5XFV
Crystal structures of FMN-bound form of dihydroorotate dehydrogenase from Trypanosoma brucei
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0004152 | molecular_function | dihydroorotate dehydrogenase activity |
| A | 0005654 | cellular_component | nucleoplasm |
| A | 0005737 | cellular_component | cytoplasm |
| A | 0006106 | biological_process | fumarate metabolic process |
| A | 0006207 | biological_process | 'de novo' pyrimidine nucleobase biosynthetic process |
| A | 0006221 | biological_process | pyrimidine nucleotide biosynthetic process |
| A | 0006222 | biological_process | UMP biosynthetic process |
| A | 0016491 | molecular_function | oxidoreductase activity |
| A | 0016627 | molecular_function | oxidoreductase activity, acting on the CH-CH group of donors |
| A | 0020015 | cellular_component | glycosome |
| A | 0044205 | biological_process | 'de novo' UMP biosynthetic process |
| A | 0097014 | cellular_component | ciliary plasm |
| A | 1990663 | molecular_function | dihydroorotate dehydrogenase (fumarate) activity |
| B | 0004152 | molecular_function | dihydroorotate dehydrogenase activity |
| B | 0005654 | cellular_component | nucleoplasm |
| B | 0005737 | cellular_component | cytoplasm |
| B | 0006106 | biological_process | fumarate metabolic process |
| B | 0006207 | biological_process | 'de novo' pyrimidine nucleobase biosynthetic process |
| B | 0006221 | biological_process | pyrimidine nucleotide biosynthetic process |
| B | 0006222 | biological_process | UMP biosynthetic process |
| B | 0016491 | molecular_function | oxidoreductase activity |
| B | 0016627 | molecular_function | oxidoreductase activity, acting on the CH-CH group of donors |
| B | 0020015 | cellular_component | glycosome |
| B | 0044205 | biological_process | 'de novo' UMP biosynthetic process |
| B | 0097014 | cellular_component | ciliary plasm |
| B | 1990663 | molecular_function | dihydroorotate dehydrogenase (fumarate) activity |
| C | 0004152 | molecular_function | dihydroorotate dehydrogenase activity |
| C | 0005654 | cellular_component | nucleoplasm |
| C | 0005737 | cellular_component | cytoplasm |
| C | 0006106 | biological_process | fumarate metabolic process |
| C | 0006207 | biological_process | 'de novo' pyrimidine nucleobase biosynthetic process |
| C | 0006221 | biological_process | pyrimidine nucleotide biosynthetic process |
| C | 0006222 | biological_process | UMP biosynthetic process |
| C | 0016491 | molecular_function | oxidoreductase activity |
| C | 0016627 | molecular_function | oxidoreductase activity, acting on the CH-CH group of donors |
| C | 0020015 | cellular_component | glycosome |
| C | 0044205 | biological_process | 'de novo' UMP biosynthetic process |
| C | 0097014 | cellular_component | ciliary plasm |
| C | 1990663 | molecular_function | dihydroorotate dehydrogenase (fumarate) activity |
| D | 0004152 | molecular_function | dihydroorotate dehydrogenase activity |
| D | 0005654 | cellular_component | nucleoplasm |
| D | 0005737 | cellular_component | cytoplasm |
| D | 0006106 | biological_process | fumarate metabolic process |
| D | 0006207 | biological_process | 'de novo' pyrimidine nucleobase biosynthetic process |
| D | 0006221 | biological_process | pyrimidine nucleotide biosynthetic process |
| D | 0006222 | biological_process | UMP biosynthetic process |
| D | 0016491 | molecular_function | oxidoreductase activity |
| D | 0016627 | molecular_function | oxidoreductase activity, acting on the CH-CH group of donors |
| D | 0020015 | cellular_component | glycosome |
| D | 0044205 | biological_process | 'de novo' UMP biosynthetic process |
| D | 0097014 | cellular_component | ciliary plasm |
| D | 1990663 | molecular_function | dihydroorotate dehydrogenase (fumarate) activity |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 23 |
| Details | binding site for residue FMN A 401 |
| Chain | Residue |
| A | ALA19 |
| A | ASN195 |
| A | SER196 |
| A | GLY223 |
| A | VAL226 |
| A | CYS249 |
| A | GLY250 |
| A | GLY251 |
| A | GLY272 |
| A | THR273 |
| A | MLI402 |
| A | ALA20 |
| A | HOH502 |
| A | HOH505 |
| A | HOH539 |
| A | HOH596 |
| A | GLY21 |
| A | LYS44 |
| A | SER45 |
| A | ASN68 |
| A | ASN128 |
| A | LYS165 |
| A | VAL194 |
| site_id | AC2 |
| Number of Residues | 12 |
| Details | binding site for residue MLI A 402 |
| Chain | Residue |
| A | LYS44 |
| A | ASN68 |
| A | MET70 |
| A | GLY71 |
| A | LEU72 |
| A | CYS131 |
| A | PRO132 |
| A | ASN133 |
| A | ASN195 |
| A | FMN401 |
| A | HOH513 |
| A | HOH530 |
| site_id | AC3 |
| Number of Residues | 7 |
| Details | binding site for residue MLI A 403 |
| Chain | Residue |
| A | ILE172 |
| A | ARG239 |
| A | ARG240 |
| A | HOH625 |
| A | HOH637 |
| B | LYS215 |
| B | GLN216 |
| site_id | AC4 |
| Number of Residues | 4 |
| Details | binding site for residue MLI A 404 |
| Chain | Residue |
| A | ARG51 |
| A | THR52 |
| A | GLY53 |
| A | HOH562 |
| site_id | AC5 |
| Number of Residues | 23 |
| Details | binding site for residue FMN B 401 |
| Chain | Residue |
| B | ALA19 |
| B | ALA20 |
| B | GLY21 |
| B | LYS44 |
| B | SER45 |
| B | ASN68 |
| B | ASN128 |
| B | LYS165 |
| B | VAL194 |
| B | ASN195 |
| B | SER196 |
| B | GLY223 |
| B | VAL226 |
| B | CYS249 |
| B | GLY250 |
| B | GLY251 |
| B | GLY272 |
| B | THR273 |
| B | MLI402 |
| B | HOH507 |
| B | HOH519 |
| B | HOH550 |
| B | HOH554 |
| site_id | AC6 |
| Number of Residues | 12 |
| Details | binding site for residue MLI B 402 |
| Chain | Residue |
| B | LYS44 |
| B | ASN68 |
| B | MET70 |
| B | GLY71 |
| B | LEU72 |
| B | CYS131 |
| B | PRO132 |
| B | ASN133 |
| B | ASN195 |
| B | FMN401 |
| B | HOH521 |
| B | HOH567 |
| site_id | AC7 |
| Number of Residues | 8 |
| Details | binding site for residue MLI B 403 |
| Chain | Residue |
| A | LYS215 |
| A | GLN216 |
| A | PHE218 |
| B | ILE172 |
| B | ARG239 |
| B | ARG240 |
| B | HOH611 |
| B | HOH670 |
| site_id | AC8 |
| Number of Residues | 6 |
| Details | binding site for residue MLI B 404 |
| Chain | Residue |
| B | ARG51 |
| B | THR52 |
| B | GLY53 |
| B | HOH552 |
| B | HOH625 |
| C | THR26 |
| site_id | AC9 |
| Number of Residues | 23 |
| Details | binding site for residue FMN C 401 |
| Chain | Residue |
| C | SER45 |
| C | ASN68 |
| C | ASN128 |
| C | LYS165 |
| C | VAL194 |
| C | ASN195 |
| C | SER196 |
| C | GLY223 |
| C | VAL226 |
| C | CYS249 |
| C | GLY250 |
| C | GLY251 |
| C | GLY272 |
| C | THR273 |
| C | MLI402 |
| C | HOH506 |
| C | HOH508 |
| C | HOH543 |
| C | HOH565 |
| C | ALA19 |
| C | ALA20 |
| C | GLY21 |
| C | LYS44 |
| site_id | AD1 |
| Number of Residues | 12 |
| Details | binding site for residue MLI C 402 |
| Chain | Residue |
| C | LYS44 |
| C | ASN68 |
| C | MET70 |
| C | GLY71 |
| C | LEU72 |
| C | CYS131 |
| C | PRO132 |
| C | ASN133 |
| C | ASN195 |
| C | FMN401 |
| C | HOH511 |
| C | HOH527 |
| site_id | AD2 |
| Number of Residues | 5 |
| Details | binding site for residue MLI C 403 |
| Chain | Residue |
| C | ILE172 |
| C | ARG239 |
| C | ARG240 |
| D | LYS215 |
| D | GLN216 |
| site_id | AD3 |
| Number of Residues | 4 |
| Details | binding site for residue MLI C 404 |
| Chain | Residue |
| C | ARG51 |
| C | THR52 |
| C | GLY53 |
| C | HOH545 |
| site_id | AD4 |
| Number of Residues | 7 |
| Details | binding site for residue MLI C 405 |
| Chain | Residue |
| C | LYS215 |
| C | GLN216 |
| C | HOH542 |
| C | HOH604 |
| D | ILE172 |
| D | ARG239 |
| D | ARG240 |
| site_id | AD5 |
| Number of Residues | 24 |
| Details | binding site for residue FMN D 401 |
| Chain | Residue |
| D | ALA19 |
| D | ALA20 |
| D | GLY21 |
| D | LYS44 |
| D | SER45 |
| D | ASN68 |
| D | ASN128 |
| D | LYS165 |
| D | VAL194 |
| D | ASN195 |
| D | SER196 |
| D | GLY223 |
| D | VAL226 |
| D | CYS249 |
| D | GLY250 |
| D | GLY251 |
| D | GLY272 |
| D | THR273 |
| D | MLI402 |
| D | HOH501 |
| D | HOH503 |
| D | HOH505 |
| D | HOH520 |
| D | HOH541 |
| site_id | AD6 |
| Number of Residues | 11 |
| Details | binding site for residue MLI D 402 |
| Chain | Residue |
| D | LYS44 |
| D | MET70 |
| D | GLY71 |
| D | LEU72 |
| D | CYS131 |
| D | PRO132 |
| D | ASN133 |
| D | ASN195 |
| D | FMN401 |
| D | HOH505 |
| D | HOH506 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 4 |
| Details | Active site: {"description":"Nucleophile","evidences":[{"evidenceCode":"ECO:0000250"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI2 |
| Number of Residues | 36 |
| Details | Binding site: {"evidences":[{"source":"PubMed","id":"18312275","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI3 |
| Number of Residues | 32 |
| Details | Binding site: {} |
| Chain | Residue | Details |
