SWS_FT_FI3
Number of Residues	2
Details	MOD_RES: Phosphoserine; by PINK1 => ECO:0000250|UniProtKB:P62979

Chain	Residue	Details
H	SER65
B	SER65

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site_id	SWS_FT_FI4
Number of Residues	2
Details	MOD_RES: ADP-ribosylglycine => ECO:0000250|UniProtKB:P62979

Chain	Residue	Details
H	GLY76
B	GLY76

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site_id	SWS_FT_FI5
Number of Residues	14
Details	CROSSLNK: Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin) => ECO:0000250|UniProtKB:P62979

Chain	Residue	Details
H	LYS6
B	LYS27
B	LYS29
B	LYS33
B	LYS48
B	LYS63
H	LYS11
H	LYS27
H	LYS29
H	LYS33
H	LYS48
H	LYS63
B	LYS6
B	LYS11

---

site_id	SWS_FT_FI6
Number of Residues	4
Details	CROSSLNK: Glycyl lysine isopeptide (Gly-Lys) (interchain with K-? in acceptor proteins) => ECO:0000255|PROSITE-ProRule:PRU00214

Chain	Residue	Details
H	GLY76
B	GLY76

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